flumazenil has been researched along with Seizures in 201 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 8.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 7.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications." | 7.69 | Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications. ( Albertson, TE; Derlet, RW, 1994) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 7.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits." | 7.68 | Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit. ( Bo, P; Dallocchio, C; Savoldi, F; Turrini, R, 1991) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 7.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 7.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 7.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "The effects of 2-chloroadenosine, aminophylline, bicuculline, beta-carboline-3-carboxylic acid methylester and Ro 15-1788 on seizures produced by pilocarpine were examined in rats." | 7.67 | Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Mello, LE; Turski, L; Turski, WA, 1985) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 7.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 7.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 5.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "We evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to our unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis." | 5.46 | Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence. ( Bongiovanni, LG; Casari, R; Faccini, M; Federico, A; Franchini, E; Lugoboni, F; Morbioli, L; Tamburin, S, 2017) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 5.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline." | 5.27 | Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats. ( Albertson, TE; Foulke, GE, 1987) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 4.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| " The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction on seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), pilocarpine (PC) and its possible action mechanisms in animal models using flumazenil (FLU), methyl-ß-carboline-3-carboxylate (BC) and bicuculline (BIC)." | 3.88 | Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock. ( Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G, 2018) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| " Flumazenil is an effective antidote but there is a risk of seizures, particularly in those who have co-ingested tricyclic antidepressants." | 3.78 | Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data. ( Cooper, G; Dyas, J; Routledge, PA; Thompson, JP; Veiraiah, A, 2012) |
| "The frequency of seizures among acutely poisoned adults who are administered flumazenil has not been well established." | 3.78 | A poison center's ten-year experience with flumazenil administration to acutely poisoned adults. ( Cantrell, FL; Clark, RF; Kreshak, AA; Tomaszewski, CA, 2012) |
| ") in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes." | 3.73 | Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. ( Fidecka, S; Listos, J; Malec, D, 2005) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 3.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "In 4 patients whose seizures were generated by mesial temporal lobe structures, BZ receptor density was measured with [11C]flumazenil PET before, and 1 year after the epilepsy surgery and cessation of seizures." | 3.70 | Regional increases in [11C]flumazenil binding after epilepsy surgery. ( Blomqvist, G; Gulyas, B; Halldin, C; Litton, JE; Savic, I, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| " In vivo tolerance was measured by a reduced ability of the alpha(1)-subunit-selective agonist zolpidem to suppress pentylenetetrazole-induced seizures." | 3.70 | Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance. ( Chen, S; Kometiani, P; Lilly, SM; Rosenberg, HC; Tietz, EI; Zeng, XJ, 1999) |
| ") produced a prompt anticonvulsant effect in pilocarpine-induced seizures in freely moving rats." | 3.70 | Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2000) |
| " The stress control group shows significant protection against picrotoxinin-induced seizures, reductions in [35S]t-butylbicyclophosphorothionate (TBPS) binding and a 3-fold increase of benzodiazepine-like substances in brain in comparison to both yoked-inescapable shock and non-shock controls." | 3.69 | The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists. ( Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH, 1994) |
| "Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications." | 3.69 | Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications. ( Albertson, TE; Derlet, RW, 1994) |
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 3.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| " administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline." | 3.69 | Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice. ( Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD, 1996) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| ") displaces [3H]flumazenil from its brain binding sites and in vivo it possesses a marked anticonflict profile in the rat Vogel conflict-punishment test and is 10 times more potent than bretazenil and 100 times more potent than diazepam or alprazolam in antagonizing bicuculline- and pentylenetetrazol-induced seizures." | 3.68 | Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors. ( Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A, 1993) |
| "The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days." | 3.68 | Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993) |
| " The four BZR ligands triazolam, diazepam, Ro 19-8022 (a benzoquinolizinone) and bretazenil (Ro 16-6028, an imidazobenzodiazepinone) were pharmacologically characterized in various neurological and behavioral paradigms in mice: two anticonvulsant tests (prevention of audiogenic and pentylenetetrazol-induced seizures), a conflict test which reveals both anxiolytic and sedative properties and two tests which mainly measure motor impairment (rotarod and horizontal wire test)." | 3.68 | Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies. ( Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P, 1992) |
| "The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits." | 3.68 | Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit. ( Bo, P; Dallocchio, C; Savoldi, F; Turrini, R, 1991) |
