flumazenil has been researched along with Sclerosis in 11 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 7.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 7.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 7.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 3.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 3.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "We objectively delineated the extent of abnormalities in central benzodiazepine receptor (cBZR) binding using [11C]flumazenil (FMZ)-PET and high resolution volumetric MRI in 12 patients with mesial temporal lobe epilepsy (mTLE) associated with unilateral hippocampal sclerosis, who underwent presurgical evaluation and subsequent temporal lobe surgery." | 3.69 | Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis. ( Brooks, DJ; Duncan, JS; Friston, KJ; Koepp, MJ; Poline, JB; Richardson, MP; Van Paesschen, W, 1996) |
| "Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS)." | 3.69 | 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. ( Ashburner, J; Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Revesz, T; Richardson, MP; Van Paesschen, W, 1997) |
| " Binding of [11C]-flumazenil to this complex in vivo is reduced in hippocampal sclerosis (HS)." | 3.69 | Central benzodiazepine receptor autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Duncan, JS; Hand, KS; Harkness, WF; Koepp, MJ; Revesz, T; Thom, M; Van Paesschen, W, 1997) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 3.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yankam Njiwa, J | 1 |
| Gray, KR | 1 |
| Costes, N | 1 |
| Mauguiere, F | 1 |
| Ryvlin, P | 1 |
| Hammers, A | 3 |
| Sata, Y | 1 |
| Matsuda, K | 1 |
| Mihara, T | 1 |
| Aihara, M | 1 |
| Yagi, K | 1 |
| Yonekura, Y | 1 |
| Koepp, MJ | 7 |
| Brooks, DJ | 6 |
| Duncan, JS | 7 |
| Panagoda, P | 1 |
| Heckemann, RA | 1 |
| Kelsch, W | 1 |
| Turkheimer, FE | 1 |
| Richardson, MP | 4 |
| Poline, JB | 1 |
| Van Paesschen, W | 5 |
| Friston, KJ | 1 |
| Labbé, C | 3 |
| Cunningham, VJ | 3 |
| Ashburner, J | 1 |
| Revesz, T | 2 |
| Hand, KS | 2 |
| Baird, VH | 2 |
| Thom, M | 1 |
| Harkness, WF | 1 |
| Bowery, NG | 2 |
| Juhász, C | 1 |
| Nagy, F | 1 |
| Muzik, O | 1 |
| Watson, C | 1 |
| Shah, J | 1 |
| Chugani, HT | 1 |
| Johnson, EW | 1 |
| de Lanerolle, NC | 1 |
| Kim, JH | 1 |
| Sundaresan, S | 1 |
| Spencer, DD | 1 |
| Mattson, RH | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Hoffer, PB | 1 |
| Seibyl, JP | 1 |
11 other studies available for flumazenil and Sclerosis
| Article | Year |
|---|---|
Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Hi | 2015 |
Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [(125)I]iomazenil autoradiographic study of surgically resected specimens.
Topics: Adolescent; Adult; Autoradiography; Benzodiazepines; Cell Count; Child; Child, Preschool; Epilepsy, | 2002 |
Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis.
Topics: Adult; Brain; Cerebral Ventricles; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; | 2005 |
[11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
Topics: Adult; Carbon Isotopes; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2008 |
Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis.
Topics: Adult; Binding, Competitive; Epilepsy; Female; Flumazenil; Hippocampus; Humans; Male; Middle Aged; R | 1996 |
11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy.
Topics: Adult; Brain Diseases; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampu | 1997 |
Central benzodiazepine receptor autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Flumazenil; GABA-A Receptor Antagonists; Hippocampu | 1997 |
Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis.
Topics: Adolescent; Adult; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy, | 1997 |
In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Carbon Radioisotopes; Electroencephalography; Epilepsy, Temporal Lobe; Femal | 1998 |
[11C]Flumazenil PET in patients with epilepsy with dual pathology.
Topics: Adolescent; Adult; Carbon Radioisotopes; Cerebral Cortex; Electroencephalography; Epilepsy; Female; | 1999 |
"Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Male; Rece | 1992 |