flumazenil has been researched along with Schizophrenia in 18 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cognitive impairment causes morbidity in schizophrenia and could be due to abnormalities of cortical interneurons using the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)." | 9.12 | Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia. ( Bullmore, E; Fletcher, P; Kamath, S; McKenna, P; Menzies, L; Ooi, C; Stephenson, C; Suckling, J, 2007) |
| "Whilst reduced signalling and gene expression related to gamma-aminobutyric acid (GABA) play a role in the presumed pathophysiology of schizophrenia, its origin is unclear." | 8.02 | In vivo gamma-aminobutyric acid-A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study. ( Cho, KIK; Jeong, JM; Kim, E; Kim, M; Kwon, JS; Lee, J; Lee, JS; Lee, TY; Seo, S; Yoon, YB, 2021) |
| "M, 385+/-44 fmol/mg ETE) and control (383+/-44 fmol/mg ETE) subjects, there was an increase in the density of [(3)H]flumazenil binding to the benzodiazepine binding site on the GABA(A) receptor in subjects with bipolar disorder (451+/-17 fmol/mg ETE; P<0." | 7.71 | A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder. ( Copolov, D; Dean, B; Keks, N; McLeod, M; Opeskin, K; Pavey, G, 2001) |
| "Cognitive impairment causes morbidity in schizophrenia and could be due to abnormalities of cortical interneurons using the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)." | 5.12 | Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia. ( Bullmore, E; Fletcher, P; Kamath, S; McKenna, P; Menzies, L; Ooi, C; Stephenson, C; Suckling, J, 2007) |
| "Whilst reduced signalling and gene expression related to gamma-aminobutyric acid (GABA) play a role in the presumed pathophysiology of schizophrenia, its origin is unclear." | 4.02 | In vivo gamma-aminobutyric acid-A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study. ( Cho, KIK; Jeong, JM; Kim, E; Kim, M; Kwon, JS; Lee, J; Lee, JS; Lee, TY; Seo, S; Yoon, YB, 2021) |
| "[(11)C]Flumazenil VT was significantly increased across all cortical brain regions in the healthy comparison group but not in the schizophrenia group." | 3.81 | In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients. ( Cho, RY; Frankle, WG; Himes, ML; Lewis, DA; Mason, NS; Narendran, R; Paris, J; Prasad, KM; Walker, C, 2015) |
| "Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia." | 3.80 | Reduced binding potential of GABA-A/benzodiazepine receptors in individuals at ultra-high risk for psychosis: an [18F]-fluoroflumazenil positron emission tomography study. ( An, SK; Kang, JI; Kim, KR; Kim, SJ; Kwon, JS; Lee, E; Lee, JD; Lee, SY; Park, HJ, 2014) |
| "Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the hippocampal GABA(A) receptor in schizophrenia." | 3.73 | Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. ( Dean, B; McLeod, M; Scarr, E, 2005) |
| "M, 385+/-44 fmol/mg ETE) and control (383+/-44 fmol/mg ETE) subjects, there was an increase in the density of [(3)H]flumazenil binding to the benzodiazepine binding site on the GABA(A) receptor in subjects with bipolar disorder (451+/-17 fmol/mg ETE; P<0." | 3.71 | A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder. ( Copolov, D; Dean, B; Keks, N; McLeod, M; Opeskin, K; Pavey, G, 2001) |
| "Although there is evidence from postmortem studies suggestive of deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) in schizophrenia, no direct in vivo evidence has been obtained to date." | 3.69 | Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia. ( Busatto, GF; Costa, DC; David, AS; Ell, PJ; Kerwin, RW; Lucey, JV; Pilowsky, LS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, J | 1 |
| Yoon, YB | 1 |
| Cho, KIK | 1 |
| Seo, S | 1 |
| Lee, JS | 1 |
| Jeong, JM | 1 |
| Kim, E | 1 |
| Kim, M | 1 |
| Lee, TY | 1 |
| Kwon, JS | 2 |
| Kang, JI | 1 |
| Park, HJ | 1 |
| Kim, SJ | 1 |
| Kim, KR | 1 |
| Lee, SY | 1 |
| Lee, E | 1 |
| An, SK | 1 |
| Lee, JD | 1 |
| Frankle, WG | 1 |
| Cho, RY | 1 |
| Prasad, KM | 1 |
| Mason, NS | 1 |
| Paris, J | 1 |
| Himes, ML | 1 |
| Walker, C | 1 |
| Lewis, DA | 1 |
| Narendran, R | 1 |
| McLeod, MC | 2 |
| Scarr, E | 2 |
| Dean, B | 4 |
| Ahn, K | 1 |
| Gil, R | 2 |
| Seibyl, J | 2 |
| Sewell, RA | 1 |
| D'Souza, DC | 1 |
| Verdurand, M | 1 |
| Fillman, SG | 1 |
| Weickert, CS | 1 |
| Zavitsanou, K | 1 |
