fluorouracil has been researched along with Abnormalities, Autosome in 55 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genomic alterations were analyzed using single-nucleotide polymorphism arrays in 46 HER2 immunohistochemistry (IHC) 3+ or 2+/fluorescent in situ hybridization (FISH)+ breast cancers that were treated with neoadjuvant chemotherapy with paclitaxel, cyclophosphamid, epirubicin, fluorouracil, and trastuzumab." | 3.79 | Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot ( Haruta, M; Higuchi, T; Inoue, K; Kaneko, Y; Kasai, F; Kurosumi, M; Miyazaki, M; Ogawa, S; Sato-Otsubo, A; Takada, M; Takei, H; Tozuka, K; Watanabe, J, 2013) |
| " To characterise the genomic changes that induce the development of resistance to fluoropyrimidines, we used comparative genomic hybridisation (CGH) to analyse and compare the parent DLD-1 human colorectal cancer cell line and two cell lines, DLD-1/5-FU and DLD-1/FdUrd, which were resistant to 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd), respectively." | 3.72 | Chromosomal imbalances associated with acquired resistance to fluoropyrimidines in human colorectal cancer cells. ( Ayabe, H; Fukushima, M; Haseba, M; Hidaka, S; Nakagoe, T; Sawai, T; Tagawa, Y; Tsuji, T; Yamaguchi, H; Yano, H; Yasutake, T, 2003) |
| "The frequencies of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were determined in peripheral blood lymphocyte cultures from women with breast cancer treated by chemotherapy (CT) with FEC (5-fluorouracil, epirubicin, and cyclophosphamide) or CMF (cyclophosphamide, methotrexate, and 5-fluorouracil) cocktail in six CT cycles." | 3.71 | Study of chromosome damage in patients with breast cancer treated by two antineoplastic treatments. ( Carrara, HH; Silva, LM; Takahashi, CS, 2002) |
| "Chromosomal aberrations were examined in a breast cancer patient 11 years after cessation of cyclophosphamide methotraxate and 5-fluorouracil (CMF) therapy." | 3.69 | Persistence of chromosomal aberrations in blood lymphocytes 11 years after cessation of CMF therapy in a breast cancer patient. ( Bhargava, MK; Udayakumar, AM, 1996) |
| "Peripheral lymphocytes of twelve rectal cancer patients who had undergone postoperative radiochemotherapy 2-3 years ago were investigated for residual chromosomal damage using 24-color fluorescence in situ hybridization (24-color FISH)." | 2.71 | Residual chromosomal damage after radiochemotherapy with and without amifostine detected by 24-color FISH. ( Claussen, U; Dreidax, M; Dunst, J; Kuechler, A; Liehr, T; Pigorsch, SU; Wendt, TG, 2003) |
| "We report the case of an 84 years old prostate cancer patient with severe side effects after radiotherapy in 2006." | 1.39 | Persisting ring chromosomes detected by mFISH in lymphocytes of a cancer patient-a case report. ( Eble, MJ; Kriehuber, R; Pinkawa, M; Schmitz, S, 2013) |
