Page last updated: 2024-10-27

flunitrazepam and Chemical Dependence

flunitrazepam has been researched along with Chemical Dependence in 94 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Research Excerpts

ExcerptRelevanceReference
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery."7.77Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011)
"The abuse of flunitrazepam (FZ) compounds is worldwide, and several studies have reflected on the consequences with regard to violence, aggression and criminal lifestyle of FZ users."3.78Flunitrazepam intake in male offenders. ( Dåderman, AM; Edman, G; Kristiansson, M; Levander, S; Meurling, AW, 2012)
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery."3.77Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011)
"In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines."3.69Benzodiazepine withdrawal syndrome seizures. ( de Iceta, M; Martínez-Cano, H; Martínez-Gras, I; Pomalima, R; Vela-Bueno, A, 1995)
"Drug abuse affects a significant number of individuals of all ages."2.42Common drugs of abuse--Part II. ( Cuddy, ML, 2004)
"This article summarizes the short-term physiological toxicity and the adverse behavioral effects of four substances (GHB, ketamine, MDMA, and Rohypnol) that have been used at latenight dance clubs."2.42Acute toxic effects of club drugs. ( Gable, RS, 2004)
"A similar association was seen in drug abuse cases."2.41Flunitrazepam: an evaluation of use, abuse and toxicity. ( Ahlner, J; Druid, H; Holmgren, P, 2001)
"Flunitrazepam is a potent benzodiazepine."2.41Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate. ( Larive, LL; Romanelli, F; Smith, KM, 2002)
"Flunitrazepam has no therapeutic advantage over benzodiazepines presently marketed in the US."2.40Use and abuse of flunitrazepam. ( Cupp, MJ; Simmons, MM, 1998)
"Flunitrazepam is a newer benzodiazepine that is preferentially used recreationally and to facilitate sexual assault."1.62Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. ( Doyno, CR; White, CM, 2021)
"To examine the prevalence rates and correlates of dependence on, misuse of, and beliefs regarding use of hypnotics in elderly psychiatric patients with long-term use of zolpidem, estazolam, or flunitrazepam."1.42Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam. ( Chang, YP; Chen, CS; Huang, MF; Ko, CH; Lin, JJ; Yeh, YC; Yen, CF; Yu, CY, 2015)
"Flunitrazepam is a potent benzodiazepine that is subject to abuse and malicious use."1.33Flunitrazepam abuse and malicious use in Texas, 1998-2003. ( Forrester, MB, 2006)
"Ketamine users were primarily employed youths."1.33Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. ( Galvin, DM; Schlenger, WE; Wu, LT, 2006)
"Only partial recovery from anterograde amnesia was shown during a period of several months."1.32The importance of a urine sample in persons intoxicated with flunitrazepam--legal issues in a forensic psychiatric case study of a serial murderer. ( Dåderman, AM; Fredriksen, SO; Lidberg, L; Strindlund, H; Wiklund, N, 2003)
"Flunitrazepam was evaluated in several procedures that have been used extensively to study the behavioral effects and abuse potential of positive GABA(A) modulators."1.31Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats. ( France, CP; Gerak, LR; Harris, LS; Nader, MA; Patrick, GA; Winger, G; Woods, JH; Woolverton, WL, 2001)
"It is evident that FZ causes anterograde amnesia."1.31Violent behavior, impulsive decision-making, and anterograde amnesia while intoxicated with flunitrazepam and alcohol or other drugs: a case study in forensic psychiatric patients. ( Dåderman, AM; Fredriksson, B; Kristiansson, M; Lidberg, L; Nilsson, LH, 2002)
"Pentobarbital dependence was assessed 24 h after abrupt withdrawal from pentobarbital."1.30Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1998)
"Flunitrazepam was taken most often with alcohol (74%), and 49% took this substance with other illicit drugs."1.30Prevalence, patterns, and correlates of voluntary flunitrazepam Use. ( Berenson, AB; Rickert, VI; Wiemann, CM, 1999)
" FZ is also associated with loss of episodic memory and with impulsive violence, particularly when combined with alcohol."1.30Flunitrazepam (Rohypnol) abuse in combination with alcohol causes premeditated, grievous violence in male juvenile offenders. ( Dåderman, AM; Lidberg, L, 1999)
"The pentobarbital dependence was assessed 24 hr after abrupt withdrawal from pentobarbital."1.29Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1995)
"Flunitrazepam was ranked first by 68."1.29Flunitrazepam consumption among heroin addicts admitted for in-patient detoxification. ( Camí, J; Castillo, C; Farré, M; San, L; Tato, J; Torrens, M, 1993)
"Dogs dosed chronically (4-7 weeks) with oral flunitrazepam (7."1.28A comparison of the physical dependence inducing properties of flunitrazepam and diazepam. ( Martin, WR; Sloan, JW; Wala, EP, 1991)

