flumazenil has been researched along with Status Epilepticus in 13 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Positron emission tomography (PET) was used to investigate, in the living baboon, the in vivo modulation of [11C]Ro 15-1788 binding to benzodiazepine receptors in brain and the changes with ligands acting at the supramolecular complex during status epilepticus induced by pentylenetetrazole." | 7.67 | Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex. ( Brouillet, E; Chavoix, C; De la Sayette, V; Fournier, D; Fukuda, H; Guibert, B; Hantraye, P; Mazière, M; Naquet, R, 1988) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 5.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| "To report a fatal case of refractory status epilepticus precipitated by flumazenil use in a mixed benzodiazepine-tricyclic antidepressant overdose." | 3.69 | Fatal seizures after flumazenil administration in a patient with mixed overdose. ( DiSalvo, RP; Haverkos, GP; Imhoff, TE, 1994) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Positron emission tomography (PET) was used to investigate, in the living baboon, the in vivo modulation of [11C]Ro 15-1788 binding to benzodiazepine receptors in brain and the changes with ligands acting at the supramolecular complex during status epilepticus induced by pentylenetetrazole." | 3.67 | Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex. ( Brouillet, E; Chavoix, C; De la Sayette, V; Fournier, D; Fukuda, H; Guibert, B; Hantraye, P; Mazière, M; Naquet, R, 1988) |
| "Stupor is defined as a deep sleep or behaviourally similar unresponsiveness from which the subject can be aroused only by vigorous repeated stimuli." | 1.35 | Idiopathic recurrent stupor mimicking status epilepticus. ( Agrawal, S; Asthana, V; Goel, D; Sharma, JP, 2008) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 1.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horino, A | 1 |
| Kawawaki, H | 1 |
| Fukuoka, M | 1 |
| Tsuji, H | 1 |
| Hattori, Y | 1 |
| Inoue, T | 1 |
| Nukui, M | 1 |
| Kuki, I | 1 |
| Okazaki, S | 1 |
| Tomiwa, K | 1 |
| Hirose, S | 1 |
| Asthana, V | 1 |
| Agrawal, S | 1 |
| Goel, D | 1 |
| Sharma, JP | 1 |
| Kuroda, H | 1 |
| Ogasawara, K | 1 |
| Aso, K | 1 |
| Beppu, T | 1 |
| Kobayashi, M | 1 |
| Chida, K | 1 |
| Ogawa, A | 1 |
| Leroy, C | 1 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Nehlig, A | 1 |
| Brierley, J | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
| Amemiya, S | 1 |
| Hamamoto, M | 1 |
| Mishina, M | 1 |
| Ueda, M | 1 |
| Kumagai, T | 1 |
| Nishiyama, Y | 1 |
| Katayama, Y | 1 |
| Haverkos, GP | 1 |
| DiSalvo, RP | 1 |
| Imhoff, TE | 1 |
| Buchanan, N | 1 |
| Steinhoff, BJ | 1 |
| Stodieck, SR | 1 |
| Chavoix, C | 2 |
| Brouillet, E | 2 |
| Hantraye, P | 2 |
| de la Sayette, V | 2 |
| Kunimoto, M | 1 |
| Varastet, M | 1 |
| Guibert, B | 2 |
| Dodd, RH | 1 |
| Fournier, D | 2 |
| Naquet, R | 2 |
| O'Connor, HJ | 1 |
| Fukuda, H | 1 |
| Mazière, M | 1 |
13 other studies available for flumazenil and Status Epilepticus
| Article | Year |
|---|---|
A case of succinic semialdehyde dehydrogenase deficiency with status epilepticus and rapid regression.
Topics: Amino Acid Metabolism, Inborn Errors; Atrophy; Brain; Developmental Disabilities; Diffusion Magnetic | 2016 |
Idiopathic recurrent stupor mimicking status epilepticus.
Topics: Diagnosis, Differential; Electroencephalography; Flumazenil; GABA Modulators; Humans; Male; Middle A | 2008 |
Spontaneous recovery of reduced cortical central benzodiazepine receptor binding potential on I-123 Iomazenil SPECT in a patient with status epilepticus.
Topics: Adult; Cerebral Cortex; Female; Flumazenil; Humans; Receptors, GABA-A; Remission, Spontaneous; Statu | 2010 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Danger of flumazenil use in pediatric status epilepticus.
Topics: Benzodiazepines; Child, Preschool; Female; Flumazenil; Humans; Infant; Male; Recurrence; Respiratory | 2006 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
Short-term plasticity of central benzodiazepine receptors in status epilepticus: case report.
Topics: Aged; Biomarkers; Brain; Brain Mapping; Down-Regulation; Female; Flumazenil; gamma-Aminobutyric Acid | 2008 |
Fatal seizures after flumazenil administration in a patient with mixed overdose.
Topics: Acute Kidney Injury; Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Charcoal; Drug Overdo | 1994 |
Temporary abolition of seizure activity by flumazenil.
Topics: Flumazenil; Humans; Status Epilepticus; Valproic Acid | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Electroencephalography; Flum | 1992 |
Status epilepticus following administration of flumazenil after endoscopy.
Topics: Adult; Endoscopy, Gastrointestinal; Female; Flumazenil; Humans; Status Epilepticus | 1991 |
Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex.
Topics: Animals; Binding, Competitive; Brain; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A | 1988 |