Page last updated: 2024-10-27

flunitrazepam and Anesthesia

flunitrazepam has been researched along with Anesthesia in 40 studies

Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"The effect of thyrotropin releasing hormone (TRH) on modified neuroleptanesthesia with fentanyl-flunitrazepam was investigated in an open pilot study of 15 neurosurgical patients."7.67Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man. ( Dangelmaier, R; Glöser, A; Hempel, V; Lenz, G, 1986)
"Flunitrazepam is a benzodiazepine with pronounced hypnotic effects in the usual dosage."5.28High-dose flunitrazepam anesthesia. ( Eldor, J, 1992)
" Oral administration of DAA1106, diazepam and buspirone but not DAA1097 significantly increased sleeping time in hexobarbital-induced anesthesia in mice."3.70Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. ( Chaki, S; Nagamine, M; Nakazato, A; Ogawa, S; Okubo, T; Okuyama, S; Suzuki, Y; Tomisawa, K; Yoshikawa, R, 1999)
" For all three drugs, a marked toxic interaction was found with chloralose/urethane anesthesia, and noticeably less distinctive with pentobarbital anesthesia."3.67Effects of brotizolam and other diazepines on respiration. ( Danneberg, P, 1986)
"The effect of thyrotropin releasing hormone (TRH) on modified neuroleptanesthesia with fentanyl-flunitrazepam was investigated in an open pilot study of 15 neurosurgical patients."3.67Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man. ( Dangelmaier, R; Glöser, A; Hempel, V; Lenz, G, 1986)
" The EEG is a proven parameter with regard to dosage determination and as objective means to find sleep-inducing quantities of drugs."2.37Modern trends in the investigation of new hypnotics in anaesthesia. ( Doenicke, A, 1984)
"Flunitrazepam is a benzodiazepine derivative whose hypnotic effect predominates over the sedative, anxiolytic, muscle-relaxing and anticonvulsant effects characteristic of benzodiazepines."2.36Flunitrazepam: a review of its pharmacological properties and therapeutic use. ( Larni, HM; Mattila, MA, 1980)
"Nitroglycerin was administered by continuous infusion before aortic clamping and we determined the dose necessary to decrease the systemic vascular resistance by 20 per cent."1.28[Intraoperative nitroglycerin: value of determining individual doses: (surgery of the abdominal aorta)]. ( Combes, P; Durand, M; Magne, JL; Payen, JF; Pra, Y, 1989)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199031 (77.50)18.7374
1990's7 (17.50)18.2507
2000's1 (2.50)29.6817
2010's1 (2.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yara, M1
Tomino, M1
Miyata, K1
Ishida, Y1
Saiki, I1
Seta, N1
Hara, N1
Uchino, H1
Klein, M1
Kramer, F1
Karliczek, G1
Birks, RJ1
Brenken, U1
Agnew, M1
Mattila, MA2
Larni, HM1
Hennart, D2
d'Hollander, A2
Primo-Dubois, J2
Guillaume, V1
Corriol, J1
Papy, JJ1
Joseph, D1
Barrois, V1
Bouchard, C1
Roullit, S1
Bastien, O1
Hercule, C1
George, M1
Girard, C1
Villard, J1
Doenicke, A1
Soret, J1
Schmutzler, S1
Uges, D1
Agoston, S1
Langrehr, D1
Meignier, M1
Gouraud, P1
Zaouter, M1
Hepner, D1
Pannier, M1
Herbeau, C1
Charlon, D1
Herbeau, S1
Mugica, J1
Parraguette, J1
Garbarini, T1
Diulcin, N1
Sicre, B1
Renum, B1
Cordebar, R1
Dubois-Primo, J1
Trotoux, J1
Copper-Royer, F1
Bail, I1
Fould, L1
Margoloff, B1
Schwender, D1
Kaiser, A1
Klasing, S1
Faber-Züllig, E1
Golling, W1
Pöppel, E1
Peter, K1
Guichard, J1
Panteix, G1
Dubost, J1
Baltassat, P1
Roche, C1
Engel, SR1
Gandet, EA1
Jackson, KA1
Allan, AM1
Karzai, W1
Haberstroh, J1
Müller, W1
Priebe, HJ2
Okuyama, S1
Chaki, S1
Yoshikawa, R1
Ogawa, S1
Suzuki, Y1
Okubo, T1
Nakazato, A1
Nagamine, M1
Tomisawa, K1
Freuchen, I1
Ostergaard, J1
Mikkelsen, BO1
De Castro, J1
Parmentier, P1
George, KA1
Dundee, JW1
Martikainen, P1
Säilä, K1
Orts Buchón, A1
Martí Viaño, JL1
Navarro Guillén, B1
Ibáñez Ballesteros, J1
Rodríguez Castañares, FJ1
Kapp, W1
Tarnow, J1
Hess, W1
Schmidt, D1
Eberlein, HJ1
Milewski, P1
Dick, W1
Kurka, P1
Dewachter, B1
Massaut, J1
Benke, A1
Erben, WD1
Schlais, H1
Eldor, J1
Nöldge, GF1
Bohle, W1
Buttler, KJ1
Geiger, K1
Combes, P1
Payen, JF1
Durand, M1
Magne, JL1
Pra, Y1
Saint-Maurice, C1
Egu, JF1
Gaudiche, O1
Loose, JP1
Murat, I1
Danneberg, P1
Lenz, G1
Hempel, V1
Glöser, A1
Dangelmaier, R1

