flunitrazepam has been researched along with Sensitivity and Specificity in 28 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The GC-MS method was successfully applied to the pharmacokinetic study of BUP, NBUP, FNZ, DMFNZ and 7-AFNZ in rats, after administration of BUP and FNZ." | 1.32 | Development and validation of a gas chromatography-mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study. ( Baud, F; Bouchonnet, S; D'Athis, P; Hervé, F; Libong, D; Milan, N; Pirnay, S; Ricordel, I, 2004) |
| "Flunitrazepam was used as an internal standard." | 1.30 | Determination of omeprazole in human plasma by high-performance liquid chromatography. ( Klíma, J; Macek, J; Ptácek, P, 1997) |
| "Flunitrazepam (Rohypnol) is a benzodiazepine used in the treatment of insomnia as a sedative hypnotic and as preanesthetic medication in European countries and Mexico." | 1.30 | Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair. ( Deitermann, D; Feeley, B; Kaleciak, K; Kronstrand, R; Lewis, D; Moore, C; Negrusz, A; Niedbala, RS, 1999) |
| "Flunitrazepam was often used alone or in combination with cannabis and cocaine." | 1.30 | Benzodiazepines in Miami-Dade County, Florida driving under the influence (DUI) cases (1995-1998) with emphasis on Rohypnol: GC-MS confirmation, patterns of use, psychomotor impairment, and results of Florida legislation. ( Raymon, LP; Steele, BW; Walls, HC, 1999) |
| "Flunitrazepam was derivatized in position 3 of the benzodiazepine ring to a hapten which was coupled to a carrier protein." | 1.29 | A specific immunoassay for the detection of flunitrazepam. ( Baudner, S; Blaschke, G; Köhler-Schmidt, H; West, A, 1995) |
| "Prazepam was used as an internal standard for the quantification of the five compounds." | 1.29 | Simultaneous high-performance liquid chromatographic analysis of flunitrazepam and four metabolites in serum. ( Berthault, F; Kintz, P; Mangin, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (57.14) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, ZH | 1 |
| Song, M | 1 |
| Wallace, MJ | 1 |
| Wang, D | 1 |
| Newton, PM | 1 |
| McMahon, T | 1 |
| Chou, WH | 1 |
| Zhang, C | 1 |
| Shokat, KM | 1 |
| Messing, RO | 1 |
| Demoranville, LT | 1 |
| Verkouteren, JR | 1 |
| Marchi, I | 1 |
| Schappler, J | 1 |
| Veuthey, JL | 1 |
| Rudaz, S | 1 |
| Guthery, B | 1 |
| Bassindale, A | 1 |
| Pillinger, CT | 1 |
| Morgan, GH | 1 |
| Cui, S | 1 |
| Tan, S | 1 |
| Ouyang, G | 1 |
| Pawliszyn, J | 1 |
| Jourdil, N | 1 |
| Bessard, J | 1 |
| Vincent, F | 1 |
| Eysseric, H | 1 |
| Bessard, G | 1 |
| Terada, M | 1 |
| Masui, S | 1 |
| Hayashi, T | 1 |
| Watanabe, R | 1 |
| Inoue, H | 1 |
| Iino, M | 1 |
| Nakatome, M | 1 |
| Matoba, R | 1 |
| Shinozuka, T | 1 |
| Murai, T | 1 |
| Tanaka, E | 1 |
| Honda, K | 1 |
| Harris, SR | 1 |
| Gedge, JI | 1 |
| Nedderman, AN | 1 |
| Roffey, SJ | 1 |
| Savage, M | 1 |
| Pirnay, S | 1 |
| Bouchonnet, S | 1 |
| Hervé, F | 1 |
| Libong, D | 1 |
| Milan, N | 1 |
| D'Athis, P | 1 |
| Baud, F | 1 |