| "In case of Head and Neck Squamous Cell Carcinoma, chromosomal changes are detectable at all stages of tumor development providing excellent opportunity for chromosomal prognosis and therapy." | 1.38 | Chromosomal rearrangements in lymphocytes of head and neck squamous cell carcinoma treated with chemotherapeutic agents. ( Desai, B; Gadhia, P, 2012) |
| "Interestingly, rare balanced chromosomal abnormalities were observed in the present cases, thus providing new insights into the leukemogenesis of therapy-related leukemia." | 1.36 | Therapy-related leukemia following chemoradiotherapy for esophageal cancer. ( Ise, M; Kumagai, K; Mimura, N; Nagata, M; Sakai, C; Takagi, T; Tsujimura, H, 2010) |
| "To measure chromosomal aberrations in blood lymphocytes from breast cancer patients treated with radiotherapy after quadrantectomy or tumorectomy." | 1.32 | Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients. ( Canale Cama, G; Cella, L; d'Alesio, V; Durante, M; Gialanella, G; Grossi, G; Pacelli, R; Pugliese, M; Punzo, G; Salvatore, M; Sardi, I; Scampoli, P; Solla, R, 2003) |
| "An analysis of chromosomal abnormalities in 10 head and neck cancer cell lines by comparative genomic hybridization was performed." | 1.32 | Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors. ( Aldosari, N; Cullen, KJ; Haddad, BR; Newkirk, KA; Rone, JD; Schumaker, LM, 2003) |
| " This indicated the gradual decline in the transmission of the induced cytogenetic toxic effects of 5-FU from spermatogonia to sperm, which might be because of gradual elimination of the grossly affected spermatogonial cells during the course of spermatogenesis." | 1.31 | Induction and transmission of cytogenetic toxic effects of 5-fluorouracil in male germline cells of Swiss mice. ( Choudhury, RC; Jagdale, MB; Misra, S; Palo, AK, 2002) |
| "Cytogenetic abnormalities were not found in the stem cell harvests of these patients by metaphase analysis or by fluorescence in situ hybridization (FISH)." | 1.31 | Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer. ( de Castro, K; Griffin, M; Hesdorffer, C; Lin, N; Murty, VV; Nichols, G; Oratzi, A; Troxel, A; Vahdat, L; Wei, LX, 2002) |
| "Early changes in karyotype detected in breast cancer patients following ASCT are transient and do not correlate with or predict development of MDS/AML." | 1.31 | Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of therapy-related leukemia or myelodysplastic syndrome. ( Arbona, C; Benet, I; Comes, AM; García Clavel, B; García-Conde, J; Lluch, A; Martínez-Climent, JA; Marugán, I; Prósper, F; Solano, C; Vizcarra, E, 2000) |
| "At 24 hrs post-treatment the induced chromosomal aberrations, mostly chromatid breaks and fragments, by all the three different concentrations of 5-FU were found statistically significant." | 1.31 | S-phase dependent cytogenetic toxicity of 5-fluorouracil in bone marrow cells of mice. ( Choudhury, RC; Jagdale, MB; Misra, S; Palo, AK, 2001) |
| "0." | 1.30 | Cytogenetic analysis of peripheral lymphocytes in medical personnel by means of FISH. ( Kucharová, S; Musilová, P; Rubes, J; Vozdová, M; Zudová, Z, 1998) |
