flunitrazepam has been researched along with Absence Seizure in 90 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The protective activity of allopregnanolone and/or phenobarbital against seizures was studied in the C57 mice, using the maximal electroshock seizure (MES) test." | 7.71 | Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice. ( Lu, YQ; Yu, R, 2001) |
| "In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)." | 7.68 | Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 7.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "The potencies of seven benzodiazepines (BDZs) were established by three tests: inhibition of [3H]flunitrazepam receptor binding, inhibition of [3H]adenosine uptake, and prevention of pentylenetetrazol-induced seizures in mice." | 7.67 | Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1984) |
| "The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures." | 7.66 | gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982) |
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 7.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| "PTZ not only induced seizures, but also inhibited specific [3H]FTZ binding to brain membranes in a dose-dependent manner." | 5.28 | Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine. ( Chang, YF; Chen, JS; Gao, XM, 1991) |
| "In a previous work, we have shown that seizures lead to an age-dependent upregulation of central benzodiazepine binding sites measured in isolated rat cerebral membranes." | 5.28 | Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat. ( Daval, JL; Werck, MC, 1991) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 5.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| " Using radioligand receptor-binding assay, we showed that only betulin bound to the GABA(A)-receptor sites in mice brain in vitro and antagonised the GABA(A)-receptor antagonist bicuculline-induced seizures in mice after intracisternal and intraperitoneal administration." | 3.74 | Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. ( Dzirkale, Z; Klusa, V; Krigere, L; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Zharkova, O, 2008) |
| "The protective activity of allopregnanolone and/or phenobarbital against seizures was studied in the C57 mice, using the maximal electroshock seizure (MES) test." | 3.71 | Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice. ( Lu, YQ; Yu, R, 2001) |
| "In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines." | 3.69 | Benzodiazepine withdrawal syndrome seizures. ( de Iceta, M; Martínez-Cano, H; Martínez-Gras, I; Pomalima, R; Vela-Bueno, A, 1995) |
| "In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)." | 3.68 | Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992) |
| "Medetomidine, a new selective alpha 2-adrenoceptor agonist, potentiated bicuculline seizures in mice." | 3.68 | The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity. ( Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V, 1991) |
| "Denzimol, a new anticonvulsant drug with a pharmacological profile similar to that of phenytoin, enhances the ataxic and antimetrazol activity of diazepam in rats without affecting its activity against picrotoxin-induced seizures." | 3.67 | Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat. ( Gobbi, M; Mennini, T; Testa, R, 1984) |
| "Subcutaneous administration of caerulein (100-500 micrograms/kg) significantly reduced the development of picrotoxin (8 mg/kg) seizures in male mice." | 3.67 | [Modulating effect of cerulein on benzodiazepine receptors]. ( Maĭmets, MO; Nurk, AM; Riago, LK; Soosaar, AKh; Vasar, EE, 1985) |
