fluorouracil has been researched along with Abnormalities, Congenital in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting." | 3.80 | Outcomes of children exposed in utero to chemotherapy for breast cancer. ( Barnett, CM; Hodge, S; Hortobagyi, GN; Litton, JK; Milbourne, A; Murthy, RK; Ramirez, MM; Rimes, SA; Theriault, RL; Valero, V, 2014) |
| " The hiPSC-EST also discerned adverse developmental outcomes driven by novel environmental toxicants." | 1.62 | An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity. ( Puig-Sanvicens, V; Rodrigues, B; Sparks, NRL; Walker, LM; Zur Nieden, NI, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, LM | 1 |
| Sparks, NRL | 1 |
| Puig-Sanvicens, V | 1 |
| Rodrigues, B | 1 |
| Zur Nieden, NI | 1 |
| Murthy, RK | 1 |
| Theriault, RL | 1 |
| Barnett, CM | 1 |
| Hodge, S | 1 |
| Ramirez, MM | 1 |
| Milbourne, A | 1 |
| Rimes, SA | 1 |
| Hortobagyi, GN | 1 |
| Valero, V | 1 |
| Litton, JK | 1 |
| DAGG, CP | 1 |
| WILSON, JG | 2 |
| Holmes, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multimodality Treatment of Primary Breast Cancer Occurring Concomitant With Pregnancy[NCT00510367] | Early Phase 1 | 61 participants (Actual) | Interventional | 2001-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Abnormalities, Congenital
| Article | Year |
|---|---|
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
5 other studies available for fluorouracil and Abnormalities, Congenital
| Article | Year |
|---|---|
An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Congenital Abnormalities; Embryonic D | 2021 |
Outcomes of children exposed in utero to chemotherapy for breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clubfoot; Congenital | 2014 |
Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil.
Topics: Animals; Congenital Abnormalities; Fluorouracil; Mice; Uracil | 1960 |
[CURRENT PROGRESS IN THE FIELD OF TERATOLOGY WITH SPECIAL REFERENCE TO THE APPLICATION OF 2 OR MORE KINDS OF AGENTS].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dactinomycin; Fluorouracil; Humans; Mercaptop | 1965 |
Penetrance and expressivity of limb malformations.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Breech Presentation; Congenital Abnormalities; Extrachr | 1979 |