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fluorodeoxyuridylate and Cancer of Colon

fluorodeoxyuridylate has been researched along with Cancer of Colon in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (38.18)	18.7374
1990's	29 (52.73)	18.2507
2000's	5 (9.09)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gmeiner, WH; Liu, C; Liu, J; Willingham, M	1
Heerschap, A; Hull, WE; Kamm, YJ; Peters, GJ; Punt, CJ	1
Gmeiner, WH; Trump, E; Wei, C	1
Corbett, TH; Heidelberger, C; Moran, RG; Shahinian, AH; Spears, CP	1
Houghton, JA; Houghton, PJ	1
Houghton, JA; Houghton, PJ; Schmidt, C	1
Morin, J; Wolberg, WH	1
Houghton, JA; Houghton, PJ; Maroda, SJ; Phillips, JO	1
Peters, GJ; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA	1
Allegra, CJ; Drake, JC; Glennon, MC; Johnston, PG; Kinsella, TJ; McGinn, CJ; Pestalozzi, BC	1
Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ	1
Baptiste, N; O'Connor, CJ; Otter, BA; Schwartz, EL; Wadler, S	1
Allegra, CJ; Chu, E	2
Hoekman, K; Meijer, S; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL; van Groeningen, CJ	1
Allegra, CJ; Drake, JC; Johnston, PG; Steinberg, SM	1
Allegra, CJ; Drake, JC; Johnston, PG	1
Furue, H; Hasegawa, K; Nakao, I; Niitani, H; Ohashi, Y; Ohta, K; Taguchi, T; Tominaga, T; Tsukagoshi, S; Wakui, A	1
Herscheid, JD; Peters, GJ; van der Wilt, CL; Visser, GW; Wedzinga, R	1
Kuiper, CM; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; Van der Wilt, CL; Van Laar, JA	1
Aherne, GW; Allegra, CJ; Geoffroy, F; Grem, JL; Hardcastle, A; Johnston, PG; Ren, Q; Van Groeningen, CJ	1
Fujimaki, M; Katuyama, S; Kuroki, Y; Okamoto, M; Sakamoto, T; Tazawa, K; Yamashita, I	1
Berger, SH; Dunlap, RB; Williams, AW	1
Noordhuis, P; Peters, GJ; Pinedo, HM; Rustum, YM; Smid, K; van der Wilt, CL; van Laar, JA	1
Jansen, G; Noordhuis, P; Peters, GJ; Pinedo, HM; Schoenmakers, PS; Smid, K; Telleman, F; van der Wilt, CL; van Hensbergen, Y; van Laar, JA; van Triest, B	1
Barbour, KW; Berger, FG; Forsthoefel, AM; Kitchens, ME; Spencer, HT	1
Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL	1
Ariki, N; Funaki, M; Gouchi, A; Iwagaki, H; Morimoto, Y; Shimamura, H; Tanaka, N	1
Griffiths, JR; Howe, FA; Lofts, F; McIntyre, DJ; McSheehy, PM; Nicholson, G; Noordhuis, P; Peters, GJ; Price, NM; Rodrigues, LM; Smid, K; Stubbs, M; Wadsworth, P	1
Danhauser, L; Rustum, YM; Wang, G	1
Fernandes, DJ; Klubes, P; Mandel, HG	1
Heidelberger, C; Moran, RG	1
Cerna, I; Connelly, K; Geelhoed, GW; Klubes, P; Mandel, HG	1
Ardalan, B; Buscaglia, MD; Schein, PS	1
Hoshi, A; Iigo, M; Nishikata, K	1
Hoshi, A; Iigo, M; Nakajima, Y	1
Akiyoshi, T; Matsuoka, H; Sugimachi, K; Ueo, H	1
Allegra, CJ; Drake, JC; Johnston, PG; Trepel, J	1
Allegra, CJ; Boarman, D; Chu, E; Zinn, S	1
Laurensse, EJ; Peters, GJ; Pinedo, HM; van Groeningen, CJ	2
Allegra, CJ; Chabner, BA; Henry, S; Johnston, PG; Liang, CM	1
Cloos, J; Marinelli, A; Peters, GJ; Pinedo, HM; Smid, K; Van der Wilt, CL	1
Fujimaki, M; Kurokawa, M; Kuroki, Y; Ochiai, H; Okamoto, M; Tazawa, K; Yamashita, I	1
Frösing, R; Gustavsson, BG; Spears, CP	1
Houghton, JA; Houghton, PJ; Radparvar, S	1
Fischer, PH; Grem, JL	1
Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E	1
Houghton, JA; Houghton, PJ; Torrance, PM; Weiss, KD; Williams, LG	1
Berne, M; Bernstein, L; Frösing, R; Gustavsson, BG; Hayes, AA; Spears, CP	1
Carlsson, G; Frösing, R; Gustavsson, BG; Spears, CP	1
Houghton, JA; Houghton, PJ; Radparvar, S; Torrance, PM; Williams, LG	2
Almersjö, O; Berne, M; Gustavsson, B; Spears, CP; Waldenström, J	1
Almersjö, O; Berne, MH; Frösing, R; Gustavsson, BG; Spears, PC	1

