fluorouracil has been researched along with ALS - Amyotrophic Lateral Sclerosis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pokrishevsky, E | 1 |
| Hong, RH | 1 |
| Mackenzie, IR | 1 |
| Cashman, NR | 1 |
| Rando, A | 1 |
| de la Torre, M | 1 |
| Martinez-Muriana, A | 1 |
| Zaragoza, P | 1 |
| Musaro, A | 1 |
| Hernández, S | 1 |
| Navarro, X | 1 |
| Toivonen, JM | 1 |
| Osta, R | 1 |
| Sato, Y | 2 |
| Takayama, T | 1 |
| Nikaido, T | 1 |
| Wada, Y | 1 |
| Sagawa, T | 1 |
| Abe, S | 1 |
| Sato, T | 1 |
| Iyama, S | 1 |
| Murase, K | 1 |
| Araki, H | 1 |
| Kato, J | 1 |
| Niitsu, Y | 1 |
| Chiba, H | 1 |
| Koike, H | 1 |
4 other studies available for fluorouracil and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.
Topics: Algorithms; Amyotrophic Lateral Sclerosis; Animals; Antibodies; Fluorouracil; Genes, Reporter; Green | 2017 |
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Disease | 2019 |
Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis.
Topics: Adenocarcinoma; Amyotrophic Lateral Sclerosis; Antineoplastic Combined Chemotherapy Protocols; Campt | 2007 |
[Free amino acid changes in rat brain after intracysternal injection of antimetabolites -- comparison to those in amyotrophic lateral sclerosis (author's transl)].
Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Animals; Brain; Brain Chemistry; Dactinomycin; Fluoroura | 1981 |