flunarizine has been researched along with Astrocytoma* in 1 studies
1 other study(ies) available for flunarizine and Astrocytoma
| Article | Year |
|---|---|
The effects of verapamil and flunarizine on epileptiform activity induced by bicuculline and low Mg2+ in neocortical tissue of epileptic and primary non-epileptic patients.
In human neocortical slices the specific L-type calcium channel blocker verapamil had been shown to be antiepileptic in the low Mg(2+)-model of epilepsy. The present investigation demonstrated: (1) verapamil exerted also an antiepileptic effect on epileptiform field potentials (EFP) induced by the GABAA-antagonist bicuculline. (2) The unspecific calcium channel modulator flunarizine, which in contrast to verapamil penetrates the blood-brain barrier, depressed EFP in the low Mg(2+)-model and in the bicuculline model. (3) There was no significant difference in the antiepileptic efficacy of verapamil and flunarizine in epileptic (epilepsy surgery) and primary non-epileptic (tumor surgery) neocortical slices. Topics: Astrocytoma; Bicuculline; Brain Neoplasms; Cerebral Cortex; Ependymoma; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; Evoked Potentials; Female; Flunarizine; Humans; In Vitro Techniques; Magnesium; Male; Oligodendroglioma; Verapamil | 1996 |