Trials

2 trial(s) available for fluorodeoxyuridylate and Cancer of Colon

Article	Year
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Remission Induction; Thymidylate Synthase	1994
[Phase I clinical study of TT-62. Research group of TT-62]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorodeoxyuridylate; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms	1993

Article

Year

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Remission Induction; Thymidylate Synthase

1994

[Phase I clinical study of TT-62. Research group of TT-62].

Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:2

Topics: Administration, Oral; Adolescent; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorodeoxyuridylate; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms

1993

Other Studies

53 other study(ies) available for fluorodeoxyuridylate and Cancer of Colon

Article	Year
Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. International journal of oncology, 2002, Volume: 21, Issue:2 Topics: Animals; Colon; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Fluorodeoxyuridylate; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Safety; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured	2002
Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma. British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4 Topics: Administration, Inhalation; Animals; Antimetabolites, Antineoplastic; Carbon Dioxide; Colonic Neoplasms; Female; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxygen; RNA, Neoplasm; Survival Rate; Thymidylate Synthase	2003
Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:1-2 Topics: Colonic Neoplasms; DNA; Fluorodeoxyuridylate; Fluorouracil; HT29 Cells; Humans	2004
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. Cancer research, 1982, Volume: 42, Issue:2 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Injections, Intraperitoneal; Kinetics; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; RNA; Thymidylate Synthase; Time Factors	1982
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice. Cancer, 1980, Mar-15, Volume: 45, Issue:5 Suppl Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine	1980
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts. European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:4 Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Folic Acid; Homocysteine; Humans; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous; Vitamin B 12	1982
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations. Cancer, 1981, Mar-15, Volume: 47, Issue:6 Topics: Adenocarcinoma; Colon; Colonic Neoplasms; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Humans; Methyltransferases; Mucous Membrane; Thymidylate Synthase	1981
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice. Cancer research, 1981, Volume: 41, Issue:1 Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous	1981
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Animals; Biotransformation; Cell Line; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; Thymidylate Synthase	1994
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. British journal of cancer, 1995, Volume: 71, Issue:6 Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Kinetics; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured	1995
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase. Cancer research, 1994, Mar-15, Volume: 54, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxyribonucleosides; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Stimulation, Chemical; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Tritium; Tumor Cells, Cultured	1994
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. Advances in experimental medicine and biology, 1993, Volume: 339 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Interferon-gamma; Nucleic Acids; Thymidylate Synthase; Tumor Cells, Cultured	1993
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Binding Sites; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leucovorin; Thymidylate Synthase	1993
Quantitation of thymidylate synthase in human tumors using an ultrasensitive enzyme-linked immunoassay. Biochemical pharmacology, 1993, Jun-22, Volume: 45, Issue:12 Topics: Breast Neoplasms; Cell Line; Colonic Neoplasms; Cytosol; Enzyme-Linked Immunosorbent Assay; Fluorodeoxyuridylate; Humans; Luminescent Measurements; Sensitivity and Specificity; Thymidylate Synthase; Tumor Cells, Cultured	1993
Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106. Anti-cancer drugs, 1993, Volume: 4, Issue:4 Topics: Antibodies, Monoclonal; Blotting, Western; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Immunoblotting; Tetrahydrofolates; Thymidylate Synthase	1993
18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results. Nuclear medicine and biology, 1996, Volume: 23, Issue:3 Topics: Animals; Cell Line; Colonic Neoplasms; Female; Fluorine Radioisotopes; Fluorodeoxyuridylate; Fluorouracil; Isotope Labeling; Kinetics; Mice; Mice, Inbred BALB C; Thymidylate Synthase; Tissue Distribution	1996
The role of thymidylate synthase in cellular regulation. Advances in enzyme regulation, 1996, Volume: 36 Topics: Antineoplastic Agents; Blotting, Southern; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Precipitin Tests; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Uridine; Uridine Monophosphate	1996
