flunitrazepam has been researched along with Schizophrenia in 13 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]-Flunitrazepam (FNT) binding was measured in the post-mortem brains of 13 chronic schizophrenics and 10 controls whose mean ages and death-to-freezing intervals were the same in each group." | 1.28 | Benzodiazepine receptors increase in post-mortem brain of chronic schizophrenics. ( Kiuchi, Y; Kobayashi, T; Ogata, H; Shimizu, H; Takeuchi, J; Toru, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishida, T | 1 |
| Obara, Y | 1 |
| Kamei, C | 1 |
| Matsumoto, M | 1 |
| Konno, T | 1 |
| Tamba, K | 1 |
| Abe, T | 1 |
| Kato, S | 1 |
| Kajii, E | 1 |
| Skilbeck, KJ | 2 |
| O'Reilly, JN | 2 |
| Johnston, GA | 2 |
| Hinton, T | 2 |
| Squires, RF | 1 |
| Lajtha, A | 1 |
| Saederup, E | 1 |
| Palkovits, M | 1 |
| Reynolds, GP | 1 |
| Stroud, D | 1 |
| Bossé, R | 2 |
| Di Paolo, T | 1 |
| DiPaolo, T | 1 |
| Suzuki, A | 1 |
| Otani, K | 1 |
| Mihara, K | 1 |
| Yasui, N | 1 |
| Kondo, T | 1 |
| Tokinaga, N | 1 |
| Furukori, H | 1 |
| Kaneko, S | 1 |
| Inoue, Y | 1 |
| Hayashi, K | 1 |
| Hatta, K | 1 |
| Takahashi, T | 1 |
| Nakamura, H | 1 |
| Fujii, S | 1 |
| Yamashiro, H | 1 |
| Asukai, N | 1 |
| Yonezawa, Y | 1 |
| Brunner, H | 1 |
| Patris, MF | 1 |
| Baudry, P | 1 |
| Feugère, T | 1 |
| Wertenschlag, H | 1 |
| Kiuchi, Y | 1 |
| Kobayashi, T | 1 |
| Takeuchi, J | 2 |
| Shimizu, H | 2 |
| Ogata, H | 1 |
| Toru, M | 1 |
| Tokeru, M | 1 |
| Kinouchi, Y | 1 |
| Kobayashi, M | 1 |
1 trial available for flunitrazepam and Schizophrenia
| Article | Year |
|---|---|
Effects of various factors including the CYP2D6 genotype and coadministration of flunitrazepam on the steady-state plasma concentrations of bromperidol and its reduced metabolite.
Topics: Adolescent; Adult; Aged; Aging; Anti-Anxiety Agents; Antipsychotic Agents; Biotransformation; Cytoch | 1998 |
12 other studies available for flunitrazepam and Schizophrenia
| Article | Year |
|---|---|
Effects of some antipsychotics and a benzodiazepine hypnotic on the sleep-wake pattern in an animal model of schizophrenia.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Dru | 2009 |
Two cases of deep vein thrombosis associated with antipsychotic drug use.
Topics: Aged; Antipsychotic Agents; Chlorpromazine; Depressive Disorder, Major; Dose-Response Relationship, | 2004 |
The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA Agonists; | 2007 |
Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Densitometry; Flunitrazepam; Halope | 2008 |
Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: is selective loss of glutamatergic neurons associated with major psychoses?
Topics: Adult; Autopsy; Brain; Cell Count; Female; Flunitrazepam; Glutamates; Glutamic Acid; Gyrus Cinguli; | 1993 |
Hippocampal benzodiazepine receptors in schizophrenia.
Topics: Aged; Female; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Kine | 1993 |
Dopamine and GABAA receptor imbalance after ovariectomy in rats: model of menopause.
Topics: Adult; Animals; Disease Models, Animal; Female; Flunitrazepam; Frontal Lobe; Globus Pallidus; Humans | 1995 |
The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Benzazepines; Binding Sites; Brain; Brain Chemistry; | 1996 |
Prolonged upper airway instability in the parenteral use of benzodiazepine with levomepromazine.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Antipsychotic Agents; Apnea; Drug Therapy, Combination; Flun | 2000 |
[Clinical study of flunitrazepam in a hospital department of psychiatry].
Topics: Adult; Aged; Anti-Anxiety Agents; Depression; Dose-Response Relationship, Drug; Drug Evaluation; Dru | 1979 |
Benzodiazepine receptors increase in post-mortem brain of chronic schizophrenics.
Topics: Adult; Aged; Brain; Brain Mapping; Cerebral Cortex; Female; Flunitrazepam; Hippocampus; Humans; Male | 1989 |
[Benzodiazepine receptors in brain of chronic schizophrenia].
Topics: Benzodiazepines; Binding, Competitive; Brain; Chronic Disease; Flunitrazepam; Humans; Receptors, GAB | 1988 |