Research

Studies (94)

TimeframeStudies, this research(%)All Research%
pre-199012 (12.77)18.7374
1990's31 (32.98)18.2507
2000's39 (41.49)29.6817
2010's11 (11.70)24.3611
2020's1 (1.06)2.80

Authors

AuthorsStudies
Doyno, CR1
White, CM1
Talbert, JJ1
Williams, JF1
Lundahl, LH1
Fortune, RS1
Yen, CF1
Ko, CH1
Chang, YP1
Yu, CY1
Huang, MF1
Yeh, YC1
Lin, JJ1
Chen, CS1
Markus, L1
Horowitz, A1
Galanter, M1
Dermatis, H1
Franklin, J1
Gerak, LR2
Laqueille, X1
Launay, C1
Dervaux, A1
Kanit, M1
Dziuban', A1
Ratecka, A1
Brzyski, P1
Foryś, Z1
Gomółka, E1
Ogonowska, D1
Pichini, S1
Farré, M6
Abanades, S2
Pacifici, R1
Zuccaro, P1
Langohr, K2
de la Torre, R3
Jung, C1
Lauten, A1
Figulla, HR1
Ferrari, M1
Dåderman, AM5
Edman, G2
Meurling, AW1
Levander, S1
Kristiansson, M2
Frauger, E2
Pauly, V2
Pradel, V2
Rouby, F1
Arditti, J1
Thirion, X2
Lapeyre Mestre, M1
Micallef, J2
Parkin, MC1
Brailsford, AD1
Radeleff, B1
Stampfl, U1
Sommer, CM1
Bellemann, N1
Hyhlik-Duerr, A1
Weber, MA1
Boeckler, D1
Kauczor, HU1
Chakraborty, K1
Neogi, R1
Basu, D1
Nordmann, S1
Pourcel, L1
Natali, F1
Sciortino, V1
Lapeyre-Mestre, M1
Eronen, M1
Shen, WW1
Chang, C1
Hsieh, WC1
Yeh, CJ1
Chiu, FY1
Chuang, YC1
Jourdil, N1
Bessard, J1
Vincent, F1
Eysseric, H1
Bessard, G1
Strindlund, H1
Wiklund, N1
Fredriksen, SO1
Lidberg, L4
Pratikto, TH1
Strubel, G1
Biro, F1
Kröger, K1
Klein, M1
Kramer, F1
Cuddy, ML1
Gahlinger, PM1
Parks, KA1
Kennedy, CL1
Gable, RS1
Britt, GC1
McCance-Katz, EF1
Bramness, JG1
Skurtveit, S1
Mørland, J2
Mintzer, MZ2
Griffiths, RR2
Cybulska, B1
Mirza, NR1
Nielsen, EØ1
Forrester, MB1
Wu, LT1
Schlenger, WE1
Galvin, DM1
Hering, J1
Angelkort, B1
Winger, G4
Galuska, CM1
Hursh, SR1
Barral, D1
Torrens, M3
Closas, N1
Pastor, A1
Mounteney, J1
Haugland, S1
Haslerud, J1
Heskestad, S1
Nabeshima, A1
Toki, S2
Saito, T2
Takahata, N2
Jing, X1
Wala, EP2
Sloan, JW2
Martin, JR1
Moreau, JL1
Jenck, F1
Suzuki, T2
Ito, T2
Wellman, SE2
Ho, IK3
Lamarche, J1
Bond, A1
Seijas, D1
Dawling, S1
Lader, M1
San, L2
Tato, J1
Castillo, C1
Camí, J5
Tseng, YT1
Miyaoka, T1
Martínez-Cano, H1
Vela-Bueno, A1
de Iceta, M1
Pomalima, R1
Martínez-Gras, I1
Hatta, S1
Amoiridis, G1
Schöls, L1
Pöhlau, D1
Berger, K1
Niemczyk, W1
Przuntek, H1
Leuschner, J1
Zimmermann, T1
Woods, JH3
Saum, CA1
Inciardi, JA1
Vázquez Torguet, A1
Pérez Albiac, JL1
Greoles Valls, MC1
Casaramona, MA1
Simmons, MM1
Cupp, MJ1
Vikander, B1
Hermansson, G1
Greitz, O1
Bragd, J1
Bragd, F1
Mas, M3
Roset, PN3
Terán, MT1
Ropero-Miller, JD1
Goldberger, BA1
Rickert, VI1
Wiemann, CM1
Berenson, AB1
Dåderman, A1
Hoffmeyer, JH1
Klebak, S1
Osler, M1
Marc, B1
Baudry, F1
Vaquero, P1
Zerrouki, L1
Hassnaoui, S1
Douceron, H1
Slaughter, L1
Woolverton, WL2
Nader, MA2
Patrick, GA2
Harris, LS2
France, CP1
Rome, ES1
Goss, J1
Franceschini, E1
Baronti, R1
Menoyo, E1
Hernández, C1
Druid, H1
Holmgren, P1
Ahlner, J1
Smith, KM1
Larive, LL1
Romanelli, F1
McGarry-Ross, C1
Fredriksson, B1
Nilsson, LH1
Teo, SH1
Chee, KT1
Tan, CT1
Salomon, C1
Powell, LJ1
Martin, WR1
Piot, O1
Betschart, J1
Stutzmann, JM1
Blanchard, JC1
Dobson, J2
Barattini, M1
Fantozzi, R1
Masini, E1
Mannaioni, PF1
Bjørneboe, A1
Bjørneboe, GE1
Gjerde, H1
Bugge, A1
Drevon, CA1
Maddaleno, M1
Florenzano, R1
Santa Cruz, X1
Vidal, R1
Guillaumet, J1
Altés, J1
Pérez, JA1
Velasco, J1
Schneider-Helmert, D1
Hermann, E1
Schoenenberger, GA1
Weijers-Everhard, JP1
Wijker, J1
Verrijk, R1
van Rooij, HH1
Soudijn, W1
de Torres, S1
Solé, A1
Guerra, D1
Ugena, B1