| "Medetomidine, a new selective alpha 2-adrenoceptor agonist, potentiated bicuculline seizures in mice." | 3.68 | The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity. ( Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V, 1991) |
| "The mechanism of action of aminophylline in prolonging seizures was tested in amygdala-kindled rats." | 3.68 | Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. ( Dragunow, M, 1990) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 3.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 3.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin." | 3.67 | Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1985) |
| " ED50 value of diazepam was established against pentylenetetrazole-induced seizures in rats." | 3.67 | Apparent pA2 estimation of benzodiazepine receptor antagonists. ( Kulkarni, SK; Kunchandy, J, 1986) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 3.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "The anticonvulsant activity of N-[beta-[4-beta-phenylethyl)phenyl]-beta-hydroxyethyl]-imidazole hydrochloride, denzimol, was studied following intraperitoneal administration in DBA/2 mice (seizures induced by sound)." | 3.67 | Anticonvulsant effect of denzimol in DBA/2 mice. ( Ascioti, C; De Sarro, GB; Libri, V; Nistico, G; Testa, R, 1987) |
| "The persistence of benzodiazepine antagonists in reversing neuronal and behavioral tolerance during chronic diazepam exposure was examined in rodents by investigating the time course for antagonist-induced alterations in iontophoretic sensitivity to gamma-aminobutyric acid on dorsal raphe neurons and the re-emergence of anticonvulsant efficacy to bicuculline-induced seizures." | 3.67 | Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration. ( Gallager, DW; Gonsalves, SF, 1988) |
| "The effects of 2-chloroadenosine, aminophylline, bicuculline, beta-carboline-3-carboxylic acid methylester and Ro 15-1788 on seizures produced by pilocarpine were examined in rats." | 3.67 | Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Mello, LE; Turski, L; Turski, WA, 1985) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 3.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 3.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "Epilepsy is one of the most prevalent neurologic disorders and affects approximately 1% of the population." | 2.41 | [Functional imaging (PET and SPECT) in epilepsy]. ( Borbély, K, 2001) |
| "Flumazenil is a benzodiazepine receptor antagonist used to reverse sedation and respiratory depression induced by benzodiazepines." | 2.39 | Seizure after flumazenil administration in a pediatric patient. ( McDuffee, AT; Tobias, JD, 1995) |
| "Additionally, FMZ prevented catalepsy, significantly restored locomotor activity, reduced seizure intensity (seizure score = 0." | 1.91 | Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice. ( Aburass, H; Alfaqih, H; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jarrar, Y; Ming, LC; Moshawih, S, 2023) |
| "The anti-seizure activity of the extract was assessed in three doses of 25, 50, and 100 mg/kg." | 1.72 | Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat. ( Arabi, M; Fatahinezhad, N; Lorigooini, Z; Rabiei, Z; Rafieian-Kopaei, M; Sheykhshabani, SK, 2022) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 1.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "In the strychnine-induced seizure test, PSE treatment did not significantly affect the latency to convulsions and time until death when compared to controls." | 1.48 | Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models. ( Abotsi, WKM; Boakye-Gyasi, E; Daanaa, S; Woode, E, 2018) |
| "We evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to our unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis." | 1.46 | Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence. ( Bongiovanni, LG; Casari, R; Faccini, M; Federico, A; Franchini, E; Lugoboni, F; Morbioli, L; Tamburin, S, 2017) |
| "We examined the anti-seizure effect of TMCA." | 1.43 | 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. ( Chen, CR; Chen, CY; Wei, XD, 2016) |
| "Pretreatment by flumazenil could inhibit the effect of Citrullus colocynthis on latency of seizure to some extent and administration of naloxone significantly inhibited changes in latency and duration of seizure produced by Citrullus colocynthis This study showed that Citrullus colocynthis has significant anticonvulsant effect in pentylenetetrazole-induced seizures in mice, and these effects may be related to its effect on γ-aminobutyric acid-ergic and opioid systems." | 1.43 | Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors. ( Mehrzadi, S; Motevalian, M; Pur, SA; Shojaii, A, 2016) |
| "Midazolam is a benzodiazepine anticonvulsant with rapid onset and short duration of action." | 1.42 | Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors. ( Clossen, BL; Reddy, DS; Reddy, SD; Younus, I, 2015) |
| "FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice." | 1.39 | Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice. ( Cui, R; Li, B; Li, Y; Liu, L; Song, Y; Tang, F; Wang, L; Wang, Y; Zhao, J; Zhou, Y, 2013) |
| "In this context, the focal seizures probably result from a diffuse decrease in the seizure threshold (caused by a generalized excitatory rebound), which may trigger focal seizures arising from cortical regions with higher intrinsic epileptogenicity." | 1.38 | Focal nonconvulsive seizures during detoxification for benzodiazepine abuse. ( Albiero, A; Bongiovanni, LG; Brigo, F; Casari, R; Faccini, M; Fiaschi, A; Lugoboni, F; Quaglio, G; Storti, M, 2012) |
| "Flumazenil pretreatment of elderly ECT patients with declining seizure quality and inadequate clinical response in the setting of repeated treatments may represent a novel strategy for managing such patients." | 1.38 | Flumazenil pretreatment in benzodiazepine-free patients: a novel method for managing declining ECT seizure quality. ( Azner, Y; Reti, IM; Schiavi, A; Torres, J; Vaidya, P; Yi, J, 2012) |
| "Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures." | 1.38 | Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. ( Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M, 2012) |
| " We employed aEEG in combination with conventional EEG in an 11-year old boy presenting with clusters of seizures and were able to accurately evaluate the frequency of seizures in real time." | 1.36 | A case of frontal lobe epilepsy in which amplitude-integrated EEG combined with conventional EEG was useful for evaluating clusters of seizures. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y, 2010) |