| "typhimurium and E." | 1.29 | Mutagenic and clastogenic properties of (3-[3-(6-benzoyloxy-3-cyano-2- pyridyloxycarbonyl) benzoyl]-1-ethoxymethyl-5-fluorouracil) (BOF-A2), a new 5-fluorouracil derivative with anti-tumour activity. ( Awogi, T; Itoh, T; Kaneko, E; Kirkland, DJ; Marshall, RR; Shibahara, T; Takahashi, N; Tsushimoto, G, 1993) |
| "The chromosomes of 111 ovarian cancer patients were studied in G- and C-banded slides from peripheral blood lymphocyte (PBL) cultures for chromosome damage caused by chemotherapy and radiotherapy and for asymmetry of the constitutive heterochromatin of chromosomes 1, 9, and 16." | 1.29 | Cytogenetic findings in 111 ovarian cancer patients: therapy-related chromosome aberrations and heterochromatic variants. ( Friberg, LG; Granberg, S; Islam, MQ; Köpf, I; Levan, A; Levan, G, 1993) |
| "The level of structural chromosomal aberrations two years after the therapeutic treatment was 0." | 1.28 | [Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy]. ( Iakovleva, TK; Moiseenko, VM; Monakhov, AS, 1992) |
| "A new human colon cancer cell line (020588) has been derived by means of a combined in vitro matrix-in vivo xenograft technique." | 1.28 | A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice. ( Agrez, MV; Chua, FK; Fagan, K; Ferguson, NW; Heath, JW, 1991) |
| "Local radiotherapy as treatment for mammary cancer induced unstable chromosome aberrations in peripheral blood lymphocytes." | 1.28 | Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. I. Chromosome aberrations induced in vivo. ( Doloy, MT; Duranton, I; Guedeney, G; Leroy, A; Magdelenat, H; Rigaud, O, 1990) |
| "Lymphocytes from 43 breast cancer patients were tested for their DNA-repair ability and in vitro chromosomal radiosensitivity." | 1.28 | Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. II. Alteration of DNA repair and chromosome radiosensitivity. ( Doloy, MT; Duranton, I; Guedeney, G; Leroy, A; Magdelenat, H; Rigaud, O, 1990) |
| "The frequency of cells with chromosome aberrations in the lymphocyte culture of the patients before the treatment was significantly higher than that in the healthy donors." | 1.26 | [Cytogenetic studies of the effects of 5-fluorouracil in vivo]. ( Akulenko, TV, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (45.45) | 18.7374 |
| 1990's | 10 (18.18) | 18.2507 |
| 2000's | 13 (23.64) | 29.6817 |
| 2010's | 7 (12.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takada, M | 1 |
| Higuchi, T | 1 |
| Tozuka, K | 1 |
| Takei, H | 1 |
| Haruta, M | 1 |
| Watanabe, J | 1 |
| Kasai, F | 1 |
| Inoue, K | 1 |
| Kurosumi, M | 1 |
| Miyazaki, M | 1 |
| Sato-Otsubo, A | 1 |
| Ogawa, S | 1 |
| Kaneko, Y | 1 |
| Schmitz, S | 1 |
| Pinkawa, M | 1 |
| Eble, MJ | 1 |
| Kriehuber, R | 1 |
| González-González, M | 1 |
| Garcia, J | 1 |
| Alcazar, JA | 1 |
| Gutiérrez, ML | 1 |
| Gónzalez, LM | 1 |
| Bengoechea, O | 1 |
| Abad, MM | 1 |
| Santos-Briz, A | 1 |
| Blanco, O | 1 |
| Martín, M | 1 |
| Rodríguez, A | 1 |
| Fuentes, M | 1 |
| Muñoz-Bellvis, L | 1 |
| Orfao, A | 1 |
| Sayagues, JM | 1 |
| Mimura, N | 1 |
