Page last updated: 2024-08-26

fluoromisonidazole and Hypoxia

fluoromisonidazole has been researched along with Hypoxia in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.99)	18.7374
1990's	4 (5.97)	18.2507
2000's	10 (14.93)	29.6817
2010's	39 (58.21)	24.3611
2020's	12 (17.91)	2.80

Authors

Authors	Studies
Angermeier, A; Della Manna, D; Larimer, BM; Li, Y; Reeves, KM; Song, PN; Sorace, AG; Wang, J; Yang, ES	1
Alber, M; Belka, C; La Fougère, C; Nikolaou, K; Paulsen, F; Pfannenberg, C; Reimold, M; Reischl, G; Thorwarth, D; Welz, S; Zips, D	1
Chu, L; Chu, X; Guo, T; Jiang, S; Li, Y; Ni, J; Yang, X; Zhou, Y; Zhu, Z; Zou, L	1
Barbier, EL; Bernaudin, M; Chakhoyan, A; Chazalviel, L; Corroyer-Dulmont, A; Divoux, D; Guillouet, S; Toutain, J; Touzani, O; Valable, S	1
Bourigault, P; Higgins, GS; Macpherson, RE; McGowan, DR; Skwarski, M	1
Boeke, S; Bowden, G; Cotton, J; Krueger, MA; Leibfarth, S; Pichler, BJ; Thorwarth, D; Winter, RM; Zips, D	1
Larimer, B; Lima, EABF; Reeves, K; Song, PN; Sorace, AG; Yankeelov, TE	1
Furuya, S; Hirata, K; Kobayashi, H; Kobayashi, K; Kudo, K; Kuge, Y; Magota, K; Manabe, O; Shiga, T; Tamaki, N; Terasaka, S; Toyonaga, T; Yamaguchi, S	1
Baell, JB; Davis, TP; Davydova, M; Goos, JACM; Greguric, I; Lengkeek, N; Lewis, JS; Quinn, JF; Whittaker, MR	1
Baumann, M; Boeke, S; Gregoire, V; Hofheinz, F; Johansen, J; Krause, M; Löck, S; Mönnich, D; Overgaard, J; Saksø Mortensen, L; Saksø, M; Seidlitz, A; Skripcak, T; Troost, EGC; Zips, D; Zöphel, K; Zschaeck, S	1
Arnberg, F; Holmin, S; Ingemann Jensen, A; Jussing, E; Little, PV; Lu, L; Mitsios, N; Mulder, J; Tran, TA	1
Andreev, DN; Bellaye, PS; Bonniaud, P; Bouchard, A; Cochet, A; Collin, B; Frenay, J; Goirand, F; Guillemin, M; Helbling, A; Kucheryavy, YA; Mayev, IV; Moreau, M; Mothes, C; Oudot, A; Tanguy, J	1
Grimes, DR; Warren, DR; Warren, S	1
Huang, Y; Li, L; Liu, W; Lu, H; Wei, Y; Yu, J; Yu, Q; Yuan, S; Zhao, S; Zheng, J	1
Dong, M; Guo, S; Han, X; Li, G; Li, H; Lin, Y; Mi, Y; Ruan, Q; Wang, B; Xu, D; Zhang, X	1
Shimizu, Y	1
Carson, RE; Chan, C; Fung, EK; Jin, X; Liu, C; Mulnix, T; Naganawa, M	1
Badimon, JJ; Fayad, ZA; Fuster, V; Izquierdo-Garcia, D; Mateo, J	1
Fatema, CN; Kitagawa, Y; Kuge, Y; Nishijima, K; Tamaki, N; Yasuda, K; Yu, W; Zhao, S; Zhao, Y	1
Hawkins-Daarud, AJ; Hendrickson, K; Jacobs, J; Kinahan, P; Krohn, KA; Mrugala, MM; Neal, ML; Rockhill, JK; Rockne, RC; Swanson, KR; Trister, AD	1
Banerjee, S; Mallia, MB; Mathur, A; Sarma, HD	1
Akula, MR; Bois, F; Carlson, DJ; Collier, L; Hammond, K; Huang, Y; Kabalka, GW; Kelada, OJ; Ropchan, J; Zheng, MQ	1
Bezak, E; Jennings, M; Marcu, LG	1
Fink, JR; Krohn, KA; Mankoff, DA; McLaughlin, LJ; Muzi, JP; Muzi, M; O'Sullivan, JN; Peterson, LM; Rajendran, JG	1
Mönnich, D; Thorwarth, D; Troost, EG; van Elmpt, W; Wack, LJ; Zegers, CM; Zips, D	1
Cui, YL; Li, XF; Wang, X	1
Hamaji, M; Harada, H; Kimura, H; Koizumi, K; Koyasu, S; Nakamoto, Y; Nobashi, T; Sano, K; Togashi, K; Tsuji, Y	1
Abolmaali, N; Appold, S; Baumann, M; Gudziol, V; Haase, R; Kotzerke, J; Krause, M; Perrin, R; Richter, C; Steinbach, J; Stützer, K; Zips, D; Zöphel, K; Zschaeck, S	1
Bittner, MI; Bucher, S; Grosu, AL; Hentschel, M; Mix, M; Nestle, U; Pfeiffer, J; Vach, W; Weber, WA; Wiedenmann, NE	1
la Fougère, C; Mauz, PS; Mönnich, D; Nikolaou, K; Pfannenberg, C; Reischl, G; Thorwarth, D; Welz, S; Zips, D	1
Higashino, K; Kuge, Y; Masaki, Y; Nishijima, K; Numata, Y; Sakamoto, S; Shimizu, Y; Tamaki, N; Tanaka, Y; Yamaguchi, Y; Yoshioka, T; Zhao, S	1
Carlin, SD; Gönen, M; Grkovski, M; Humm, JL; Lee, NY; Nehmeh, SA; Schöder, H; Schwartz, J; Zanzonico, PB	1
Yoshimoto, M	1
Aigbirhio, FI; Carter, EL; Coles, JP; Fryer, TD; Gee, GS; Geeraerts, T; Grossac, J; Hong, YT; Lupson, V; Menon, DK; Newcombe, VF; Outtrim, J; Smith, R; Veenith, TV	1
Hu, X; Huang, Y; Wang, S; Wei, Y; Yu, J; Yu, Q; Yuan, S; Zhao, S; Zhao, W; Zhu, S	1
Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D	1
Anzellotti, AI; Frank, JE; Hillesheim, DA; Khachaturian, MH; Merrill, JR; Yuan, H	1
Partridge, M; Warren, DR	1
Cheguillaume, A; De Bast, M; de Groot, T; Gillart, J; Grégoire, V; Haustermans, K; Labar, D; Mahy, P	1
Bol, A; Bormans, G; Cloetens, L; Dubois, L; Grégoire, V; Haustermans, K; Labar, D; Landuyt, W; Mortelmans, L; Nuyts, J	1
Adamsen, TC; Chakraborty, G; Harpold, HL; Krohn, KA; Muzi, M; Rockne, R; Spence, AM; Swanson, KR; Wang, CH	1
Ametamey, S; Dominietto, M; Honer, M; Keist, R; Kotevic, I; Lehmann, S; Rudin, M; Stiehl, DP; Wenger, RH; Wollenick, K	1
Georgi, JC; Guillem, J; Humm, JL; Lee, NY; Narayanan, M; Schöder, H; Wang, W	1
Bentzen, L; Buus, S; Keiding, S; Mortensen, LS; Munk, OL; Nordsmark, M; Overgaard, J	1
Donnan, GA; Howells, DW; McLeod, DD; Spratt, NJ	1
Alber, M; Kaanders, JH; Mönnich, D; Oyen, WJ; Thorwarth, D; Troost, EG	2
Alessio, AM; Alvord, EC; Anderson, AR; Chakraborty, G; Champley, K; Claridge, J; Gu, S; Kinahan, PE; Krohn, KA; Muzi, M; Rockne, R; Spence, AM; Swanson, KR	1
Blower, PJ; Handley, MG; Medina, RA; Nagel, E; Southworth, R	1
Allen, PD; Cornelissen, B; Dilworth, JR; Falzone, N; Gouverneur, V; Hill, SA; Hueting, R; Hussien, K; Kersemans, V; Muschel, RJ; Smart, SC; Tredwell, M	1
Aga, F; Kawai, N; Kudomi, N; Maeda, Y; Nishiyama, Y; Ono, Y; Yamamoto, Y	1
Chowdhury, NF; Kuge, Y; Murakami, M; Nishijima, K; Takiguchi, M; Tamaki, N; Yu, W; Zhao, S; Zhao, Y	1
Askoxylakis, V; Bischof, M; Debus, J; Dimitrakopoulou-Strauss, A; Dinkel, J; Eichinger, M; Haberkorn, U; Huber, PE; Kopp-Schneider, A; Sommer, G; Stieltjes, B; Strauss, LG; Thieke, C	1
Ito, YM; Kasai, K; Kuge, Y; Magota, K; Okamoto, S; Shiga, T; Shirato, H; Tamaki, N; Yasuda, K	1
Barré, L; Bernaudin, M; Corroyer-Dulmont, A; Divoux, D; Durand, L; MacKenzie, ET; Marteau, L; Pérès, EA; Petit, E; Roussel, S; Toutain, J; Valable, S	1
Bolton, DM; Davis, ID; Foo, SS; Lawrentschuk, N; Murone, C; Poon, AM; Putra, LG; Scott, AM	1
Alber, M; Eschmann, SM; Paulsen, F; Scheiderbauer, J; Thorwarth, D	1
Buell, U; Coenen, HH; DiMartino, E; Eble, M; Gagel, B; Hamacher, K; Reinartz, P; Westhofen, M; Zimny, M	1
Chang, CW; Chen, CH; Chou, TK; Lin, WJ; Liu, RS; Wang, HE; Wang, SJ	1
Brader, P; Fong, Y; Hricak, H; Humm, JL; Ling, CC; Reid, V; Riedl, CC; Wen, B; Woo, Y; Zanzonico, P	1
Casciari, JJ; Graham, MM; Rasey, JS	1
Berridge, MS; Lim, JL	1
Donnan, GA; Hirano, T; Kazui, S; Markus, R; O'Keefe, GJ; Read, S; Reutens, DC; Sachinidis, JI; Scott, AM; Tochon-Danguy, HJ	1
Dence, CS; Hotchkiss, RS; Hwang, DR; Karl, IE; Rust, RS; Song, SK; Wasserman, TH; Welch, MJ	1
Caldwell, JH; Cerqueira, MD; Embree, L; Krohn, KA; Martin, GV; Rasey, JS	1
Dischino, DD; Jerabek, PA; Kilbourn, MR; Patrick, TB; Welch, MJ	1
Durand, RE; Grunbaum, Z; Krohn, KA; Magee, S; Nelson, NJ; Olive, PL; Rasey, JS	1

Reviews

7 review(s) available for fluoromisonidazole and Hypoxia

Article	Year
Individual patient data meta-analysis of FMISO and FAZA hypoxia PET scans from head and neck cancer patients undergoing definitive radio-chemotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020, Volume: 149 Topics: Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Misonidazole; Multicenter Studies as Topic; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals	2020
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2021, Volume: 121, Issue:1 Topics: Abdominal Pain; Animals; Biomarkers; Disease Progression; Dyspepsia; Fluorodeoxyglucose F18; Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Mice; Misonidazole; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Prevalence; Radiopharmaceuticals; Sleep Wake Disorders	2021
Hypoxia imaging and radiotherapy: bridging the resolution gap. The British journal of radiology, 2017, Volume: 90, Issue:1076 Topics: Cell Hypoxia; Humans; Hypoxia; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiotherapy Dosage	2017
