Page last updated: 2024-10-27

flunitrazepam and Epilepsy

flunitrazepam has been researched along with Epilepsy in 14 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bowser, DN1
Wagner, DA1
Czajkowski, C2
Cromer, BA1
Parker, MW1
Wallace, RH1
Harkin, LA1
Mulley, JC1
Marini, C1
Berkovic, SF1
Williams, DA1
Jones, MV1
Petrou, S1
Sancar, F1
Kawakami, Y1
Matsumoto, Y1
Hashimoto, K1
Kuwabara, K1
Hirata, K1
Fujita, T1
Fujino, O1
Rovei, V1
Sanjuan, M1
Nakamoto, Y1
Watabe, S1
Shiotani, T1
Yoshii, M1
Shirasaka, Y2
Ito, M3
Mitsuyoshi, I1
Mikawa, H3
Serikawa, T1
Yamada, J1
Tsuda, H1
Shiraishi, H1
Oguro, K1
Mutoh, K1
Caboche, J1
Mitrovic, N1
Le Saux, F1
Besson, MJ1
Sauter, A1
Maurin, Y1
Psarropoulou, C1
Angelatou, F1
Matsokis, N1
Veronikis, DK1
Kostopoulos, G1
McGeer, E1
McGeer, PL1
Fisher, TE1
Davis, LG1
Tuchek, JM1
Johnson, DD1
Crawford, RD1
Chambon, JP1
Brochard, J1
Hallot, A1
Heaulme, M1
Brodin, R1
Roncucci, R1
Biziere, K1
Shin, C1
Pedersen, HB1
McNamara, JO1
Hattori, H1

Other Studies

14 other studies available for flunitrazepam and Epilepsy

ArticleYear
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Nov-12, Volume: 99, Issue:23

    Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam;

2002
A GABAA receptor mutation linked to human epilepsy (gamma2R43Q) impairs cell surface expression of alphabetagamma receptors.
    The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45

    Topics: Allosteric Site; Arginine; Binding Sites; Biotinylation; Blotting, Western; Cell Line; Cell Membrane

2004
Treatment with flunitrazepam of continuous spikes and waves during slow wave sleep (CSWS) in children.
    Seizure, 2007, Volume: 16, Issue:2

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Flunitrazepam; Humans; Landau-Kleffner Syn

2007
Simple and specific high performance liquid chromatographic method for the routine monitoring of clonazepam in plasma.
    Therapeutic drug monitoring, 1980, Volume: 2, Issue:3

    Topics: Adult; Benzodiazepinones; Chromatography, High Pressure Liquid; Clonazepam; Epilepsy; Flunitrazepam;

1980
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
    Brain research, 1996, Apr-22, Volume: 717, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epi

1996
Benzodiazepine receptor binding in the spontaneously epileptic rat and its parent strains.
    Experimental neurology, 1991, Volume: 113, Issue:2

    Topics: Animals; Brain; Epilepsy; Female; Flunitrazepam; Male; Organ Size; Rats; Rats, Inbred WKY; Rats, Mut

1991
Decreased benzodiazepine receptor binding in epileptic El mice: a quantitative autoradiographic study.
    Neurochemical research, 1990, Volume: 15, Issue:9

    Topics: Animals; Autoradiography; Binding, Competitive; Disease Models, Animal; Epilepsy; Flunitrazepam; In

1990
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm

1989
Absence of modification in GABA and benzodiazepine binding and in choline acetyltransferase activity in brain areas of the epileptic mutant mouse tottering.
    General pharmacology, 1987, Volume: 18, Issue:6

    Topics: Acetylcholine; Animals; Brain; Cerebellar Ataxia; Cerebellum; Cerebral Cortex; Choline O-Acetyltrans

1987
Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:3

    Topics: Animals; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Diazepam; Epilepsy; Flunitrazepam;

1986
Benzodiazepine receptors and seizure susceptibility in epileptic fowl.
    Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:2

    Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Diazepam; Epilepsy; Flunitrazepam; GABA Antago

1985
CM 40907: a structurally novel anticonvulsant in mice, rats and baboons.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Electroshock; Epilepsy; Female; Flunitr

1985
gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:10

    Topics: Animals; Binding Sites; Epilepsy; Flunitrazepam; Histocytochemistry; Kindling, Neurologic; Male; Mus

1985
gamma-Aminobutyric acid, benzodiazepine binding sites and gamma-aminobutyric acid concentrations in epileptic E1 mouse brain.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: Animals; Binding Sites; Brain; Epilepsy; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice;

1985