| "Stupor is defined as a deep sleep or behaviourally similar unresponsiveness from which the subject can be aroused only by vigorous repeated stimuli." | 1.35 | Idiopathic recurrent stupor mimicking status epilepticus. ( Agrawal, S; Asthana, V; Goel, D; Sharma, JP, 2008) |
| "Flumazenil is a benzodiazepine antagonist." | 1.35 | [Seizure triggered by benzodiazepine receptor antagonist]. ( Pedersen, LM; Petersen, M; Søndergaard, I, 2009) |
| "Flumazenil pretreatment decreased the prolongation of seizure latency induced by both diazepam and isopulegol, although it was not able to reverse the latency and protection percent for mortality." | 1.35 | Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. ( de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM, 2009) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "In PTZ-induced seizure, the intraperitoneally injection of thymoquinone with doses of 40 and 80 mg/kg, prolonged the onset of seizures and reduced the duration of myoclonic seizures." | 1.32 | Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. ( Hosseinzadeh, H; Parvardeh, S, 2004) |
| " Usually, the slope of the dose-response lines for RWJ-51204 was more shallow than the full agonist anxiolytics but steeper than partial agonists in efficacy tests but typically shallow in tests for central nervous system side effects." | 1.31 | 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. ( Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH, 2002) |
| "Diazepam was used as a reference drug." | 1.31 | The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. ( Chojnacka-Wójcik, E; Przegaliński, E; Tatarczyńska, E, 2000) |
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| "Flumazenil failed to affect seizure thresholds for bicuculline either in handling stressed or in swim stressed animals." | 1.30 | Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites. ( Bujas, M; Pericić, D, 1997) |
| " FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
| "Treatment with diazepam (25 mg/kg; p." | 1.30 | Abecarnil enhances recovery from diazepam tolerance. ( Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A, 1999) |
| "These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity." | 1.29 | Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1994) |
| "Pentylenetetrazole-induced seizure thresholds were similar in mice treated for 14 days with lorazepam or alprazolam, 2 mg/kg/day." | 1.29 | Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam. ( Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shader, RI, 1993) |
| "1." | 1.29 | Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. ( Hönack, D; Löscher, W, 1994) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| "When flumazenil or ZK 93426 was given to diazepam tolerant mice, this reversal was complete." | 1.29 | A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice. ( Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1993) |
| "Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam." | 1.29 | Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases. ( Hseu, SS; Hsing, CH; Lee, TY; Ng, KO; Tang, GJ, 1994) |
| "2." | 1.29 | Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines. ( Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M, 1993) |
| " Development of anticonvulsant tolerance and benzodiazepine (BZD) receptor down-regulation has been reported to occur upon chronic administration of conventional BZDs." | 1.29 | Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats. ( Contarino, A; Giusti, P; Lipartiti, M; Mariot, R; Zanotti, A, 1996) |
| "Pretreatment with diazepam alone increased both cumulative convulsant doses and plasma concentrations of lidocaine at the onset of convulsions." | 1.28 | Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. ( Arakawa, K; Benson, KT; Goto, H; Yokoyama, M, 1992) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 1.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "Locomotor activity, analgesia, and seizure susceptibility were maximal at the beginning of the scotophase and minimal at noon." | 1.28 | Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. ( Burin, LJ; Cardinali, DP; De Brito Sánchez, MG; Escolar, E; Fernández Duque, D; Golombek, DA, 1992) |
| "Midazolam was replaced by saline in the other 12." | 1.28 | Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992) |
| "Convulsions were induced by administering 3-mercaptopropionic acid (3-MP)." | 1.28 | Time-dependent anticonvulsant activity of melatonin in hamsters. ( Burin, L; Cardinali, DP; De Brito Sánchez, MG; Fernández Duque, D; Golombek, DA, 1992) |
| "Flumazenil did not produce any significant pharmacological effect." | 1.28 | In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates. ( Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M, 1991) |
| "For PTZ-induced convulsions, DN-2327, 0." | 1.28 | Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. ( Fukuda, N; Wada, T, 1991) |
| "Dogs dosed chronically (4-7 weeks) with oral flunitrazepam (7." | 1.28 | A comparison of the physical dependence inducing properties of flunitrazepam and diazepam. ( Martin, WR; Sloan, JW; Wala, EP, 1991) |
| "Two cases of convulsions following intake of the benzodiazepine antagonist, flumazepil, are presented." | 1.28 | [Convulsions after flumazepil]. ( Nielsen, J; Olesen, KL; Qvist, J, 1990) |
| "When diazepam was used as the dependence-producing drug, a 2." | 1.28 | Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice. ( Belknap, JK; Crabbe, JC; Laursen, SE, 1989) |
| "Seizures were induced in male, Swiss Webster mice with pentylenetetrazol (PTZ) or 3-mercaptoproprionic acid (3-MP)." | 1.27 | Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors. ( Baldino, F; Geller, HM; Krespan, B, 1984) |
| "Ro 15-1788 completely blocked type B myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the BZs in the photosensitive ones, permitting the reappearance of myoclonus following EEG paroxysmal discharges (type A)." | 1.27 | Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio. ( Bryere, P; Kaijima, M; Naquet, R; Valin, A, 1983) |
| "In experiments with audiogenic seizures in DBA/2 mice, we observed that several socalled benzodiazepine receptor antagonists exhibited either anticonvulsive (Ro 15-1788, PrCC) or proconvulsive (FG 7142, beta-CCE, CGS 8216) effects at high receptor occupancy (17-85%), as compared to benzodiazepines and DMCM which had anticonvulsive and proconvulsive actions, respectively, at very low receptor occupancy (less than 10%)." | 1.27 | Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodiazepine receptor agonists and inverse agonists. ( Braestrup, C; Jensen, LH; Petersen, EN, 1983) |