[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2018, Volume: 138, Issue:11 Topics: Animals; Glutathione; Glutathione Transferase; Humans; Hypoxia; Mass Spectrometry; Mice; Misonidazole; Molecular Imaging; Molecular Probes; Multidrug Resistance-Associated Proteins; Neoplasms; Nitroimidazoles; Positron-Emission Tomography	2018
PET-specific parameters and radiotracers in theoretical tumour modelling. Computational and mathematical methods in medicine, 2015, Volume: 2015 Topics: Cell Proliferation; Coordination Complexes; Dideoxynucleosides; Diffusion; Fluorodeoxyglucose F18; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hydrogen-Ion Concentration; Hypoxia; Misonidazole; Models, Theoretical; Multimodal Imaging; Neoplasms; Neovascularization, Pathologic; Organometallic Compounds; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones; Tomography, X-Ray Computed	2015
[Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy]. Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 2015, Volume: 35, Issue:1 Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Coordination Complexes; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones	2015
PET imaging of cardiac hypoxia: opportunities and challenges. Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:5 Topics: Acidosis; Animals; Copper; Copper Radioisotopes; Coronary Artery Disease; Coronary Circulation; Humans; Hypoxia; Misonidazole; Myocardial Ischemia; Myocardium; Oxygen; Positron-Emission Tomography; Radiation-Sensitizing Agents; Rats; Reducing Agents; Sensitivity and Specificity; Thiosemicarbazones; Tissue Distribution	2011

Trials

6 trial(s) available for fluoromisonidazole and Hypoxia

Article	Year
Dose escalation to hypoxic subvolumes in head and neck cancer: A randomized phase II study using dynamic [ Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2022, Volume: 171 Topics: Head and Neck Neoplasms; Humans; Hypoxia; Misonidazole; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals	2022
Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure. Acta oncologica (Stockholm, Sweden), 2015, Volume: 54, Issue:9 Topics: Carcinoma, Squamous Cell; Chemoradiotherapy; Female; Head and Neck Neoplasms; Humans; Hypoxia; Image Interpretation, Computer-Assisted; Male; Middle Aged; Misonidazole; Multimodal Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed	2015
Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 117, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chemoradiotherapy; Feasibility Studies; Female; Fluorine Radioisotopes; Head and Neck Neoplasms; Humans; Hypoxia; Kaplan-Meier Estimate; Male; Middle Aged; Misonidazole; Positron-Emission Tomography; Treatment Outcome; Tumor Burden	2015
Robustness of quantitative hypoxia PET image analysis for predicting local tumor control. Acta oncologica (Stockholm, Sweden), 2015, Volume: 54, Issue:9 Topics: Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Image Interpretation, Computer-Assisted; Male; Middle Aged; Misonidazole; Multicenter Studies as Topic; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Squamous Cell Carcinoma of Head and Neck	2015
A Comparative Study of Noninvasive Hypoxia Imaging with 18F-Fluoroerythronitroimidazole and 18F-Fluoromisonidazole PET/CT in Patients with Lung Cancer. PloS one, 2016, Volume: 11, Issue:6 Topics: Adult; Aged; Demography; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Tissue Distribution	2016
Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial. Radiation oncology (London, England), 2012, Sep-14, Volume: 7 Topics: Algorithms; Carcinoma, Non-Small-Cell Lung; Humans; Hypoxia; Lung Neoplasms; Magnetic Resonance Imaging; Misonidazole; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Salvage Therapy; Tomography, X-Ray Computed; Treatment Outcome	2012

