fluorouracil has been researched along with AIDS Seroconversion in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anal cancer is an increasing issue in HIV-positive men who have sex with men (MSM)." | 6.78 | Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial. ( de Vries, HJ; Dijkgraaf, MG; Prins, JM; Richel, O; van Noesel, CJ, 2013) |
| "Forty-two consecutive patients with anal canal cancer were treated with 15 fractions of 30-Gy photon beam radiation therapy administered anteroposterior-posteroanterior in conjunction with chemotherapy with 5-fluorouracil and mitomycin C." | 3.69 | Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy. ( Anderson, PJ; Frost, DB; Kagan, AR; Latino, F; Peddada, AV; Rao, AR; Shah, KH; Smith, DE, 1994) |
| "Anal cancer is an increasing issue in HIV-positive men who have sex with men (MSM)." | 2.78 | Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial. ( de Vries, HJ; Dijkgraaf, MG; Prins, JM; Richel, O; van Noesel, CJ, 2013) |
| "Although anal canal squamous cell carcinoma is rare, the general practitioner should consider this diagnosis in a patient with persistent lower abdominal symptoms." | 2.47 | [Management of anal canal carcinoma]. ( Betz, M; Cochet, S; George, AC; Roth, A; Thang, NN, 2011) |
| "In response to repeated observations of cervical cancers in HIV-infected women, moderate and severe cervical dysplasia were designated as early symptomatic HIV infection (Category B) by the Centers for Disease Control and Prevention (CDC) in 1993, and invasive cervical cancer as an AIDS-defining condition (Category C)." | 2.43 | Cervical screening and management of cervical intraepithelial neoplasia in HIV-positive women. ( Bradbeer, C; Danso, D; Lyons, F, 2006) |
| "During the past two decades, anal cancer has served as a paradigm for the successful application of chemoradiation to solid tumours; so far, it remains one of the few carcinomas of the gastrointestinal tract which are curable without the need for definitive surgery." | 2.42 | Chemotherapeutic options in the management of anal cancer. ( Allal, AS; Gervaz, P; Morel, P; Roth, A, 2004) |
| "HIV-positive patients with anal cancer can be treated with standard CRT, with the same tolerability and toxicity as HIV-negative patients." | 1.37 | Concurrent chemoradiotherapy with 5-fluorouracil and mitomycin C for anal carcinoma: are there differences between HIV-positive and HIV-negative patients in the era of highly active antiretroviral therapy? ( Fraunholz, I; Gerstein, J; Haberl, A; Jäck, K; Rabeneck, D; Rödel, C; Weiss, C, 2011) |
| "We report a case of squamous cell carcinoma of the anus with associated HIV infection." | 1.36 | [A case of squamous cell carcinoma of the anal cancer with associated human immunodeficiency virus]. ( Fujitani, K; Hirao, M; Ikenaga, M; Mishima, H; Miyamoto, A; Miyazaki, M; Nakamori, S; Omiya, H; Sueda, K; Takami, K; Tsujie, M; Tsujinaka, T; Yasui, M; Yoshida, K, 2010) |
| "Among them, three patients had acquired immunodeficiency syndrome (AIDS)." | 1.29 | Squamous-cell carcinoma of the anus in HIV-positive patients. ( Berson, A; Chadha, M; Malamud, S; Pisch, J; Rosenblatt, EA, 1994) |
| "Seven patients had HIV, four of whom had acquired immunodeficiency syndrome." | 1.29 | Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy. ( Holland, JM; Swift, PS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richel, O | 1 |
| de Vries, HJ | 1 |
| van Noesel, CJ | 1 |
| Dijkgraaf, MG | 1 |
| Prins, JM | 1 |
| Seo, Y | 1 |
| Kinsella, MT | 1 |
| Reynolds, HL | 1 |
| Chipman, G | 1 |
| Remick, SC | 1 |
| Kinsella, TJ | 1 |
| Myerson, RJ | 1 |
| Outlaw, ED | 1 |
| Chang, A | 1 |
| Birnbaum, EH | 1 |
| Fleshman, JW | 1 |
| Grigsby, PW | 1 |
| Kodner, IJ | 1 |
| Malayapa, RS | 1 |
| Mutch, MG | 1 |
| Parikh, P | 1 |
| Picus, J | 1 |
| Tan, BR | 1 |
| Fraunholz, I | 1 |
| Rabeneck, D | 1 |
| Gerstein, J | 1 |
| Jäck, K | 1 |
| Haberl, A | 1 |
| Weiss, C | 1 |
| Rödel, C | 1 |
| Sueda, K | 1 |