| "The present study was designed to investigate whether D,L-laudanosine (a breakdown product of the neuromuscular relaxant atracurium besylate) interacts with benzodiazepinergic receptors or muscarinic receptors, both of which are involved in epilepsy and other types of seizures." | 3.67 | Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors. ( Gavish, M; Katz, Y, 1989) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 3.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "The potencies of seven benzodiazepines (BDZs) were established by three tests: inhibition of [3H]flunitrazepam receptor binding, inhibition of [3H]adenosine uptake, and prevention of pentylenetetrazol-induced seizures in mice." | 3.67 | Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1984) |
| " Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice." | 3.67 | Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. ( Kato, R; Muraki, T; Yamazoe, Y, 1984) |
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 3.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| " Since electrophysiological and pharmacological data suggest the view that gamma-aminobutyric acid (GABA) plays an important role in controlling convulsive seizures, the effect of lindane on the GABAergic system, on different areas of the rat brain, has been evaluated." | 3.66 | Convulsions induced by lindane and the involvement of the GABAergic system. ( Cattabeni, F; Eli, M; Pastorello, MC, 1983) |
| "The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures." | 3.66 | gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982) |
| "Effects of hyperthermia-induced seizures (HS) on GABAA and benzodiazepine (BDZ) receptor binding in immature rat brain were evaluated using in vitro autoradiography." | 1.33 | Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain. ( Feria, A; González-Ramírez, M; Orozco, S; Rocha, L; Salgado, H, 2005) |
| "Pentylenetetrazole-induced seizure threshold was increased with the administration of 2 and 10 mg/kg zolpidem as well as with lorazepam." | 1.33 | Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Reddi, JM, 2006) |
| "Ganaxolone (CCD 1042) is a 3beta-methyl-substituted analog of the endogenous neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one." | 1.30 | Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. ( Belelli, D; Bolger, MB; Carter, RB; Gee, KW; Hawkinson, JE; Lambert, JJ; Lan, NC; Mirsadeghi, S; Tahir, SH; White, HS; Wieland, S; Wolf, HH; Wood, PL, 1997) |
| "Seizures were detected in 25% of the animals during withdrawal episode 10-13." | 1.29 | Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence. ( Allerup, P; Bech, B; Diemer, NH; Ebert, B; Hemmingsen, R; Ulrichsen, J, 1996) |
| "The morphine-pretreated animals showed faster acquisition of seizure activity." | 1.29 | Effects of chronic morphine pretreatment on amygdaloid kindling development, postictal seizure and suppression and benzodiazepine receptor binding in rats. ( Ackermann, RF; Engel, J; Rocha, L, 1996) |
| "On day 1 the clonic and tonic seizure latencies were increased from 160." | 1.29 | Chronic L-lysine develops anti-pentylenetetrazol tolerance and reduces synaptic GABAergic sensitivity. ( Cauley, RK; Chang, YF; Gao, XM; Wang, Y, 1993) |
| "2." | 1.29 | Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines. ( Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M, 1993) |
| " Alzet 2001 osmotic pumps deliver at a constant rate (1 microliter/h) and dosage can be easily adjusted." | 1.29 | A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice. ( Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1993) |
| "In a previous work, we have shown that seizures lead to an age-dependent upregulation of central benzodiazepine binding sites measured in isolated rat cerebral membranes." | 1.28 | Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat. ( Daval, JL; Werck, MC, 1991) |