Reviews

15 reviews available for flunitrazepam and Chemical Dependence

ArticleYear
Evolving array of substances used by adolescents.
    Adolescent medicine: state of the art reviews, 2014, Volume: 25, Issue:1

    Topics: Adolescent; Adolescent Behavior; Adolescent Medicine; Amphetamines; Flunitrazepam; Hallucinogens; Hu

2014
[Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature].
    L'Encephale, 2009, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Clonazepam; Clorazepate Dipotassium;

2009
Retrospective drug detection in cases of drug-facilitated sexual assault: challenges and perspectives for the forensic toxicologist.
    Bioanalysis, 2009, Volume: 1, Issue:5

    Topics: Female; Flunitrazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Male; Sex Offenses; Sod

2009
Club drugs: review of the 'rave' with a note of concern for the Indian scenario.
    The Indian journal of medical research, 2011, Volume: 133

    Topics: Anesthetics, Dissociative; Anti-Anxiety Agents; Designer Drugs; Flunitrazepam; Hallucinogens; Humans

2011
Rave drugs: pharmacological considerations.
    AANA journal, 2004, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Anesthesia; Dancing; Designer Drugs; Emergency Treatment; Flunitrazepam; Hallucin

2004
Common drugs of abuse--Part II.
    The Journal of practical nursing, 2004,Spring, Volume: 54, Issue:1

    Topics: 4-Butyrolactone; Catha; Designer Drugs; Dibenzothiazepines; Diterpenes; Diterpenes, Clerodane; DOM 2

