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flunitrazepam and Neuroblastoma

flunitrazepam has been researched along with Neuroblastoma in 4 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with intracranial C6 gliomas resulted in high levels of tritiated-drug binding to the tumor as shown by quantitative autoradiography."3.67Imaging of a glioma using peripheral benzodiazepine receptor ligands. ( Ciliax, BJ; McKeever, P; Penney, JB; Starosta-Rubinstein, S; Young, AB, 1987)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rohde, BH1
Harris, RA1
Anderson, SM1
De Souza, RJ1
Cross, AJ1
Lummis, SC1
Nielsen, M1
Kilpatrick, GJ1
Martin, IL1
Starosta-Rubinstein, S1
Ciliax, BJ1
Penney, JB1
McKeever, P1
Young, AB1

Other Studies

4 other studies available for flunitrazepam and Neuroblastoma

ArticleYear
GABA and flunitrazepam binding to neuroblastoma cell membranes--effects of growth conditions, ethanol and pentobarbital.
    Brain research, 1982, Dec-16, Volume: 253, Issue:1-2

    Topics: Anti-Anxiety Agents; Binding, Competitive; Cell Line; Culture Media; Culture Techniques; Ethanol; Fl

1982
The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory site.
    Neuropharmacology, 1993, Volume: 32, Issue:5

    Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic

1993
Target size of 5-HT3 receptors in N1E-115 neuroblastoma cells and rat brain.
    European journal of pharmacology, 1990, Sep-18, Volume: 189, Issue:2-3

    Topics: Animals; Brain; Cerebral Cortex; Flunitrazepam; Imidazoles; Indoles; Kinetics; Mice; Molecular Weigh

1990
Imaging of a glioma using peripheral benzodiazepine receptor ligands.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:3

    Topics: Adrenal Gland Neoplasms; Animals; Flunitrazepam; Glioma; Humans; Isoquinolines; Kidney; Mice; Mice,

1987