| "However, generalized seizures induced by kindling the inferior collicular cortex did not alter the kindling rate in the contralateral side." | 1.28 | Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding. ( Breese, GR; Edgar, PP; McCown, TJ; Schwartz, RD, 1991) |
| "PTZ not only induced seizures, but also inhibited specific [3H]FTZ binding to brain membranes in a dose-dependent manner." | 1.28 | Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine. ( Chang, YF; Chen, JS; Gao, XM, 1991) |
| "Dogs dosed chronically (4-7 weeks) with oral flunitrazepam (7." | 1.28 | A comparison of the physical dependence inducing properties of flunitrazepam and diazepam. ( Martin, WR; Sloan, JW; Wala, EP, 1991) |
| "When the soman-induced convulsions were blocked, the decrease in muscarinic receptors at 3 days was less extensive than when convulsions occurred and at 10 days they approached control levels in most of the brain areas." | 1.28 | Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors. ( Churchill, L; Cross, RS; Nelson, SR; Pazdernik, TL; Samson, FE, 1990) |
| "Chrysin was found to be a ligand for the benzodiazepine receptors, both central (Ki = 3 microM, competitive mechanism) and peripheral (Ki = 13 microM, mixed-type mechanism)." | 1.28 | Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. ( Calvo, D; Diaz, LE; Levi de Stein, M; Medina, JH; Paladini, AC; Peña, C; Wolfman, C, 1990) |
| "The effects of acute and chronic administration of a subconvulsive dose of picrotoxin on t-[35S]butylbicyclophosphorothionate ([3S]TBPS), [3H]muscimol, and [3H]flunitrazepam binding characteristics in various regions and on the convulsant potency of picrotoxin in Sprague-Dawley rats were examined." | 1.28 | Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain. ( Ho, IK; Ito, Y; Lim, DK; Nabeshima, T, 1989) |
| "We think this decline is caused by seizures since phenobarbital pretreatment prevented the appearance of limbic seizures and blocked the receptor decline." | 1.27 | Benzodiazepine receptor declines in hippocampal formation following limbic seizures. ( Dasheiff, RM; Fanelli, RJ; Kraus, VM; McNamara, JO, 1983) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 1.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| "For each strain, when equivalent seizure thresholds were observed at different time points, equivalent receptor occupancies were also observed." | 1.27 | Evidence of strain differences in GABA-benzodiazepine coupling. ( File, SE; Martin, IL; Wilks, L, 1987) |
| "In behavioral studies, ethanol prevents convulsions induced by bicuculline, picrotoxin and maximal electroshock seizures." | 1.27 | Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol. ( Ticku, MK, 1987) |
| "The effects of chronic cortical seizures on the autoradiographic distributions of two markers of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor--chloride ionophore complex within local and long circuits connected to the focus were examined." | 1.27 | Effects of chronic cortical seizures on GABA and benzodiazepine receptors within seizure pathways. ( Collins, RC; Santori, EM, 1988) |
| "Ethyl loflazepate was designed to be a prodrug that would gradually release within the organism an active 1,4-BZD." | 1.27 | Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities. ( Bizière, K; Chambon, JP; Dantzer, R; Demarne, H; Hallot, A; Perio, A; Roncucci, R, 1985) |
| "With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine." | 1.27 | A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983) |
| "The acute effects of seizures were also studied in both S/D rats and audiogenic seizure rats." | 1.27 | Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain. ( Laird, H; Mimaki, T; Yabuuchi, H; Yamamura, HI, 1984) |