2004
Club drugs: MDMA, gamma-hydroxybutyrate (GHB), Rohypnol, and ketamine.
    American family physician, 2004, Jun-01, Volume: 69, Issue:11

    Topics: Anesthetics, Dissociative; Drug Overdose; Flunitrazepam; Hallucinogens; Humans; Ketamine; Leisure Ac

2004
Acute toxic effects of club drugs.
    Journal of psychoactive drugs, 2004, Volume: 36, Issue:3

    Topics: Alcohol Drinking; Animals; Behavior; Drug Interactions; Flunitrazepam; Hallucinogens; Humans; Illici

2004
A brief overview of the clinical pharmacology of "club drugs".
    Substance use & misuse, 2005, Volume: 40, Issue:9-10

    Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Dancing; Flunitrazepam; GABA Modulators; Hallucino

2005
Abuse liability of flunitrazepam.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:3 Suppl 2

    Topics: Animals; Anti-Anxiety Agents; Drug Overdose; Flunitrazepam; Humans; Psychomotor Performance; Substan

1997
Use and abuse of flunitrazepam.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:1

    Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Substance Abuse Detection; Substance-Related Disorders;

1998
Recreational drugs. Current trends in the 90s.
    Clinics in laboratory medicine, 1998, Volume: 18, Issue:4

    Topics: Amphetamine-Related Disorders; Flunitrazepam; Humans; Illicit Drugs; Sodium Oxybate; Substance-Relat

1998
It's a rave new world: rave culture and illicit drug use in the young.
    Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Ephedrine; Flunitrazepam; Humans; Illicit Drugs; Ketamine

2001
Flunitrazepam: an evaluation of use, abuse and toxicity.
    Forensic science international, 2001, Nov-01, Volume: 122, Issue:2-3

    Topics: Anti-Anxiety Agents; Crime; Flunitrazepam; Forensic Medicine; Gas Chromatography-Mass Spectrometry;

2001
Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Jun-01, Volume: 59, Issue:11

    Topics: Flunitrazepam; Humans; Illicit Drugs; Ketamine; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Oxyba

2002

Trials

7 trials available for flunitrazepam and Chemical Dependence

ArticleYear
Immunomodulating properties of gamma-hydroxybutyrate (GHB), flunitrazepam and ethanol in 'club drugs' users.
    Addiction biology, 2010, Volume: 15, Issue:3

    Topics: Adjuvants, Anesthesia; Adult; Alcoholic Intoxication; CD4-CD8 Ratio; Dose-Response Relationship, Dru

2010
An abuse liability comparison of flunitrazepam and triazolam in sedative drug abusers.
    Behavioural pharmacology, 2005, Volume: 16, Issue:7

    Topics: Adult; Anti-Anxiety Agents; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Doub

2005
Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Administration, Oral; Anti-Anxiety Agents; Area Under Curve; Blood Pressure; Body Temperature; Centr

2007
Systemic absorption and abuse liability of snorted flunitrazepam.
    Addiction (Abingdon, England), 1994, Volume: 89, Issue:7

    Topics: Administration, Inhalation; Adult; Affect; Arousal; Dose-Response Relationship, Drug; Drug Administr

1994
Abuse liability of flunitrazepam among methadone-maintained patients.
    Psychopharmacology, 1998, Volume: 140, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Blood Pressure; Body Temperature; Cross-Over Studies; Double-Blind Metho

1998
Flunitrazepam and triazolam: a comparison of behavioral effects and abuse liability.
    Drug and alcohol dependence, 1998, Dec-01, Volume: 53, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Arousal; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Bl

1998
Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males.
    Drug and alcohol dependence, 2001, Nov-01, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Affect; Analysis of Variance; Anti-Anxiety Agents; Area Under Curve; Cross-Over S

2001

Other Studies

72 other studies available for flunitrazepam and Chemical Dependence

ArticleYear
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
    Journal of clinical pharmacology, 2021, Volume: 61 Suppl 2

    Topics: Drug Overdose; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Oligopeptide

2021
Club drugs: coming to a patient near you.
    The Nurse practitioner, 2014, Mar-13, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Female; Flunitrazepam; Humans; Illicit Drugs; Ketamine; Lysergic Acid Diethylamid