| Tsujimura, H | 1 |
| Ise, M | 1 |
| Sakai, C | 1 |
| Takagi, T | 1 |
| Nagata, M | 1 |
| Kumagai, K | 1 |
| Wolff, HA | 1 |
| Hennies, S | 1 |
| Herrmann, MK | 1 |
| Rave-Fränk, M | 1 |
| Eickelmann, D | 1 |
| Virsik, P | 1 |
| Jung, K | 1 |
| Schirmer, M | 1 |
| Ghadimi, M | 1 |
| Hess, CF | 1 |
| Hermann, RM | 1 |
| Christiansen, H | 1 |
| Katsube, T | 1 |
| Mori, M | 1 |
| Tsuji, H | 1 |
| Shiomi, T | 1 |
| Shiomi, N | 1 |
| Onoda, M | 1 |
| Desai, B | 1 |
| Gadhia, P | 1 |
| Silva, LM | 1 |
| Takahashi, CS | 1 |
| Carrara, HH | 1 |
| Choudhury, RC | 2 |
| Misra, S | 2 |
| Jagdale, MB | 2 |
| Palo, AK | 2 |
| Nichols, G | 1 |
| de Castro, K | 1 |
| Wei, LX | 1 |
| Griffin, M | 1 |
| Lin, N | 1 |
| Oratzi, A | 1 |
| Murty, VV | 1 |
| Troxel, A | 1 |
| Vahdat, L | 1 |
| Hesdorffer, C | 1 |
| Plasencia, C | 1 |
| Rooney, PH | 1 |
| Taron, M | 1 |
| Martinez-Balibrea, E | 1 |
| McLeod, HL | 1 |
| Abad, A | 1 |
| Hidaka, S | 1 |
| Yasutake, T | 1 |
| Fukushima, M | 2 |
| Yano, H | 1 |
| Haseba, M | 1 |
| Tsuji, T | 1 |
| Sawai, T | 1 |
| Yamaguchi, H | 1 |
| Nakagoe, T | 1 |
| Ayabe, H | 1 |
| Tagawa, Y | 1 |
| Kuechler, A | 1 |
| Dreidax, M | 1 |
| Pigorsch, SU | 1 |
| Liehr, T | 1 |
| Claussen, U | 1 |
| Wendt, TG | 1 |
| Dunst, J | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| d'Alesio, V | 1 |
| Pacelli, R | 1 |
| Durante, M | 1 |
| Canale Cama, G | 1 |
| Cella, L | 1 |
| Gialanella, G | 1 |
| Grossi, G | 1 |
| Pugliese, M | 1 |
| Punzo, G | 1 |
| Sardi, I | 1 |
| Scampoli, P | 1 |
| Solla, R | 1 |
| Salvatore, M | 1 |
| Cullen, KJ | 1 |
| Newkirk, KA | 1 |
| Schumaker, LM | 1 |
| Aldosari, N | 1 |
| Rone, JD | 1 |
| Haddad, BR | 1 |
| Dertinger, SD | 1 |
| Camphausen, K | 1 |
| Macgregor, JT | 1 |
| Bishop, ME | 1 |
| Torous, DK | 1 |
| Avlasevich, S | 1 |
| Cairns, S | 1 |
| Tometsko, CR | 1 |
| Menard, C | 1 |
| Muanza, T | 1 |
| Chen, Y | 1 |
| Miller, RK | 1 |
| Cederbrant, K | 1 |
| Sandelin, K | 1 |
| Pontén, I | 1 |
| Bolcsfoldi, G | 1 |
| Ooyama, A | 1 |
| Okayama, Y | 1 |
| Takechi, T | 1 |
| Sugimoto, Y | 1 |
| Oka, T | 1 |
| Yajima, N | 1 |
| Kondo, K | 1 |
| Morita, K | 1 |
| Chudina, AP | 1 |
| Sel'chuk, VIu | 1 |
| Goetz, P | 1 |
| Novotná, B | 1 |
| Volgareva, GM | 3 |
| Stavrovskaia, AA | 1 |
| Pogosiants, EE | 3 |
| Akulenko, TV | 1 |
| Gebhart, E | 1 |
| Lösing, J | 1 |
| Wopfner, F | 1 |
| Shibahara, T | 1 |
| Kaneko, E | 1 |
| Itoh, T | 1 |
| Awogi, T | 1 |
| Tsushimoto, G | 1 |
| Takahashi, N | 1 |
| Marshall, RR | 1 |
| Kirkland, DJ | 1 |
| Islam, MQ | 1 |
| Köpf, I | 1 |
| Levan, A | 1 |
| Granberg, S | 1 |
| Friberg, LG | 1 |
| Levan, G | 1 |
| Udayakumar, AM | 1 |
| Bhargava, MK | 1 |
| Rubes, J | 1 |
| Kucharová, S | 1 |
| Vozdová, M | 1 |
| Musilová, P | 1 |
| Zudová, Z | 1 |
| Martínez-Climent, JA | 1 |
| Comes, AM | 1 |
| Vizcarra, E | 1 |
| Benet, I | 1 |
| Arbona, C | 1 |
| Prósper, F | 1 |
| Solano, C | 1 |
| García Clavel, B | 1 |
| Marugán, I | 1 |
| Lluch, A | 1 |
| García-Conde, J | 1 |
| Bex, A | 1 |
| Wullich, B | 1 |
| Endris, V | 1 |
