flunitrazepam has been researched along with Pregnancy in 52 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
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"A prospective single-blind study was conducted to compare flunitrazepam vs trazodone in the premedication of patients undergoing day-case surgery for termination of pregnancy, with particular regard to the degree of preoperative sedation, intraoperative analgesia and postoperative recovery." | 5.07 | [Trazodone versus flunitrazepam in premedication in day-care surgery]. ( Andriolli, A; Bonazzi, M; Laveneziana, D; Marsicano, M; Prampolini, F; Riva, A; Speranza, R, 1994) |
" We here examined autoradiographic binding of [(3)H]muscimol to measure the total population of GABA(A) receptors and [(3)H]flunitrazepam to assess density of benzodiazepine sites in the medial prefrontal cortex, bed nucleus of the stria terminalis, amygdala, hippocampus, and periaqueductal gray of female rats sacrificed on day 7 postpartum, day 10 of pregnancy, or as diestrous virgins." | 3.77 | Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats. ( Lonstein, JS; Miller, SM, 2011) |
"The sensitivity of prenatally protein-malnourished rats to the amnestic properties of the benzodiazepine (BZ) receptor agonist, chlordiazepoxide (CDP), was studied in the male offspring of rats provided with a protein-deficient diet (6% casein) for 5 weeks prior to mating and throughout pregnancy." | 3.70 | Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition. ( Fiacco, TT; Galler, JR; Rosene, DL; Shultz, PL; Shumsky, JS; Tonkiss, J; Vincitore, M, 2000) |
"Flunitrazepam is a new oral premedicant with prominent sedative and anxiolytic actions." | 2.65 | Flunitrazepam versus placebo premedication for minor surgery. ( Kangas, L; Kanto, J; Mansikka, M, 1979) |
" On several counts, the combination of ketamine and flunitrazepam was proved to reduce the adverse reactions seen with ketamine alone." | 2.64 | Reduction of psychotomimetic side effects of Ketalar (ketamine) by Rohypnol (flunitrazepam). A randomized, double-blind trial. ( Freuchen, I; Kühl, JB; Mikkelsen, BO; Ostergaard, J, 1976) |
"Knowledge of the pharmacokinetic properties of the benzodiazepines is playing an increasingly important role in their use during pregnancy, labour and lactation." | 2.36 | Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. ( Kanto, JH, 1982) |
"Carvone is a natural terpene which can be purified as R-(-) or S-(+) enantiomers." | 1.40 | Inhibitory effects of carvone isomers on the GABAA receptor in primary cultures of rat cortical neurons. ( Delgado-Marín, L; García, DA; Sánchez-Borzone, M, 2014) |
"Thymol is a naturally occurring phenolic monoterpene known for its anti-microbial and anti-oxidant properties." | 1.33 | Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons. ( Bujons, J; García, DA; Suñol, C; Vale, C, 2006) |
"Effects of hyperthermia-induced seizures (HS) on GABAA and benzodiazepine (BDZ) receptor binding in immature rat brain were evaluated using in vitro autoradiography." | 1.33 | Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain. ( Feria, A; González-Ramírez, M; Orozco, S; Rocha, L; Salgado, H, 2005) |
"Phenobarbital (PhB) was administered to pregnant mice during days 9-18 of gestation." | 1.28 | Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors. ( Fares, F; Gavish, M; Pick, CG; Weizman, A; Yanai, J, 1990) |
"Phenobarbital (PB) was administered to pregnant mice during days 9-21 of gestation." | 1.27 | Effects of prenatal phenobarbital on benzodiazepine receptor development. ( Garrett, KM; Tabakoff, B, 1986) |
"[3H]muscimol was used for the labeling of GABA receptors and [3H]flunitrazepam for benzodiazepine receptors." | 1.26 | Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study. ( Kuhar, MJ; Palacios, JM, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 30 (57.69) | 18.7374 |