| "The relationship of seizure susceptibility to alterations in the GABA receptor complex was investigated in six different populations of mice consisting of four inbred strains (C57BL, DBA, C3H, and BALB) and two selected lines (long sleep and short sleep)." | 1.27 | Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice. ( Marley, RJ; Wehner, JM, 1987) |
| "Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WSR) lines of mice have been genetically selected based on the severity of handling-induced convulsions after identical chronic ethanol exposure." | 1.27 | Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice. ( Crabbe, JC; Feller, DJ; Harris, RA, 1988) |
| "Repeated seizures, whether induced by kindling or electroshock, result in increased numbers of benzodiazepine receptors in hippocampal formation membranes." | 1.26 | Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells. ( Birmingham, F; Crutcher, KA; Dasheiff, RM; McNamara, JO; Valdes, F, 1982) |
| "Like seizure susceptibility, the differences in benzodiazepine binding were age-related." | 1.26 | Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice. ( Robertson, HA, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (51.11) | 18.7374 |
| 1990's | 29 (32.22) | 18.2507 |
| 2000's | 10 (11.11) | 29.6817 |
| 2010's | 5 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lukovits, I | 1 |
| Lopata, A | 1 |
| Cox, ED | 1 |
| Diaz-Arauzo, H | 1 |
| Huang, Q | 1 |
| Reddy, MS | 1 |
| Ma, C | 1 |
| Harris, B | 1 |
| McKernan, R | 1 |
| Skolnick, P | 1 |
| Cook, JM | 1 |
| Anzini, M | 1 |
| Braile, C | 1 |
| Valenti, S | 1 |
| Cappelli, A | 1 |
| Vomero, S | 1 |
| Marinelli, L | 1 |
| Limongelli, V | 1 |
| Novellino, E | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Ghelardini, C | 1 |
| Norcini, M | 1 |
| Makovec, F | 1 |
| Giorgi, G | 1 |
| Ian Fryer, R | 1 |
| Liu, Z | 1 |
| Lindemeyer, AK | 1 |
| Liang, J | 1 |
| Wallner, M | 1 |
| Shao, XM | 1 |
| Shao, Y | 1 |
| Tao, Y | 1 |
| Olsen, RW | 3 |
| Gerbatin, RR | 1 |
| Silva, LFA | 1 |
| Hoffmann, MS | 1 |
| Della-Pace, ID | 1 |
| do Nascimento, PS | 1 |
| Kegler, A | 1 |
| de Zorzi, VN | 1 |
| Cunha, JM | 1 |
| Botelho, P | 1 |
| Neto, JBT | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fighera, MR | 1 |
| Royes, LFF | 1 |
| Pastore, V | 1 |
| Wasowski, C | 2 |
| Higgs, J | 1 |
| Mangialavori, IC | 1 |
| Bruno-Blanch, LE | 1 |
| Marder, M | 2 |
| Svob Strac, D | 1 |
| Vlainic, J | 1 |
| Samardzic, J | 1 |
| Erhardt, J | 1 |
| Krsnik, Z | 1 |
| Muceniece, R | 1 |
| Saleniece, K | 1 |
| Rumaks, J | 1 |
| Krigere, L | 1 |
| Dzirkale, Z | 1 |
| Mezhapuke, R | 1 |
| Zharkova, O | 1 |
| Klusa, V | 1 |
| Contó, MB | 1 |
| Hipólide, DC | 1 |
| de Carvalho, JG | 1 |
| Venditti, MA | 1 |
| Verleye, M | 1 |
| Pansart, Y | 1 |
| Gillardin, J | 1 |
| Kralic, JE | 1 |
| O'Buckley, TK | 1 |
| Khisti, RT | 1 |
| Hodge, CW | 1 |
| Homanics, GE | 1 |
| Morrow, AL | 1 |
| Chadda, R | 1 |
| Devaud, LL | 1 |
| González-Ramírez, M | 1 |
| Orozco, S | 1 |
| Salgado, H | 1 |
| Feria, A | 1 |
| Rocha, L | 3 |
| Fahey, JM | 1 |
| Grassi, JM | 1 |
| Reddi, JM | 1 |
| Greenblatt, DJ | 1 |
| Niznik, HB | 2 |
| Burnham, WM | 2 |
| Kish, SJ | 2 |
| Mennini, T | 2 |
| Gobbi, M | 1 |
| Testa, R | 1 |
| Tacke, U | 1 |
| Braestrup, C | 1 |
| Mimaki, T | 1 |
| Yabuuchi, H | 1 |
| Laird, H | 1 |
| Yamamura, HI | 2 |
| Soubrie, P | 1 |
| Thiebot, MH | 1 |
| Jobert, A | 1 |
| Montastruc, JL | 1 |
| Hery, F | 1 |
| Hamon, M | 1 |
| Antoniadis, A | 1 |
| Múller, WE | 1 |
| Wollert, U | 1 |
| Robertson, HA | 1 |
| Vatashsky, E | 3 |
| Aronson, HB | 3 |
| Zaroura, S | 1 |
| Janicki, P | 1 |
| Libich, J | 1 |
| Szreniawski, Z | 1 |
| Cattabeni, F | 2 |
| Pastorello, MC | 1 |
| Eli, M | 1 |
| Valdes, F | 1 |
| Dasheiff, RM | 2 |
| Birmingham, F | 1 |
| Crutcher, KA | 1 |
| McNamara, JO | 3 |
| Horton, RW | 1 |
| Prestwich, SA | 1 |
| Meldrum, BS | 1 |
| Saano, V | 2 |
| Airaksinen, MM | 2 |
| Abbiati, A | 1 |