| Ikenaga, M | 1 |
| Miyazaki, M | 1 |
| Yasui, M | 1 |
| Mishima, H | 1 |
| Tsujie, M | 1 |
| Omiya, H | 1 |
| Miyamoto, A | 1 |
| Hirao, M | 1 |
| Takami, K | 1 |
| Fujitani, K | 1 |
| Nakamori, S | 1 |
| Yoshida, K | 1 |
| Tsujinaka, T | 1 |
| Thang, NN | 1 |
| Cochet, S | 1 |
| George, AC | 1 |
| Betz, M | 1 |
| Roth, A | 2 |
| Gervaz, P | 1 |
| Allal, AS | 1 |
| Morel, P | 1 |
| Ortholan, C | 1 |
| François, E | 1 |
| Gérard, JP | 1 |
| Oehler-Jänne, C | 1 |
| Seifert, B | 1 |
| Lütolf, UM | 1 |
| Ciernik, IF | 1 |
| Danso, D | 1 |
| Lyons, F | 1 |
| Bradbeer, C | 1 |
| Deniaud-Alexandre, E | 1 |
| Touboul, E | 1 |
| Tiret, E | 1 |
| Sezeur, A | 1 |
| Hannoun, L | 1 |
| Houry, S | 1 |
| Huguet, F | 1 |
| Pène, F | 1 |
| Parc, R | 1 |
| Schlienger, M | 1 |
| Chadha, M | 1 |
| Rosenblatt, EA | 1 |
| Malamud, S | 1 |
| Pisch, J | 1 |
| Berson, A | 1 |
| Holland, JM | 1 |
| Swift, PS | 1 |
| Smith, DE | 1 |
| Shah, KH | 1 |
| Rao, AR | 1 |
| Frost, DB | 1 |
| Latino, F | 1 |
| Anderson, PJ | 1 |
| Peddada, AV | 1 |
| Kagan, AR | 1 |
| Hoffman, R | 1 |
| Welton, ML | 1 |
| Klencke, B | 1 |
| Weinberg, V | 1 |
| Krieg, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Pomalidomide in Anal Cancer Precursors (SPACE): a Phase 2 Study of Immunomodulation in People With Persistent HPV-associated High Grade Squamous Intraepithelial Lesions[NCT03113942] | Phase 2 | 26 participants (Actual) | Interventional | 2017-06-14 | Active, not recruiting | ||
| Efficacy and Safety of Topical Trichloroacetic Acid vs. Electrocautery for the Treatment of Anal Intraepithelial Neoplasia in HIV-positive Patients (TECAIN) - a Randomized Controlled Trial[NCT02615860] | 560 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and AIDS Seroconversion
| Article | Year |
|---|---|
[Management of anal canal carcinoma].
Topics: Anal Canal; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell | 2011 |
Chemotherapeutic options in the management of anal cancer.
Topics: Anus Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Fluorouracil; HIV Se | 2004 |
Cervical screening and management of cervical intraepithelial neoplasia in HIV-positive women.
Topics: Antiretroviral Therapy, Highly Active; Female; Fluorouracil; Follow-Up Studies; Forecasting; HIV Inf | 2006 |
2 trials available for fluorouracil and AIDS Seroconversion
10 other studies available for fluorouracil and AIDS Seroconversion
| Article | Year |
|---|---|
Outcomes of chemoradiotherapy with 5-Fluorouracil and mitomycin C for anal cancer in immunocompetent versus immunodeficient patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carc | 2009 |
Radiotherapy for epidermoid carcinoma of the anus: thirty years' experience.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols | 2009 |
Concurrent chemoradiotherapy with 5-fluorouracil and mitomycin C for anal carcinoma: are there differences between HIV-positive and HIV-negative patients in the era of highly active antiretroviral therapy?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; | 2011 |
[A case of squamous cell carcinoma of the anal cancer with associated human immunodeficiency virus].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2010 |
[Chemoradiotherapy and anal canal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Clinical Trials, Phase III as Topic; | 2005 |
[Epidermoid carcinomas of anal canal treated with radiation therapy and concomitant chemotherapy (5-fluorouracil and cisplatin)].
Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Antimetabolites, Antineoplastic; Antineoplastic Combined | 2006 |
Squamous-cell carcinoma of the anus in HIV-positive patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anu | 1994 |
Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Combined Chemotherapy Protocols; Anus Neop | 1994 |
Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Carcinoma, | 1994 |
The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; CD4 Lymphocyte Count; Cisplatin; Com | 1999 |