flumazenil has been researched along with Stiff-Person Syndrome in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Stiff-Person Syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We re-investigated a 53 year old woman with SPS and profound anxiety for GABA-A receptor binding in the amygdala with (11)C-flumazenil PET scan and studied the potential pathogenic role of purified IgG from her plasma filtrates containing high-titer antibodies against GAD 65." | 3.77 | Human stiff-person syndrome IgG induces anxious behavior in rats. ( Dirkx, R; Folli, F; Geis, C; Gerlach, M; Grünewald, B; Heckmann, M; Perani, D; Reif, A; Solimena, M; Sommer, C; Toyka, KV; Weishaupt, A; Wultsch, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galldiks, N | 1 |
| Thiel, A | 1 |
| Haense, C | 1 |
| Fink, GR | 1 |
| Hilker, R | 1 |
| Geis, C | 1 |
| Weishaupt, A | 1 |
| Grünewald, B | 1 |
| Wultsch, T | 1 |
| Reif, A | 1 |
| Gerlach, M | 1 |
| Dirkx, R | 1 |
| Solimena, M | 1 |
| Perani, D | 1 |
| Heckmann, M | 1 |
| Toyka, KV | 1 |
| Folli, F | 1 |
| Sommer, C | 1 |
| Kim, MJ | 1 |
| Lim, YM | 1 |
| Kim, JS | 1 |
| Kim, KK | 1 |
3 other studies available for flumazenil and Stiff-Person Syndrome
| Article | Year |
|---|---|
11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome.
Topics: Aged; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebral Cortex; Dominance, Cerebral; Femal | 2008 |
Human stiff-person syndrome IgG induces anxious behavior in rats.
Topics: Adult; Amygdala; Animals; Anxiety; Behavior, Animal; Carbon Radioisotopes; Cells, Cultured; Female; | 2011 |
GABAergic changes in (11)C-flumazenil PET in the drug-naïve Stiff-Person syndrome.
Topics: Adult; Carbon Radioisotopes; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glutamate | 2013 |