Page last updated: 2024-10-27

flunitrazepam and Anxiety

flunitrazepam has been researched along with Anxiety in 52 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication."9.07[Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)]. ( Augeri, C; De Grandi, R; Focacci, V; Germi, MR; Launo, C; Palermo, S; Riello, R; Riverso, P; Spirandelli, P, 1992)
"The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication."5.07[Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)]. ( Augeri, C; De Grandi, R; Focacci, V; Germi, MR; Launo, C; Palermo, S; Riello, R; Riverso, P; Spirandelli, P, 1992)
" We here examined autoradiographic binding of [(3)H]muscimol to measure the total population of GABA(A) receptors and [(3)H]flunitrazepam to assess density of benzodiazepine sites in the medial prefrontal cortex, bed nucleus of the stria terminalis, amygdala, hippocampus, and periaqueductal gray of female rats sacrificed on day 7 postpartum, day 10 of pregnancy, or as diestrous virgins."3.77Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats. ( Lonstein, JS; Miller, SM, 2011)
" The reduced anxiety in homozygous (-/-) mice probably explains why the administration of a higher dose of diazepam is necessary to induce an anxiolytic-like action in these animals."3.72Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice. ( Abramov, U; Bourin, M; Kõks, S; Matsui, T; Nelovkov, A; Raud, S; Reimets, A; Rünkorg, K; Vasar, E; Veraksits, A; Volke, V, 2003)
"Triazolam was found to have an antidepressant effect (alpha less than 0."2.67[Premedication with triazolam]. ( Glaser, KH; Höfler, H; Smonig, H, 1990)
" We concluded that there are no major differences between the three drugs in the dosage used."2.66Diazepam, flunitrazepam and midazolam for elective endoscopy--a comparative study. ( Badran, I; Hunjul, N; Sbeih, Z; Takrouri, MS; Toukan, A, 1988)
"Zopiclone was slightly superior to nitrazepam but was inferior both to flurazepam and flunitrazepam."2.65Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines. ( Giercksky, KE; Wickstrøm, E, 1980)
"The combination of fentanyl and droperidol, Innovar, was compared to flunitrazepam (1-2 mg) in a higher dosage (2."2.65[High-dose thalamonal-rohypnol for premedication. A randomized double-blind study]. ( Schmidt, R; Tolksdorf, W; Wagener, M, 1984)
"Obovatol was muscle relaxant by rota-rod test, but its effect was weaker than diazepam."1.34Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex. ( Hong, JT; Hwang, BY; Kwon, BM; Lee, SH; Lee, YS; Ma, Y; Oh, KW; Seo, JJ, 2007)
"Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity often associated with drug-induced coma."1.32Drug-induced sweat gland necrosis in a non-comatose patient: a case presentation. ( Aste, N; Atzori, L; Biggio, P; Ferreli, C; Pinna, M; Sulica, VI, 2003)
" were subcutaneously injected in two-day-old chicks and a dose-response curve assessed for escape performance in a T-maze test."1.30Anxiogenic-like effects of Tagetes minuta L essential oil on T-maze and tonic immobility behaviour in domestic chicks. ( Arce, A; Garcia, DA; Marin, RH; Martijena, ID; Perillo, MA; Zygadlo, JA, 1998)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199027 (51.92)18.7374