| Caccia, S | 1 |
| Cotecchia, S | 1 |
| Gomez, A | 1 |
| Garattini, S | 1 |
| Gee, KW | 2 |
| Brinton, RE | 1 |
| Fanelli, RJ | 2 |
| Wong, DT | 2 |
| Rathbun, RC | 2 |
| Bymaster, FP | 1 |
| Lacefield, WB | 1 |
| Kraus, VM | 1 |
| Okazaki, MM | 1 |
| Abbracchio, MP | 1 |
| Balduini, W | 1 |
| Coen, E | 1 |
| Lombardelli, G | 1 |
| Peruzzi, G | 1 |
| Chweh, AY | 3 |
| Swinyard, EA | 3 |
| Wolf, HH | 3 |
| Muraki, T | 1 |
| Yamazoe, Y | 1 |
| Kato, R | 1 |
| Beilin, B | 1 |
| Weinstock, M | 1 |
| Kupferberg, HJ | 2 |
| Titulaer, MN | 1 |
| Kamphuis, W | 1 |
| Lopes da Silva, FH | 1 |
| Clark, M | 1 |
| Massenburg, GS | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Torchin, CD | 1 |
| Kapetanovic, IM | 1 |
| Chimirri, A | 2 |
| Gitto, R | 1 |
| Grasso, S | 2 |
| Zappalà, M | 2 |
| De Sarro, A | 1 |
| Battista De Sarro, G | 1 |
| DeSarro, GB | 1 |
| DeSarro, A | 1 |
| Concas, A | 1 |
| Santoro, G | 1 |
| Mascia, MP | 1 |
| Maciocco, E | 1 |
| Dazzi, L | 1 |
| Ongini, E | 1 |
| Biggio, G | 1 |
| Chang, YF | 3 |
| Wang, Y | 1 |
| Cauley, RK | 1 |
| Gao, XM | 2 |
| Ackermann, RF | 2 |
| Engel, J | 2 |
| Martínez-Cano, H | 1 |
| Vela-Bueno, A | 1 |
| de Iceta, M | 1 |
| Pomalima, R | 1 |
| Martínez-Gras, I | 1 |
| Ulrichsen, J | 1 |
| Bech, B | 1 |
| Ebert, B | 1 |
| Diemer, NH | 1 |
| Allerup, P | 1 |
| Hemmingsen, R | 1 |
| Ono, T | 1 |
| Fueta, Y | 1 |
| Janjua, NA | 1 |
| Ohmori, O | 1 |
| Ohno, K | 1 |
| Murai, Y | 1 |
| Mita, T | 1 |
| Carter, RB | 1 |
| Wood, PL | 1 |
| Wieland, S | 1 |
| Hawkinson, JE | 1 |
| Belelli, D | 1 |
| Lambert, JJ | 1 |
| White, HS | 1 |
| Mirsadeghi, S | 1 |
| Tahir, SH | 1 |
| Bolger, MB | 1 |
| Lan, NC | 1 |
| Raveh, L | 1 |
| Chapman, S | 1 |
| Cohen, G | 1 |
| Alkalay, D | 1 |
| Gilat, E | 1 |
| Rabinovitz, I | 1 |
| Weissman, BA | 1 |
| Viola, H | 1 |
| Wolfman, C | 2 |
| Goutman, JD | 1 |
| Bianchin, M | 1 |
| Calvo, DJ | 1 |
| Izquierdo, I | 1 |
| Paladini, AC | 2 |
| Medina, JH | 2 |
| Calixto, E | 1 |
| López-Colomé, AM | 1 |
| Casasola, C | 1 |
| Montiel, T | 1 |
| Bargas, J | 1 |
| Brailowsky, S | 1 |
| Lu, YQ | 1 |
| Yu, R | 1 |
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| Sapp, DW | 1 |
| Witte, U | 1 |
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| Marrama, D | 1 |
| Vergoni, AV | 1 |
| Bertolini, A | 1 |
| Werck, MC | 1 |
| Daval, JL | 1 |
| Chapouthier, G | 1 |
| Bondoux, D | 1 |
| Martin, B | 1 |
| Desforges, C | 1 |
| Launay, JM | 1 |
| Buck, KJ | 1 |
| McQuilkin, SJ | 1 |
| Harris, RA | 2 |
| Rägo, L | 1 |
| MacDonald, E | 1 |
| McCown, TJ | 1 |
| Edgar, PP | 1 |
| Schwartz, RD | 1 |
| Breese, GR | 1 |
| Chen, JS | 2 |
| Sloan, JW | 1 |
| Martin, WR | 1 |
| Wala, EP | 1 |
| Fiakpui, CY | 1 |
| Namchuk, MN | 1 |
| Knaus, EE | 1 |
| Diggs, HE | 1 |
| Feller, DJ | 2 |
| Crabbe, JC | 2 |
| Merrill, C | 1 |
| Farrell, E | 1 |
| Churchill, L | 1 |
| Pazdernik, TL | 1 |
| Cross, RS | 1 |
| Nelson, SR | 1 |
| Samson, FE | 1 |
| Levi de Stein, M | 1 |
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90 other studies available for flunitrazepam and Absence Seizure
| Article | Year |
|---|---|
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifam | 1980 |
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423)
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Carbolines; Cell Line; Cerebral | 1998 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Cr | 2008 |
Flavonoids isolated from Tibetan medicines, binding to GABA
Topics: Animals; Anticonvulsants; Arenaria Plant; Asteraceae; China; Flavonoids; Flunitrazepam; GABA-A Recep | 2018 |
Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats.
Topics: Animals; Brain Injuries, Traumatic; Brain Waves; CA3 Region, Hippocampal; Cell Death; Creatine; Epil | 2019 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice.
