fluorouracil has been researched along with 2019 Novel Coronavirus Disease in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The outbreak of coronavirus disease 2019 (COVID-19) has affected the treatment of cancer patients, with particular regard to the management of both chemotherapy and side effects." | 5.62 | NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study. ( Caputo, V; Cicero, G; De Luca, R; Ferrera, G; Mistretta, O; Paci, R; Rosati, G; Volpe, C, 2021) |
| "Carmofur, 1-hexylcarbamoyl-5-fluorouracil (HCFU) is an antineoplastic drug, which has been in clinics in Japan since 1981 for the treatment of colorectal cancer." | 5.22 | Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology. ( Islam, MM; Mirza, SP, 2022) |
| "The outbreak of coronavirus disease 2019 (COVID-19) has affected the treatment of cancer patients, with particular regard to the management of both chemotherapy and side effects." | 1.62 | NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study. ( Caputo, V; Cicero, G; De Luca, R; Ferrera, G; Mistretta, O; Paci, R; Rosati, G; Volpe, C, 2021) |
| " The author here is proposing to test 5-FU in combination with a number of deoxynucleosides on animal models infected with this Covid-19." | 1.56 | 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection. ( Ahmad, SI, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 9 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Luca, R | 1 |
| Volpe, C | 1 |
| Mistretta, O | 1 |
| Paci, R | 1 |
| Ferrera, G | 1 |
| Caputo, V | 1 |
| Rosati, G | 1 |
| Cicero, G | 1 |
| Giudetti, G | 1 |
| Polyakov, I | 1 |
| Grigorenko, BL | 1 |
| Faraji, S | 1 |
| Nemukhin, AV | 1 |
| Krylov, AI | 1 |
| Islam, MM | 1 |
| Mirza, SP | 1 |
| Kasuga, A | 1 |
| Nojima, M | 1 |
| Okamoto, T | 1 |
| Ishitsuka, T | 1 |
| Yamada, M | 1 |
| Nakagawa, H | 1 |
| Udagawa, S | 1 |
| Mori, C | 1 |
| Mie, T | 1 |
| Furukawa, T | 1 |
| Yamada, Y | 1 |
| Takeda, T | 1 |
| Matsuyama, M | 1 |
| Sasaki, T | 1 |
| Ozaka, M | 1 |
| Sasahira, N | 1 |
| Kang, KM | 1 |
| Jang, Y | 1 |
| Lee, SS | 1 |
| Jin, MS | 1 |
| Jun, CD | 1 |
| Kim, M | 1 |
| Kim, YC | 1 |
| Jin, Z | 1 |
| Zhao, Y | 1 |
| Sun, Y | 1 |
| Zhang, B | 1 |
| Wang, H | 1 |
| Wu, Y | 1 |
| Zhu, Y | 1 |
| Zhu, C | 1 |
| Hu, T | 1 |
| Du, X | 1 |
| Duan, Y | 1 |
| Yu, J | 1 |
| Yang, X | 2 |
| Yang, K | 1 |
| Liu, X | 1 |
| Guddat, LW | 1 |
| Xiao, G | 1 |
| Zhang, L | 1 |
| Yang, H | 1 |
| Rao, Z | 1 |
| Ahmad, SI | 1 |
| Vidra, R | 1 |
| Bodea, R | 1 |
| Mercea, V | 1 |
| Nemes, A | 1 |
| Hanna, CR | 1 |
| Boyd, KA | 1 |
| Wincenciak, J | 1 |
| Graham, J | 1 |
| Iveson, T | 1 |
| Jones, RJ | 1 |
| Wilson, R | 1 |
1 review available for fluorouracil and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Colorectal Neoplasms; COVID-19; Fluorouracil; Humans | 2022 |
8 other studies available for fluorouracil and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study.
Topics: Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms | 2021 |
How Reproducible Are QM/MM Simulations? Lessons from Computational Studies of the Covalent Inhibition of the SARS-CoV-2 Main Protease by Carmofur.
Topics: Coronavirus 3C Proteases; COVID-19; Fluorouracil; Humans; Quantum Theory; Reproducibility of Results | 2022 |
Impact of the COVID-19 Pandemic on the Management and End-of-life Care of Unresectable Pancreatic Cancer.
Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; COVID-19; Deoxycytidine; Fluorouracil; Hum | 2022 |
Discovery of antiviral SARS-CoV-2 main protease inhibitors by structure-guided hit-to-lead optimization of carmofur.
Topics: Antiviral Agents; COVID-19; Fluorouracil; Humans; SARS-CoV-2 | 2023 |
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Topics: Animals; Betacoronavirus; Chlorocebus aethiops; Coronavirus 3C Proteases; Coronavirus Infections; CO | 2020 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronaviru | 2020 |
Challenges of pancreatic cancer chemotherapy in the COVID-19 era.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Betacoronavirus; Capeci | 2020 |
Do clinical trials change practice? A longitudinal, international assessment of colorectal cancer prescribing practices.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials as Top | 2021 |