1990's12 (23.08)18.2507
2000's6 (11.54)29.6817
2010's6 (11.54)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Islas-Preciado, D1
Ugalde-Fuentes, G1
Sollozo-Dupont, I1
González Trujano, ME1
Cervantes-Anaya, N1
Estrada-Camarena, E1
López-Rubalcava, C1
Rivera, EM1
Cid, MP1
Zunino, P1
Baiardi, G1
Salvatierra, NA1
Chekina, KS1
Yarkova, MA1
Seredenin, SB1
Avolio, E1
Alò, R1
Carelli, A1
Canonaco, M1
Miller, SM1
Lonstein, JS1
Wasowski, C1
Gavernet, L1
Barrios, IA1
Villalba, ML1
Pastore, V1
Samaja, G1
Enrique, A1
Bruno-Blanch, LE1
Marder, M1
Iarkova, MA1
Laukkanen, V1
Storvik, M1
Häkkinen, M1
Akamine, Y1
Tupala, E1
Virkkunen, M1
Tiihonen, J1
Katsura, M1
Mohri, Y1
Shuto, K1
Tsujimura, A1
Ukai, M1
Ohkuma, S1
Raud, S1
Rünkorg, K1
Veraksits, A1
Reimets, A1
Nelovkov, A1
Abramov, U1
Matsui, T1
Bourin, M1
Volke, V1
Kõks, S1
Vasar, E1
Ferreli, C1
Sulica, VI1
Aste, N1
Atzori, L1
Pinna, M1
Biggio, P1
Caldji, C1
Diorio, J1
Anisman, H1
Meaney, MJ1
Seo, JJ1
Lee, SH1
Lee, YS1
Kwon, BM1
Ma, Y1
Hwang, BY1
Hong, JT1
Oh, KW1
Lindgren, L2
Saarnivaara, L2
Himberg, JJ2
Wickstrøm, E2
Giercksky, KE1
Male, CG1
Lim, YT1
Male, M1
Stewart, JM1
Gibbs, JM1
Robertson, HA1
Tolksdorf, W2
Berlin, J1
Bethke, U1
Nieder, G1
Cano, JP1
Coassolo, P1
Petersen, EN1
Paschelke, G1
Kehr, W1
Nielsen, M1
Braestrup, C1
Lippa, AS1
Meyerson, LR1
Beer, B1
Wagener, M1
Schmidt, R1
Parraguette, J1
Garbarini, T1
Diulcin, N1
Sicre, B1
Renum, B1
Fitzal, S1
Groll-Knapp, E1
Länger, W1
Riegler, R1
Böttiger, BW1
Rauch, H1
Haussmann, R1
Keller, M1
Christmann, G1
Fleischer, F1
Martin, E1
Assié, MB1
Chopin, P1
Stenger, A1
Palmier, C1
Briley, M1
Jacobsen, EJ1
TenBrink, RE1
Stelzer, LS1
Belonga, KL1
Carter, DB1
Im, HK1
Im, WB1
Sethy, VH1
Tang, AH1
VonVoigtlander, PF1
Petke, JD1
Marin, RH1
Garcia, DA1
Martijena, ID1
Zygadlo, JA1
Arce, A1
Perillo, MA1
Homanics, GE1
Harrison, NL1
Quinlan, JJ1
Krasowski, MD1
Rick, CE1
de Blas, AL1
Mehta, AK1
Kist, F1
Mihalek, RM1
Aul, JJ1
Firestone, LL1
Knoche, E1
Traub, E1
Dick, W1
Onaivi, ES1
Maguire, PA1
Tsai, NF1
Davies, MF1
Loew, GH1
Haavik, PE2
Søreide, E1
Hofstad, B2
Steen, PA2
Launo, C1
De Grandi, R1
Augeri, C1
Palermo, S1
Riello, R1
Germi, MR1
Focacci, V1
Spirandelli, P1
Riverso, P1
Kaltwasser, MT1
Primus, RJ1
Kellogg, CK1
Hofmann, M1
Kleemann, PP1
Smonig, H1
Glaser, KH1
Höfler, H1
Rägo, L2
Kiivet, RA2
Harro, J2
Pŏld, M2
Marczynski, TJ1
Urbancic, M1
Duka, T1
Ackenheil, M1
Noderer, J1
Doenicke, A1
Dorow, R1
Manchon, M1
Kopp, N1
Bobillier, P1
Miachon, S1
Skolnick, P1
Trullas, R1
Havoundjian, H1
Paul, S1
Sukhotina, IA1
Rozhanets, VV1
Poshivalov, VP1
Takrouri, MS1
Toukan, A1
Badran, I1
Sbeih, Z1
Hunjul, N1
Spinnato, G1
Pantuso, G1
Giordano, PL1
La Barbera, D1
Iacoponelli, R1
Latteri, M1
Hüttel, MS1
Bang, U1
Camí, J1
de Torres, S1
San, L1
Solé, A1
Guerra, D1
Ugena, B1
Smith, TM1
Suckow, RF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Observed Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia[NCT03672734]100 participants (Anticipated)Observational2018-09-20Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for flunitrazepam and Anxiety