| McLeod, M | 2 |
| Menzies, L | 1 |
| Ooi, C | 1 |
| Kamath, S | 1 |
| Suckling, J | 1 |
| McKenna, P | 1 |
| Fletcher, P | 1 |
| Bullmore, E | 1 |
| Stephenson, C | 1 |
| Sundram, S | 1 |
| Bailine, SH | 1 |
| Safferman, A | 1 |
| Vital-Herne, J | 1 |
| Bernstein, S | 1 |
| Busatto, GF | 2 |
| Pilowsky, LS | 2 |
| Costa, DC | 2 |
| Ell, PJ | 2 |
| David, AS | 2 |
| Lucey, JV | 1 |
| Kerwin, RW | 2 |
| Schröder, J | 1 |
| Bubeck, B | 1 |
| Demisch, S | 1 |
| Sauer, H | 1 |
| Pandey, GN | 1 |
| Conley, RR | 1 |
| Pandey, SC | 1 |
| Goel, S | 1 |
| Roberts, RC | 1 |
| Tamminga, CA | 1 |
| Chute, D | 1 |
| Smialek, J | 1 |
| Verhoeff, NP | 2 |
| Ball, S | 1 |
| Jones, SH | 1 |
| Hemsley, DR | 1 |
| Abi-Dargham, A | 2 |
| Laruelle, M | 1 |
| Krystal, J | 1 |
| D'Souza, C | 1 |
| Zoghbi, S | 1 |
| Baldwin, RM | 1 |
| Mawlawi, O | 1 |
| de Erasquin, G | 1 |
| Charney, D | 1 |
| Innis, RB | 2 |
| Soares, JC | 1 |
| D'Souza, CD | 1 |
| Degen, K | 1 |
| Zoghbi, SS | 1 |
| Fujita, M | 1 |
| Rajeevan, N | 1 |
| Seibyl, JP | 1 |
| Krystal, JH | 1 |
| van Dyck, CH | 1 |
| Charney, DS | 1 |
| Pavey, G | 1 |
| Opeskin, K | 1 |
| Keks, N | 1 |
| Copolov, D | 1 |
3 trials available for flumazenil and Schizophrenia
| Article | Year |
|---|---|
Probing GABA receptor function in schizophrenia with iomazenil.
Topics: Adult; Analysis of Variance; Anxiety; Brief Psychiatric Rating Scale; Double-Blind Method; Flumazeni | 2011 |
Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia.
Topics: Adult; Brain; Cerebral Cortex; Cognition Disorders; Double-Blind Method; Flumazenil; GABA Modulators | 2007 |
Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: a 123I-iomazenil SPET study.
Topics: Adult; Cognition; Female; Flumazenil; Humans; Image Processing, Computer-Assisted; Iodine Radioisoto | 1998 |
15 other studies available for flumazenil and Schizophrenia
| Article | Year |
|---|---|
In vivo gamma-aminobutyric acid-A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study.
Topics: Brain; Carbon Radioisotopes; Flumazenil; gamma-Aminobutyric Acid; Humans; Positron-Emission Tomograp | 2021 |
Reduced binding potential of GABA-A/benzodiazepine receptors in individuals at ultra-high risk for psychosis: an [18F]-fluoroflumazenil positron emission tomography study.
Topics: Adolescent; Brain; Case-Control Studies; Caudate Nucleus; Female; Flumazenil; gamma-Aminobutyric Aci | 2014 |
In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Female; Flumazenil; GABA Modulat | 2015 |
Effects of benzodiazepine treatment on cortical GABA(A) and muscarinic receptors: studies in schizophrenia and rats.
Topics: Adult; Aged; Analysis of Variance; Animals; Benzodiazepines; Cerebral Cortex; Female; Flumazenil; GA | 2010 |
Increases in [3H]muscimol and [3H]flumazenil binding in the dorsolateral prefrontal cortex in schizophrenia are linked to α4 and γ2S mRNA levels respectively.
Topics: Adult; Aged; Allosteric Site; Autoradiography; Case-Control Studies; Cohort Studies; Female; Flumaze | 2013 |
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil | 2005 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Dis | 2008 |
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Electroconvulsive Therapy; Flumazenil; Humans; Lorazepam; Male; | 1994 |
Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia.
Topics: Adolescent; Adult; Cerebral Cortex; Female; Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Human | 1997 |
Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study.
Topics: Adult; Benzodiazepines; Binding Sites; Chronic Disease; Diazepam; Flumazenil; Frontal Lobe; Growth H | 1997 |
Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Drug Therapy, Combination; Fema | 1997 |
Benzodiazepine receptor binding and schizophrenia.
Topics: Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Prefrontal Co | 1997 |
No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia.
Topics: Adult; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Middle Aged; Outc | 1999 |
[123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia.
Topics: Adult; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Female; Flumazenil; Frontal Lobe; | 1999 |
A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder.
Topics: Adult; Aged; Autoradiography; Bipolar Disorder; Brain Mapping; Female; Flumazenil; Frontal Lobe; Hum | 2001 |