fluorouracil has been researched along with AIDS-Related Opportunistic Infections in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richel, O | 1 |
| Wieland, U | 1 |
| de Vries, HJ | 1 |
| Brockmeyer, NH | 1 |
| van Noesel, C | 1 |
| Potthoff, A | 1 |
| Prins, JM | 1 |
| Kreuter, A | 1 |
| Dhiver, C | 1 |
| Milandre, C | 1 |
| Poizot-Martin, I | 1 |
| Drogoul, MP | 1 |
| Gastaut, JL | 1 |
| Gastaut, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Topical Trichloroacetic Acid vs. Electrocautery for the Treatment of Anal Intraepithelial Neoplasia in HIV-positive Patients (TECAIN) - a Randomized Controlled Trial[NCT02615860] | 560 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for fluorouracil and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
Topics: Administration, Topical; Adult; Aged; AIDS-Related Opportunistic Infections; Antimetabolites, Antine | 2010 |
Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
Topics: Administration, Topical; Adult; Aged; AIDS-Related Opportunistic Infections; Antimetabolites, Antine | 2010 |
Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
Topics: Administration, Topical; Adult; Aged; AIDS-Related Opportunistic Infections; Antimetabolites, Antine | 2010 |
Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
Topics: Administration, Topical; Adult; Aged; AIDS-Related Opportunistic Infections; Antimetabolites, Antine | 2010 |
5-Fluoro-uracil-clindamycin for treatment of cerebral toxoplasmosis.
Topics: AIDS-Related Opportunistic Infections; Clindamycin; Drug Therapy, Combination; Fluorouracil; Humans; | 1993 |