| "Diazepam was selectively antagonized by RO15-1788." | 1.27 | Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB. ( Ashton, D, 1983) |
| "Ro 15-1788 antagonised the tonic convulsions triggered by the drug combinations when it was given at the same time as Ro 5-4864; this antagonism was not observed when the drugs were injected at different times." | 1.27 | On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain. ( File, SE; Green, AR; Nutt, DJ; Vincent, ND, 1984) |
| "Low doses of CL 218,872 enhanced the convulsions produced by all agents except PTZ." | 1.27 | A benzodiazepine antagonist action of CL 218,872. ( Garrett, KM; Melchior, CL; Tabakoff, B, 1984) |
| "Ro 15-1788 suppressed generalized convulsive seizures induced by a minimal convulsive dose of pentylenetetrazol (25-35 mg/kg), but did not block the effects of higher doses (35-45 mg/kg)." | 1.27 | The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats. ( Kaijima, M; Le Gal La Salle, G; Rossier, J, 1983) |
| "Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline." | 1.27 | Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats. ( Albertson, TE; Foulke, GE, 1987) |
| "Pentylenetetrazole and picrotoxin seizure thresholds, measured during constant rate iv infusion, were significantly lowered by pretreatment with diazepam (250 mg/kg) and Ro 15-1788 (20 mg/kg) administered 30 and 20 minutes, respectively, before seizure threshold measurement." | 1.27 | Convulsant component of a depressant benzodiazepine. ( Bourn, WM; Garrett, RL, 1985) |
| "When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss." | 1.27 | Physical dependence on clonazepam in dogs. ( Frey, HH; Scherkl, R, 1986) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| "No alleviation of convulsions was found with Ro 15-1788." | 1.27 | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. ( Cowen, PJ; Little, HJ; Nutt, DJ; Taylor, SC, 1985) |
| ", failed to produce any relevant shift of the isoniazid dose-response curves to the left (proconvulsant) or to the right (anticonvulsant)." | 1.27 | Isoniazid-induced convulsions in rats: effects of Ro 15-1788 and beta-CCE. ( Biry, P; Pieri, L, 1985) |
| "In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788." | 1.26 | Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663. ( Cowen, PJ; Green, AR; Nutt, DJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (32.84) | 18.7374 |
| 1990's | 68 (33.83) | 18.2507 |
| 2000's | 34 (16.92) | 29.6817 |
| 2010's | 25 (12.44) | 24.3611 |
| 2020's | 8 (3.98) | 2.80 |
| Authors | Studies |
|---|---|
| Toja, E | 1 |
| Tarzia, G | 1 |
| Barone, D | 1 |
| Luzzani, F | 1 |
| Gallico, L | 1 |
| Da Settimo, A | 1 |
| Primofiore, G | 1 |
| Da Settimo, F | 1 |
| Marini, AM | 1 |
| Novellino, E | 2 |
| Greco, G | 1 |
| Gesi, M | 1 |
| Martini, C | 3 |
| Giannaccini, G | 2 |
| Lucacchini, A | 2 |
| Costanzo, A | 2 |
| Guerrini, G | 2 |
| Ciciani, G | 2 |
| Bruni, F | 2 |
| Costagli, C | 1 |
| Selleri, S | 2 |
| Besnard, F | 1 |
| Costa, B | 1 |
| Malmberg-Aiello, P | 1 |
| Cambi, G | 1 |
| Melani, F | 1 |
| Montali, M | 1 |
| Ghelardini, C | 2 |
| Norcini, M | 2 |
| Anzini, M | 1 |
| Braile, C | 1 |
| Valenti, S | 1 |
| Cappelli, A | 1 |
| Vomero, S | 1 |
| Marinelli, L | 1 |
| Limongelli, V | 1 |
| Betti, L | 1 |
| Makovec, F | 1 |
| Giorgi, G | 1 |
| Ian Fryer, R | 1 |
| Yamada, N | 1 |
| Kuki, I | 1 |
| Hattori, T | 1 |
| Yamamoto, N | 1 |
| Nagase, S | 1 |
| Nukui, M | 1 |
| Inoue, T | 1 |
| Okazaki, S | 1 |
| Kawawaki, H | 1 |
| Horino, A | 1 |
| Sakuma, H | 1 |
| Olubodun-Obadun, TG | 1 |
| Ishola, IO | 1 |
| Ben-Azu, B | 1 |
| Afolayan, O | 1 |
| Nwose, E | 1 |
| James, AB | 1 |
| Ajayi, AM | 1 |
| Umukoro, S | 1 |
| Adeyemi, OO | 1 |
| Fatahinezhad, N | 1 |
| Lorigooini, Z | 2 |
| Arabi, M | 2 |
| Rabiei, Z | 2 |
| Sheykhshabani, SK | 1 |
| Rafieian-Kopaei, M | 2 |
| Gonzalez-Rivera, ML | 1 |
| Barragan-Galvez, JC | 1 |
| Gasca-Martínez, D | 2 |
| Hidalgo-Figueroa, S | 1 |
| Isiordia-Espinoza, M | 1 |
| Alonso-Castro, AJ | 2 |
| Jarrar, Q | 1 |
| Ayoub, R | 1 |
| Jarrar, Y | 1 |
| Aburass, H | 1 |
| Goh, KW | 1 |
| Ardianto, C | 1 |
| Ming, LC | 1 |
| Moshawih, S | 1 |
| Alfaqih, H | 1 |
| Alba-Betancourt, C | 1 |
| Rocha-González, E | 1 |
| Ruiz-Arredondo, A | 1 |
| Zapata-Morales, JR | 1 |
| Pérez-Gutiérrez, S | 1 |
| Avendaño-Estrada, A | 1 |
| Velasco, F | 1 |
| Velasco, AL | 1 |
| Cuellar-Herrera, M | 1 |
| Saucedo-Alvarado, PE | 1 |
| Marquez-Franco, R | 1 |
| Rivera-Bravo, B | 1 |
| Ávila-Rodríguez, MA | 1 |
| da Silva Oliveira, GL | 1 |
| da Silva, JCCL | 1 |
| Dos Santos C L da Silva, AP | 1 |
| Feitosa, CM | 1 |
| de Castro Almeida, FR | 1 |
| Mahmoudi, T | 1 |
| Bijad, E | 1 |
| Kazemi, S | 1 |
| Hacke, ACM | 1 |
| Miyoshi, E | 1 |
| Marques, JA | 1 |
| Pereira, RP | 1 |
| Tamburin, S | 1 |
| Faccini, M | 3 |
| Casari, R | 3 |
| Federico, A | 1 |
| Morbioli, L | 1 |
| Franchini, E | 1 |
| Bongiovanni, LG | 2 |
| Lugoboni, F | 3 |
| Garlet, QI | 1 |
| Pires, LDC | 1 |
| Milanesi, LH | 1 |
| Marafiga, JR | 1 |
| Baldisserotto, B | 1 |
| Mello, CF | 2 |
| Heinzmann, BM | 1 |
| Nkamguie Nkantchoua, GC | 1 |
| Kameni Njapdounke, JS | 1 |
| Jules Fifen, J | 1 |
| Sotoing Taiwe, G | 1 |
| Josiane Ojong, L | 1 |
| Kavaye Kandeda, A | 1 |
| Ngo Bum, E | 1 |
| Ahn, JO | 1 |
| Jaung, WJ | 1 |
| Won, SH | 1 |
| Ryu, MO | 1 |
| Song, WJ | 1 |
| Jeon, KO | 1 |
| Chung, JY | 1 |
| Youn, HY | 1 |
| Daanaa, S | 1 |
| Abotsi, WKM | 1 |
| Boakye-Gyasi, E | 1 |
| Woode, E | 1 |
| Fujitani, S | 1 |
| Matsuda, K | 1 |
| Nakamura, F | 1 |
| Baba, K | 1 |
| Usui, N | 1 |
| Tottori, T | 1 |
| Mihara, T | 1 |
| Terada, K | 1 |
| Usui, K | 1 |
| Inoue, Y | 1 |
| Kajita, Y | 1 |
| Wakabayashi, T | 1 |
| Oyemitan, IA | 1 |
| Elusiyan, CA | 1 |
| Akanmu, MA | 1 |
| Olugbade, TA | 1 |
| Li, B | 1 |
| Tang, F | 1 |
| Wang, L | 1 |
| Liu, L | 1 |
| Zhao, J | 1 |
| Zhou, Y | 1 |
| Wang, Y | 1 |
| Song, Y | 1 |
| Li, Y | 1 |
| Cui, R | 1 |
| Nóbrega, FF | 1 |
| Salvadori, MG | 1 |
| Masson, CJ | 1 |
| Nascimento, TS | 1 |
| Leal-Cardoso, JH | 1 |
| de Sousa, DP | 2 |
| Almeida, RN | 1 |
| Asadi-Shekaari, M | 1 |
| Eslami, A | 1 |
| Kalantaripour, T | 1 |
| Joukar, S | 1 |
| Reddy, SD | 1 |
| Younus, I | 1 |
| Clossen, BL | 1 |
| Reddy, DS | 1 |
| Chen, CY | 1 |
| Wei, XD | 1 |
| Chen, CR | 1 |
| Stanišić, M | 1 |
| Coello, C | 1 |
| Ivanović, J | 1 |
| Egge, A | 1 |
| Danfors, T | 1 |
| Hald, J | 1 |
| Heminghyt, E | 1 |
| Mikkelsen, MM | 1 |
| Krossnes, BK | 1 |
| Pripp, AH | 1 |
| Larsson, PG | 1 |
| Mehrzadi, S | 1 |
| Shojaii, A | 1 |
