Page last updated: 2024-10-27

fluorouracil and Aberrant Crypt Foci

fluorouracil has been researched along with Aberrant Crypt Foci in 5 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.

Research Excerpts

ExcerptRelevanceReference
" In the present study, we examined the potential of DECPR to prevent colon cancer development in rats treated with azoxymethane (AOM) (15 mg/kg) by determining the percentage inhibition in incidence of aberrant crypt foci (ACF)."7.81The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. ( Abd Malek, SN; Abdulla, MA; Al-Henhena, N; Awang, K; Hasanpourghadi, M; Kunasegaran, T; Looi, CY; Moghadamtousi, SZ; Mohamed, Z; Rouhollahi, E, 2015)
"The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (Japanese: Reishi or Mannentake) (designated as MAK) exerted a protective effect against induction of aberrant crypt foci (ACF) by azoxymethane (AOM) and small-intestinal damage induced by the anticancer drug 5-FU."7.79Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats. ( Kashimoto, N; Tamura, K; Ushijima, M; Watanabe, H, 2013)
" In vivo pellet coating led to reduced drug bioavailability and enhanced drug accumulation at colon (179."5.40Oral 5-fluorouracil colon-specific delivery through in vivo pellet coating for colon cancer and aberrant crypt foci treatment. ( Bose, A; Elyagoby, A; Wong, TW, 2014)
" In the present study, we examined the potential of DECPR to prevent colon cancer development in rats treated with azoxymethane (AOM) (15 mg/kg) by determining the percentage inhibition in incidence of aberrant crypt foci (ACF)."3.81The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. ( Abd Malek, SN; Abdulla, MA; Al-Henhena, N; Awang, K; Hasanpourghadi, M; Kunasegaran, T; Looi, CY; Moghadamtousi, SZ; Mohamed, Z; Rouhollahi, E, 2015)
"The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (Japanese: Reishi or Mannentake) (designated as MAK) exerted a protective effect against induction of aberrant crypt foci (ACF) by azoxymethane (AOM) and small-intestinal damage induced by the anticancer drug 5-FU."3.79Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats. ( Kashimoto, N; Tamura, K; Ushijima, M; Watanabe, H, 2013)
" In vivo pellet coating led to reduced drug bioavailability and enhanced drug accumulation at colon (179."1.40Oral 5-fluorouracil colon-specific delivery through in vivo pellet coating for colon cancer and aberrant crypt foci treatment. ( Bose, A; Elyagoby, A; Wong, TW, 2014)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Socca, EAR1
Reis, SK1
Genaro, SC1
Leite, SK1
Reis, IB1
Bockëlmann, PK1
Durán, N1
Fávaro, WJ1
Bose, A1
Elyagoby, A1
Wong, TW1
Wang, K1
Kim, MK1
Di Caro, G1
Wong, J1
Shalapour, S1
Wan, J1
Zhang, W1
Zhong, Z1
Sanchez-Lopez, E1
Wu, LW1
Taniguchi, K1
Feng, Y1
Fearon, E1
Grivennikov, SI1
Karin, M1
Rouhollahi, E1
Moghadamtousi, SZ1
Al-Henhena, N1
Kunasegaran, T1
Hasanpourghadi, M1
Looi, CY1
Abd Malek, SN1
Awang, K1
Abdulla, MA1
Mohamed, Z1
Watanabe, H1
Kashimoto, N1
Ushijima, M1
Tamura, K1

Other Studies

5 other studies available for fluorouracil and Aberrant Crypt Foci

ArticleYear
P-mapa, a promisor immunomodulator against tumor cells of colonic tissues: An investigation of the action mechanism over the TLR4 signaling pathway.
    Life sciences, 2020, Feb-01, Volume: 242

    Topics: Aberrant Crypt Foci; Animals; Antineoplastic Agents; Biopolymers; Colonic Neoplasms; Enzyme-Linked I

2020
Oral 5-fluorouracil colon-specific delivery through in vivo pellet coating for colon cancer and aberrant crypt foci treatment.
    International journal of pharmaceutics, 2014, Jul-01, Volume: 468, Issue:1-2

    Topics: Aberrant Crypt Foci; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Antimetabolites, Antine

2014
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
    Immunity, 2014, Dec-18, Volume: 41, Issue:6

    Topics: Aberrant Crypt Foci; Animals; Antibodies, Blocking; Antineoplastic Combined Chemotherapy Protocols;

2014
The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Aberrant Crypt Foci; Animals; Antioxidants; Apoptosis; Azoxymethane; Chemoprevention; Colonic Neopla

2015
Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats.
    Medical molecular morphology, 2013, Volume: 46, Issue:2

    Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Colonic Neoplasms; Culture Media; Fluorouracil; Intestin

2013