Page last updated: 2024-10-27

flunitrazepam and Glioma

flunitrazepam has been researched along with Glioma in 6 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with intracranial C6 gliomas resulted in high levels of tritiated-drug binding to the tumor as shown by quantitative autoradiography."3.67Imaging of a glioma using peripheral benzodiazepine receptor ligands. ( Ciliax, BJ; McKeever, P; Penney, JB; Starosta-Rubinstein, S; Young, AB, 1987)
"Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues."3.67Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thomas, JW1
Tallman, JF1
Zhang, L1
Tardy, M1
Berry, JP1
Escaig, F1
Galle, P1
Ikezaki, K2
Black, KL2
Santori, EM1
Smith, ML1
Becker, DP1
Payne, BA1
Toga, AW2
Starosta-Rubinstein, S1
Ciliax, BJ1
Penney, JB2
McKeever, P1
Young, AB2
Olson, JM1
Junck, L1
Mancini, WR1

Other Studies

6 other studies available for flunitrazepam and Glioma

ArticleYear
Characterization of photoaffinity labeling of benzodiazepine binding sites.
    The Journal of biological chemistry, 1981, Oct-10, Volume: 256, Issue:19

    Topics: Affinity Labels; Animals; Benzodiazepines; Brain; Cell Line; Cell Membrane; Cerebral Cortex; Corpus

1981
[Localization of two neurotropic molecules in cultured glial cells by ion microscopy].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1992, Volume: 314, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Astrocytes; Flunitrazepam; Flurazepam; Glioma; M

1992
Three-dimensional comparison of peripheral benzodiazepine binding and histological findings in rat brain tumor.
    Neurosurgery, 1990, Volume: 27, Issue:1

    Topics: Animals; Brain Neoplasms; Female; Flunitrazepam; Glioma; Isoquinolines; Rats; Rats, Inbred Strains;

1990
Imaging of brain tumors using peripheral benzodiazepine receptor ligands.
    Journal of neurosurgery, 1989, Volume: 71, Issue:1

    Topics: Animals; Autoradiography; Brain Neoplasms; Clonazepam; Female; Flunitrazepam; Glioma; Image Processi

1989
Imaging of a glioma using peripheral benzodiazepine receptor ligands.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:3

    Topics: Adrenal Gland Neoplasms; Animals; Flunitrazepam; Glioma; Humans; Isoquinolines; Kidney; Mice; Mice,

1987
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
    Cancer research, 1988, Oct-15, Volume: 48, Issue:20

    Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans;

1988