ArticleYear
The benzodiazepine receptor: the pharmacology of emotion.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1980, Volume: 7, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Central Nervous System; Cerebral Cortex; Diazepam

1980
Molecular substrates of anxiety: clues from the heterogeneity of benzodiazepine receptors.
    Life sciences, 1982, Oct-04, Volume: 31, Issue:14

    Topics: Aging; Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Chemical Phenomen

1982

Trials

14 trials available for flunitrazepam and Anxiety

ArticleYear
Comparison of oral triclofos, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery.
    British journal of anaesthesia, 1980, Volume: 52, Issue:3

    Topics: Administration, Oral; Adolescent; Anti-Anxiety Agents; Anxiety; Atropine; Child; Child, Preschool; C

1980
Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines.
    European journal of clinical pharmacology, 1980, Volume: 17, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Attention; Azabicyclo Compounds; Female; Flunitrazepam; Fluraze

1980
Comparison of three benzodiazepines for oral premedication in minor gynaecological surgery.
    British journal of anaesthesia, 1980, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Dilatation and

1980
[Psychosomatic effects of intramuscular premedication wtih flunitrazepam, innovar and a placebo in combination with atropine (author's transl)].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:1

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Atropine; Droperidol; Drug Combinations; Drug Therapy,

1981
[High-dose thalamonal-rohypnol for premedication. A randomized double-blind study].
    Der Anaesthesist, 1984, Volume: 33, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthetics; Anxiety; Blood Pressure; Body Weight; Clinical Trials as Topic

1984
[Premedication with flunitrazepam, lormetazepam or pethidine-promethazine. Psychometric study of subjective conditions].
    Der Anaesthesist, 1983, Volume: 32, Issue:6

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Depression; Emotions; Flunitrazepam;

1983
[Effects of diazepam and flunitrazepam on the undesired postoperative side-effects of ketamine anaesthesia (author's transl)].
    Der Anaesthesist, 1978, Volume: 27, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Atropine; Diazepam; Double-Blind Method; Female; Flunitrazepam;

1978
Comparison of I.M. pethidine, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery.
    British journal of anaesthesia, 1979, Volume: 51, Issue:4

    Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anxiety; Child; Child, Preschool; Clinical Trials as T

1979
Does preoperative anxiety influence gastric fluid volume and acidity?
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Anxiety; Double-Blind Method; Female; Flunitrazepam; Ga

1992
[Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)].
    Minerva anestesiologica, 1992, Volume: 58, Issue:5

    Topics: Adult; Aged; Anxiety; Diazepam; Diazepam Binding Inhibitor; Female; Flunitrazepam; Humans; Male; Mid

1992
[Premedication with triazolam].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1990, Volume: 25 Suppl 1

    Topics: Adult; Anxiety; Blood Pressure; Depression; Depression, Chemical; Female; Flunitrazepam; Heart Rate;

1990
Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788.
    Psychopharmacology, 1986, Volume: 90, Issue:3

    Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Blood Pressure; Double-Blind Method;

1986
Diazepam, flunitrazepam and midazolam for elective endoscopy--a comparative study.
    Middle East journal of anaesthesiology, 1988, Volume: 9, Issue:6

    Topics: Adult; Anxiety; Clinical Trials as Topic; Diazepam; Female; Flunitrazepam; Gastroscopy; Humans; Infu

1988
Benzodiazepines as oral premedication. A comparison between oxazepam, flunitrazepam and placebo.
    Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anxiety; Benzodiazepines; Clinical Trials as Topic; D

1987

Other Studies

36 other studies available for flunitrazepam and Anxiety

ArticleYear
Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats.
    International journal of molecular sciences, 2022, Jun-30, Volume: 23, Issue:13

    Topics: Animals; Anxiety; Behavior, Animal; Binding Sites; Corticosterone; Diazepam; Female; Flunitrazepam;

2022
Central α- and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks.
    Brain research, 2014, Mar-25, Volume: 1555

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Bicyclic Monoterpenes; Chickens; Fear; Fema

2014
Benzodiazepine reception in C57BL/6 and BALB/c mice depending on the type of stress factor.
    Bulletin of experimental biology and medicine, 2009, Volume: 148, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Cats; Fear; Female; Flunit

2009
Amygdalar orexinergic-GABAergic interactions regulate anxiety behaviors of the Syrian golden hamster.
    Behavioural brain research, 2011, Apr-15, Volume: 218, Issue:2

    Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cricetinae; Exploratory Behavior

2011
Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats.
    Brain research bulletin, 2011, Aug-10, Volume: 86, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Brain; Female; Flunitrazepam; GABA-A Recepto

2011
N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.
    Biochemical pharmacology, 2012, Jan-15, Volume: 83, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding Sites; Flunitrazepa

2012
[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:8

    Topics: Adamantane; Animals; Anti-Anxiety Agents; Anxiety; Benzimidazoles; Benzodiazepines; Brain; Cats; Dip

2011
Decreased GABA(A) benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics.
    Alcohol (Fayetteville, N.Y.), 2013, Volume: 47, Issue:2

    Topics: Adult; Alcoholism; Anxiety; Autopsy; Autoradiography; Brain Chemistry; Dentate Gyrus; Female; Flunit

2013
Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains.
    Brain research. Molecular brain research, 2002, Jul-15, Volume: 104, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Cerebral Cortex; Conditioning, Psychological; Diazepam Bindin

2002
Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.
    Psychopharmacology, 2003, Volume: 168, Issue:4

    Topics: Animals; Anxiety; Cerebellum; Cerebral Cortex; Diazepam; Exploratory Behavior; Female; Flunitrazepam

2003
Drug-induced sweat gland necrosis in a non-comatose patient: a case presentation.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2003, Volume: 17, Issue:4

    Topics: Adult; Anxiety; Biopsy, Needle; Blister; Bromazepam; Coma; Female; Flunitrazepam; Follow-Up Studies;