| Ricordel, I | 1 |
| Lin, DL | 1 |
| Yin, RM | 1 |
| Chen, CH | 1 |
| Chen, YL | 1 |
| Liu, RH | 1 |
| Huang, CW | 1 |
| Jen, HP | 1 |
| Wang, RD | 1 |
| Hsieh, YZ | 1 |
| Martijena, ID | 1 |
| Arce, A | 1 |
| Schafroth, M | 1 |
| Thormann, W | 1 |
| Allemann, D | 1 |
| Knoflach, F | 1 |
| Drescher, U | 1 |
| Scheurer, L | 1 |
| Malherbe, P | 1 |
| Mohler, H | 1 |
| West, A | 1 |
| Köhler-Schmidt, H | 1 |
| Baudner, S | 1 |
| Blaschke, G | 1 |
| Berthault, F | 1 |
| Kintz, P | 1 |
| Mangin, P | 1 |
| Macek, J | 1 |
| Ptácek, P | 1 |
| Klíma, J | 1 |
| Browne, R | 1 |
| Sloan, D | 1 |
| Fahy, S | 1 |
| Talbot, D | 1 |
| O'Connor, J | 1 |
| elSohly, MA | 1 |
| Feng, S | 1 |
| Salamone, SJ | 1 |
| Wu, R | 1 |
| Mellor, JR | 1 |
| Randall, AD | 1 |
| Paasch, BD | 1 |
| Lin, YS | 1 |
| Porter, S | 1 |
| Modi, NB | 1 |
| Barder, TJ | 1 |
| Deinl, I | 1 |
| Angermaier, L | 1 |
| Franzelius, C | 1 |
| Machbert, G | 1 |
| Bogusz, MJ | 1 |
| Maier, RD | 1 |
| Krüger, KD | 1 |
| Früchtnicht, W | 1 |
| McKibben, T | 1 |
| Negrusz, A | 1 |
| Moore, C | 1 |
| Deitermann, D | 1 |
| Lewis, D | 1 |
| Kaleciak, K | 1 |
| Kronstrand, R | 1 |
| Feeley, B | 1 |
| Niedbala, RS | 1 |
| Raymon, LP | 1 |
| Steele, BW | 1 |
| Walls, HC | 1 |
| Darius, J | 1 |
| Banditt, P | 1 |
| Hales, TG | 1 |
| Kim, H | 1 |
| Longoni, B | 1 |
| Olsen, RW | 1 |
| Tobin, AJ | 1 |
28 other studies available for flunitrazepam and Sensitivity and Specificity
| Article | Year |
|---|---|
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Act | 2007 |
Measurement of drug facilitated sexual assault agents in simulated sweat by ion mobility spectrometry.
Topics: Flunitrazepam; Forensic Toxicology; Humans; Ketamine; Models, Biological; N-Methyl-3,4-methylenediox | 2013 |
Development and validation of a liquid chromatography-atmospheric pressure photoionization-mass spectrometry method for the quantification of alprazolam, flunitrazepam, and their main metabolites in haemolysed blood.
Topics: Alprazolam; Anti-Anxiety Agents; Chromatography, Liquid; Flunitrazepam; Humans; Sensitivity and Spec | 2009 |
The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
Topics: Acetamides; Benzodiazepines; Chromatography, Gas; Flunitrazepam; Fluoroacetates; Heroin; Humans; Lin | 2009 |
Automated polyvinylidene difluoride hollow fiber liquid-phase microextraction of flunitrazepam in plasma and urine samples for gas chromatography/tandem mass spectrometry.
Topics: Automation; Chemical Fractionation; Flunitrazepam; Gas Chromatography-Mass Spectrometry; Hydrogen-Io | 2009 |
Automated solid-phase extraction and liquid chromatography-electrospray ionization-mass spectrometry for the determination of flunitrazepam and its metabolites in human urine and plasma samples.
Topics: Adult; Anti-Anxiety Agents; Automation; Calibration; Chromatography, High Pressure Liquid; Flunitraz | 2003 |
Simultaneous determination of flunitrazepam and 7-aminoflunitrazepam in human serum by ion trap gas chromatography-tandem mass spectrometry.