| Pur, SA | 1 |
| Motevalian, M | 1 |
| Ya'u, J | 1 |
| Yaro, AH | 1 |
| Abubakar, MS | 1 |
| Anuka, JA | 1 |
| Hussaini, IM | 1 |
| Asthana, V | 1 |
| Agrawal, S | 1 |
| Goel, D | 1 |
| Sharma, JP | 1 |
| Vasconcelos, SM | 2 |
| Lima, SR | 1 |
| Soares, PM | 1 |
| Assreuy, AM | 1 |
| de Sousa, FC | 2 |
| Lobato, Rde F | 1 |
| Vasconcelos, GS | 1 |
| Santi-Gadelha, T | 1 |
| Bezerra, EH | 1 |
| Cavada, BS | 1 |
| Patrocínio, MC | 1 |
| Liu, DS | 1 |
| O'Brien, TJ | 1 |
| Williams, DA | 1 |
| Hicks, RJ | 1 |
| Myers, DE | 1 |
| Pedersen, LM | 1 |
| Petersen, M | 1 |
| Søndergaard, I | 1 |
| Silva, MI | 1 |
| Silva, MA | 1 |
| de Aquino Neto, MR | 1 |
| Moura, BA | 1 |
| de Sousa, HL | 1 |
| de Lavor, EP | 1 |
| de Vasconcelos, PF | 1 |
| Macêdo, DS | 1 |
| Ishikawa, N | 1 |
| Kobayashi, Y | 1 |
| Kobayashi, M | 1 |
| Quaglio, GL | 1 |
| Albiero, A | 2 |
| Pajusco, B | 1 |
| de Carvalho, RS | 1 |
| Duarte, FS | 1 |
| de Lima, TC | 1 |
| Veiraiah, A | 1 |
| Dyas, J | 1 |
| Cooper, G | 1 |
| Routledge, PA | 1 |
| Thompson, JP | 1 |
| Brigo, F | 1 |
| Quaglio, G | 1 |
| Storti, M | 1 |
| Fiaschi, A | 1 |
| Yi, J | 1 |
| Torres, J | 1 |
| Azner, Y | 1 |
| Vaidya, P | 1 |
| Schiavi, A | 1 |
| Reti, IM | 1 |
| Abbasi, E | 1 |
| Nassiri-Asl, M | 3 |
| Shafeei, M | 1 |
| Sheikhi, M | 1 |
| Kreshak, AA | 1 |
| Cantrell, FL | 1 |
| Clark, RF | 1 |
| Tomaszewski, CA | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 2 |
| de Barros Viana, GS | 1 |
| Dubinsky, B | 1 |
| Vaidya, AH | 1 |
| Rosenthal, DI | 1 |
| Hochman, C | 1 |
| Crooke, JJ | 1 |
| DeLuca, S | 1 |
| DeVine, A | 1 |
| Cheo-Isaacs, CT | 1 |
| Carter, AR | 1 |
| Jordan, AD | 1 |
| Reitz, AB | 1 |
| Shank, RP | 1 |
| Little, HJ | 5 |
| Tewary, S | 1 |
| Mediratta, PK | 1 |
| Mahajan, P | 1 |
| Sharma, KK | 1 |
| Bhandari, R | 1 |
| Rodenberg, H | 1 |
| Hosseinzadeh, H | 2 |
| Parvardeh, S | 2 |
| Seger, DL | 1 |
| Löscher, W | 2 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Mansouri, MT | 1 |
| Zarghi, A | 1 |
| Faizi, M | 1 |
| Shafaghi, B | 1 |
| Ahadian, A | 1 |
| Khojastehpoor, HR | 1 |
| Zanganeh, V | 1 |
| Tabatabai, SA | 1 |
| Shafiee, A | 1 |
| Listos, J | 1 |
| Malec, D | 1 |
| Fidecka, S | 1 |
| Hashimoto, Y | 1 |
| Araki, H | 1 |
| Suemaru, K | 1 |
| Gomita, Y | 1 |
| Atack, JR | 1 |
| Bayley, PJ | 1 |
| Fletcher, SR | 1 |
| McKernan, RM | 1 |
| Wafford, KA | 1 |
| Dawson, GR | 1 |
| Fukumitsu, N | 1 |
| Ogi, S | 1 |
| Uchiyama, M | 1 |
| Mori, Y | 1 |
| Trailović, SM | 1 |
| Varagić, VM | 1 |
| Shariati-Rad, S | 1 |
| Zamansoltani, F | 1 |
| Baldino, F | 1 |
| Krespan, B | 1 |
| Geller, HM | 1 |
| Valin, A | 4 |
| Kaijima, M | 3 |
| Bryere, P | 2 |
| Naquet, R | 4 |
| Nutt, D | 1 |
| Prado de Carvalho, L | 3 |
| Venault, P | 6 |
| Cavalheiro, E | 1 |
| Dodd, RH | 8 |
| Potier, P | 2 |
| Rossier, J | 6 |
| Chapouthier, G | 7 |
| Costa, E | 5 |
| File, SE | 5 |
| Hunkeler, W | 1 |
| Möhler, H | 1 |
| Pieri, L | 3 |
| Polc, P | 1 |
| Bonetti, EP | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study[NCT02899156] | Phase 4 | 22 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis.) | ||
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
average duration of time patient was randomized to each infusion up to 72 hours (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | hours (Mean) |
|---|---|
| Flumazenil Group | 54.8 |
| Placebo Group | 58.2 |
average maximum rate (ml/hr) during the 72 hours after study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | milliliters per hour (Mean) |
|---|---|
| Flumazenil Group | 5 |
| Placebo Group | 5.2 |
length of time that the patient was admitted to an intensive care unit service during the hospital stay (NCT02899156)
Timeframe: duration of admission to the intensive care unit
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 7.8 |
| Placebo Group | 7 |
Defined by the number of days in the 14-day period after randomization that the patient was alive and not delirious (i.e. CAM-ICU negative). Zero delirium-free days will be observed for patients that die within the 14-day period. (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | days (Median) |
|---|---|
| Flumazenil Group | 12.7 |
| Placebo Group | 9.2 |
number of days within the first 28 days after enrollment that the patient was free from needing mechanical ventilation (NCT02899156)
Timeframe: up to 28 days after randomization
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 23.6 |
| Placebo Group | 24.9 |
defined by the proportion of patients who were delirium free at 14 days after randomization (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 9 |
| Placebo Group | 7 |
number of times that a RASS score of + 2 to +4 occurred that did not resolve with decreasing study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 0 |
| Placebo Group | 0 |
4 reviews available for flumazenil and Seizures
| Article | Year |
|---|---|
Flumazenil--treatment or toxin.
Topics: Antidotes; Drug Interactions; Drug Therapy, Combination; Emergency Service, Hospital; Flumazenil; Hu | 2004 |
Seizure after flumazenil administration in a pediatric patient.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Overdose; Female; Flumaz | 1995 |
[Functional imaging (PET and SPECT) in epilepsy].
Topics: Animals; Brain; Cerebrovascular Circulation; Epilepsy; Flumazenil; Fluorodeoxyglucose F18; GABA Modu | 2001 |
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
Topics: Aggression; Animals; Anticonvulsants; Anxiety; Avoidance Learning; Benzodiazepinones; Body Temperatu | 1986 |
197 other studies available for flumazenil and Seizures
| Article | Year |
|---|---|
Benzodiazepine receptor binding and anticonflict activity in a series of 3,6-disubstituted pyridazino[4,3-c]isoquinolines devoid of anticonvulsant properties.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Conflict, Psychological; Diazepam; Iso | 1985 |
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Convulsants; Diazepa | 1998 |
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Cell Line; Cerebral Cortex; Cycli | 2002 |
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Ligands; Male; Memory; Models, Molecular; Molecular Str | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Cr | 2008 |
Late relapse of anti-N-methyl-d-aspartate receptor encephalitis with amusia and transiently reduced uptake in
Topics: Adolescent; Adult; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Female; Flumazenil; Humans; Iodi | 2022 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanos | 2022 |
Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat.
