flumazenil has been researched along with Sleep Initiation and Maintenance Disorders in 6 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The limitations in their use both as choice of therapy and with respect to conservative dosage and duration of use are highlighted." | 2.47 | Benzodiazepines revisited--will we ever learn? ( Lader, M, 2011) |
| "Pretreatment with flumazenil abolished the somnogenic effects and activation of the VLPO neurons by honokiol." | 1.38 | Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice. ( Chen, CR; Fan, K; Hou, YP; Huang, ZL; Qu, WM; Sun, Y; Urade, Y; Yue, XF, 2012) |
| "Kava-kava extract is an herbal medicine having not only hypnotic effects, but also sleep quality-enhancement effects." | 1.33 | Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. ( Inoue, T; Kamei, C; Masuoka, T; Ohmori, A; Shinomiya, K; Tokunaga, S; Utsu, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oyemitan, IA | 1 |
| Elusiyan, CA | 1 |
| Akanmu, MA | 1 |
| Olugbade, TA | 1 |
| Zhang, C | 1 |
| Mao, X | 1 |
| Zhao, X | 1 |
| Liu, Z | 1 |
| Liu, B | 1 |
| Li, H | 1 |
| Bi, K | 1 |
| Jia, Y | 1 |
| Lader, M | 1 |
| Qu, WM | 1 |
| Yue, XF | 1 |
| Sun, Y | 1 |
| Fan, K | 1 |
| Chen, CR | 1 |
| Hou, YP | 1 |
| Urade, Y | 1 |
| Huang, ZL | 1 |
| Shinomiya, K | 1 |
| Inoue, T | 1 |
| Utsu, Y | 1 |
| Tokunaga, S | 1 |
| Masuoka, T | 1 |
| Ohmori, A | 1 |
| Kamei, C | 1 |
| Ohayon, MM | 1 |
1 review available for flumazenil and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Benzodiazepines revisited--will we ever learn?
Topics: Accidents; Age Factors; Antidotes; Anxiety Disorders; Benzodiazepines; Cognition; Drug Prescriptions | 2011 |
5 other studies available for flumazenil and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Hypnotic, anticonvulsant and anxiolytic effects of 1-nitro-2-phenylethane isolated from the essential oil of Dennettia tripetala in mice.
Topics: Animals; Annonaceae; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Avoidance Learning; Benzene Deri | 2013 |
Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Topics: Animals; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Drug Synergism; Flumazenil; Fruit; | 2014 |
Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Electroencephalography; Electromyogra | 2012 |
Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats.
Topics: Animals; Delta Rhythm; Dose-Response Relationship, Drug; Electromyography; Flumazenil; Flunitrazepam | 2005 |
Insomnia: a ticking clock for depression?
Topics: Combined Modality Therapy; Comorbidity; Depressive Disorder; Flumazenil; GABA Modulators; GABA-A Rec | 2007 |