Page last updated: 2024-10-27

flunitrazepam and Huntington Disease

flunitrazepam has been researched along with Huntington Disease in 8 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reisine, TD2
Overstreet, D1
Gale, K1
Rossor, M1
Iversen, L1
Yamamura, HI3
Kish, SJ1
Shannak, KS1
Perry, TL1
Hornykiewicz, O1
Schoemaker, H1
Morelli, M1
Deshmukh, P1
Penney, JB1
Young, AB1
Nicholson, LF2
Faull, RL2
Waldvogel, HJ2
Dragunow, M1
Synek, BJ1
Wastek, GJ1
Speth, RC1
Bird, ED1
Lloyd, GK1
Lowenthal, A1
Javoy-Agid, F1
Constantidinis, J1

Other Studies

8 other studies available for flunitrazepam and Huntington Disease

ArticleYear
Benzodiazepine receptors: the effect of GABA on their characteristics in human brain and their alteration in Huntington's disease.
    Brain research, 1980, Oct-13, Volume: 199, Issue:1

    Topics: Aged; Anti-Anxiety Agents; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Huntington Disease; Putam

1980
Neuronal [3H]benzodiazepine binding and levels of GABA, glutamate, and taurine are normal in Huntington's disease cerebellum.
    Journal of neurochemistry, 1983, Volume: 41, Issue:5

    Topics: Amino Acids; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Haloperi

1983
[3H]Ro5-4864 benzodiazepine binding in the kainate lesioned striatum and Huntington's diseased basal ganglia.
    Brain research, 1982, Sep-30, Volume: 248, Issue:2

    Topics: Aged; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Flunitrazepam; Humans; Huntington

1982
Quantitative autoradiography of neurotransmitter receptors in Huntington disease.
    Neurology, 1982, Volume: 32, Issue:12

    Topics: Adult; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Huntington Di

1982
GABA and GABAA receptor changes in the substantia nigra of the rat following quinolinic acid lesions in the striatum closely resemble Huntington's disease.
    Neuroscience, 1995, Volume: 66, Issue:3

    Topics: Animals; Autoradiography; Disease Models, Animal; Flunitrazepam; Gene Expression; Huntington Disease

1995
The distribution of GABAA-benzodiazepine receptors in the basal ganglia in Huntington's disease and in the quinolinic acid-lesioned rat.
    Progress in brain research, 1993, Volume: 99

    Topics: Adult; Aged; Animals; Autoradiography; Basal Ganglia; Female; Flunitrazepam; Humans; Huntington Dise

1993
Alterations in the benzodiazepine receptor of Huntington's diseased human brain.
    Brain research, 1979, Apr-06, Volume: 165, Issue:1

    Topics: Aged; Anti-Anxiety Agents; Brain; Cerebellum; Clonazepam; Diazepam; Flunitrazepam; Frontal Lobe; Hum

1979
GABAA receptor complex function in frontal cortex membranes from control and neurological patients.
    European journal of pharmacology, 1991, May-02, Volume: 197, Issue:1

    Topics: Adult; Aged; Alzheimer Disease; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic;

1991