2014
Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam.
    Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2015, Volume: 7, Issue:3

    Topics: Aged; Attitude to Health; Estazolam; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; P

2015
[Flunitrazepame--report based on experience with a dangerous drug].
    MMW Fortschritte der Medizin, 2008, Apr-10, Volume: 150 Suppl 1

    Topics: Anti-Anxiety Agents; Drug and Narcotic Control; Drug Interactions; Ethanol; Family Practice; Flunitr

2008
Use of and attitudes toward club drugs by medical students.
    Journal of addictive diseases, 2008, Volume: 27, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Anti-Anxiety Agents; Central Nervous System Stimulants; Dextrometho

2008
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
    Psychopharmacology, 2009, Volume: 204, Issue:4

    Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitraz

2009
[The knowledge about "date rape drugs" among Polish students].
    Przeglad lekarski, 2009, Volume: 66, Issue:6

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Crime Victims; Female; Flunitrazepam; Health Knowl

2009
[Accidental arterial injection].
    MMW Fortschritte der Medizin, 2010, May-27, Volume: 152, Issue:21

    Topics: Creatine Kinase; Flunitrazepam; Heroin; Humans; Illicit Drugs; Injections, Intra-Articular; Leg; Mal

2010
Flunitrazepam intake in male offenders.
    Nordic journal of psychiatry, 2012, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Aggression; Anti-Anxiety Agents; Antisocial Personality Disorder; Checklist; Crim

2012
Evidence of clonazepam abuse liability: results of the tools developed by the French Centers for Evaluation and Information on Pharmacodependence (CEIP) network.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:5

    Topics: Behavior, Addictive; Benzodiazepines; Clonazepam; Data Collection; Databases, Factual; Drug Prescrip

2011
Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets.
    Cardiovascular and interventional radiology, 2011, Volume: 34, Issue:5

    Topics: Acute Disease; Adult; Alprostadil; Anesthetics, Local; Anti-Anxiety Agents; Fibrinolytic Agents; Flu

2011
Monitoring of benzodiazepine diversion using a multi-indicator approach.
    International clinical psychopharmacology, 2011, Volume: 26, Issue:5

    Topics: Benzodiazepines; Clonazepam; Cross-Sectional Studies; Data Collection; Databases, Factual; Diazepam;

2011
Comment. Flunitrazepam intake in male offenders.
    Nordic journal of psychiatry, 2012, Volume: 66, Issue:2

    Topics: Aggression; Anti-Anxiety Agents; Antisocial Personality Disorder; Flunitrazepam; Humans; Male; Subst

2012
The flunitrazepam abuse prevention program at a general hospital in Taiwan: a descriptive study.
    Psychiatry and clinical neurosciences, 2002, Volume: 56, Issue:4

    Topics: Drug Administration Schedule; Drug Prescriptions; Flunitrazepam; GABA Modulators; Humans; Practice P

2002
Automated solid-phase extraction and liquid chromatography-electrospray ionization-mass spectrometry for the determination of flunitrazepam and its metabolites in human urine and plasma samples.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, May-25, Volume: 788, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Automation; Calibration; Chromatography, High Pressure Liquid; Flunitraz

2003
The importance of a urine sample in persons intoxicated with flunitrazepam--legal issues in a forensic psychiatric case study of a serial murderer.
    Forensic science international, 2003, Oct-14, Volume: 137, Issue:1

    Topics: Adult; Aggression; Amnesia, Anterograde; Anti-Anxiety Agents; Female; Flunitrazepam; Forensic Psychi

2003
Intra-arterial injection of dissolved flunitrazepam tablets.
    VASA. Zeitschrift fur Gefasskrankheiten, 2004, Volume: 33, Issue:1

    Topics: Adult; Alprostadil; Angiography; Anti-Anxiety Agents; Female; Fingers; Flunitrazepam; Hand; Heparin;

2004
Information from your family doctor. Club drugs--myths and risks.
    American family physician, 2004, Jun-01, Volume: 69, Issue:11

    Topics: Flunitrazepam; Humans; Ketamine; Leisure Activities; N-Methyl-3,4-methylenedioxyamphetamine; Sodium