2003
Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:7

    Topics: Adoption; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Autoradiography; Behavior, Anima

2004
Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Oct-01, Volume: 31, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Anti-Infective Agents; Anxiety; Biphenyl Compounds; Chlorides; Flunitr

2007
Three more benzodiazepines.
    Drug and therapeutics bulletin, 1983, Aug-12, Volume: 21, Issue:16

    Topics: Alprazolam; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Bromazepam; Flunitrazepam; Humans; Sleep

1983
[Concept of half-life and benzodiazepine metabolism. Critical study].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Anxiety; Biotransformation; Flunitrazepam; Half-Life; Humans; Kinetics; Metabol

1983
Does the reversal of the anticonflict effect of phenobarbital by beta-CCE and FG 7142 indicate benzodiazepine receptor-mediated anxiogenic properties?
    European journal of pharmacology, 1982, Aug-27, Volume: 82, Issue:3-4

    Topics: Animals; Anxiety; Carbolines; Conflict, Psychological; Diazepam; Flunitrazepam; Humans; Indoles; Mal

1982
[Comparison of the effects of flunitrazepam and diazepam used in premedication].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adult; Aged; Amnesia; Anesthesia; Anxiety; Diazepam; Drug Tolerance; Female; Flunitrazepam; Hemodyna

1984
Safety and effectiveness of an oral premedication regimen before cardiac surgery.
    European journal of anaesthesiology, 1995, Volume: 12, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Anxiety; Blood Pressure;

1995
Neuropharmacology of a new potential anxiolytic compound, F 2692, 1-(3'-trifluoromethyl phenyl) 1,4-dihydro 3-amino 4-oxo 6-methyl pyridazine. 1. Acute and in vitro effects.
    Psychopharmacology, 1993, Volume: 110, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Binding, Competitive; Drinking Behavior; Exp

1993
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyc

1996
Anxiogenic-like effects of Tagetes minuta L essential oil on T-maze and tonic immobility behaviour in domestic chicks.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Cell Membrane; Chickens; Flunitrazepam; Maze Learning; Moveme

1998
Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.
    Neuropharmacology, 1999, Volume: 38, Issue:2

    Topics: Alternative Splicing; Animals; Anxiety; Brain; Cell Membrane; Chimera; Crosses, Genetic; Ethanol; Ex

1999
Comparison of behavioral and central BDZ binding profile in three rat lines.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body

1992
Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?
    Behavioural brain research, 1991, May-15, Volume: 43, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Arousal; Carbolines; Diazepam; Disease

1991
Experience influences environmental modulation of function at the benzodiazepine (BZD)/GABA receptor chloride channel complex.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: Animals; Anxiety; Cell Membrane; Cerebral Cortex; Chloride Channels; Chlorides; Flunitrazepam; gamma

1991
[Free fatty acids as an indicator of preoperative stress and effects of premedication with flunitrazepam, morphine and promethazine on blood fatty acid level].
    Infusionstherapie (Basel, Switzerland), 1991, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Anxiety; Face; Fatty Acids, Nonesterified; Female; Flunitrazepam; Humans; Male; M

1991
Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4

    Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Flunitrazepam

1989
Animal models of chronic anxiety and "fearlessness".
    Brain research bulletin, 1988, Volume: 21, Issue:3

    Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz

1988
Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 337, Issue:6

    Topics: Animals; Anxiety; Brain; Carbolines; Cerebral Cortex; Diazepam; Exploratory Behavior; Flunitrazepam;

1988
Autoradiographic and quantitative study of benzodiazepine-binding sites in human hippocampus.
    Neuroscience letters, 1985, Nov-20, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Anxiety; Autoradiography; Benzodiazepines; Binding Sites; Binding, Competit

1985
The benzodiazepine/GABA receptor complex in anxiety.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Animals; Anxiety; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam;

1986
[Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and anxious-defensive mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:6

    Topics: Aggression; Animals; Anxiety; Binding Sites; Brain; Carbolines; Diazepam; Flunitrazepam; Ligands; Ma

1987
[Use of flunitrazepam for sedation in digestive endoscopy. Our experience].
    Minerva chirurgica, 1988, Mar-31, Volume: 43, Issue:6

    Topics: Adolescent; Adult; Aged; Anxiety; Endoscopy; Female; Flunitrazepam; Gastroscopy; Humans; Male; Middl

1988
Sublingual flunitrazepam for premedication.
    Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Anxiety; Blood Pressure; Body Weight; Fe

1985
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr

1985
Trazodone and m-chlorophenylpiperazine. Concentration in brain and receptor activity in regions in the brain associated with anxiety.
    Neuropharmacology, 1985, Volume: 24, Issue:11

    Topics: Animals; Anxiety; Brain; Clonidine; Flunitrazepam; In Vitro Techniques; Isomerism; Male; Membranes;

1985