Reviews

5 reviews available for flunitrazepam and Anesthesia

ArticleYear
Rave drugs: pharmacological considerations.
    AANA journal, 2004, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Anesthesia; Dancing; Designer Drugs; Emergency Treatment; Flunitrazepam; Hallucin

2004
Flunitrazepam: a review of its pharmacological properties and therapeutic use.
    Drugs, 1980, Volume: 20, Issue:5

    Topics: Anesthesia; Anti-Anxiety Agents; Brain; Flunitrazepam; Hemodynamics; Humans; Hypnotics and Sedatives

1980
Modern trends in the investigation of new hypnotics in anaesthesia.
    Psychopharmacology. Supplementum, 1984, Volume: 1

    Topics: Anesthesia; Anti-Anxiety Agents; Arousal; Benzodiazepines; Electroencephalography; Electrophysiology

1984
[The pharmacology of flunitrazepam (provided under the trade name Rohypnol)].
    Klinische Anasthesiologie und Intensivtherapie, 1978, Issue:17

    Topics: Aggression; Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Chemical Phenom

1978
[Anesthesia in patients with Duchenne muscular dystrophy].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8, Issue:5

    Topics: Adolescent; Anesthesia; Anesthesia Recovery Period; Anesthetics; Cardiovascular Diseases; Child; Chi

1989

Trials

6 trials available for flunitrazepam and Anesthesia

ArticleYear
Termination of anaesthesia--do we pay enough attention to its consequences? Haemodynamic studies following the use of piritramide, flunitrazepam and nitrous oxide anaesthesia for open heart surgery.
    Der Anaesthesist, 1980, Volume: 29, Issue:7

    Topics: Adult; Anesthesia; Anti-Anxiety Agents; Blood Pressure; Cardiac Surgical Procedures; Coronary Artery

1980
[Anesthesia with flunitrazepam/fentanyl and isoflurane/fentanyl. Unconscious perception and mid-latency auditory evoked potentials].
    Der Anaesthesist, 1994, Volume: 43, Issue:5

    Topics: Adult; Aged; Anesthesia; Auditory Perception; Cardiac Surgical Procedures; Consciousness; Evoked Pot

1994
Flunitrazepam (Rohypnol) compared with enibomal (Narcodorm) as an anaesthetic induction agents: a controlled clinical trial.
    Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:1

    Topics: Anesthesia; Anti-Anxiety Agents; Barbiturates; Blood Pressure; Clinical Trials as Topic; Female; Flu

1976
Relative amnesic actions of diazepam, flunitrazepam and lorazepam in man.
    British journal of clinical pharmacology, 1977, Volume: 4, Issue:1

    Topics: Amnesia; Anesthesia; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Humans; Lorazepam; Time F

