flunitrazepam has been researched along with Sleep Wake Disorders in 28 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These results clearly indicate that long-term administration of ACTH causes sleep disturbance, and stimulating the 5-HT1A receptor by tandospirone may be efficacious for improving sleep in cases in which benzodiazepine hypnotics are ineffective." | 1.42 | Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. ( Kamei, C; Kitamura, Y; Sendo, T; Shinomiya, K; Tsutsui, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (71.43) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsutsui, R | 1 |
| Shinomiya, K | 1 |
| Sendo, T | 1 |
| Kitamura, Y | 1 |
| Kamei, C | 2 |
| Ishida, T | 1 |
| Obara, Y | 1 |
| Tanaka, H | 2 |
| Kakutani, S | 1 |
| Araki, A | 2 |
| Fukuda, I | 1 |
| Oka, R | 1 |
| Cho, K | 2 |
| Takahashi, T | 1 |
| Okajima, Y | 1 |
| Otsubo, T | 1 |
| Shinoda, J | 1 |
| Mimura, M | 1 |
| Nakagome, K | 1 |
| Kamijima, K | 1 |
| Rizzo, PA | 1 |
| Caporali, M | 1 |
| Spadaro, M | 1 |
| Zanasi, M | 1 |
| Wickstrøm, E | 1 |
| Amrein, R | 1 |
| Haefelfinger, P | 1 |
| Hartmann, D | 1 |
| Fernández Labriola, R | 1 |
| Satre y Hernández, M | 1 |
| Fichte, K | 1 |
| Pöldinger, W | 1 |
| Cordingley, GJ | 1 |
| Dean, BC | 2 |
| Harris, RI | 1 |
| Goetzke, E | 1 |
| Findeisen, P | 1 |
| Welbers, IB | 1 |
| Wolfrum, C | 1 |
| Klieser, E | 1 |
| Lehmann, E | 1 |
| Nolen, WA | 1 |
| Haffmans, PM | 1 |
| Bouvy, PF | 1 |
| Duivenvoorden, HJ | 1 |
| Ito, J | 1 |
| Tasaki, T | 1 |
| Miyamoto, A | 1 |
| Rodenbeck, A | 1 |
| Huether, G | 1 |
| Rüther, E | 1 |
| Hajak, G | 1 |
| Samec, V | 1 |
| Lassenius Kramp, J | 1 |
| Mikkelsen, BO | 1 |
| Jovanović, UJ | 2 |
| Bixler, EO | 1 |
| Kales, A | 1 |
| Soldatos, CR | 1 |
| Kales, JD | 1 |
| Singer, K | 1 |
| Lo, CW | 1 |
| Tam, YK | 1 |
| Hartelius, H | 1 |
| Larsson, AK | 1 |
| Lepp, M | 1 |
| Malm, U | 1 |
| Arvidsson, A | 1 |
| Dahlström, H | 1 |
| Brocklehurst, JC | 1 |
| Carty, MH | 1 |
| Skorecki, J | 1 |
| Brunner, H | 1 |
| Patris, MF | 1 |
| Baudry, P | 1 |
| Feugère, T | 1 |
| Wertenschlag, H | 1 |
| Schohn, D | 1 |
| Jahn, H | 1 |
| Fisher, RJ | 1 |
| Schmidt, U | 1 |
| Brendemühl, D | 1 |
| Dellen, R | 1 |
| Meurer-Krüll, BC | 1 |
| Helm, V | 1 |
| Trechot, P | 1 |
| Sirbat, D | 1 |
| Rupin, D | 1 |
| Netter, P | 1 |
| Moneret-Vautrin, DA | 1 |
1 review available for flunitrazepam and Sleep Wake Disorders
| Article | Year |
|---|---|
Nocturnal melatonin secretion and its modification by treatment in patients with sleep disorders.
Topics: Adult; Circadian Rhythm; Doxepin; Flunitrazepam; Humans; Hypnotics and Sedatives; Melatonin; Middle | 1999 |
17 trials available for flunitrazepam and Sleep Wake Disorders
| Article | Year |
|---|---|
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: a preliminary report.
Topics: Activities of Daily Living; Adult; Anti-Anxiety Agents; Benzodiazepines; Cross-Over Studies; Fatigue | 2003 |
[Slow cerebral potentials after administration of flunitrazepam to subjects with sleep disorders].
Topics: Adult; Anti-Anxiety Agents; Brain; Drug Evaluation; Electroencephalography; Female; Flunitrazepam; H | 1980 |
[Comparison of lormetazepam, flunitrazepam and placebo in a long-term effect and long-term tolerance study in 105 patients with chronic sleep disorders].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Drug Tolerance; Female; Fluni | 1981 |
[Triazolam and flunitrazepam in a double-blind cross-over trial].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; | 1983 |
A double-blind comparison of two benzodiazepine hypnotics, flunitrazepam and triazolam, in general practice.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Double-Blind Method; Family Practice; Female; Flunitra | 1984 |
Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam.
