flunitrazepam has been researched along with Status Epilepticus in 9 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have now applied autoradiography to study properties of GABA(A)/benzodiazepine receptors in 9-day-old rats acutely (6 h) and sub-acutely (7 days) after kainic acid-induced status epilepticus by analyzing displacement of [(3)H]flunitrazepam binding by zolpidem, a ligand selective for the alpha1beta2gamma2 receptor subtype." | 7.74 | Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain. ( Holopainen, IE; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Uusi-Oukari, M, 2007) |
| "Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus." | 7.67 | Intravenous flunitrazepam for status epilepticus. ( Akagi, M; Nagaura, T; Nishigaki, T; Sakata, N; Sumi, K, 1989) |
| "Two cases of status epilepticus are reported, whose seizures responded well to the injection of flunitrazepam." | 7.67 | Intravenous injection of flunitrazepam for status epilepticus in children--two case reports. ( Mimaki, T; Ono, J; Tagawa, T; Tanaka, J, 1988) |
| " We have now applied autoradiography to study properties of GABA(A)/benzodiazepine receptors in 9-day-old rats acutely (6 h) and sub-acutely (7 days) after kainic acid-induced status epilepticus by analyzing displacement of [(3)H]flunitrazepam binding by zolpidem, a ligand selective for the alpha1beta2gamma2 receptor subtype." | 3.74 | Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain. ( Holopainen, IE; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Uusi-Oukari, M, 2007) |
| "Effects of status epilepticus and chronic temporal lobe epilepsy on benzodiazepine (BDZ) receptor binding in the rat brain were evaluated using in vitro autoradiography, 24 h and 40 days after kainic acid (KA) administration (10 mg/kg i." | 3.70 | Characterization of benzodiazepine receptor binding following kainic acid administration: an autoradiography study in rats. ( Ondarza-Rovira, R; Rocha, L, 1999) |
| " Three cases of convulsive status epilepticus (CSE) following abrupt discontinuation of long-term use of 25 mg of lorazepam in one patient and more than 20 mg of flunitrazepam in two patients are presented; they were non-epileptics and free of other high-risk factors for seizures." | 3.70 | Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation. ( Angelopoulos, EK; Chioni, A; Daskalopoulou, EG; Gatzonis, SD; Mantouvalos, V; Siafakas, A; Zournas, C, 2000) |
| " Status epilepticus was induced in immature animals by administration of kainic acid (7 mg/kg intraperitoneal), whereas adults rats received saline." | 3.70 | Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration. ( Gaona, A; González-Trujano, ME; Jiménez, G; Ondarza, R; Rocha, L, 2000) |
| "Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus." | 3.67 | Intravenous flunitrazepam for status epilepticus. ( Akagi, M; Nagaura, T; Nishigaki, T; Sakata, N; Sumi, K, 1989) |
| "Two cases of status epilepticus are reported, whose seizures responded well to the injection of flunitrazepam." | 3.67 | Intravenous injection of flunitrazepam for status epilepticus in children--two case reports. ( Mimaki, T; Ono, J; Tagawa, T; Tanaka, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawakami, Y | 1 |
| Matsumoto, Y | 1 |
| Hashimoto, K | 1 |
| Kuwabara, K | 1 |
| Hirata, K | 1 |
| Fujita, T | 1 |
| Fujino, O | 1 |
| Laurén, HB | 1 |
| Lopez-Picon, FR | 1 |
| Kukko-Lukjanov, TK | 1 |
| Uusi-Oukari, M | 1 |
| Holopainen, IE | 1 |
| Primavera, A | 1 |
| Cocito, L | 1 |
| Briefer, JP | 1 |
| Unger, PF | 1 |
| Rocha, L | 2 |
| Ondarza-Rovira, R | 1 |
| Gatzonis, SD | 1 |
| Angelopoulos, EK | 1 |
| Daskalopoulou, EG | 1 |
| Mantouvalos, V | 1 |
| Chioni, A | 1 |
| Zournas, C | 1 |
| Siafakas, A | 1 |
| González-Trujano, ME | 1 |
| Jiménez, G | 1 |
| Gaona, A | 1 |
| Ondarza, R | 1 |
| Sumi, K | 1 |
| Nagaura, T | 1 |
| Sakata, N | 1 |
| Nishigaki, T | 1 |
| Akagi, M | 1 |
| Ono, J | 1 |
| Mimaki, T | 1 |
| Tagawa, T | 1 |
| Tanaka, J | 1 |
9 other studies available for flunitrazepam and Status Epilepticus
| Article | Year |
|---|---|
Treatment with flunitrazepam of continuous spikes and waves during slow wave sleep (CSWS) in children.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Flunitrazepam; Humans; Landau-Kleffner Syn | 2007 |
Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Disease Models | 2007 |
Acute confusion in a chronic benzodiazepine patient. Withdrawal-related nonconvulsive status epilepticus misdiagnosed as acute intoxication.
Topics: Aged; Anti-Anxiety Agents; Anxiety Disorders; Confusion; Diagnostic Errors; Drug Overdose; Flunitraz | 1995 |
[Emergency medicine for the practitioner: coma and confusional states].
Topics: Adult; Aged; Anti-Anxiety Agents; Cognition Disorders; Coma; Epilepsy, Absence; Family Practice; Fem | 1997 |
Characterization of benzodiazepine receptor binding following kainic acid administration: an autoradiography study in rats.
Topics: Animals; Autoradiography; Brain; Flunitrazepam; Kainic Acid; Male; Neurons; Organ Specificity; Rats; | 1999 |
Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation.
Topics: Adult; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; Flunit | 2000 |
Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration.
Topics: Age Factors; Animals; Autoradiography; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsy, Tem | 2000 |
Intravenous flunitrazepam for status epilepticus.
Topics: Child; Child, Preschool; Electroencephalography; Female; Flunitrazepam; Humans; Injections, Intraven | 1989 |
Intravenous injection of flunitrazepam for status epilepticus in children--two case reports.
Topics: Electroencephalography; Female; Flunitrazepam; Humans; Infant; Infant, Newborn; Injections, Intraven | 1988 |