Topics: Animals; Anticonvulsants; Antioxidants; Flumazenil; Hyssopus Plant; Kindling, Neurologic; Nitric Oxi | 2022 |
In Vivo Neuropharmacological Effects of Neophytadiene.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Flumazenil; | 2023 |
Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice.
Topics: Animals; Behavior, Animal; Catalepsy; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; M | 2023 |
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Flumazenil; Hypnotics and Seda | 2019 |
Quantitative Analysis of [18F]FFMZ and [18F]FDG PET Studies in the Localization of Seizure Onset Zone in Drug-Resistant Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Female; Flumazen | 2019 |
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Arginine; Behavior, Animal; Be | 2021 |
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Convulsants; Curcuma; Flumazenil; GABA Modu | 2020 |
Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Brain Chemistry; Catalase; Cymbopogon; Disease Model | 2021 |
Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Benzodiazepines; Female; Flumaze | 2017 |
(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice.
Topics: Animals; Anticonvulsants; Female; Flumazenil; GABA Modulators; Membrane Potentials; Mice; Pentylenet | 2017 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pe | 2018 |
Accidental afloqualone intoxication in two dogs.
Topics: Animals; Ataxia; Bradycardia; Dog Diseases; Dogs; Flumazenil; Male; Quinazolines; Respiratory Insuff | 2018 |
Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Antagonis | 2018 |
Statistical parametric mapping of interictal 123I-iomazenil SPECT in temporal lobe epilepsy surgery.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistance; Epilepsy, Temporal Lobe; Female; Flumazenil; Func | 2013 |
Hypnotic, anticonvulsant and anxiolytic effects of 1-nitro-2-phenylethane isolated from the essential oil of Dennettia tripetala in mice.
Topics: Animals; Annonaceae; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Avoidance Learning; Benzene Deri | 2013 |
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Diterpenes; Dose-Response Relatio | 2013 |
Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Electrophysiological Phenomena; Flumazeni | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors.
Topics: Animals; Anticonvulsants; Brain Chemistry; Female; Flumazenil; GABA Modulators; Hippocampus; Hypnoti | 2015 |
3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice.
Topics: Animals; Anticonvulsants; Cinnamates; Electroshock; Flumazenil; GABA Antagonists; Male; Mice; Pentyl | 2016 |
Seizure outcomes in relation to the extent of resection of the perifocal fluorodeoxyglucose and flumazenil PET abnormalities in anteromedial temporal lobectomy.
Topics: Adolescent; Adult; Anterior Temporal Lobectomy; Child; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2015 |
Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors.
Topics: Animals; Anticonvulsants; Benzodiazepines; Citrullus colocynthis; Flavonoids; Flumazenil; Fruit; Her | 2016 |
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract.
Topics: Administration, Oral; Animals; Anticonvulsants; Apocynaceae; Chickens; Disease Models, Animal; Dose- | 2008 |
Idiopathic recurrent stupor mimicking status epilepticus.
Topics: Diagnosis, Differential; Electroencephalography; Flumazenil; GABA Modulators; Humans; Male; Middle A | 2008 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Lamina-specific changes in hippocampal GABA(A)/cBZR and mossy fibre sprouting during and following amygdala kindling in the rat.
Topics: Amygdala; Animals; Autoradiography; Cell Count; Cell Death; Electric Stimulation; Electrodes, Implan | 2009 |
[Seizure triggered by benzodiazepine receptor antagonist].
Topics: Aged; Antidepressive Agents, Tricyclic; Antidotes; Drug Overdose; Female; Flumazenil; Humans; Seizur | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationsh | 2009 |
A case of frontal lobe epilepsy in which amplitude-integrated EEG combined with conventional EEG was useful for evaluating clusters of seizures.
Topics: Child; Cluster Analysis; Electroencephalography; Epilepsy, Frontal Lobe; Flumazenil; Humans; Iodine | 2010 |
Intravenous flumazenil infusion to treat benzodiazepine dependence should be performed in the inpatient clinical setting for high risk of seizure.
Topics: Benzodiazepines; Flumazenil; Humans; Infusions, Intravenous; Seizures; Substance-Related Disorders | 2011 |
Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response | 2011 |
Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data.
Topics: Adult; Antidotes; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans; Incidence; Male; Middl | 2012 |
Focal nonconvulsive seizures during detoxification for benzodiazepine abuse.
Topics: Adult; Anticonvulsants; Benzodiazepines; Female; Flumazenil; GABA Modulators; Humans; Infusions, Int | 2012 |
Flumazenil pretreatment in benzodiazepine-free patients: a novel method for managing declining ECT seizure quality.
Topics: Aged; Aged, 80 and over; Benzodiazepines; Combined Modality Therapy; Depressive Disorder, Major; Dos | 2012 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neur | 2012 |
A poison center's ten-year experience with flumazenil administration to acutely poisoned adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; California; Confidence Inter | 2012 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide | 2002 |
Comment on the paper by Horowski and Dorow.
Topics: Benzodiazepines; Carbolines; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Huma | 2003 |
Modulation of development of tolerance to anticonvulsant effect of diazepam by flumazenil.
Topics: Animals; Anticonvulsants; Diazepam; Drug Tolerance; Female; Flumazenil; Male; Mice; Seizures | 2002 |
The new toy.
Topics: Anti-Anxiety Agents; Antidotes; Benzodiazepines; Drug Overdose; Emergency Medical Services; Emergenc | 2003 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Inject | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumaze | 2005 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodi | 2005 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; | 2006 |
The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
Topics: Alkynes; Animals; Benzodiazepines; Cells, Cultured; Convulsants; Female; Flumazenil; GABA Modulators | 2006 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Antiparasitic Agents; Convulsants; Dose-Response Relat | 2007 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon | 2008 |
Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors.
Topics: 3-Mercaptopropionic Acid; Aminophylline; Animals; Anticonvulsants; Benzodiazepinones; Binding, Compe | 1984 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; g | 1983 |
Pharmacological and behavioural studies of benzodiazepine antagonists and contragonists.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Carbolines; Conditioning, Operant | 1983 |
Distinct behavioral and pharmacological effects of two benzodiazepine antagonists: Ro 15-1788 and methyl beta-carboline.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Carbolines; Cats; Drug Synergism; | 1983 |
Are benzodiazepine recognition sites functional entities for the action of endogenous effector(s) or merely drug receptor(s)?
