flunitrazepam has been researched along with Disease Models, Animal in 19 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have now applied autoradiography to study properties of GABA(A)/benzodiazepine receptors in 9-day-old rats acutely (6 h) and sub-acutely (7 days) after kainic acid-induced status epilepticus by analyzing displacement of [(3)H]flunitrazepam binding by zolpidem, a ligand selective for the alpha1beta2gamma2 receptor subtype." | 7.74 | Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain. ( Holopainen, IE; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Uusi-Oukari, M, 2007) |
| " We have now applied autoradiography to study properties of GABA(A)/benzodiazepine receptors in 9-day-old rats acutely (6 h) and sub-acutely (7 days) after kainic acid-induced status epilepticus by analyzing displacement of [(3)H]flunitrazepam binding by zolpidem, a ligand selective for the alpha1beta2gamma2 receptor subtype." | 3.74 | Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain. ( Holopainen, IE; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Uusi-Oukari, M, 2007) |
| " Status epilepticus was induced in immature animals by administration of kainic acid (7 mg/kg intraperitoneal), whereas adults rats received saline." | 3.70 | Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration. ( Gaona, A; González-Trujano, ME; Jiménez, G; Ondarza, R; Rocha, L, 2000) |
| " These results clearly indicate that long-term administration of ACTH causes sleep disturbance, and stimulating the 5-HT1A receptor by tandospirone may be efficacious for improving sleep in cases in which benzodiazepine hypnotics are ineffective." | 1.42 | Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. ( Kamei, C; Kitamura, Y; Sendo, T; Shinomiya, K; Tsutsui, R, 2015) |
| " To substantiate this finding, a dose-response study was performed, and the changes in locomotor activity incurred by different FLU (low-dose, 0." | 1.36 | Superadditive effects of ethanol and flunitrazepam: implications of using immunopharmacotherapy as a therapeutic. ( Janda, KD; Roberts, AJ; Treweek, JB, 2010) |
| "Hepatic coma was associated with no changes in the affinities of these receptors but with significant increases in their densities: 0." | 1.27 | Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure. ( Fowler, JM; Jones, EA; Munson, PJ; Schafer, DF; Thakur, AK; Waggoner, JG, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Revilla, S | 1 |
| Suñol, C | 1 |
| García-Mesa, Y | 1 |
| Giménez-Llort, L | 1 |
| Sanfeliu, C | 1 |
| Cristòfol, R | 1 |
| Pastore, V | 1 |
| Wasowski, C | 1 |
| Higgs, J | 1 |
| Mangialavori, IC | 1 |
| Bruno-Blanch, LE | 1 |
| Marder, M | 1 |
| Tsutsui, R | 1 |
| Shinomiya, K | 1 |
| Sendo, T | 1 |
| Kitamura, Y | 1 |
| Kamei, C | 2 |
| Ishida, T | 1 |
| Obara, Y | 1 |
| Treweek, JB | 1 |
| Roberts, AJ | 1 |
| Janda, KD | 1 |
| Contó, MB | 1 |
| Hipólide, DC | 1 |
| de Carvalho, JG | 1 |
| Venditti, MA | 1 |
| Saavedra, JM | 1 |
| Armando, I | 1 |
| Bregonzio, C | 1 |
| Juorio, A | 1 |
| Macova, M | 1 |
| Pavel, J | 1 |
| Sanchez-Lemus, E | 1 |
| Laurén, HB | 1 |
| Lopez-Picon, FR | 1 |
| Kukko-Lukjanov, TK | 1 |
| Uusi-Oukari, M | 1 |
| Holopainen, IE | 1 |
| Samadi, P | 1 |
| Morissette, M | 1 |
| Calon, F | 1 |
| Hadj Tahar, A | 1 |
| Dridi, M | 1 |
| Belanger, N | 1 |
| Meltzer, LT | 1 |
| Bédard, PJ | 1 |
| Di Paolo, T | 2 |
| Schafer, DF | 1 |
| Fowler, JM | 1 |
| Munson, PJ | 1 |
| Thakur, AK | 1 |
| Waggoner, JG | 1 |
| Jones, EA | 1 |
| Nicholson, LF | 1 |
| Faull, RL | 1 |
| Waldvogel, HJ | 1 |
| Dragunow, M | 1 |
| Bossé, R | 1 |
| Dodd, PR | 1 |
| Thomas, GJ | 1 |
| McCloskey, A | 1 |
| Crane, DI | 1 |
| Smith, ID | 1 |
| Rocha, L | 1 |
| González-Trujano, ME | 1 |
| Jiménez, G | 1 |
| Gaona, A | 1 |
| Ondarza, R | 1 |
| Kaltwasser, MT | 1 |
| Shirasaka, Y | 1 |
| Ito, M | 1 |
| Tsuda, H | 1 |
| Shiraishi, H | 1 |
| Oguro, K | 1 |
| Mutoh, K | 1 |
| Mikawa, H | 1 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| Marczynski, TJ | 1 |
| Urbancic, M | 1 |
| Olsen, RW | 1 |
| Wamsley, JK | 1 |
| McCabe, RT | 1 |
| Lee, RJ | 1 |
| Lomax, P | 1 |
19 other studies available for flunitrazepam and Disease Models, Animal
| Article | Year |
|---|---|
Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis Regulatory Proteins; Cerebral | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats.
Topics: Adrenocorticotropic Hormone; Animals; Disease Models, Animal; Electroencephalography; Flunitrazepam; | 2015 |
Effects of some antipsychotics and a benzodiazepine hypnotic on the sleep-wake pattern in an animal model of schizophrenia.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Dru | 2009 |
Superadditive effects of ethanol and flunitrazepam: implications of using immunopharmacotherapy as a therapeutic.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; | 2010 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.
Topics: Amphibian Proteins; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; A | 2006 |
Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Disease Models | 2007 |
Normalization of GABAA receptor specific binding in the substantia nigra reticulata and the prevention of L-dopa-induced dyskinesias in MPTP parkinsonian monkeys.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Benzoxazoles | 2008 |
Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure.
Topics: Animals; Coma; Disease Models, Animal; Female; Flunitrazepam; Galactosamine; Hepatic Encephalopathy; | 1983 |
GABA and GABAA receptor changes in the substantia nigra of the rat following quinolinic acid lesions in the striatum closely resemble Huntington's disease.
Topics: Animals; Autoradiography; Disease Models, Animal; Flunitrazepam; Gene Expression; Huntington Disease | 1995 |
Dopamine and GABAA receptor imbalance after ovariectomy in rats: model of menopause.
Topics: Adult; Animals; Disease Models, Animal; Female; Flunitrazepam; Frontal Lobe; Globus Pallidus; Humans | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration.
Topics: Age Factors; Animals; Autoradiography; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsy, Tem | 2000 |
Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Arousal; Carbolines; Diazepam; Disease | 1991 |
Decreased benzodiazepine receptor binding in epileptic El mice: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Binding, Competitive; Disease Models, Animal; Epilepsy; Flunitrazepam; In | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |