flumazenil has been researched along with Sensitivity and Specificity in 24 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare abnormalities determined in 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and [11C]flumazenil (FMZ) PET images with intracranial EEG data in patients with extratemporal lobe epilepsy." | 7.70 | Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. ( Canady, A; Chugani, DC; Chugani, HT; da Silva, EA; Frost, M; Gates, J; Herholz, K; Juhasz, C; Muzik, O; Nagy, F; Ritter, F; Shah, J; von Stockhausen, HM; Watson, C, 2000) |
| " We evaluated the visual EP, brain stem auditory EP, and somatosensory EP (SSEP) and the effect of benzodiazepine receptor antagonist flumazenil in patients with liver cirrhosis." | 7.69 | Evoked potentials and the effect of flumazenil in patients with liver cirrhosis. ( Arik, Z; Kahraman, H; Kesim, G; Onar, M; Ozyilkan, E, 1997) |
| "To compare abnormalities determined in 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and [11C]flumazenil (FMZ) PET images with intracranial EEG data in patients with extratemporal lobe epilepsy." | 3.70 | Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. ( Canady, A; Chugani, DC; Chugani, HT; da Silva, EA; Frost, M; Gates, J; Herholz, K; Juhasz, C; Muzik, O; Nagy, F; Ritter, F; Shah, J; von Stockhausen, HM; Watson, C, 2000) |
| " We evaluated the visual EP, brain stem auditory EP, and somatosensory EP (SSEP) and the effect of benzodiazepine receptor antagonist flumazenil in patients with liver cirrhosis." | 3.69 | Evoked potentials and the effect of flumazenil in patients with liver cirrhosis. ( Arik, Z; Kahraman, H; Kesim, G; Onar, M; Ozyilkan, E, 1997) |
| "Epilepsy is one of the most prevalent neurologic disorders and affects approximately 1% of the population." | 2.41 | [Functional imaging (PET and SPECT) in epilepsy]. ( Borbély, K, 2001) |
| "Malignant MCA infarction seems to be determined more by the volume of severe perfusional deficit than that of total perfusional deficit." | 1.38 | The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction. ( Bosche, B; Dohmen, C; Galldiks, N; Graf, R; Kracht, L, 2012) |
| " Cumulative dose-response curves for chlordiazepoxide were obtained before and during chronic chlordiazepoxide administration and during chronic saline administration." | 1.29 | Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity. ( Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 14 (58.33) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Mourik, JE | 1 |
| van Velden, FH | 2 |
| Lubberink, M | 1 |
| Kloet, RW | 2 |
| van Berckel, BN | 2 |
| Lammertsma, AA | 4 |
| Boellaard, R | 4 |
| Yamauchi, H | 1 |
| Nishii, R | 1 |
| Higashi, T | 1 |
| Kagawa, S | 1 |
| Fukuyama, H | 1 |
| Dohmen, C | 1 |
| Galldiks, N | 1 |
| Bosche, B | 1 |
| Kracht, L | 1 |
| Graf, R | 1 |
| Kuroda, H | 1 |
| Ogasawara, K | 1 |
| Suzuki, T | 1 |
| Chida, K | 1 |
| Aso, K | 1 |
| Kobayashi, M | 1 |
| Yoshida, K | 1 |
| Terasaki, K | 1 |
| Fujiwara, S | 1 |
| Kubo, Y | 1 |
| Ogawa, A | 1 |
| Kato, H | 2 |
| Matsuda, K | 1 |
| Baba, K | 1 |
| Shimosegawa, E | 2 |
| Isohashi, K | 1 |
| Imaizumi, M | 1 |
| Hatazawa, J | 3 |
| Csaba, J | 1 |
| Tsukamoto, M | 1 |
| Katoh, C | 1 |
| Shiga, T | 1 |
| Kaji, T | 1 |
| Kuge, Y | 1 |
| Nakada, K | 1 |
| Tamaki, N | 1 |
| Greuter, HN | 1 |
| van Ophemert, PL | 1 |
| Luurtsema, G | 1 |
| Franssen, EJ | 1 |
| Abe, K | 2 |
| Kashiwagi, Y | 1 |
| Tokumura, M | 1 |
| Hosoi, R | 1 |
| Inoue, O | 1 |
| Seike, Y | 1 |
| Hashikawa, K | 1 |
| Oku, N | 2 |
| Moriwaki, H | 1 |
| Yamamoto, H | 1 |
| Fukuchi, K | 1 |
| Watanabe, Y | 2 |
| Matsumoto, M | 1 |
| Hori, M | 1 |
| Nishimura, T | 1 |
| Yaqub, M | 1 |
| Kropholler, MA | 1 |
| Kaneko, K | 1 |
| Sasaki, M | 1 |
| Morioka, T | 1 |
| Koga, H | 1 |
| Sawamoto, H | 1 |
| Ohya, N | 1 |
| Yoshiura, T | 1 |
| Mihara, F | 1 |
| Honda, H | 1 |
| Kitagawa, K | 1 |
| Kishima, H | 1 |
| Saitoh, Y | 1 |
| Kato, A | 1 |
| Yoshimine, T | 1 |
| Acri, JB | 1 |
| Wong, G | 1 |
| Witkin, JM | 1 |
| Sannerud, CA | 1 |
| Marley, RJ | 1 |
| Serdikoff, SL | 1 |
| Alastra, AJ | 1 |
| Cohen, C | 1 |
| Goldberg, SR | 1 |
| Whittemore, ER | 1 |
| Yang, W | 1 |
| Drewe, JA | 1 |
| Woodward, RM | 1 |
| Ozyilkan, E | 1 |
| Kahraman, H | 1 |
| Onar, M | 1 |
| Kesim, G | 1 |
| Arik, Z | 1 |
| Sihver, W | 1 |
| Sihver, S | 1 |
| Bergström, M | 1 |
| Murata, T | 1 |
| Matsumura, K | 1 |
| Onoe, H | 1 |
| Andersson, Y | 1 |
| Bjurling, P | 1 |
| Fasth, KJ | 1 |
| Westerberg, G | 1 |
| Ogren, M | 1 |
| Jacobsson, G | 1 |
| Lundqvist, H | 1 |
| Oreland, L | 1 |
| Långström, B | 1 |
| Prohovnik, I | 1 |
| Endres, CJ | 1 |
