flunitrazepam has been researched along with Encephalopathy, Hepatic in 9 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested." | 7.68 | Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993) |
| "To assess the possible implication of the allosteric coupling of different modulatory sites at the GABA-A receptor complex in hepatic encephalopathy (HE), we investigated in autopsied frontal cortex of six cirrhotic patients and six appropriately-matched controls, the modulatory effects of the benzodiazepine site agonist flunitrazepam on the binding of [3H]muscimol and the effect of the neurosteroid site agonist allopregnanolone (5alpha-pregnan-3alpha-ol-20-one) on the binding of [3H]muscimol and [3H]flunitrazepam." | 3.72 | Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. ( Ahboucha, S; Butterworth, RF; Chatauret, N; Desjardins, P; Pomier-Layrargues, G, 2003) |
| " The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested." | 3.68 | Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. ( Ferenci, P; Herneth, A; Püspök, A; Steindl, P, 1993) |
| "The role of the GABA-benzodiazepine receptor complex in the pathogenesis of hepatic encephalopathy was investigated by recording the electrophysiological responses of single cerebellar Purkinje neurons from rabbits with hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure." | 3.67 | Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy. ( Basile, AS; Gammal, SH; Jones, EA; Mullen, KD; Skolnick, P, 1988) |
| "Hepatic coma was associated with no changes in the affinities of these receptors but with significant increases in their densities: 0." | 1.27 | Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure. ( Fowler, JM; Jones, EA; Munson, PJ; Schafer, DF; Thakur, AK; Waggoner, JG, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahboucha, S | 3 |
| Desjardins, P | 1 |
| Chatauret, N | 1 |
| Pomier-Layrargues, G | 2 |
| Butterworth, RF | 3 |
| Araqi, F | 1 |
| Layrargues, GP | 1 |
| Mamer, O | 1 |
| Schafer, DF | 1 |
| Fowler, JM | 1 |
| Munson, PJ | 1 |
| Thakur, AK | 1 |
| Waggoner, JG | 1 |
| Jones, EA | 4 |
| Püspök, A | 1 |
| Herneth, A | 1 |
| Steindl, P | 1 |
| Ferenci, P | 1 |
| Ha, JH | 1 |
| Basile, AS | 3 |
| Ostrowski, NL | 1 |
| Gammal, SH | 2 |
| Skolnick, P | 2 |
| Rössle, M | 1 |
| Mullen, KD | 2 |
9 other studies available for flunitrazepam and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Brain; Female; Flumazenil; Flunitrazepam; Hepatic Encephalopathy; Hu | 2003 |
Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
Topics: Ammonia; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug | 2005 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Fem | 2006 |
Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure.
Topics: Animals; Coma; Disease Models, Animal; Female; Flunitrazepam; Galactosamine; Hepatic Encephalopathy; | 1983 |
Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Flunitrazepam; Hepatic Encephalopathy; Li | 1993 |
Modulation of ligand binding to components of the GABAA receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes.
Topics: Ammonia; Animals; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Ligands; Ma | 1996 |
The GABAA receptor complex in hepatic encephalopathy. Autoradiographic evidence for the presence of elevated levels of a benzodiazepine receptor ligand.
Topics: Animals; Autoradiography; Brain; Flunitrazepam; Galactosamine; Hepatic Encephalopathy; Muscimol; Org | 1990 |
Cortical benzodiazepine receptor binding in a rabbit model of hepatic encephalopathy: the effect of Triton X-100 on receptor solubilization.
Topics: Animals; Cerebral Cortex; Flunitrazepam; Hepatic Encephalopathy; Male; Membrane Proteins; Octoxynol; | 1989 |
Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy.
Topics: Animals; Benzodiazepines; Flumazenil; Flunitrazepam; GABA Antagonists; Galactosamine; Hepatic Enceph | 1988 |