Topics: Adult; Aged; Azepines; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Flunit | 1983 |
Hypnotics as concurrent medication in depression. A placebo-controlled, double-blind comparison of flunitrazepam and lormetazepam in patients with major depression, treated with a (tri)cyclic antidepressant.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Depressive Disorder; | 1993 |
Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage.
Topics: Adolescent; Brain Diseases; Child; Electroencephalography; Female; Flunitrazepam; GABA Modulators; H | 1997 |
[Therapeutic modification of sleep disorders in geriatric patients by means of a new hypnotic. Double-blind and long-term study].
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Drug Evaluation; Fatigue; Female; Flunitrazepam; Huma | 1976 |
[Treatment of sleep disturbances with flunitrazepam (Rohypnol) and allypropymal. A controlled clinical trial in a psychiatric hospital].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Barbiturates; Clinical Trials as Topic; Drug Evaluatio | 1976 |
Polygraphic sleep recordings before and after the administration of flunitrazepam.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Female; Flunitrazepam; Humans; Male; Sleep; Sl | 1977 |
Comparative evaluation of hypnotic efficacy of flunitrazepam in psychiatric in-patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Fe | 1978 |
[Vigilance pattern and sleep quality under the effect of flunitrazepam].
Topics: Adult; Anti-Anxiety Agents; Attention; Clinical Trials as Topic; Diazepam; Electroencephalography; F | 1978 |
A controlled long-term study of flunitrazepam, nitrazepam and placebo, with special regard to withdrawal effects.
Topics: Adult; Aged; Ambulatory Care; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Dr | 1978 |
The use of a kymograph in a comparative trial of flunitrazepam and meprobamate in elderly patients.
Topics: Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Flunitrazepam; Hum | 1978 |
A multi-centre, double-blind trial in general practice comparing the hypnotic efficacy and event profiles of flunitrazepam and temazepam.
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Flunitrazepam; Humans; Random Al | 1985 |
[Adverse medical aspects of hypnotic therapy with temazepam].
Topics: Adult; Anti-Anxiety Agents; Automobile Driving; Clinical Trials as Topic; Double-Blind Method; Femal | 1985 |
10 other studies available for flunitrazepam and Sleep Wake Disorders
| Article | Year |
|---|---|
Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats.
Topics: Adrenocorticotropic Hormone; Animals; Disease Models, Animal; Electroencephalography; Flunitrazepam; | 2015 |
Effects of some antipsychotics and a benzodiazepine hypnotic on the sleep-wake pattern in an animal model of schizophrenia.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Dru | 2009 |
[Combined use of melatonin and low-dose flunitrazepam for treatment of sleep disturbance in a child with spastic quadriplegia: evaluation using polysomnography].
Topics: Adolescent; Anti-Anxiety Agents; Circadian Rhythm; Drug Therapy, Combination; Evaluation Studies as | 2002 |
Pharmacokinetic and clinical observations on prolonged administration of flunitrazepam.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Female; Flunitrazepam; Humans; Kinetics; Male; Middle | 1980 |
Single case experiments in psychopharmacological trials.
Topics: Adult; Amitriptyline; Chlordiazepoxide; Clinical Trials as Topic; Drug Combinations; Female; Flunitr | 1984 |
Flunitrazepam misuse and abuse in South Africa.
Topics: Amnesia; Anti-Anxiety Agents; Depression; Female; Flunitrazepam; Humans; Illicit Drugs; Rape; Sleep | 1999 |
Flunitrazepam, an investigational hypnotic drug: sleep laboratory evaluations.
Topics: Anti-Anxiety Agents; Dose-Response Relationship, Drug; Drug Evaluation; Flunitrazepam; Humans; Place | 1977 |
[Clinical study of flunitrazepam in a hospital department of psychiatry].
Topics: Adult; Aged; Anti-Anxiety Agents; Depression; Dose-Response Relationship, Drug; Drug Evaluation; Dru | 1979 |
[Action of flunitrazepam on organic and functional sleep disorders].
Topics: Adult; Anti-Anxiety Agents; Chronic Disease; Dreams; Drug Tolerance; Female; Flunitrazepam; Humans; | 1979 |
[Diplopia and hypersomnia caused by flunitrazepam].
Topics: Adult; Diplopia; Disorders of Excessive Somnolence; Female; Flunitrazepam; Humans; Sleep Wake Disord | 1985 |