Topics: Age Factors; Animals; Brain; Dehydroepiandrosterone Sulfate; Drug Administration Schedule; Female; F | 2016 |
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Betulinic | 2008 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
Effects of etifoxine on ligand binding to GABA(A) receptors in rodents.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Flunitrazepam | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepa | 2002 |
Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Chlorides; Corticosterone; Female; | 2005 |
Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Child; Female; Fever; Flunitrazepam; GABA Agonist | 2005 |
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Topics: Animals; Anticonvulsants; Binding, Competitive; Convulsants; Dose-Response Relationship, Drug; Fluni | 2006 |
Benzodiazepine receptor binding following amygdala-kindled convulsions: differing results in washed and unwashed brain membranes.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Buffers; Cell Membrane; Cerebral Cortex; Flunitrazepam; | 1984 |
Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat.
Topics: Animals; Anticonvulsants; Biological Assay; Cerebellum; Cerebral Cortex; Female; Flunitrazepam; Hipp | 1984 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; C | 1984 |
Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Flunitr | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
Benzodiazepine receptor interactions may be involved in the neurotoxicity of various penicillin derivatives.
Topics: Animals; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Flunitrazepam; Male; Penicillins; Ra | 1980 |
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Binding Sites; Brain; Diazepam; Flunitrazepam; g | 1980 |
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Dr | 1983 |
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizure | 1983 |
Effects of new benzodiazepine estazolam on ECOG pattern and maximal electroshock (MES) in the rat.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Electroshock; Estazolam; Flunitrazepam; Mal | 1983 |
Convulsions induced by lindane and the involvement of the GABAergic system.
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Male; Rats; Rats, Inbred Str | 1983 |
Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells.
Topics: Animals; Cell Membrane; Colchicine; Flunitrazepam; Hippocampus; Kinetics; Male; Rats; Rats, Inbred S | 1982 |
gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice.
Topics: Acoustic Stimulation; Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Flunitrazepam; gamma-Am | 1982 |
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats, | 1982 |
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Flunitrazepam; Kinetics; Male; Membranes; Pent | 1982 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitraze | 1983 |
Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentobarbital; Rats; Ra | 1983 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric | 1983 |
Benzodiazepine receptor declines in hippocampal formation following limbic seizures.
Topics: Afferent Pathways; Animals; Diazepam; Dominance, Cerebral; Flunitrazepam; Hippocampus; Limbic System | 1983 |
Binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled rat brain: two months post-seizure.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Flunitrazepam; Kindling, Neurologic; Kinetics; Male; Mu | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; | 1983 |
Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice.
Topics: Adenosine; Animals; Benzodiazepines; Flunitrazepam; Male; Mice; Pentylenetetrazole; Receptors, Cell | 1984 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion | 1984 |
Oral flunitrazepam in the prevention of local anaesthetic-induced convulsions in mice.
Topics: Administration, Oral; Anesthetics, Local; Animals; Bupivacaine; Flunitrazepam; Lidocaine; Male; Mice | 1984 |
Correlations among minimal neurotoxicity, anticonvulsant activity, and displacing potencies in [3H]flunitrazepam binding of benzodiazepines.
Topics: Animals; Benzodiazepines; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Nervous System; Seizur | 1983 |
Long-term and regional specific changes in [3H]flunitrazepam binding in kindled rat hippocampus.
Topics: Animals; Autoradiography; Electrodes, Implanted; Flunitrazepam; GABA Modulators; Hippocampus; Image | 1995 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compou | 1994 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flu | 1993 |
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Benz | 1994 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperat | 1993 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
Chronic L-lysine develops anti-pentylenetetrazol tolerance and reduces synaptic GABAergic sensitivity.
Topics: Animals; Binding, Competitive; Brain; Chloride Channels; Chromatography, High Pressure Liquid; Drug | 1993 |
Effects of chronic morphine pretreatment on amygdaloid kindling development, postictal seizure and suppression and benzodiazepine receptor binding in rats.
Topics: Amygdala; Animals; Autoradiography; Brain; Flunitrazepam; GABA Modulators; Hippocampus; Kindling, Ne | 1996 |
Benzodiazepine withdrawal syndrome seizures.