| Otto, T | 1 |
| Rembrink, K | 1 |
| Stöckle, M | 1 |
| Rübben, H | 1 |
| Maier, P | 1 |
| Schmid, W | 1 |
| Sokova, OI | 3 |
| Rosenberg, N | 1 |
| Schaeffer, WI | 1 |
| Diamond, L | 1 |
| Tanneberger, S | 1 |
| Hahn, S | 1 |
| Kim, DS | 1 |
| Musilová, J | 1 |
| Michalová, K | 1 |
| Urban, J | 1 |
| Iakovleva, TK | 1 |
| Monakhov, AS | 1 |
| Moiseenko, VM | 1 |
| Agrez, MV | 1 |
| Chua, FK | 1 |
| Fagan, K | 1 |
| Heath, JW | 1 |
| Ferguson, NW | 1 |
| Rosselli, F | 1 |
| Zaccaro, L | 1 |
| Venturi, M | 1 |
| Rossi, AM | 1 |
| Rigaud, O | 2 |
| Guedeney, G | 2 |
| Duranton, I | 2 |
| Leroy, A | 2 |
| Doloy, MT | 2 |
| Magdelenat, H | 2 |
| Konishi, Y | 1 |
| Kanamaru, R | 1 |
| Ishioka, C | 1 |
| Ishikawa, A | 1 |
| Shibata, H | 1 |
| Wakui, A | 1 |
| Dei, T | 1 |
| Li, GR | 1 |
| Vilpo, JA | 1 |
| Andreesu, M | 1 |
| Matefsu, C | 1 |
| Mogos, I | 1 |
| Mudric, V | 1 |
| Ehling, UH | 1 |
| Lychev, VA | 1 |
| Bridge, MF | 1 |
| Melamed, MR | 1 |
| Aingorn, ED | 2 |
| Akif'ev, AP | 2 |
| Miller, E | 1 |
| Pinsky, L | 1 |
| Fraser, FC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Cabazitaxel - Platinum Fluorouracil Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck[NCT01379339] | Phase 1 | 40 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Abnormalities, Autosome
| Article | Year |
|---|---|
Individual cell biology: basis and prospects for a rational cancer chemotherapy.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cell Cycle; Chromosome Aberrations; Cyclophospham | 1977 |
The DNA-repair enzyme uracil-DNA glycosylase in the human hematopoietic system.
Topics: Anemia, Megaloblastic; Bromodeoxyuridine; Cell Division; Chromosome Aberrations; DNA Glycosylases; D | 1988 |
The metabolism and pharmacology of 5-fluorouracil.
Topics: Adenocarcinoma; Alopecia; Animals; Breast Neoplasms; Carbon Isotopes; Cell Division; Chromosome Aber | 1971 |
2 trials available for fluorouracil and Abnormalities, Autosome
| Article | Year |
|---|---|
Comparison of the micronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy-treated patients with rectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Combined Modality Ther | 2011 |
Residual chromosomal damage after radiochemotherapy with and without amifostine detected by 24-color FISH.
Topics: Aged; Amifostine; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chromosome Aberrations; C | 2003 |
50 other studies available for fluorouracil and Abnormalities, Autosome
| Article | Year |
|---|---|
Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; | 2013 |
Persisting ring chromosomes detected by mFISH in lymphocytes of a cancer patient-a case report.
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Chromosome Aberratio | 2013 |
Association between the cytogenetic profile of tumor cells and response to preoperative radiochemotherapy in locally advanced rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Chemoradiotherapy, Ad | 2014 |
Therapy-related leukemia following chemoradiotherapy for esophageal cancer.
