flunitrazepam has been researched along with Alzheimer Disease in 6 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss." | 1.27 | [3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. ( Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Waddington, JL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Revilla, S | 1 |
| Suñol, C | 1 |
| García-Mesa, Y | 1 |
| Giménez-Llort, L | 1 |
| Sanfeliu, C | 1 |
| Cristòfol, R | 1 |
| Owen, F | 1 |
| Poulter, M | 1 |
| Waddington, JL | 1 |
| Mashal, RD | 1 |
| Crow, TJ | 1 |
| Zaman, SH | 1 |
| Parent, A | 1 |
| Laskey, A | 1 |
| Lee, MK | 1 |
| Borchelt, DR | 1 |
| Sisodia, SS | 1 |
| Malinow, R | 1 |
| Lloyd, GK | 1 |
| Lowenthal, A | 1 |
| Javoy-Agid, F | 1 |
| Constantidinis, J | 1 |
| Shimohama, S | 1 |
| Taniguchi, T | 1 |
| Fujiwara, M | 1 |
| Kameyama, M | 1 |
| Greenamyre, JT | 1 |
| Penney, JB | 1 |
| D'Amato, CJ | 1 |
| Young, AB | 1 |
6 other studies available for flunitrazepam and Alzheimer Disease
| Article | Year |
|---|---|
Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis Regulatory Proteins; Cerebral | 2014 |
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Female; Flunitr | 1983 |
Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Electric Stimulation; Excitatory Postsynaptic Poten | 2000 |
GABAA receptor complex function in frontal cortex membranes from control and neurological patients.
Topics: Adult; Aged; Alzheimer Disease; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; | 1991 |
Changes in benzodiazepine receptors in Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Brain; Flunitrazepam; Humans; Receptors, GABA-A | 1988 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippoca | 1987 |