Topics: Adult; Anti-Anxiety Agents; Female; Flunitrazepam; Heroin Dependence; Humans; Hypnotics and Sedative | 1995 |
Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Convulsants; Densitometry; Flunitrazepam; Male; Penty | 1996 |
Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence.
Topics: Alcoholism; Animals; Autoradiography; Brain; Dizocilpine Maleate; Down-Regulation; Ethanol; Excitato | 1996 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; E | 1997 |
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; G | 1997 |
The involvement of the NMDA receptor complex in the protective effect of anticholinergic drugs against soman poisoning.
Topics: Animals; Brain; Cholinesterase Inhibitors; Cyclopentanes; Dizocilpine Maleate; Dose-Response Relatio | 1999 |
6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity.
Topics: Animals; Anticonvulsants; Diazepam; Flavonoids; Flunitrazepam; GABA Modulators; GABA-A Receptor Anta | 2000 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex | 2000 |
Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Flunitrazepam; GABA Modulat | 2001 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds | 1992 |
Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
Topics: Animals; Binding Sites; Cerebral Cortex; Flunitrazepam; Hippocampus; Hyperthyroidism; Isoniazid; Mal | 1992 |
Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobu | 1991 |
Genetic difference in sensitivity to beta-carboline: evidence for the involvement of brain benzodiazepine receptors.
Topics: Animals; Brain; Carbolines; Clonazepam; Convulsants; Flunitrazepam; Kinetics; Mice; Mice, Inbred BAL | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitraze | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flu | 1991 |
Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding.
Topics: Animals; Autoradiography; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebr | 1991 |
Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Membranes; Mice; Pent | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relations | 1991 |
Synthesis and anticonvulsant activity of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoylpyridines .
Topics: Animals; Anticonvulsants; Binding, Competitive; Biotransformation; Brain; Electroshock; Flunitrazepa | 1990 |
Effect of chronic ivermectin treatment on GABA receptor function in ethanol withdrawal-seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain Chemistry; Ethanol; Flunitrazepam; Ivermectin; Mice; Ovum; Oxyuroidea; R | 1990 |
Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors.
Topics: Animals; Autoradiography; Diazepam; Flunitrazepam; Kainic Acid; Quinuclidinyl Benzilate; Rats; Rats, | 1990 |
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
Topics: Animals; Anticonvulsants; Binding, Competitive; Flavonoids; Flunitrazepam; Mass Spectrometry; Mice; | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Flunitrazepam; Isoquinolines; Kidney; Quinuclidinyl Ben | 1989 |
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Re | 1989 |
Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.
Topics: Animals; Anticonvulsants; Central Nervous System; Chromatography, Gas; Flunitrazepam; Male; Pentylen | 1989 |
Quantitative autoradiographic study of benzodiazepine receptors: comparative study between normal ddY mouse and El mouse.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Electroencephalography; Flunitrazepam; Mice; | 1989 |
Evidence of strain differences in GABA-benzodiazepine coupling.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepa | 1987 |
Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1987 |
Effects of chronic cortical seizures on GABA and benzodiazepine receptors within seizure pathways.
Topics: Animals; Brain; Cerebral Cortex; Electric Stimulation; Flunitrazepam; Male; Models, Neurological; Mu | 1988 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lys | 1988 |
The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency.
Topics: Animals; Brain; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Kynurenine; Male; Rat | 1988 |
Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Conflict, Ps | 1985 |
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Caffeine; Flumazenil; Flunitr | 1986 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
[Modulating effect of cerulein on benzodiazepine receptors].
Topics: Animals; Brain; Ceruletide; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; Male | 1985 |
[3H]-Flunitrazepam binding in the presence of beta-phenylethylamine and its metabolites.
Topics: Animals; Binding, Competitive; Brain; Female; Flunitrazepam; In Vitro Techniques; Mice; Phenethylami | 1985 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1986 |
Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice.
Topics: 3-Mercaptopropionic Acid; Allosteric Regulation; Animals; Brain Chemistry; Dose-Response Relationshi | 1987 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Con | 1988 |
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Benzodiazepinones; Brain Chemistry; Carbolines; Chro | 1986 |
Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Chemical Phenomena; Chemistry; Drug Synergism; Female; Fl | 1986 |