2004
Club drugs: reasons for and consequences of use.
    Journal of psychoactive drugs, 2004, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Central Nervous System Stimulants; Dextromethorphan; Female; Flunitrazepam; Hallu

2004
Flunitrazepam: psychomotor impairment, agitation and paradoxical reactions.
    Forensic science international, 2006, Jun-02, Volume: 159, Issue:2-3

    Topics: Adult; Aggression; Anti-Anxiety Agents; Automobile Driving; Conduct Disorder; Crime; Databases, Fact

2006
Drug-facilitated rape.
    The journal of family planning and reproductive health care, 2002, Volume: 28, Issue:3

    Topics: Alcohol Drinking; Crime Victims; Flunitrazepam; Forensic Medicine; Humans; Memory Disorders; N-Methy

2002
Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Animals; Benzimidazoles; Benzodiazepines; Carbolines; Female; Flunitrazepam; GABA Modulators; GABA-A

2006
Flunitrazepam abuse and malicious use in Texas, 1998-2003.
    Substance use & misuse, 2006, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Female; Flunitrazepam; GABA Modulators; Humans; Incidence; Male; Retrospective St

2006
Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths.
    Drug and alcohol dependence, 2006, Sep-01, Volume: 84, Issue:1

    Topics: Adolescent; Adult; Age of Onset; Data Collection; Demography; Female; Flunitrazepam; Humans; Inciden

2006
[Acute ischemia of the hand after intra-arterial injection of flunitrazepam. Local combined fibrinolysis therapy in three cases].
    Deutsche medizinische Wochenschrift (1946), 2006, Jun-16, Volume: 131, Issue:24

    Topics: Adult; Alprostadil; Angiography; Anti-Anxiety Agents; Fibrinolytic Agents; Flunitrazepam; Hand; Huma

2006
Modification of ethanol's reinforcing effectiveness in rhesus monkeys by cocaine, flunitrazepam, or gamma-hydroxybutyrate.
    Psychopharmacology, 2007, Volume: 193, Issue:4

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Central Nervous System Depressants; Cocaine; Dopamin

2007
Earlier warning: a multi-indicator approach to monitoring trends in the illicit use of medicines.
    The International journal on drug policy, 2009, Volume: 20, Issue:2

    Topics: Buprenorphine; Data Collection; Flunitrazepam; Humans; Illicit Drugs; Models, Theoretical; Norway; S

2009
[Abstinence and confusion reactions after use of Rohypnol].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1981, Jan-10, Volume: 101, Issue:1B

    Topics: Adult; Anti-Anxiety Agents; Cognition Disorders; Confusion; Female; Flunitrazepam; Humans; Middle Ag

1981
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat. II: Strain differences between Lewis and Wistar-Kyoto rats].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:4

    Topics: Animals; Bicuculline; Brain; Chlorine; Ethanol; Female; Flunitrazepam; GABA Antagonists; GABA Modula

1995
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
    Drug and alcohol dependence, 1995, Volume: 39, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diaze

1995
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
    Psychopharmacology, 1995, Volume: 118, Issue:3

    Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, D

1995
Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital.
    Life sciences, 1995, Volume: 57, Issue:5

    Topics: Animals; Brain; Drug Tolerance; Flunitrazepam; Injections, Intraventricular; Male; Pentobarbital; Ra

1995
[Proposal of dispensary pharmacists to improve current practices of substitution. Self-substitution and prescribed substitution].
    Annales de medecine interne, 1994, Volume: 145 Suppl 3

    Topics: Buprenorphine; Codeine; Family Practice; Flunitrazepam; Heroin Dependence; Humans; Morphine; Pharmac

1994
Flunitrazepam consumption among heroin addicts admitted for in-patient detoxification.
    Drug and alcohol dependence, 1993, Volume: 32, Issue:3

    Topics: Anti-Anxiety Agents; Comorbidity; Cross-Cultural Comparison; Cross-Sectional Studies; Flunitrazepam;

1993
Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cereb

1993
Benzodiazepine withdrawal syndrome seizures.
    Pharmacopsychiatry, 1995, Volume: 28, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Female; Flunitrazepam; Heroin Dependence; Humans; Hypnotics and Sedative