Other Studies

54 other study(ies) available for fluoromisonidazole and Hypoxia

Article	Year
Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 01-15, Volume: 28, Issue:2 Topics: Cell Hypoxia; CTLA-4 Antigen; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Programmed Cell Death 1 Receptor; Tumor Microenvironment	2022
Low- dose Apatinib promotes vascular normalization and hypoxia reduction and sensitizes radiotherapy in lung cancer. Cancer medicine, 2023, Volume: 12, Issue:4 Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Female; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Inbred C57BL; Radiation-Sensitizing Agents; Tumor Microenvironment	2023
Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study? NMR in biomedicine, 2023, Volume: 36, Issue:3 Topics: Animals; Hypoxia; Ischemic Stroke; Magnetic Resonance Imaging; Misonidazole; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Stroke	2023
Timing of hypoxia PET/CT imaging after 18F-fluoromisonidazole injection in non-small cell lung cancer patients. Scientific reports, 2022, 12-16, Volume: 12, Issue:1 Topics: Atovaquone; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Humans; Hypoxia; Lung Neoplasms; Misonidazole; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals	2022
Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models. European journal of nuclear medicine and molecular imaging, 2023, Volume: 50, Issue:10 Topics: Animals; Diffusion Magnetic Resonance Imaging; Head and Neck Neoplasms; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Misonidazole; Positron-Emission Tomography; Radiopharmaceuticals	2023
Predicting response to combination evofosfamide and immunotherapy under hypoxic conditions in murine models of colon cancer. Mathematical biosciences and engineering : MBE, 2023, Sep-15, Volume: 20, Issue:10 Topics: Adenocarcinoma; Animals; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Hypoxia; Immunotherapy; Mice; Tumor Microenvironment	2023
Influence of the scan time point when assessing hypoxia in European journal of nuclear medicine and molecular imaging, 2020, Volume: 47, Issue:8 Topics: Glioblastoma; Humans; Hypoxia; Misonidazole; Positron-Emission Tomography; Radiopharmaceuticals	2020
pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [ Macromolecular rapid communications, 2020, Volume: 41, Issue:11 Topics: Fluorine Radioisotopes; Humans; Hydrogen-Ion Concentration; Hypoxia; Misonidazole; Molecular Structure; Positron-Emission Tomography; Signal-To-Noise Ratio	2020
The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021, Volume: 41, Issue:3 Topics: Animals; Astrocytes; Autoradiography; Brain; Brain Ischemia; Cerebellar Cortex; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorine Radioisotopes; Hypoxia; Male; Misonidazole; Neurons; Organometallic Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiosemicarbazones	2021
To Explore a Representative Hypoxic Parameter to Predict the Treatment Response and Prognosis Obtained by [ Molecular imaging and biology, 2018, Volume: 20, Issue:6 Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Hypoxia; Kaplan-Meier Estimate; Logistic Models; Lung Neoplasms; Male; Middle Aged; Misonidazole; Progression-Free Survival; Proportional Hazards Models; Treatment Outcome	2018
Dosimetry study of Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2018, Volume: 20, Issue:10 Topics: Aged; Carcinoma, Non-Small-Cell Lung; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Misonidazole; Multimodal Imaging; Positron Emission Tomography Computed Tomography; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated	2018
Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation. Medical physics, 2013, Volume: 40, Issue:11 Topics: Carcinoma, Non-Small-Cell Lung; Fluorine Radioisotopes; Healthy Volunteers; Humans; Hypoxia; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Insulin-Secreting Cells; Kidney; Lung Neoplasms; Misonidazole; Movement; Pancreas; Positron-Emission Tomography; Regression Analysis; Reproducibility of Results; Respiration; Signal Processing, Computer-Assisted; Tetrabenazine; X-Ray Microtomography	2013
Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using ¹⁸F-fluoromisonidazole positron emission tomographic imaging. Circulation. Cardiovascular imaging, 2014, Volume: 7, Issue:2 Topics: Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Disease Progression; Fluorine Radioisotopes; Hypoxia; Male; Misonidazole; Positron-Emission Tomography; Rabbits; Radiation-Sensitizing Agents; Reproducibility of Results; Severity of Illness Index	2014
Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT. BMC cancer, 2014, Sep-22, Volume: 14 Topics: Animals; Cell Proliferation; Disease Models, Animal; Head and Neck Neoplasms; Heterografts; Humans; Hypoxia; Male; Mice; Misonidazole; Radionuclide Imaging; Radiopharmaceuticals; Tumor Burden	2014
A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET. Journal of the Royal Society, Interface, 2015, Feb-06, Volume: 12, Issue:103 Topics: Aged; Brain Neoplasms; Glioma; Humans; Hypoxia; Male; Misonidazole; Models, Biological; Positron-Emission Tomography; Precision Medicine; Radiation-Sensitizing Agents; Radiography	2015
A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia. Cancer biotherapy & radiopharmaceuticals, 2015, Volume: 30, Issue:2 Topics: Animals; Fibrosarcoma; Hypoxia; Mice; Misonidazole; Organotechnetium Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed, Single-Photon	2015
Synthesis of [(18)F]FMISO in a flow-through microfluidic reactor: Development and clinical application. Nuclear medicine and biology, 2015, Volume: 42, Issue:6 Topics: Adenocarcinoma; Aged; Carcinoma, Non-Small-Cell Lung; Fluorine Radioisotopes; Humans; Hypoxia; Image Processing, Computer-Assisted; Lung Neoplasms; Male; Microfluidics; Misonidazole; Pilot Projects; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiochemistry; Tissue Distribution	2015
18F-Fluoromisonidazole Quantification of Hypoxia in Human Cancer Patients Using Image-Derived Blood Surrogate Tissue Reference Regions. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Aorta; Brain Neoplasms; Cerebellum; Disease Progression; Female; Heart; Humans; Hypoxia; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Misonidazole; Neoplasms; Oxygen; Positron-Emission Tomography; Predictive Value of Tests; Proportional Hazards Models; Radiopharmaceuticals; Tissue Distribution; Treatment Outcome	2015
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study. Acta oncologica (Stockholm, Sweden), 2015, Volume: 54, Issue:9 Topics: Humans; Hypoxia; Imidazoles; Misonidazole; Models, Theoretical; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles	2015
(18)F-fluoromisonidazole PET reveals spatial and temporal heterogeneity of hypoxia in mouse models of human non-small-cell lung cancer. Future oncology (London, England), 2015, Volume: 11, Issue:20 Topics: Animals; Autoradiography; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Heterografts; Humans; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Nude; Misonidazole; Positron-Emission Tomography; Radiopharmaceuticals	2015
Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and (18)F Misonidazole PET in Murine Tumor Models. Radiology, 2016, Volume: 278, Issue:3 Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Female; Glioblastoma; Hypoxia; Immunohistochemistry; Mice; Misonidazole; Pancreatic Neoplasms; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Tomography, X-Ray Computed	2016