Topics: Anti-Anxiety Agents; Flunitrazepam; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; | 2003 |
A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Calibration; Chromatography, H | 2004 |
Development and validation of a gas chromatography-mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Flunitrazepam; GABA Modulators; Gas Chromatography-Mass | 2004 |
Performance characteristics of 7-aminoflunitrazepam specific enzyme-linked immunosorbent assays.
Topics: Anti-Anxiety Agents; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Flunitrazepam; Forensic Med | 2005 |
Sweeping technique combined with micellar electrokinetic chromatography for the simultaneous determination of flunitrazepam and its major metabolites.
Topics: Anti-Anxiety Agents; Buffers; Calibration; Cetrimonium; Cetrimonium Compounds; Chromatography, Micel | 2006 |
Transient benzodiazepine-GABAA receptor increase after a passive avoidance learning in synaptosomal membranes from chick forebrain.
Topics: Animals; Avoidance Learning; Chickens; Female; Flunitrazepam; Kinetics; Male; Membranes; Prosencepha | 1994 |
Micellar electrokinetic capillary chromatography of benzodiazepines in human urine.
Topics: Benzodiazepines; Capillary Action; Chromatography; Enzyme Multiplied Immunoassay Technique; Flunitra | 1994 |
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
Topics: Benzodiazepinones; Carbolines; Cells, Cultured; DNA; Drug Synergism; Flunitrazepam; gamma-Aminobutyr | 1993 |
A specific immunoassay for the detection of flunitrazepam.
Topics: Animals; Anti-Anxiety Agents; Cross Reactions; Flunitrazepam; Forensic Medicine; Humans; Rabbits; Ra | 1995 |
Simultaneous high-performance liquid chromatographic analysis of flunitrazepam and four metabolites in serum.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Flunitrazepam; Hydrogen-Ion Concentration | 1996 |
Determination of omeprazole in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Flunitrazepam; Humans; Indicators and Reagents | 1997 |
Urine screening for drugs.
Topics: Amphetamines; Anti-Anxiety Agents; False Negative Reactions; Flunitrazepam; Humans; Sensitivity and | 1997 |
A sensitive GC-MS procedure for the analysis of flunitrazepam and its metabolites in urine.
Topics: Anti-Anxiety Agents; Flunitrazepam; Gas Chromatography-Mass Spectrometry; Glucuronidase; Humans; Hyd | 1997 |
Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells.
Topics: Animals; Cerebellum; Dose-Response Relationship, Drug; Electric Conductivity; Electric Stimulation; | 1998 |
Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography. Comparison of 1.5-microm nonporous silica to 3.5-microm porous silica analytical columns.
Topics: Animals; Chromatography, High Pressure Liquid; Edetic Acid; Flunitrazepam; Heterocyclic Compounds; M | 1997 |
Simple high-performance liquid chromatographic column-switching technique for the on-line immunoaffinity extraction and analysis of flunitrazepam and its main metabolites in urine.
Topics: Anti-Anxiety Agents; Centrifugation; Chromatography, High Pressure Liquid; Flunitrazepam; Humans; Hy | 1997 |
Determination of flunitrazepam and its metabolites in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Flunitrazepam; Forensic Medicine; Humans; | 1998 |
Simple and rapid color screening tests for flunitrazepam (Rohypnol).
Topics: Anti-Anxiety Agents; Colorimetry; Flunitrazepam; Gas Chromatography-Mass Spectrometry; Sensitivity a | 1999 |
Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair.
Topics: Anti-Anxiety Agents; Autopsy; Benzodiazepines; Emergency Medical Services; Flunitrazepam; Gas Chroma | 1999 |
Benzodiazepines in Miami-Dade County, Florida driving under the influence (DUI) cases (1995-1998) with emphasis on Rohypnol: GC-MS confirmation, patterns of use, psychomotor impairment, and results of Florida legislation.
Topics: Benzodiazepines; Cross Reactions; Florida; Flunitrazepam; Gas Chromatography-Mass Spectrometry; Huma | 1999 |
Validated method for the therapeutic drug monitoring of flunitrazepam in human serum using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry with an ion trap detector.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Flunitrazepam; Humans; M | 2000 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membran | 1992 |