1995
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
    Life sciences, 1996, Volume: 59, Issue:19

    Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Fluni

1996
[Drug-induced rhabdomyolysis and lesions of peripheral nerves. Sequelae of local ischemia within the scope of circulatory collapse?].
    Der Nervenarzt, 1996, Volume: 67, Issue:12

    Topics: Adolescent; Adult; Cannabinoids; Ethanol; Fatal Outcome; Female; Flunitrazepam; Heart Arrest; Heroin

1996
Examination of the dependence potential of chloral hydrate by oral administration to normal monkeys.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:8

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Chloral Hydrate; Flunitrazepam; Hypnotics and Se

1996
Rohypnol misuse in the United States.
    Substance use & misuse, 1997, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Drug and Narcotic Control; Drug Industry; Female; Flunitraze

1997
[Rohypnol, drug addicts and family physicians].
    Atencion primaria, 1997, Jun-15, Volume: 20, Issue:1

    Topics: Anti-Anxiety Agents; Family Practice; Flunitrazepam; Humans; Primary Health Care; Spain; Substance-R

1997
[Rohypnol--not only a sleeping pill].
    Lakartidningen, 1998, Jun-17, Volume: 95, Issue:25

    Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Hypnotics and Sedatives; Illicit Drugs; Substance-Relate

1998
[A case report: can "smoking" of Rohypnol give lung symptoms?].
    Lakartidningen, 1998, Jun-24, Volume: 95, Issue:26-27

    Topics: Adolescent; Anti-Anxiety Agents; Female; Flunitrazepam; Humans; Lung Diseases, Obstructive; Male; Re

1998
Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital.
    European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3

    Topics: Animals; Autoradiography; Binding Sites; Drug Tolerance; Flunitrazepam; GABA Modulators; Hypnotics a

1998
Comment: use and abuse of flunitrazepam.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:9

    Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Substance-Related Disorders

1998
Prevalence, patterns, and correlates of voluntary flunitrazepam Use.
    Pediatrics, 1999, Volume: 103, Issue:1

    Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Flunitrazepam; Humans; Logistic Models; Peer Gro

1999
[Rohypnol should be classified as a narcotic].
    Lakartidningen, 1999, Mar-03, Volume: 96, Issue:9

    Topics: Adult; Aggression; Alcohol Drinking; Anti-Anxiety Agents; Crime; Drug and Narcotic Control; Flunitra

1999
Flunitrazepam (Rohypnol) abuse in combination with alcohol causes premeditated, grievous violence in male juvenile offenders.
    The journal of the American Academy of Psychiatry and the Law, 1999, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Alcoholic Intoxication; Analysis of Variance; Anti-Anxiety Agents; Case-Control S

1999
[Control of medical practitioners' prescription of flunitrazepam preparations in the County of Copenhagen and municipality of Frederiksberg].
    Ugeskrift for laeger, 1999, Sep-27, Volume: 161, Issue:39

    Topics: Anti-Anxiety Agents; Denmark; Drug and Narcotic Control; Drug Prescriptions; Drug Utilization; Fluni

1999
Flunitrazepam misuse and abuse in South Africa.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:11

    Topics: Amnesia; Anti-Anxiety Agents; Depression; Female; Flunitrazepam; Humans; Illicit Drugs; Rape; Sleep

1999
Sexual assault under benzodiazepine submission in a Paris suburb.
    Archives of gynecology and obstetrics, 2000, Volume: 263, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Dronabinol; Estazolam; Female; Flu

2000
Involvement of drugs in sexual assault.
    The Journal of reproductive medicine, 2000, Volume: 45, Issue:5

    Topics: Dronabinol; Ethanol; Flunitrazepam; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Inc

2000
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
    Drug and alcohol dependence, 2001, Jun-01, Volume: 63, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination Learning; Female; Flunitrazepam; GABA

2001
Designer drugs. Assess & manage patients intoxicated with ecstasy, GHB or rohypnol--the three most commonly abused designer drugs.
    JEMS : a journal of emergency medical services, 2001, Volume: 26, Issue:6