The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites. Scientific reports, 2015, Nov-19, Volume: 5 Topics: Animals; Diagnostic Imaging; Hypoxia; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Molecular Probes; Molecular Weight; Neoplasms; Radionuclide Imaging; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Distribution	2015
Feasibility of 18F-Fluoromisonidazole Kinetic Modeling in Head and Neck Cancer Using Shortened Acquisition Times. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:3 Topics: Algorithms; Animals; Carcinoma, Squamous Cell; Cohort Studies; Colorectal Neoplasms; Head and Neck Neoplasms; HT29 Cells; Humans; Hypoxia; Image Processing, Computer-Assisted; Misonidazole; Neoplasm Transplantation; Perfusion; Radionuclide Imaging; Radiopharmaceuticals; Rats; Reproducibility of Results; Retrospective Studies; ROC Curve	2016
Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury. JAMA neurology, 2016, 05-01, Volume: 73, Issue:5 Topics: Adult; Aged; Brain Injuries, Traumatic; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulation; Female; Humans; Hypoxia; Male; Middle Aged; Misonidazole; Oximetry; Oxygen; Positron-Emission Tomography	2016
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption? Medical physics, 2016, Volume: 43, Issue:7 Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment	2016
Hypoxia Radiotracer Produced Automatically in Dose-on-Demand Fashion. Current radiopharmaceuticals, 2016, Volume: 9, Issue:2 Topics: Animals; Automation; Chemistry Techniques, Synthetic; Drug Industry; Humans; Hypoxia; Mice; Misonidazole; Positron-Emission Tomography; Quality Control; Radiopharmaceuticals	2016
The role of necrosis, acute hypoxia and chronic hypoxia in Physics in medicine and biology, 2016, 12-21, Volume: 61, Issue:24 Topics: Computer Simulation; Humans; Hypoxia; Misonidazole; Models, Theoretical; Necrosis; Neoplasms; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Spheroids, Cellular	2016
Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2008, Volume: 89, Issue:3 Topics: Animals; Fluorine Radioisotopes; Hypoxia; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiopharmaceuticals; Tissue Distribution	2008
[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model. European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:2 Topics: Animals; Autoradiography; Biomarkers; Heart; Hypoxia; Male; Misonidazole; Myocardium; Nitroimidazoles; Positron-Emission Tomography; Rats; Reference Values; Rhabdomyosarcoma; Tissue Distribution	2009
Complementary but distinct roles for MRI and 18F-fluoromisonidazole PET in the assessment of human glioblastomas. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:1 Topics: Adult; Aged; Female; Gadolinium; Glioblastoma; Humans; Hypoxia; Magnetic Resonance Imaging; Male; Middle Aged; Misonidazole; Neovascularization, Pathologic; Positron-Emission Tomography; Prognosis; Survival Analysis; Tumor Burden	2009
Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events. Proceedings of the National Academy of Sciences of the United States of America, 2009, Aug-18, Volume: 106, Issue:33 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Mice; Misonidazole; Models, Biological; Neoplasm Transplantation; Positron-Emission Tomography; Response Elements; Time Factors; Transcription, Genetic	2009
Pharmacokinetic analysis of hypoxia (18)F-fluoromisonidazole dynamic PET in head and neck cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:1 Topics: Aged; Female; Head and Neck Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Male; Middle Aged; Misonidazole; Neoplasm Staging; Plasma; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow	2010
Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode. Acta oncologica (Stockholm, Sweden), 2010, Volume: 49, Issue:7 Topics: Biosensing Techniques; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hypoxia; Microchemistry; Microelectrodes; Misonidazole; Neoplasms; Oxygen; Positron-Emission Tomography; Sarcoma; Soft Tissue Neoplasms	2010
