flunitrazepam has been researched along with Alcoholism in 24 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "An analysis of kinetic parameters (Kd and Bmax) of [3H]flunitrazepam and [3H]PK-11195 binding with synaptosomal and mitochondrial membranes in the human brain showed that BDR was decreased and capacity increased in different human brain areas under the influence of alcohol abuse." | 3.80 | [Brain benzodiazepine receptors in humans and rats with alcohol addiction]. ( Bokhan, NA; Semke, VIa; Shushpanova, TB; Solonskiĭ, AV; Udut, VV, 2014) |
| "Long-term alcohol abuse is known to target specific areas of the brain such as the superior frontal cortex (SFC), resulting in neuronal cell loss." | 1.31 | Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. ( Buckley, ST; Dodd, PR; Eckert, AL, 2000) |
| "Seizures were detected in 25% of the animals during withdrawal episode 10-13." | 1.29 | Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence. ( Allerup, P; Bech, B; Diemer, NH; Ebert, B; Hemmingsen, R; Ulrichsen, J, 1996) |
| "Whereas cases with concomitant Wernicke encephalopathy may also have had greater numbers of superior frontal [3H]muscimol binding sites than controls, alcoholics with cirrhosis of the liver showed more muted differences." | 1.29 | GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics. ( Dodd, PR, 1994) |
| "The effect of alcohol dependence induced by ethanol inhalation on GABA-dependent 36Cl- influx into membrane vesicles prepared from the mouse brain has been examined." | 1.28 | Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles. ( Kuriyama, K; Ueha, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shushpanova, TV | 1 |
| Solonskii, AV | 2 |
| Novozheeva, TP | 1 |
| Udut, VV | 2 |
| Shushpanova, TB | 1 |
| Semke, VIa | 1 |
| Bokhan, NA | 1 |
| Laqueille, X | 1 |
| Launay, C | 1 |
| Dervaux, A | 1 |
| Kanit, M | 1 |
| Laukkanen, V | 1 |
| Storvik, M | 1 |
| Häkkinen, M | 1 |
| Akamine, Y | 1 |
| Tupala, E | 1 |
| Virkkunen, M | 1 |
| Tiihonen, J | 1 |
| Kumar, S | 1 |
| Kralic, JE | 1 |
| O'Buckley, TK | 1 |
| Grobin, AC | 1 |
| Morrow, AL | 2 |
| Mehta, AK | 2 |
| Ticku, MK | 3 |
| Hemmingsen, R | 2 |
| Braestrup, C | 1 |
| Nielsen, M | 1 |
| Barry, DI | 1 |
| Harro, J | 1 |
| Wahlström, G | 1 |
| Oreland, L | 1 |
| Katsura, M | 1 |
| Ohkuma, S | 1 |
| Kuriyama, K | 2 |
| Klein, RL | 1 |
| Mascia, MP | 1 |
| Whiting, PJ | 1 |
| Harris, RA | 1 |
| Devaud, LL | 1 |
| Purdy, RH | 1 |
| Paul, SM | 1 |
| Dodd, PR | 6 |
| Thomas, GJ | 2 |
| McCloskey, A | 1 |
| Crane, DI | 2 |
| Smith, ID | 1 |
| Ulrichsen, J | 1 |
| Bech, B | 1 |
| Ebert, B | 1 |
| Diemer, NH | 1 |
| Allerup, P | 1 |
| Kril, JJ | 2 |
| Watson, WE | 2 |
| Johnston, GA | 2 |
| Harper, CG | 2 |
| Lewohl, JM | 1 |
| Buckley, ST | 1 |
| Eckert, AL | 1 |
| Gisselmann, A | 1 |
| Ueha, T | 1 |
| Freund, G | 2 |
| Ballinger, WE | 2 |
| Mhatre, M | 1 |
| Gundlach, AL | 1 |
| Davies, N | 1 |
3 reviews available for flunitrazepam and Alcoholism
| Article | Year |
|---|---|
[Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature].
Topics: Adolescent; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Clonazepam; Clorazepate Dipotassium; | 2009 |
[Functional significance of diazepam binding inhibitor (DBI) in establishment of alcohol dependence].
Topics: Alcoholism; Animals; Brain; Carrier Proteins; Diazepam Binding Inhibitor; Ethanol; Flunitrazepam; GA | 1995 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; E | 1995 |
21 other studies available for flunitrazepam and Alcoholism
| Article | Year |
|---|---|
Effect of meta-chlorobenzhydryl urea (m-ClBHU) on benzodiazepine receptor system in rat brain during experimental alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Benzodiazepinones; Brain; Flunitrazepam; gamma-Aminobutyric Ac | 2014 |
[Brain benzodiazepine receptors in humans and rats with alcohol addiction].
Topics: Alcoholism; Animals; Cerebral Cortex; Ethanol; Flunitrazepam; Humans; Male; Mitochondria; Rats; Rats | 2014 |
Decreased GABA(A) benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics.
Topics: Adult; Alcoholism; Anxiety; Autopsy; Autoradiography; Brain Chemistry; Dentate Gyrus; Female; Flunit | 2013 |
Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex.
Topics: Administration, Oral; Alcoholism; Animals; Binding, Competitive; Blotting, Western; Cerebral Cortex; | 2003 |
Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Flunitrazepam; GA | 2005 |
The benzodiazepine/GABA receptor complex during severe ethanol intoxication and withdrawal in the rat.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Diazepam; Ethanol; Flunitrazepam; Humans; Male; Rats; R | 1982 |
Cholecystokinin receptor binding after long-term ethanol treatment in rats.
Topics: Alcoholism; Animals; Binding, Competitive; Brain; Corpus Striatum; Dose-Response Relationship, Drug; | 1994 |
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Topics: Alcoholism; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Ge | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence.
Topics: Alcoholism; Animals; Autoradiography; Brain; Dizocilpine Maleate; Down-Regulation; Ethanol; Excitato | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazep | 1994 |
Zolpidem binding sites on the GABA(A) receptor in brain from human cirrhotic and non-cirrhotic alcoholics.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Brain; Female; Flunitrazepam; Frontal Lob | 1997 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.
Topics: Alcoholism; Autoradiography; Blotting, Northern; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA | 2000 |
[Insomnia in alcoholics recently detoxified: treatment with flunitrazepam].
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Drug Tolerance; Female; Fl | 1979 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo | 1992 |
Neuroreceptor changes in the putamen of alcohol abusers.
Topics: Adult; Aging; Alcoholism; Binding, Competitive; Flunitrazepam; Humans; Hypoxia; Putamen; Quinuclidin | 1989 |
Loss of muscarinic cholinergic receptors from the temporal cortex of alcohol abusers.
Topics: Aged; Alcoholism; Flunitrazepam; Humans; Middle Aged; Postmortem Changes; Quinuclidinyl Benzilate; R | 1989 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Ma | 1989 |
Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients.
Topics: Alcoholism; Brain; Diazepam; Flunitrazepam; Humans; Receptors, GABA-A | 1988 |