1990's | 11 (21.15) | 18.2507 |
2000's | 9 (17.31) | 29.6817 |
2010's | 2 (3.85) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Sánchez-Borzone, M | 1 |
Delgado-Marín, L | 1 |
García, DA | 2 |
Miller, SM | 1 |
Lonstein, JS | 1 |
Andersen, DL | 1 |
Eckert, AL | 1 |
Tsai, VW | 1 |
Burke, CJ | 1 |
Tannenberg, AE | 1 |
Dodd, PR | 1 |
Iqbal, U | 1 |
Dringenberg, HC | 1 |
Brien, JF | 2 |
Reynolds, JN | 2 |
Lopes, DV | 1 |
Caruso, RR | 1 |
Castro, NG | 1 |
Costa, PR | 1 |
da Silva, AJ | 1 |
Noël, F | 1 |
Bujons, J | 1 |
Vale, C | 1 |
Suñol, C | 1 |
González-Ramírez, M | 1 |
Orozco, S | 1 |
Salgado, H | 1 |
Feria, A | 1 |
Rocha, L | 2 |
González Ramírez, M | 1 |
Orozco Suárez, S | 1 |
Salgado Ceballos, H | 1 |
Feria Velasco, A | 1 |
McClain, RM | 1 |
Hoar, RM | 1 |
Maltby, JR | 1 |
Hamilton, RC | 1 |
Phillips, R | 1 |
Hösli, E | 2 |
Möhler, H | 1 |
Richards, JG | 1 |
Hösli, L | 2 |
Kanto, JH | 1 |
Brooksbank, BW | 1 |
Atkinson, DJ | 1 |
Balázs, R | 1 |
Olive, G | 1 |
Rey, E | 1 |
Lippa, AS | 1 |
Beer, B | 1 |
Sano, MC | 1 |
Vogel, RA | 1 |
Meyerson, LR | 1 |
Palacios, JM | 2 |
Kuhar, MJ | 2 |
Shibagaki, M | 1 |
Seo, M | 1 |
Asano, T | 1 |
Kiyono, S | 1 |
Aaltonen, L | 1 |
Erkkola, R | 2 |
Kanto, J | 3 |
Bonnardot, JP | 1 |
Cordebar, R | 1 |
Regan, JW | 1 |
Roeske, WR | 1 |
Yamamura, HI | 1 |
Giorgi, O | 1 |
Lecca, D | 1 |
Cancedda, E | 1 |
Serra, GP | 1 |
Corda, MG | 1 |
Hendrickson, A | 1 |
March, D | 1 |
Richards, G | 1 |
Erickson, A | 1 |
Shaw, C | 1 |
Bonazzi, M | 2 |
Riva, A | 2 |
Marsicano, M | 1 |
Prampolini, F | 1 |
Speranza, R | 1 |
Andriolli, A | 1 |
Laveneziana, D | 2 |
Revel, MP | 1 |
Pons, JC | 1 |
Lelaidier, C | 1 |
Fournet, P | 1 |
Vial, M | 1 |
Musset, D | 1 |
Labrune, M | 1 |
Frydman, R | 1 |
McAuley, JW | 1 |
Kroboth, PD | 1 |
Stiff, DD | 1 |
Reynolds, IJ | 1 |
Morrow, AL | 2 |
Devaud, LL | 1 |
Purdy, RH | 2 |
Paul, SM | 1 |
Concas, A | 1 |
Follesa, P | 1 |
Barbaccia, ML | 1 |
Biggio, G | 1 |
Bailey, CD | 1 |
Tonkiss, J | 1 |
Shultz, PL | 1 |
Shumsky, JS | 1 |
Fiacco, TT | 1 |
Vincitore, M | 1 |
Rosene, DL | 1 |
Galler, JR | 1 |
Rumpel, E | 1 |
Behrends, JC | 1 |
Grobin, AC | 1 |
Freuchen, I | 1 |
Ostergaard, J | 1 |
Kühl, JB | 1 |
Mikkelsen, BO | 1 |
Chiefari, M | 1 |
Mastronardi, P | 1 |
Palmieri, AM | 1 |
Martí Viaño, JL | 1 |
Núñez-Cacho de Lis, A | 1 |
Llombart Rosa, MC | 1 |
Bellvert Ortiz, C | 1 |
Niehoff, DL | 1 |
Kangas, L | 2 |
Mansikka, M | 1 |
Vitorica, J | 1 |
Park, D | 1 |
de Blas, AL | 1 |
Fares, F | 1 |
Weizman, A | 1 |
Pick, CG | 1 |
Yanai, J | 1 |
Gavish, M | 2 |
Lan, NC | 1 |
Chen, JS | 1 |
Belelli, D | 1 |
Pritchett, DB | 1 |
Seeburg, PH | 1 |
Gee, KW | 1 |
Rothe, T | 1 |
Bigl, V | 1 |
Miller, LG | 1 |
Roy, RB | 1 |
Weill, CL | 1 |
Lopez, F | 1 |
Ruiz, G | 1 |
Hamon, M | 1 |
Vergé, D | 1 |
Soyannwo, OA | 1 |
Elegbe, EO | 1 |
Odugbesan, CO | 1 |
Marczynski, TJ | 1 |
Urbancic, M | 1 |
Vitali, C | 1 |
Avnimelech-Gigus, N | 1 |
Feldon, J | 1 |
Myslobodsky, M | 1 |
Fioretti, P | 1 |
Melis, GB | 1 |
Gambacciani, M | 1 |
Galbani, P | 1 |
Ronca-Testoni, S | 1 |
Garrett, KM | 1 |
Tabakoff, B | 1 |
Pitkänen, Y | 1 |
Amoia, M | 1 |
Azzollini, CV | 1 |
Ippedico, M | 1 |
Donadio, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion[NCT03751423] | Phase 3 | 123 participants (Anticipated) | Interventional | 2019-06-10 | Suspended (stopped due to Study on-hold due to COVID-19 pandemic restrictions. Will resume when possible.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for flunitrazepam and Pregnancy
Article | Year |
---|---|
Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; Flunitrazepam; Hum | 1982 |
[Benzodiazepines and pregnancy. Transplacental passage, labor and lactation].