'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISO. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:3 Topics: Animals; Autoradiography; Brain; Brain Ischemia; Cerebral Infarction; Hypoxia; Misonidazole; Rats; Rats, Sprague-Dawley; Stroke; Time Factors; Tissue Distribution	2011
Modelling and simulation of [18F]fluoromisonidazole dynamics based on histology-derived microvessel maps. Physics in medicine and biology, 2011, Apr-07, Volume: 56, Issue:7 Topics: Diffusion; Finite Element Analysis; Hypoxia; Microvessels; Misonidazole; Models, Biological; Oxygen; Positron-Emission Tomography; Staining and Labeling	2011
Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images. Mathematical medicine and biology : a journal of the IMA, 2012, Volume: 29, Issue:1 Topics: Adult; Brain Neoplasms; Cell Proliferation; Computer Simulation; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Hypoxia; Image Interpretation, Computer-Assisted; Male; Mathematical Concepts; Misonidazole; Models, Biological; Necrosis; Neoplasm Invasiveness; Neovascularization, Pathologic; Positron-Emission Tomography; Precision Medicine; Radiopharmaceuticals; User-Computer Interface	2012
Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation. PloS one, 2011, Volume: 6, Issue:11 Topics: Adenocarcinoma; Anesthesia; Animals; Coordination Complexes; Copper Radioisotopes; Female; Fluorine Radioisotopes; Gases; Hypoxia; Mice; Mice, Inbred CBA; Misonidazole; Muscles; Neoplasms, Experimental; Organometallic Compounds; Organotechnetium Compounds; Oxygen; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Thiosemicarbazones; Tissue Distribution; Tomography, Emission-Computed, Single-Photon	2011
Modelling and simulation of the influence of acute and chronic hypoxia on [18F]fluoromisonidazole PET imaging. Physics in medicine and biology, 2012, Mar-21, Volume: 57, Issue:6 Topics: Acute Disease; Chronic Disease; Computer Simulation; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Models, Biological; Neoplasms; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals	2012
Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas. Nuclear medicine communications, 2012, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Hypoxia; Male; Middle Aged; Misonidazole; Positron-Emission Tomography; Radiation-Sensitizing Agents; Retrospective Studies; Young Adult	2012
Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma. International journal of oncology, 2012, Volume: 41, Issue:5 Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Humans; Hypoxia; Kidney Neoplasms; Mice; Mice, Nude; Misonidazole; Niacinamide; Phenylurea Compounds; Platelet Endothelial Cell Adhesion Molecule-1; Radiopharmaceuticals; Sorafenib; Tumor Microenvironment; Xenograft Model Antitumor Assays	2012
High reproducibility of tumor hypoxia evaluated by 18F-fluoromisonidazole PET for head and neck cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:2 Topics: Adult; Aged; Fluorine Radioisotopes; Head and Neck Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Male; Middle Aged; Misonidazole; Nuclear Medicine; Positron-Emission Tomography; Prognosis; Radiation Oncology; Radiopharmaceuticals; Reproducibility of Results; Time Factors	2013
Noninvasive assessment of hypoxia with 3-[18F]-fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([18F]-FMISO): a PET study in two experimental models of human glioma. Biological chemistry, 2013, Volume: 394, Issue:4 Topics: Glioma; Humans; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Misonidazole; Positron-Emission Tomography	2013
