Page last updated: 2024-10-27

flumazenil and Sleep Apnea Syndromes

flumazenil has been researched along with Sleep Apnea Syndromes in 2 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Research Excerpts

Excerpt	Relevance	Reference
"Flumazenil is a selective benzodiazepine-antagonist."	2.68	Benzodiazepine receptor antagonist (flumazenil) does not affect sleep-related breathing disorders. ( Köhler, D; Schönhofer, B, 1996)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Schönhofer, B	1
Köhler, D	1
Dhonneur, G	1
Combes, X	1
Leroux, B	1
Duvaldestin, P	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study[NCT01075087]				19 participants (Actual)	Interventional	2010-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

24 Hour Total Opioid Consumption.

24 Hour total opioid consumption translated into IV morphine equivalents. (NCT01075087)
Timeframe: 24 hours

Intervention	miligram IV morphine equivalents (Median)
Placebo	13
Active Comparator	7.5

Quality of Recovery 40 Score

Quality of Recovery 40 Score at 24 hours postoperative. (NCT01075087)
Timeframe: 24 hours post operatively

Intervention	units on scale 40 (low) - 200 (high) (Median)
Placebo	170
Active Comparator	175.5

Trials

2 trials available for flumazenil and Sleep Apnea Syndromes

Article	Year
Benzodiazepine receptor antagonist (flumazenil) does not affect sleep-related breathing disorders. The European respiratory journal, 1996, Volume: 9, Issue:9 Topics: Body Mass Index; Cross-Over Studies; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Human	1996
Postoperative obstructive apnea. Anesthesia and analgesia, 1999, Volume: 89, Issue:3 Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Diaphragm; Electromyography; Flumazenil; GABA	1999