flumazenil has been researched along with Stroke in 14 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "Central benzodiazepine receptor ligands, such as [(11)C]flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the differentiation of functionally and morphologically damaged tissue early in ischemic stroke." | 7.70 | Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. ( Bauer, B; Grond, M; Heiss, WD; Kracht, L; Pawlik, G; Rudolf, J; Wienhard, K, 2000) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "To establish the mechanism of neuroplasticity during the recovery phase following ischemic stroke by assessing the changes in cerebral GABA activity using [(18)F]flumazenil ([(18)F]FMZ) positron emission tomography (PET)." | 3.80 | Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study. ( Cho, K; Kim, YK; Lim, JY; Paik, NJ; Yang, EJ, 2014) |
| "Central benzodiazepine receptor ligands, such as [(11)C]flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the differentiation of functionally and morphologically damaged tissue early in ischemic stroke." | 3.70 | Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. ( Bauer, B; Grond, M; Heiss, WD; Kracht, L; Pawlik, G; Rudolf, J; Wienhard, K, 2000) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taguchi, Y | 1 |
| Takashima, S | 1 |
| Noguchi, K | 1 |
| Tanaka, K | 1 |
| Kim, YK | 1 |
| Yang, EJ | 1 |
| Cho, K | 1 |
| Lim, JY | 1 |
| Paik, NJ | 1 |
| Heiss, WD | 7 |
| Schirrmacher, R | 1 |
| Dea, M | 1 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 2 |
| Sobesky, J | 2 |
| Molinaro, P | 1 |
| Cantile, M | 1 |
| Cuomo, O | 1 |
| Secondo, A | 1 |
| Pannaccione, A | 1 |
| Ambrosino, P | 1 |
| Pignataro, G | 1 |
| Fiorino, F | 1 |
| Severino, B | 1 |
| Gatta, E | 1 |
| Sisalli, MJ | 1 |
| Milanese, M | 1 |
| Scorziello, A | 1 |
| Bonanno, G | 1 |
| Robello, M | 1 |
| Santagada, V | 1 |
| Caliendo, G | 1 |
| Di Renzo, G | 1 |
| Annunziato, L | 1 |
| Müller, V | 1 |
| Saur, D | 2 |
| Klutmann, S | 1 |
| Weiller, C | 2 |
| Röther, J | 2 |
| Clausen, M | 1 |
| Dohmen, C | 1 |
| Kracht, L | 2 |
| Bosche, B | 1 |
| Staub, F | 1 |
| Toyota, S | 1 |
| Valentino, M | 1 |
| Graf, R | 1 |
| Yamauchi, H | 1 |
| Kudoh, T | 1 |
| Kishibe, Y | 1 |
| Iwasaki, J | 1 |
| Kagawa, S | 1 |
| Buchert, R | 1 |
| Knab, R | 1 |
| Grond, M | 2 |
| Rudolf, J | 1 |
| Bauer, B | 1 |
| Wienhard, K | 1 |
| Pawlik, G | 2 |
| Kracht, LW | 1 |
| Buylaert, WA | 1 |
4 reviews available for flumazenil and Stroke
| Article | Year |
|---|---|
PET imaging in ischemic cerebrovascular disease: current status and future directions.
Topics: Brain Ischemia; Flumazenil; Humans; Microglia; Positron-Emission Tomography; Stroke | 2014 |
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
Comparison of PET and DW/PW-MRI in acute ischemic stroke.
Topics: Brain; Brain Ischemia; Carbon Radioisotopes; Diagnostic Imaging; Diffusion Magnetic Resonance Imagin | 2008 |
Coma induced by intoxication.
Topics: Accidental Falls; Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Antidotes; Brai | 2000 |
2 trials available for flumazenil and Stroke
| Article | Year |
|---|---|
Experience with 123I-iomazenil SPECT in acute cerebral infarction.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Data Interpretation, Statistical; Female; Fluma | 2002 |
Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia.
Topics: Aged; Blood Flow Velocity; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Pro | 2001 |
8 other studies available for flumazenil and Stroke
| Article | Year |
|---|---|
Findings of 123I-iomazenil SPECT during and after stroke-like episodes in a patient with MELAS.
Topics: Adult; Female; Flumazenil; Humans; Iodine Radioisotopes; MELAS Syndrome; Stroke; Tomography, Emissio | 2014 |
Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study.
Topics: Aged; Brain Ischemia; Cerebellum; Cerebral Cortex; Female; Flumazenil; Fluorine Radioisotopes; Follo | 2014 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA | 2013 |
Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis.
Topics: Amino Acids; Animals; Brain Edema; Cats; Cerebral Infarction; Cerebrovascular Circulation; Flumazeni | 2003 |
Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: a 11C-flumazenil PET study.
Topics: Arterial Occlusive Diseases; Carotid Artery Diseases; Cerebellum; Cerebral Cortex; Flumazenil; GABA | 2005 |
Iomazenil-single-photon emission computed tomography reveals selective neuronal loss in magnetic resonance-defined mismatch areas.
Topics: Adult; Aged; Cell Count; Cerebral Infarction; Female; Flumazenil; Follow-Up Studies; Humans; Magneti | 2006 |
Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy.
Topics: Aged; Cerebral Cortex; Female; Fibrinolytic Agents; Flumazenil; Humans; Male; Middle Aged; Predictiv | 2000 |