Topics: Anti-Anxiety Agents; Biotransformation; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; | 1983 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; E | 1995 |
6 trials available for flunitrazepam and Pregnancy
Article | Year |
---|---|
Comparison of flunitrazepam and thiopentone for induction of general anaesthesia.
Topics: Abortion, Therapeutic; Adult; Anesthesia, Inhalation; Anti-Anxiety Agents; Female; Flunitrazepam; Hu | 1980 |
[Trazodone versus flunitrazepam in premedication in day-care surgery].
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery | 1994 |
Reduction of psychotomimetic side effects of Ketalar (ketamine) by Rohypnol (flunitrazepam). A randomized, double-blind trial.
Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Intravenous; Anti-Anxiety Agents; Blood Pressure; | 1976 |
[Comparison between flunitrazepam and thiopental in the induction of anesthesia in abdominal cesarean section].
Topics: Adult; Anesthesia, Obstetrical; Anti-Anxiety Agents; Apgar Score; Blood Circulation; Cesarean Sectio | 1978 |
Flunitrazepam versus placebo premedication for minor surgery.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Dilatation and Curettage; Double-Blind Method; | 1979 |
[Clotiazepam vs flunitrazepam in premedication in a day hospital regimen].
Topics: Abortion, Induced; Adult; Ambulatory Surgical Procedures; Azepines; Drug Evaluation; Female; Flunitr | 1987 |
43 other studies available for flunitrazepam and Pregnancy
Article | Year |
---|---|
Inhibitory effects of carvone isomers on the GABAA receptor in primary cultures of rat cortical neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexane Monoterpenes; Dose-Response Re | 2014 |
Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Brain; Female; Flunitrazepam; GABA-A Recepto | 2011 |
GABA(A) receptor sites in the developing human foetus.
Topics: Adult; Aged; Binding Sites; Cell Differentiation; Cerebral Cortex; Diazepam; Female; Fetus; Flunitra | 2002 |
Chronic prenatal ethanol exposure alters hippocampal GABA(A) receptors and impairs spatial learning in the guinea pig.
Topics: Animals; Body Weight; Brain; Central Nervous System Depressants; Ethanol; Female; Flunitrazepam; GAB | 2004 |
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor.
Topics: Analysis of Variance; Animals; Bicuculline; Binding, Competitive; Brain; Dose-Response Relationship, | 2004 |
Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons.
Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channel | 2006 |
Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Child; Female; Fever; Flunitrazepam; GABA Agonist | 2005 |
Hyperthermia-induced seizures modify the GABA(A) and benzodiazepine receptor binding in immature rat brain.
Topics: Age Factors; Animals; Autoradiography; Brain; Female; Fever; Flunitrazepam; GABA Agonists; GABA Modu | 2007 |
The effect of flunitrazepam on reproduction in the rat. The use of cross-fostering in the evaluation of postnatal parameters in rat reproduction studies.
Topics: Animals; Anti-Anxiety Agents; Cesarean Section; Female; Fertility; Flunitrazepam; Growth; Maternal B | 1980 |
Autoradiographic localization of binding sites for [3H]gamma-aminobutyrate, [3H]muscimol,(+)[3H]bicuculline methiodide and [3H] flunitrazepam in cultures of rat cerebellum and spinal cord.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Autoradiography; Bicuculline; Binding Sites; Cells, | 1980 |
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lo | 1982 |
Differential ontogeny of type 1 and type 2 benzodiazepine receptors.
Topics: Animals; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Pregnancy; Protein Binding | 1981 |
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric A | 1981 |
Environmental enrichment to alleviate maze performance deficits in rats with microcephaly induced by x-irradiation.
Topics: Animals; Brain; Discrimination Learning; Dose-Response Relationship, Radiation; Female; Flunitrazepa | 1981 |
Benzodiazepine receptors in the human fetus.
Topics: Adult; Animals; Benzodiazepines; Binding Sites; Brain; Cerebral Cortex; Female; Fetus; Flunitrazepam | 1983 |
Autoradiographic localization of binding sites for inhibitory amino acids and their antagonists in cultured rat CNS.
Topics: Amino Acids; Animals; Animals, Newborn; Autoradiography; Bicuculline; Brain Stem; Cells, Cultured; C | 1983 |
[A narcotic ketamine-flunitrazepam combination for cesarean section].