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas. Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2 Topics: Adenocarcinoma; Animals; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Immunosuppressive Agents; Leucovorin; Mice; Mice, Inbred BALB C; Weight Loss	1996
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells. Oncology research, 1997, Volume: 9, Issue:2 Topics: Cell Division; Cell Survival; Colonic Neoplasms; Deoxyribonucleotides; Deoxyuracil Nucleotides; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorodeoxyuridylate; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Leucovorin; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate	1997
Inhibitory effects of fluorinated pyrimidines, 5'-DFUR, UFT and T-506, in a model of hepatic metastasis of mouse colon 26 adenocarcinoma-assessment of inhibitory activity and adverse reactions at the maximum tolerated dose. Clinical & experimental metastasis, 1997, Volume: 15, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Female; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Tegafur; Uracil	1997
A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase. Biochemistry, 1998, May-19, Volume: 37, Issue:20 Topics: Antibodies, Monoclonal; Catalysis; Colonic Neoplasms; Dithionitrobenzoic Acid; Fluorodeoxyuridylate; Genetic Complementation Test; Humans; Hydroxyl Radical; Kinetics; Ligands; Mutagenesis, Site-Directed; Protein Binding; Structure-Activity Relationship; Thymidylate Synthase; Titrimetry; Tumor Cells, Cultured	1998
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Mice; Mice, Inbred BALB C; RNA; Thymidylate Synthase; Time Factors	1996
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3 Topics: Antimetabolites, Antineoplastic; Binding Sites; Biological Transport; Blotting, Western; Catalysis; Cell Division; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Humans; Peptide Synthases; Pteroylpolyglutamic Acids; Thymidylate Synthase; Tritium; Tumor Cells, Cultured	1999
Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Molecular pharmacology, 1999, Volume: 56, Issue:5 Topics: Amino Acid Substitution; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme Stability; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Half-Life; Humans; Peptides; RNA, Messenger; Thymidylate Synthase; Tumor Cells, Cultured	1999
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil. Journal of cancer research and clinical oncology, 1999, Volume: 125, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine	1999
Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma. Acta medica Okayama, 2000, Volume: 54, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Male; Mice; Picibanil; RNA; Thymidine Kinase; Thymidylate Synthase	2000
Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment. Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:5 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Biological Availability; Bone Marrow; Carbon Dioxide; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Combined Modality Therapy; Fatal Outcome; Female; Fluorine Radioisotopes; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestine, Small; Leucovorin; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Middle Aged; Neoplasms, Multiple Primary; Oxygen; Rats; Rats, Inbred WF; Sigmoid Neoplasms; Tomography, X-Ray Computed; Ultrasonography; Urinary Bladder Neoplasms	2001
Selectivity of action of 5-FU: biochemical basis. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine	1979
Studies of the antitumor action of 5-fluorouracil (FU). Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Animals; Antineoplastic Agents; Bone Marrow; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine; DNA; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestine, Small; Leukemia L1210; Mice; Rats; Ribosomes	1979
Determinants of 5-fluorouracil sensitivity in human tumors. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: Biopsy, Needle; Breast Neoplasms; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Thymidylate Synthase	1979
Effects of 5-fluorouracil on human colon carcinoma and solid rat Walker 256 carcinosarcoma: evaluation as in vitro predictors of clinical response. Cancer treatment reports, 1978, Volume: 62, Issue:7 Topics: Animals; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Mice; Ribosomes	1978
Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response. Biochemical pharmacology, 1978, Volume: 27, Issue:16 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental	1978
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin. Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:4 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine	1992
Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate. Anti-cancer drugs, 1992, Volume: 3, Issue:3 Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Injections, Intravenous; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Nude; Neoplasms, Experimental	1992