Topics: Aged; Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 5; Combined Modality T | 2010 |
Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chromosome Aberrations; DNA; DNA Damage; DNA | 2011 |
Chromosomal rearrangements in lymphocytes of head and neck squamous cell carcinoma treated with chemotherapeutic agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Case-Control Studies; Chro | 2012 |
Study of chromosome damage in patients with breast cancer treated by two antineoplastic treatments.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2002 |
Induction and transmission of cytogenetic toxic effects of 5-fluorouracil in male germline cells of Swiss mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Chromosome Aberrations; | 2002 |
Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, D | 2002 |
Chromosomal imbalance maps of human 5FU-resistant colorectal cancer cell lines: implications in the analysis of 5FU-acquired resistance mechanisms.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Chromosome Aberrations; Colorectal Neoplasms; Drug R | 2003 |
Chromosomal imbalances associated with acquired resistance to fluoropyrimidines in human colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Chromosome Aberrations; Colorectal Neoplasms; DNA, Neoplasm; Drug R | 2003 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chromosome | 2003 |
Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma, Squamous C | 2003 |
Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.
Topics: Adult; Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Antimetabolites, Antineoplast | 2004 |
Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.
Topics: Algorithms; Animals; Chromosome Aberrations; Drug Resistance, Neoplasm; Drug Screening Assays, Antit | 2007 |
Reverse mutation tests in Salmonella typhimurium and chromosomal aberration tests in mammalian cells in culture on fluorinated pyrimidine derivatives.
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Floxuridine; Fluorouracil; Mutag | 1981 |
[Induced chromosome aberrations in multiple primary neoplasms].
Topics: Adult; Chromosome Aberrations; Female; Fluorouracil; Humans; In Vitro Techniques; Lymphocytes; Male; | 1980 |
Clastogenic effects of ftorafur. II. Cytogenetic analyses of bone marrow in mice.
Topics: Animals; Bone Marrow; Carcinogens; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, | 1981 |
[Gene mutation induction by the antitumor preparation ftorafur].
Topics: Animals; Azaguanine; Cell Line; Cells, Cultured; Chromosome Aberrations; Cricetinae; Dose-Response R | 1982 |
[Cytogenetic studies of the effects of 5-fluorouracil in vivo].
Topics: Adult; Chromosome Aberrations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Lymphocytes; Middle | 1981 |
Chromosome studies on lymphocytes of patients under cytostatic therapy. I. Conventional chromosome studies in cytostatic interval therapy.
Topics: Adult; Aged; Antineoplastic Agents; Chromosome Aberrations; Chromosomes; Drug Administration Schedul | 1980 |
Mutagenic and clastogenic properties of (3-[3-(6-benzoyloxy-3-cyano-2- pyridyloxycarbonyl) benzoyl]-1-ethoxymethyl-5-fluorouracil) (BOF-A2), a new 5-fluorouracil derivative with anti-tumour activity.
Topics: Animals; Antineoplastic Agents; Bone Marrow; CHO Cells; Chromosome Aberrations; Cricetinae; Escheric | 1993 |
Cytogenetic findings in 111 ovarian cancer patients: therapy-related chromosome aberrations and heterochromatic variants.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chil | 1993 |
Persistence of chromosomal aberrations in blood lymphocytes 11 years after cessation of CMF therapy in a breast cancer patient.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromosome Aberrations; Cisplatin; | 1996 |
Cytogenetic analysis of peripheral lymphocytes in medical personnel by means of FISH.
Topics: Adult; Antineoplastic Agents; Chromosome Aberrations; Chromosome Banding; Cisplatin; Cyclophosphamid | 1998 |
Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of therapy-related leukemia or myelodysplastic syndrome.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Chemotherapy, | 2000 |
Comparison of the malignant phenotype and genotype of the human androgen-independent cell line DU 145 and a subline derived from metastasis after orthotopic implantation in nude mice.
Topics: Androgens; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Chromosome Aberrations; C | 2001 |
S-phase dependent cytogenetic toxicity of 5-fluorouracil in bone marrow cells of mice.
Topics: Animals; Bone Marrow Cells; Cell Line; Chromatids; Chromosome Aberrations; Cricetinae; Cyclophospham | 2001 |
Ten model mutagens evaluated by the micronucleus test.