Topics: Animals; Benzodiazepinones; Brain; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Neurotran | 1983 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Fl | 1984 |
Selective antagonists of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Brain; Cats; Flumazenil; Rats; Recept | 1981 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Re | 1981 |
Unusual interactions of benzodiazepine receptor antagonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Biological Assay; Carbolines; Flumazen | 1982 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; | 1982 |
Caerulein and cholecystokinin octapeptide (CCK-8): sedative and anticonvulsive effects in mice unaffected by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Blepharoptosis; Body Temperature; Ceruletide; Cholecyst | 1982 |
Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Conditioning, Operant; Dogs; Dose- | 1982 |
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Exploratory | 1982 |
Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodiazepine receptor agonists and inverse agonists.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Conv | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; F | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; M | 1984 |
Chronic neonatal treatment with CGS 8216: effects on the behaviour of adolescent rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Benzodiazepinones; Brain; Chlordiazepoxide; Dose-Respon | 1984 |
A benzodiazepine antagonist action of CL 218,872.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Convulsants; Diazepam; Flumazenil; Mal | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synerg | 1983 |
A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Kindling, Neur | 1983 |
The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cats; Drug Interactions; Electroenceph | 1983 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors | 1984 |
Antiepileptic effects of amphetamine may require GABA (benzodiazepine) activity.
Topics: Amphetamine; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Female; Flumazenil; gamma | 1984 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug | 1984 |
Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Disease Models, Animal; Dose-Respon | 1982 |
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome.
Topics: Animals; Benzodiazepinones; Bicuculline; Flumazenil; Flurazepam; Male; Mice; Nervous System Diseases | 1982 |
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu | 1982 |
Methyl-beta-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-beta-carboline.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Indoles; Papio; Photosensitivity Disor | 1982 |
Effects of flumazenil on ethanol withdrawal syndrome in rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Flumazenil; | 1995 |
Evidence for central benzodiazepine receptor heterogeneity from behavior tests.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Body Temperature; Central Nervous System; Dose- | 1994 |
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocy | 1994 |
Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Diazepam; Ethanol; Female; Flumazenil; Handling, Psycholo | 1994 |
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.
Topics: Alprazolam; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Down-Regulation; Drug Tolera | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship | 1994 |
Gender differences in diazepam withdrawal syndrome in mice.
Topics: Animals; Body Weight; Castration; Diazepam; Disease Models, Animal; Estrogens; Female; Flumazenil; I | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Drug Interactions; Flumazenil; Kindling, Neurologic; Male; P | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flu | 1993 |
Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases.
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged; Receptors, GABA; Seizures | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; | 1993 |
Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?
Topics: Animals; Circadian Rhythm; Drug Interactions; Flumazenil; Lidocaine; Male; Mice; Seizures | 1993 |
Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.
Topics: Animals; Cocaine; Diazepam; Electroencephalography; Flumazenil; Male; Rats; Rats, Sprague-Dawley; Se | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
Imidazenil, a new partial agonist of benzodiazepine receptors, reverses the inhibitory action of isoniazid and stress on gamma-aminobutyric acidA receptor function.
Topics: Animals; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds | 1994 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperat | 1993 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psy | 1993 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F | 1993 |
Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Huma | 1996 |
Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Diazepam; Down-Regulation; Drug Tolerance; F | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diaze | 1996 |
Flumazenil-induced seizure accompanying benzodiazepine and baclofen intoxication.
Topics: Adult; Antidotes; Baclofen; Benzodiazepines; Drug Interactions; Drug Overdose; Female; Flumazenil; H | 1996 |
[A case of convulsion induced by flumazenil].
Topics: Female; Flumazenil; GABA Modulators; Humans; Middle Aged; Seizures; Ventriculoperitoneal Shunt | 1996 |
Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Carbolines; C | 1996 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites.
Topics: Animals; Benzodiazepines; Bicuculline; Binding Sites; Cold Temperature; Diazepam; Differential Thres | 1997 |
Convulsive effects of a benzodiazepine receptor inverse agonist: are they related to anxiogenic processes?
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Convulsants; Female; Flumazenil; GABA Modulators; GA | 1997 |
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Cell Line; Convulsants; Flumazenil; GABA Modu | 1997 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
Opisthotonos after flumazenil administered to antagonize midazolam previously administered to treat developing local anesthetic toxicity.
Topics: Adolescent; Flumazenil; Humans; Male; Midazolam; Seizures | 1998 |
Regional increases in [11C]flumazenil binding after epilepsy surgery.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Confidence Intervals; Epilepsy, Temporal Lobe; Female; | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABA(A) receptors.
Topics: Allosteric Regulation; Animals; Binding Sites; Cerebellum; Flumazenil; GABA Modulators; In Vitro Tec | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; | 1999 |
Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Behavior, Animal; Benzodiazepines; C | 1999 |
Benzodiazepine receptor affinities, behavioral, and anticonvulsant activity of 2-aryl-2,5-dihydropyridazino[4,3-b]indol- 3(3H)-ones in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Body Temperature; | 2000 |
Reduction of pentylenetetrazol-induced convulsions by the octadecaneuropeptide ODN.
Topics: Acoustic Stimulation; Amino Acid Sequence; Animals; Carbolines; Convulsants; Diazepam Binding Inhibi | 1999 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Po | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypn | 2000 |
Changes in benzodiazepine binding in a subkindling situation.
Topics: Animals; Carbolines; Convulsants; Disease Models, Animal; Epilepsy; Flumazenil; GABA Antagonists; Ki | 2000 |
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Conflic | 2000 |
Chromosomes 4 and 13 in beta-carboline-induced seizures in mice: benzodiazepine binding.
Topics: Animals; Brain; Carbolines; Chromosome Mapping; Convulsants; Flumazenil; Mice; Mice, Inbred Strains; | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glutamic Acid; Male; P | 2000 |
Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy--lomanzenil-binding in de-novo TLE.
Topics: Adolescent; Adult; Binding Sites; Disease Progression; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2001 |
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female | 1992 |
Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats.
Topics: Animals; Anticonvulsants; Bicarbonates; Blood Pressure; Carbon Dioxide; Convulsants; Diazepam; Dose- | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; | 1992 |
In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Electroencephalography; Flum | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate D | 1992 |
[Flumazenil-induced contractile seizure in poisoning by a combination of tricyclic antidepressants and benzodiazepine in a young woman].
Topics: Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans; | 1991 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GAB | 1992 |
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic | 1992 |
Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Cricetinae; Flumazenil; Male; Melatonin; Mesocricetus; | 1992 |
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog | 1992 |
Time-dependent anticonvulsant activity of melatonin in hamsters.