Assessing regional hypoxia in human renal tumours using 18F-fluoromisonidazole positron emission tomography. BJU international, 2005, Volume: 96, Issue:4 Topics: Adult; Aged; Carcinoma, Renal Cell; Female; Humans; Hypoxia; Immunohistochemistry; Kidney Neoplasms; Male; Middle Aged; Misonidazole; Neovascularization, Pathologic; Nephrectomy; Oxygen; Polarography; Positron-Emission Tomography; Radiopharmaceuticals	2005
Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer. BMC cancer, 2005, Dec-01, Volume: 5 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Head and Neck Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Kinetics; Male; Middle Aged; Misonidazole; Models, Statistical; Positron-Emission Tomography; Radiation-Sensitizing Agents; Software; Treatment Outcome	2005
FDG--a marker of tumour hypoxia? A comparison with [18F]fluoromisonidazole and pO2-polarography in metastatic head and neck cancer. European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:12 Topics: Biomarkers, Tumor; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Misonidazole; Neoplasm Metastasis; Oxygen; Polarography; Positron-Emission Tomography; Reference Standards	2006
A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO). Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2007, Volume: 65, Issue:6 Topics: Fluorine Radioisotopes; Hypoxia; Misonidazole; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Robotics	2007
Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort. European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:1 Topics: Animals; Disease Models, Animal; Half-Life; Hypoxia; Liver Neoplasms, Experimental; Misonidazole; Monosaccharides; Nitroimidazoles; Peritoneal Neoplasms; Positron-Emission Tomography; Rats; Tissue Distribution	2008
A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data. Medical physics, 1995, Volume: 22, Issue:7 Topics: Animals; Biological Transport, Active; Biophysical Phenomena; Biophysics; Computer Simulation; Evaluation Studies as Topic; Humans; Hypoxia; Misonidazole; Models, Biological; Monte Carlo Method; Neoplasms; Radiation-Sensitizing Agents; Rats; Tomography, Emission-Computed	1995
An efficient radiosynthesis of [18F]fluoromisonidazole. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 1993, Volume: 44, Issue:8 Topics: Fluorine Radioisotopes; Hypoxia; Isotope Labeling; Misonidazole; Tomography, Emission-Computed	1993
Statistical parametric mapping of hypoxic tissue identified by [(18)F]fluoromisonidazole and positron emission tomography following acute ischemic stroke. NeuroImage, 2002, Volume: 16, Issue:2 Topics: Acute Disease; Aged; Brain; Brain Ischemia; Female; Fluorine Radioisotopes; Humans; Hypoxia; Male; Middle Aged; Misonidazole; Reference Values; Statistics as Topic; Stroke; Tomography, Emission-Computed	2002
Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole. The American journal of physiology, 1991, Volume: 261, Issue:4 Pt 2 Topics: Animals; Female; Fluorine Radioisotopes; Gases; Hypoxia; Infections; Misonidazole; Rats; Rats, Inbred Strains; Regional Blood Flow; Time Factors	1991
Fluoromisonidazole. A metabolic marker of myocyte hypoxia. Circulation research, 1990, Volume: 67, Issue:1 Topics: Animals; Creatine Kinase; Hypoxia; Misonidazole; Myocardium; Oxygen; Partial Pressure; Reference Values	1990
Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1986, Volume: 37, Issue:7 Topics: Animals; Fluorine; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radioisotopes; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tissue Distribution	1986
Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiation research, 1987, Volume: 111, Issue:2 Topics: Animals; Autoradiography; Biotransformation; Carbon Radioisotopes; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hypoxia; Mice; Mice, Inbred C3H; Misonidazole; Oxygen; Radionuclide Imaging; Sarcoma, Experimental; Tritium	1987