Topics: Animals; Bleomycin; Bone Marrow; Bone Marrow Cells; Cell Line; Cell Nucleus; Chromosome Aberrations; | 1976 |
[Mechanism of the chromosome damaging effect of ftorafur].
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Floxuridine; Fluorouracil; Mito | 1977 |
Isolation of variant cells from SV-40 transformed human diploid fibroblasts.
Topics: Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Contact Inhibition; Fibroblasts; | 1975 |
[Effect of fluorofur on the chromosomes of normal and tumorous Djungarian hamster cells].
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosom | 1976 |
[Chromosome aberrations and sister chromatid exchanges following exposure of cultured Chinese hamster cells to ftorafur and 5-fluorouracil].
Topics: Cell Line; Chromatids; Chromosome Aberrations; Chromosomes; Fluorouracil; Mutagens; Tegafur | 1978 |
Detailed analysis of chromosome aberrations in human leukocyte induced by anti-malignant tumor agent (FT-207).
Topics: Cells, Cultured; Chromosome Aberrations; Female; Fluorouracil; Humans; Leukocytes; Male; Mitotic Ind | 1978 |
Sister-chromatid exchanges and chromosal breakage in patients treated with cytostatics.
Topics: Bromodeoxyuridine; Busulfan; Chromatids; Chromosome Aberrations; Cyclophosphamide; Doxorubicin; Fluo | 1979 |
[Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltr | 1992 |
A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice.
Topics: Animals; Carcinoembryonic Antigen; Cell Line; Chromosome Aberrations; Chromosome Disorders; Collagen | 1991 |
Persistence of drug-induced chromosome aberrations in peripheral blood lymphocytes of the rat.
Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; DNA; Doxorubicin; Fluorouracil | 1990 |
Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. I. Chromosome aberrations induced in vivo.
Topics: Breast Neoplasms; Cells, Cultured; Chromosome Aberrations; Cobalt; Combined Modality Therapy; Cyclop | 1990 |
Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. II. Alteration of DNA repair and chromosome radiosensitivity.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromosome Aberrations; Com | 1990 |
The changes in the levels of dihydrofolate reductase mRNA and its gene dosage in 5-fluorouracil-resistant L1210 cells.
Topics: Animals; Chromosome Aberrations; DNA, Neoplasm; Drug Resistance; Fluorouracil; Gene Amplification; L | 1990 |
[Chromosomal studies in patients with trophoblastic diseases before and after chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, Human, 1-3; Fem | 1986 |
[Chromosomal studies in correlation with other biologic constants in neoplasms treated by chemotherapy].
Topics: Adult; Antibody Formation; Bone Marrow; Cell Division; Chromosome Aberrations; Female; Fluorouracil; | 1974 |
[Proof of mutagenicity of foreign substances].
Topics: Animals; Busulfan; Carcinogens; Chromosome Aberrations; Drug Tolerance; Female; Fluorouracil; Genes, | 1973 |
[Characteristics of the cell mitotic cycle and the possibility of enhancing the effect of radiotherapy].
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Deoxyuridine; DNA, Neoplasm; Esopha | 1974 |
Leukocyte chromosome abnormalities in advanced nonhematopoietic cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; C | 1972 |
DNA synthesis outside the replication phase. Report II. An autoradiographic study of H3-thymidine incorporation into the nuclei of PHA-stimulated human lymphocytes during the G1 period.
Topics: Autoradiography; Cell Nucleus; Chromosome Aberrations; Colchicine; DNA; DNA Replication; Fluorouraci | 1972 |
DNA synthesis outside the replication phase. Report I. Cytogenetic analysis of the action of DNA-synthesis inhibitors on human lymphocytes in vitro as it relates to the functional state of the genome.
Topics: Autoradiography; Cell Division; Chromosome Aberrations; Dactinomycin; DNA; DNA Replication; Drug Int | 1974 |
Atypical malformation syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Chromosome Aberrations; Environment; Fluoroura | 1972 |