1977
Flunitrazepam compared with althesin as an induction agent in balanced anaesthesia.
    British journal of anaesthesia, 1977, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Aged; Alfaxalone Alfadolone Mixture; Anesthesia; Anti-Anxiety Agents; Blood Press

1977
[Administration and dosage of flunitrazepam in combination with analgesics].
    Klinische Anasthesiologie und Intensivtherapie, 1978, Issue:17

    Topics: Adult; Aged; Analgesics; Anesthesia; Anti-Anxiety Agents; Blood Gas Analysis; Blood Pressure; Clinic

1978

Other Studies

29 other studies available for flunitrazepam and Anesthesia

ArticleYear
[Perioperative management of off-pump CABG for a 93-year-old man].
    Masui. The Japanese journal of anesthesiology, 2014, Volume: 63, Issue:10

    Topics: Aged, 80 and over; Anesthesia; Brain; Cerebrovascular Circulation; Consciousness Monitors; Coronary

2014
The haemodynamic effects of flunitrazepam in anaesthetized patients with valvular or coronary artery lesions.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:3

    Topics: Adult; Anesthesia; Anti-Anxiety Agents; Blood Pressure; Cardiac Output; Coronary Disease; Electrocar

1982
[A safe technic for anesthesia of the rabbit].
    Journal de physiologie, 1982, Volume: 78, Issue:3

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Flunitrazepam; Injections, Intramuscular; Injections, Subc

1982
[The use of benzodiazepines].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Anesthesia; Anti-Anxiety Agents; Flunitrazepam; Humans; Kinetics

1984
[Combined flunitrazepam-fentanyl and curare in emergency internal surgery].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adolescent; Adult; Aged; Anesthesia; Atropine; Emergencies; Female; Fentanyl; Flunitrazepam; Humans;

1984
[Anesthesia with flunitrazepam/fentanyl in the severe coronary patient. Hemodynamic study].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Aged; Anesthesia; Coronary Artery Bypass; Coronary Disease; Female; Fentanyl; Flunitrazepam; Hemodyn

1984
[The flunitrazepam-phenoperidine combination in neuroradiology without intubation].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adolescent; Adult; Aged; Anesthesia; Carbon Dioxide; Consciousness; Female; Flunitrazepam; Humans; M

1984
[Rohypnol poisoning as a cause of postanesthetic coma and the success of 4-aminopyridine therapy].
    Der Anaesthesist, 1984, Volume: 33, Issue:6

    Topics: 4-Aminopyridine; Adult; Aminopyridines; Anesthesia; Coma; Female; Flunitrazepam; Humans; Naloxone; P

1984
[Use of flunitrazepam in balneotherapy of the burned patient].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adult; Anesthesia; Baths; Burns; Child; Consciousness; Flunitrazepam; Heart Rate; Hemodynamics; Huma

1984
[Flunitrazepam-fentanyl for the intracavitary placement of pacemakers].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adolescent; Adult; Aged; Anesthesia; Arrhythmias, Cardiac; Cardiovascular System; Child; Electric St

1984
[Comparison of the effects of flunitrazepam and diazepam used in premedication].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Adult; Aged; Amnesia; Anesthesia; Anxiety; Diazepam; Drug Tolerance; Female; Flunitrazepam; Hemodyna

1984
[Importance of the ketamine-flunitrazepam combination in elective abortion].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl

    Topics: Abortion, Induced; Adolescent; Adult; Aging; Anesthesia; Consciousness; Female; Flunitrazepam; Human

1984
Anesthesia with flunitrazepam and fentanyl supplemented with droperidol or chlorpromazine (Largactil) in coronary surgery.
    Acta anaesthesiologica Belgica, 1981, Volume: 32, Issue:2

    Topics: Anesthesia; Cardiac Surgical Procedures; Chlorpromazine; Coronary Artery Bypass; Droperidol; Female;

1981
[Personal experience of anaesthesia in ear surgery. Two year study].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1982, Volume: 99, Issue:7-8

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Alfaxalone Alfadolone Mixture; Anesthesia; Ear; Flun