Topics: 3-Mercaptopropionic Acid; Animals; Circadian Rhythm; Cricetinae; Flumazenil; Injections, Intraperito | 1992 |
Repeated anticonvulsant testing: contingent tolerance to diazepam and clobazam in kindled rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa | 1992 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cort | 1991 |
Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit.
Topics: Acute Disease; Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electroencephalography; Flu | 1991 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diaz | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flu | 1991 |
Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Conflict, Psychological; Drinking Beha | 1991 |
Flumazenil (Ro15-1788) does not affect ethanol tolerance and dependence.
Topics: Animals; Ataxia; Behavior, Animal; Body Temperature; Diet; Drug Tolerance; Ethanol; Flumazenil; Hand | 1991 |
Flumazenil and bupivacaine-induced toxicity: inverse agonist type activity.
Topics: Animals; Bupivacaine; Chi-Square Distribution; Drug Interactions; Flumazenil; Male; Mice; Mice, Inbr | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relations | 1991 |
The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors.
Topics: Animals; Diterpenes; Flumazenil; Hippocampus; In Vitro Techniques; Male; Mice; Pentylenetetrazole; R | 1990 |
Precipitated abstinence in orally dosed benzodiazepine-dependent dogs.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Behavior, Animal; Dogs; Dose-Response Relationsh | 1990 |
Administration of flumazenil.
Topics: Animals; Benzodiazepines; Dogs; Drug Overdose; Flumazenil; Humans; Seizures; Swine | 1991 |
Dependence-producing properties of alprazolam in the dog.
Topics: Administration, Oral; Alprazolam; Animals; Dogs; Dose-Response Relationship, Drug; Female; Flumazeni | 1990 |
Anticonvulsive properties of F1933 (dulozafone) on kindled seizures in the rat.
Topics: Acetanilides; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Flumazenil; Kindli | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neur | 1990 |
[Convulsions after flumazepil].
Topics: Adult; Aged; Female; Flumazenil; Humans; Male; Seizures | 1990 |
Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice.
Topics: Animals; Diazepam; Ethanol; Flumazenil; Mice; Mice, Inbred Strains; Seizures; Substance Withdrawal S | 1989 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazo | 1989 |
Flumazenil causing convulsions and ventricular tachycardia.
Topics: Female; Flumazenil; Heart Ventricles; Humans; Middle Aged; Seizures; Tachycardia | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain C | 1989 |
Repeated swim stress alters brain benzodiazepine receptors measured in vivo.
Topics: Animals; Brain; Cerebrovascular Circulation; Clonazepam; Flumazenil; Male; Mice; Pentylenetetrazole; | 1989 |
Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo.
Topics: Animals; Electroencephalography; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Sei | 1987 |
In vivo binding of beta-carbolines in mice: regional differences and correlation of occupancy to pharmacological effects.
Topics: Animals; Benzodiazepines; Brain; Brain Mapping; Carbolines; Conflict, Psychological; Dose-Response R | 1988 |
3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Cerebellum; Cerebral Cortex; Convulsants; Drug Syn | 1988 |
Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain.
Topics: Acoustic Stimulation; Animals; Azides; Benzodiazepines; Body Temperature; Brain Chemistry; Diazepam; | 1988 |
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Caffeine; Flumazenil; Flunitr | 1986 |
Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats.
Topics: Aminophylline; Amygdala; Animals; Anti-Anxiety Agents; Diazepam; Drug Interactions; Flumazenil; Kind | 1987 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumaz | 1988 |
Benzodiazepines increase tonic component of postdecapitation convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Decerebrate State; Flumazenil; Male; Mice; Mice, Inbred S | 1988 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; | 1985 |
Supraspinal convulsions induced by inverse benzodiazepine agonists in rabbits.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electroencephalography; Flumazenil; Male; Pyrazole | 1985 |
Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.
Topics: Animals; Benzodiazepinones; Clonazepam; Drug Interactions; Electroshock; Flumazenil; Male; Mice; Phe | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenet | 1985 |
The peripheral benzodiazepine receptor ligand Ro 5-4864 induces supraspinal convulsions in rabbits. Reversal by the central benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepinones; Convulsants; Electrodes, Implanted; Electroencephalography; Flumazenil; | 1986 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; | 1986 |
The benzodiazepine receptor ligand, methyl beta-carboline-3-carboxylate, is both sedative and proconvulsant in chicks.
Topics: Animals; Benzodiazepinones; Carbolines; Chickens; Convulsants; Flumazenil; Hypnotics and Sedatives; | 1986 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; | 1986 |
Physical dependence on clonazepam in dogs.
Topics: Animals; Benzodiazepinones; Body Temperature; Body Weight; Clonazepam; Dogs; Female; Flumazenil; Mal | 1986 |
Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity.
Topics: Animals; Anxiety; Autoradiography; Brain; Carbolines; Convulsants; Deoxyglucose; Flumazenil; Glucose | 1987 |
Anticonvulsant effect of denzimol in DBA/2 mice.
Topics: Acoustic Stimulation; Aminophylline; Animals; Anticonvulsants; Flumazenil; Imidazoles; Mice; Mice, I | 1987 |
Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.
Topics: Animals; Behavior, Animal; Benzodiazepines; Bicuculline; Drug Tolerance; Flumazenil; gamma-Aminobuty | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Flurothyl seizure thresholds associated with acute and chronic chlordiazepoxide dependence and withdrawal.
Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Flurothyl; Male; Rats; Rats | 1988 |
Rapid induction of lorazepam dependence and reversal with flumazenil.
Topics: Animals; Carbolines; Flumazenil; Lorazepam; Male; Mice; Mice, Inbred Strains; Seizures; Substance-Re | 1988 |
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Benzodiazepinones; Brain Chemistry; Carbolines; Chro | 1986 |
The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Ethanol; Flumazenil; Humans; Male; Rats; Rats, Inbred S | 1985 |
Reduction of flurazepam convulsive threshold by Ro 15-1788.
Topics: Animals; Benzodiazepinones; Convulsants; Electric Stimulation; Electroencephalography; Flumazenil; F | 1985 |
In vivo interactions between the benzodiazepine antagonist Ro 15-1788 and the steroid anaesthetic althesin in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Benzodiazepinones; Bicuculline; Drug Synergism; | 1985 |
Isoniazid-induced convulsions in rats: effects of Ro 15-1788 and beta-CCE.
Topics: Animals; Benzodiazepinones; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumaze | 1985 |
Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates.
Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Animals; Benzodiazepinones; Bicuculline; Brain; Carboli | 1985 |