Topics: Adult; Anesthesia, Endotracheal; Apgar Score; Cesarean Section; Consciousness; Female; Flunitrazepam | 1984 |
[Importance of the ketamine-flunitrazepam combination in elective abortion].
Topics: Abortion, Induced; Adolescent; Adult; Aging; Anesthesia; Consciousness; Female; Flunitrazepam; Human | 1984 |
The benzodiazepine receptor: its development and its modulation by gamma-aminobutyric acid.
Topics: Age Factors; Aminobutyrates; Animals; Benzodiazepines; Bicuculline; Brain Chemistry; Female; Fetus; | 1980 |
Modulation of [35S]TBPS binding by ligands with preferential affinity for benzodiazepine BZ1 sites in the cerebral cortex of newborn and adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Co | 1995 |
Coincidental appearance of the alpha 1 subunit of the GABA-A receptor and the type I benzodiazepine receptor near birth in macaque monkey visual cortex.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antibodies, Monoclonal; Autoradiography; Binding, Co | 1994 |
Magnetic resonance imaging of the fetus: a study of 20 cases performed without curarization.
Topics: Adipose Tissue; Agenesis of Corpus Callosum; Brain; Curare; Female; Fetal Diseases; Fetal Growth Ret | 1993 |
Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents.
Topics: Animals; Cerebral Cortex; Female; Flunitrazepam; Male; Medroxyprogesterone; Pregnancy; Progesterone; | 1993 |
Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants | 1999 |
Altered GABA(A)-benzodiazepine receptor number and pharmacology in the adult guinea pig cerebral cortex after chronic prenatal ethanol exposure.
Topics: Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Female; Flunitrazepam; GABA M | 1999 |
Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Chlordiazepoxide; Chlorides; Dose-Response Relationship, | 2000 |
Postsynaptic receptor occupancy during evoked transmission at striatal GABAergic synapses in vitro.
Topics: Animals; Cells, Cultured; Corpus Striatum; Electrophysiology; Female; Flunitrazepam; GABA Modulators | 2000 |
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Anti-Anxiety Agents; Biological Transport; Cerebra | 2001 |
[Preliminary clinical considerations on the use of Roipnol in general anesthesia according to surgical specialty].
Topics: Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiety Agents; Cerebral Angiography; Cerebral Ve | 1978 |
Ontogeny of GABA and benzodiazepine receptors: effects of Triton X-100, bromide and muscimol.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Bromides; Cerebellum; Female; Flunitrazepam; gamma-Aminob | 1979 |
The GABAA/benzodiazepine receptor complex in rat brain neuronal cultures. Characterization by immunoprecipitation.
Topics: Affinity Labels; Animals; Animals, Newborn; Brain; Cattle; Cells, Cultured; Female; Flunitrazepam; I | 1990 |
Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors.
Topics: Aging; Animals; Brain; Female; Flunitrazepam; Male; Mice; Muscimol; Phenobarbital; Pregnancy; Prenat | 1990 |
A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor.
Topics: Cells, Cultured; Female; Flunitrazepam; Humans; Kidney; Pregnancy; Pregnanes; Receptors, GABA-A; Rec | 1990 |
The ontogeny of benzodiazepine receptors in selected regions of the rat brain: effect of perinatal exposure to diazepam.
Topics: Animals; Brain; Brain Chemistry; Diazepam; Female; Flunitrazepam; Nerve Tissue Proteins; Pregnancy; | 1989 |
Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Chickens; | 1989 |
Chronic phenytoin treatment decreases GABAA but not beta-adrenoceptors in the cerebellum of young rats.
Topics: Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebellum; Female; Flunitrazepam; Kinetics; | 1989 |
Effect of flunitrazepam (Rohypnol) on awareness during anaesthesia for caesarean section.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Obstetrical; Awareness; Cesarean Section; Cognition; Fema | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |
Evidence of specific benzodiazepine binding to myometrial membrane preparations from human pregnant uterus.
Topics: Adult; Benzodiazepines; Benzodiazepinones; Cell Membrane; Chlordiazepoxide; Diazepam; Female; Flunit | 1986 |
Effects of prenatal phenobarbital on benzodiazepine receptor development.
Topics: Animals; Brain; Cerebellum; Diencephalon; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice | 1986 |
Placental transfer of flunitrazepam following intramuscular administration during labour.
Topics: Adult; Female; Flunitrazepam; Humans; Injections, Intramuscular; Labor, Obstetric; Maternal-Fetal Ex | 1987 |
[Hyperkinetic effects of flunitrazepam and diazepam on the fetus].
Topics: Diazepam; Drug Interactions; Female; Fetal Movement; Flunitrazepam; Heart Rate; Humans; Hyperkinesis | 1987 |