Preliminary evidence that incorporation of 5-fluorouracil into RNA correlates with antitumor response. Cancer investigation, 1992, Volume: 10, Issue:4 Topics: Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Liver Neoplasms; Rectal Neoplasms; Remission Induction; RNA, Neoplasm; Stomach Neoplasms	1992
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer research, 1992, Aug-15, Volume: 52, Issue:16 Topics: Antibodies, Monoclonal; Antibody Specificity; Blotting, Western; Breast Neoplasms; Colonic Neoplasms; Doxorubicin; Drug Resistance; Fluorescent Antibody Technique; Fluorodeoxyuridylate; Fluorouracil; Humans; Molecular Weight; Stomach Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured	1992
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer research, 1990, Sep-15, Volume: 50, Issue:18 Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; Drug Interactions; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Interferon-gamma; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured	1990
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer, 1991, Nov-01, Volume: 68, Issue:9 Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Middle Aged; Orotate Phosphoribosyltransferase; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Pyrimidine Phosphorylases; Rectal Neoplasms; Ribosemonophosphates; Uracil Nucleotides; Uridine Triphosphate	1991
Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue. Cancer research, 1991, Dec-15, Volume: 51, Issue:24 Topics: Antibodies, Monoclonal; Antibody Affinity; Blotting, Western; Carcinoma; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Epitopes; Fluorodeoxyuridylate; Humans; Immunoenzyme Techniques; Precipitin Tests; Thymidylate Synthase	1991
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Animals; Binding Sites; Bone Marrow; Cell Line; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Perfusion; Rats; Thymidylate Synthase	1991
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate. European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:3 Topics: Aged; Aged, 80 and over; Binding Sites; Colon; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Intestinal Mucosa; Middle Aged; Rectal Neoplasms; Thymidylate Synthase	1991
[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis]. Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:8 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms; Mice; Mice, Inbred BALB C; Tegafur; Uracil	1991
Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration. Investigational new drugs, 1989, Volume: 7, Issue:1 Topics: Aged; Biotransformation; Colonic Neoplasms; Cytosol; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Lacticaseibacillus casei; Leucovorin; Male; Middle Aged; Thymidylate Synthase	1989
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Biochemical pharmacology, 1989, Jan-15, Volume: 38, Issue:2 Topics: Adenocarcinoma; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Humans; In Vitro Techniques; Kinetics; Pteroylpolyglutamic Acids; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase	1989
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels. Cancer research, 1986, Volume: 46, Issue:12 Pt 1 Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Ribonucleotides; Time Factors; Uridine Triphosphate	1986
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Cancer investigation, 1988, Volume: 6, Issue:4 Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase	1988
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas. Biochemical pharmacology, 1986, Apr-15, Volume: 35, Issue:8 Topics: Adenocarcinoma; Adenosine Monophosphate; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mice; Neoplasm Transplantation; Phosphoric Monoester Hydrolases; Thymidylate Synthase; Transplantation, Heterologous	1986
Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Cancer research, 1988, Oct-15, Volume: 48, Issue:20 Topics: Adenocarcinoma; Breast Neoplasms; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Humans; Pancreatic Neoplasms; Stomach Neoplasms; Thymidylate Synthase	1988
Pharmacodynamics of 5-fluorouracil and leucovorin. Advances in experimental medicine and biology, 1988, Volume: 244 Topics: Adenocarcinoma; Animals; Bone Marrow; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Intestinal Mucosa; Leucovorin; Liver; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Thymidylate Synthase	1988
Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil. Biochemical pharmacology, 1987, Apr-15, Volume: 36, Issue:8 Topics: Adenocarcinoma; Charcoal; Colonic Neoplasms; Fluorodeoxyuridylate; Fluorouracil; Humans; Thymidylate Synthase	1987
Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2'-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3 Topics: Adenocarcinoma; Allopurinol; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Fluorouracil; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Thymidylate Synthase; Time Factors	1987
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:3 Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Male; Methotrexate; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase	1986
Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts. European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:4 Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Thymidylate Synthase; Transplantation, Heterologous	1986