flumazenil has been researched along with Tremor in 11 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 7.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| " Only non-impairing doses were used to evaluate for anti-tremor efficacy in the harmaline model, which was assessed in wildtype and α6 subunit knockout littermates." | 4.31 | Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA ( Ernst, M; Handforth, A; Singh, RP; Treven, M, 2023) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 3.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "Carisoprodol treatment resulted in tolerance and antagonist-precipitated withdrawal, suggesting it may have an addiction potential similar to that of other long-acting benzodiazepine or barbiturate compounds." | 1.38 | Carisoprodol tolerance and precipitated withdrawal. ( Carbonaro, T; Forster, MJ; Gatch, MB; Nguyen, JD, 2012) |
| "When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss." | 1.27 | Physical dependence on clonazepam in dogs. ( Frey, HH; Scherkl, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Handforth, A | 1 |
| Singh, RP | 1 |
| Treven, M | 1 |
| Ernst, M | 1 |
| Gatch, MB | 1 |
| Nguyen, JD | 1 |
| Carbonaro, T | 1 |
| Forster, MJ | 1 |
| Okamoto, R | 1 |
| Itoh, Y | 1 |
| Murata, Y | 1 |
| Kobayashi, D | 1 |
| Hosoi, M | 1 |
| Mine, K | 1 |
| Bichard, AR | 1 |
| Little, HJ | 1 |
| Schweri, M | 1 |
| Cain, M | 1 |
| Cook, J | 1 |
| Paul, S | 1 |
| Skolnick, P | 1 |
| Martin, JR | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Wala, EP | 1 |
| Sloan, JW | 1 |
| Jing, X | 1 |
| Holtman, PH | 1 |
| File, SE | 1 |
| Zharkovsky, A | 1 |
| Hitchcott, PK | 1 |
| Orliaguet, G | 1 |
| Nguyen, JP | 1 |
| Abay, K | 1 |
| Berberich, E | 1 |
| Melon, E | 1 |
| Duvaldestin, P | 1 |
| Lamb, RJ | 1 |
| Griffiths, RR | 1 |
| Scherkl, R | 1 |
| Frey, HH | 1 |
11 other studies available for flumazenil and Tremor
| Article | Year |
|---|---|
Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA
Topics: Animals; Essential Tremor; Flumazenil; gamma-Aminobutyric Acid; Harmaline; Humans; Ketamine; Mice; M | 2023 |
Carisoprodol tolerance and precipitated withdrawal.
Topics: Animals; Bemegride; Carisoprodol; Central Nervous System Stimulants; Dose-Response Relationship, Dru | 2012 |
Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzodiazepines; Cerebral Cortex; Dopamine; Flumazenil; GAB | 2013 |
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome.
Topics: Animals; Benzodiazepinones; Bicuculline; Flumazenil; Flurazepam; Male; Mice; Nervous System Diseases | 1982 |
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu | 1982 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, D | 1995 |
Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; | 1996 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations | 1992 |
[Anesthesia for thalamic stimulations: value of flumazenil].
Topics: Adult; Aged; Anesthesia, General; Electric Stimulation; Flumazenil; Humans; Intraoperative Period; M | 1991 |
Effects of repeated RO 15-1788 administration in benzodiazepine-dependent baboons.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Convulsants; Diazepam; Drug Tolerance; Flumazenil; | 1985 |
Physical dependence on clonazepam in dogs.
Topics: Animals; Benzodiazepinones; Body Temperature; Body Weight; Clonazepam; Dogs; Female; Flumazenil; Mal | 1986 |