| Carson, RE | 1 |
| Muzik, O | 1 |
| da Silva, EA | 1 |
| Juhasz, C | 1 |
| Chugani, DC | 1 |
| Shah, J | 1 |
| Nagy, F | 1 |
| Canady, A | 1 |
| von Stockhausen, HM | 1 |
| Herholz, K | 1 |
| Gates, J | 1 |
| Frost, M | 1 |
| Ritter, F | 1 |
| Watson, C | 1 |
| Chugani, HT | 1 |
| Borbély, K | 1 |
1 review available for flumazenil and Sensitivity and Specificity
| Article | Year |
|---|---|
[Functional imaging (PET and SPECT) in epilepsy].
Topics: Animals; Brain; Cerebrovascular Circulation; Epilepsy; Flumazenil; Fluorodeoxyglucose F18; GABA Modu | 2001 |
3 trials available for flumazenil and Sensitivity and Specificity
| Article | Year |
|---|---|
Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [11C]flumazenil brain PET.
Topics: Adult; Brain; Cerebrovascular Disorders; Female; Flumazenil; Humans; Image Enhancement; Image Interp | 2004 |
Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results.
Topics: Adolescent; Adult; Aged; Algorithms; Alzheimer Disease; Brain; Cerebrovascular Disorders; Epilepsy; | 2004 |
Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.
Topics: Adolescent; Adult; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Humans; Iodi | 2006 |
20 other studies available for flumazenil and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain; Computer Simulation; Contrast Media; Female; Flum | 2008 |
Accuracy of 3-dimensional reconstruction algorithms for the high-resolution research tomograph.
Topics: Algorithms; Artifacts; Brain; Carbon Radioisotopes; Cold Temperature; Flumazenil; Hot Temperature; H | 2009 |
Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease.
Topics: Aged; Carbon Radioisotopes; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Disease | 2009 |
The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction.
Topics: Aged; Brain Edema; Cerebrovascular Circulation; Chi-Square Distribution; Decompressive Craniectomy; | 2012 |
Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases: comparison with cerebrovascular reactivity to acetazolamid
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Area Under Curve; Arterial Occlusive Diseases; Carbon | 2012 |
MR imaging-based correction for partial volume effect improves detectability of intractable epileptogenic foci on iodine 123 iomazenil brain SPECT images: an extended study with a larger sample size.
Topics: Adult; Algorithms; Artifacts; Brain; Epilepsy; False Negative Reactions; Female; Flumazenil; Humans; | 2012 |
Positron emission tomography in presurgical localization of epileptic foci.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Electroencephalography; Epilepsy; Female; Flumazenil | 2003 |
Validation of a multiwell gamma-counter for measuring high-pressure liquid chromatography metabolite profiles.
Topics: Carbon Radioisotopes; Cesium Radioisotopes; Chromatography, High Pressure Liquid; Flumazenil; Humans | 2004 |
Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats.
Topics: Animals; Autoradiography; Benzazepines; Benzilates; Binding Sites; Binding, Competitive; Cerebral Co | 2004 |
Optimization algorithms and weighting factors for analysis of dynamic PET studies.
Topics: Algorithms; Analysis of Variance; Body Burden; Flumazenil; Humans; Models, Biological; Pharmacogenet | 2006 |
MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images.
Topics: Adult; Artifacts; Brain; Epilepsy; Female; Flumazenil; Humans; Image Enhancement; Imaging, Three-Dim | 2008 |
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; | 1995 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; | 1993 |
Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Electrophysiology; Flumazenil; GABA Agonists; GAB | 1996 |
Evoked potentials and the effect of flumazenil in patients with liver cirrhosis.
Topics: Adult; Aged; Case-Control Studies; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Somat | 1997 |
Methodological aspects for in vitro characterization of receptor binding using 11C-labeled receptor ligands: a detailed study with the benzodiazepine receptor antagonist [11C]Ro 15-1788.
Topics: Animals; Carbon Radioisotopes; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Ligands; Ma | 1997 |
Iodine-123-iomazenil SPECT in Alzheimer's disease.
Topics: Alzheimer Disease; Flumazenil; Humans; Iodine Radioisotopes; Radiopharmaceuticals; Sensitivity and S | 1998 |
Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands.
Topics: Brain; Carbon Radioisotopes; Computer Simulation; Dopamine; Dopamine Antagonists; Flumazenil; Humans | 1998 |
Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy.
Topics: Adolescent; Blood Glucose; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; | 2000 |