1982
Simultaneous high-performance liquid chromatographic assay of droperidol and flunitrazepam in human plasma. Application to haemodilution blood samples collected during clinical anaesthesia.
    Journal of chromatography, 1993, Feb-26, Volume: 612, Issue:2

    Topics: Adolescent; Adult; Anesthesia; Chromatography, High Pressure Liquid; Droperidol; Female; Flunitrazep

1993
Effect of in vivo administration of anesthetics on GABAA receptor function.
    Laboratory animal science, 1996, Volume: 46, Issue:4

    Topics: Anesthesia; Anesthetics; Anesthetics, Inhalation; Animals; Brain; Carbon Dioxide; Chlorides; Ethanol

1996
Rapid increase in inspired desflurane concentration does not elicit a hyperdynamic circulatory response in the pig.
    Laboratory animals, 1997, Volume: 31, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; Catecholamin

1997
Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.
    Life sciences, 1999, Volume: 64, Issue:16

    Topics: Acetamides; Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Buspirone; Cell Memb

1999
[Choice of a potentiator of analgesics].
    Annales de l'anesthesiologie francaise, 1976, Volume: 17, Issue:10

    Topics: Amnesia; Analgesics, Opioid; Anesthesia; Anesthetics; Autonomic Nerve Block; Barbiturates; Diazepam;

1976
[Cardiorespiratory effects of flunitrazepam].
    Revista espanola de anestesiologia y reanimacion, 1977, Volume: 24, Issue:5

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Drug Evaluation; Flunitrazepam; Myocardial Contraction; Pu

1977
[The effect of flunitrazepam and diazepam on circulation in coronary surgical patients after anesthesia induction and during extracorporeal circulation].
    Klinische Anasthesiologie und Intensivtherapie, 1978, Issue:17

    Topics: Anesthesia; Anti-Anxiety Agents; Coronary Vessels; Diazepam; Extracorporeal Circulation; Female; Flu

1978
[Clinical experience with flunitrazepam combination anesthesia].
    Klinische Anasthesiologie und Intensivtherapie, 1978, Issue:17

    Topics: Anesthesia; Anti-Anxiety Agents; Barbiturates; Droperidol; Drug Combinations; Drug Interactions; Ele

1978
Hemodynamic effects of flunitrazepam in the coronary patient under moderated analgesic anesthesia.
    Acta anaesthesiologica Belgica, 1979, Volume: 30 Suppl

    Topics: Anesthesia; Anti-Anxiety Agents; Coronary Disease; Dose-Response Relationship, Drug; Flunitrazepam;

1979
[Anaesthesia for peripheral angiographies (author's transl)].
    Praktische Anasthesie, Wiederbelebung und Intensivtherapie, 1979, Volume: 14, Issue:1

    Topics: Aged; Anesthesia; Angiography; Flunitrazepam; Humans; Meperidine; Methohexital; Middle Aged; Premedi

1979
High-dose flunitrazepam anesthesia.
    Medical hypotheses, 1992, Volume: 38, Issue:4

    Topics: Anesthesia; Binding Sites; Blood Vessels; Flunitrazepam; Humans

1992
Effects of acute normovolemic hemodilution on splanchnic oxygenation and on hepatic histology and metabolism in anesthetized pigs.
    Anesthesiology, 1991, Volume: 74, Issue:5

    Topics: Anesthesia; Animals; Female; Flunitrazepam; Hemodilution; Hemodynamics; Hydroxyethyl Starch Derivati

1991
[Intraoperative nitroglycerin: value of determining individual doses: (surgery of the abdominal aorta)].
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1989, Volume: 36, Issue:6

    Topics: Aged; Anesthesia; Aorta, Abdominal; Aortic Aneurysm; Aortic Diseases; Arterial Occlusive Diseases; C

1989
Effects of brotizolam and other diazepines on respiration.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:3A

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azepines; Cats; Chloralose; Female; Flunitrazepam; Hypnoti

1986
Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man.
    Acta anaesthesiologica Belgica, 1986, Volume: 37, Issue:3

    Topics: Adult; Anesthesia; Arousal; Carbon Dioxide; Female; Fentanyl; Flunitrazepam; Humans; Male; Middle Ag

1986