    Topics: 4-Butyrolactone; Designer Drugs; Education, Continuing; Emergency Medical Services; Emergency Treatm

2001
Flunitrazepam abuse and personality characteristics in male forensic psychiatric patients.
    Psychiatry research, 2001, Aug-05, Volume: 103, Issue:1

    Topics: Adult; Benzodiazepines; Flunitrazepam; Humans; Male; Mental Disorders; Personality Disorders; Prison

2001
[Clinical aspects of abuse drugs mainly used by adolescents].
    Minerva pediatrica, 2001, Volume: 53, Issue:5

    Topics: Adolescent; Adolescent Behavior; Age Factors; Amphetamine-Related Disorders; Amphetamines; Anti-Anxi

2001
More on Rohypnol.
    The Canadian nurse, 2002, Volume: 98, Issue:6

    Topics: Canada; Female; Flunitrazepam; Humans; Illicit Drugs; Incidence; Male; Primary Prevention; Risk Asse

2002
Violent behavior, impulsive decision-making, and anterograde amnesia while intoxicated with flunitrazepam and alcohol or other drugs: a case study in forensic psychiatric patients.
    The journal of the American Academy of Psychiatry and the Law, 2002, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Amnesia, Anterograde; Anti-Anxiety Agents; Antisocial Personality Disorder; Crimi

2002
Psychiatric complications of Rohypnol abuse.
    Singapore medical journal, 1979, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Flunitrazepam; Humans; Male; Psychoses, Substance-Induced; S

1979
[Study of flunitrazepam in a psychiatric practice].
    La Nouvelle presse medicale, 1979, Jul-11, Volume: 8, Issue:31

    Topics: Acepromazine; Anti-Anxiety Agents; Barbiturates; Clorazepate Dipotassium; Drug Combinations; Drug To

1979
Progress report from the Testing Program for Stimulant and Depressant Drugs (1991).
    NIDA research monograph, 1992, Volume: 119

    Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Central Nervous System Stimulants;

1992
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:2

    Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relations

1991
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
    Neuroscience letters, 1990, Sep-04, Volume: 117, Issue:1-2

    Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze

1990
Sedatives/hypnotics for abuse.
    The New Zealand medical journal, 1989, Dec-13, Volume: 102, Issue:881

    Topics: Flunitrazepam; Humans; Substance-Related Disorders

1989
[Abuse of licit drugs in heroin addicts].
    La Clinica terapeutica, 1987, Feb-15, Volume: 120, Issue:3

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Heroin Dependence; Humans;

1987
A retrospective study of drugged driving in Norway.
    Forensic science international, 1987, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Age Factors; Amphetamine; Automobile Driving; Diazepam; Dronabinol; Ethanol; Fema

1987
[Abuse of flunitrazepam by the nasal route among slum adolescents of Santiago, Chile].
    Revista medica de Chile, 1988, Volume: 116, Issue:7

    Topics: Administration, Inhalation; Adolescent; Adult; Chile; Family; Female; Flunitrazepam; Humans; Male; P

1988
Drug abuse.
    The New Zealand medical journal, 1987, Aug-12, Volume: 100, Issue:829

    Topics: Flunitrazepam; Humans; Illicit Drugs; New Zealand; Social Control, Formal; Substance-Related Disorde

1987
[Rhabdomyolysis and drug abuse].
    Medicina clinica, 1987, Feb-14, Volume: 88, Issue:6

    Topics: Adolescent; Flunitrazepam; Heroin; Humans; Male; Rhabdomyolysis; Substance-Related Disorders

1987
[The use of DSIP (delta sleep-inducing peptide) in the correction of phase-shifted insomnia].
    Deutsche medizinische Wochenschrift (1946), 1987, Jun-05, Volume: 112, Issue:23

    Topics: Circadian Rhythm; Delta Sleep-Inducing Peptide; Electroencephalography; Electromyography; Female; Fl

1987
Improved qualitative method for establishing flunitrazepam abuse using urine samples and column liquid chromatography with fluorimetric detection.
    Journal of chromatography, 1986, Jan-24, Volume: 374, Issue:2

    Topics: Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyclization;

1986
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr

1985