flumazenil has been researched along with Respiratory Insufficiency in 24 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 7.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 5.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| " A 67-year-old man with chlordiazepoxide toxicity required a 9-day infusion of flumazenil to prevent resedation and respiratory insufficiency; he initially was admitted to the hospital for alcohol detoxification." | 3.72 | Continuous-infusion flumazenil in the management of chlordiazepoxide toxicity. ( Adeeko, MA; Maxa, JL; Ogu, CC; Swaner, TG, 2003) |
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 3.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "Flumazenil is a competitive inhibitor of the benzodiazepines that is available for reversal at the end of such a procedure or when too much sedation has been achieved." | 2.40 | Reversal of midazolam-induced laryngospasm with flumazenil. ( Davis, DP; Hamilton, RS; Webster, TH, 1998) |
| "The incidence of coma was significantly higher, and the length of hospital stay significantly longer in elderly." | 1.43 | Benzodiazepine poisoning in elderly. ( Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP, 2016) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 1.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| "Flumazenil was administered as escalating bolus doses followed by a continuous infusion." | 1.31 | Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines. ( Baud, FJ; Borron, SW; Gueye, PN; Harf, A; Lofaso, F; Mellerio, F; Vicaut, E, 2002) |
| "Flumazenil was administered by a randomly selected route [0." | 1.30 | Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model. ( Cordell, WH; Heniff, MS; Moore, GP; Nelson, DR; Trout, A, 1997) |
| "Severe respiratory depression and somnolence supervened 3." | 1.30 | [Persisting respiratory depression following intrathecal administration of morphine and simultaneous sedation with midazolam]. ( Büttner, T; Dworzak, H; Fuss, F, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 13 (54.17) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, JO | 1 |
| Jaung, WJ | 1 |
| Won, SH | 1 |
| Ryu, MO | 1 |
| Song, WJ | 1 |
| Jeon, KO | 1 |
| Chung, JY | 1 |
| Youn, HY | 1 |
| Ninomiya, A | 1 |
| Matsuura, N | 1 |
| Ichinohe, T | 1 |
| Vukcević, NP | 1 |
| Ercegović, GV | 1 |
| Segrt, Z | 1 |
| Djordjević, S | 1 |
| Stosić, JJ | 1 |
| Wilson, KE | 1 |
| Thorpe, RJ | 1 |
| McCabe, JF | 1 |
| Girdler, NM | 1 |
| Maxa, JL | 1 |
| Ogu, CC | 1 |
| Adeeko, MA | 1 |
| Swaner, TG | 1 |
| Brierley, J | 1 |
| Mainwaring, CJ | 1 |
| Wong, C | 1 |
| Lush, RJ | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Heniff, MS | 1 |
| Moore, GP | 1 |
| Trout, A | 1 |
| Cordell, WH | 1 |
| Nelson, DR | 1 |
| Kasaba, T | 1 |
| Takeshita, M | 1 |
| Takasaki, M | 1 |
| Davis, DP | 1 |
| Hamilton, RS | 1 |
| Webster, TH | 1 |
| Dworzak, H | 1 |
| Fuss, F | 1 |
| Büttner, T | 1 |
| Gueye, PN | 1 |
| Lofaso, F | 1 |
| Borron, SW | 1 |
| Mellerio, F | 1 |
| Vicaut, E | 1 |
| Harf, A | 1 |
| Baud, FJ | 1 |
| Gröger, P | 1 |
| Sydow, M | 1 |
| Michaelis, HC | 1 |
| Steinwachs, M | 1 |
| Kolenda, H | 1 |
| Kettler, D | 1 |
| Saissy, JM | 1 |
| Demazière, J | 1 |
| Vitris, M | 1 |
| Seck, M | 1 |
| Marcoux, L | 1 |
| Gaye, M | 1 |
| Ndiaye, M | 1 |
| Linowiecki, K | 1 |
| Paloucek, F | 1 |
| Donnelly, A | 1 |
| Leikin, JB | 1 |
| Varache, N | 1 |
| Bouachour, G | 1 |
| Tirot, P | 1 |
| Alquier, P | 1 |
| Gross, JB | 1 |
| Weller, RS | 1 |
| Conard, P | 1 |
| Schaer, H | 1 |
| Baasch, K | 1 |
| Achtari, R | 1 |
| Carter, AS | 1 |
| Bell, GD | 1 |
| Coady, T | 1 |
| Lee, J | 1 |
| Morden, A | 1 |
| Baartmans, MG | 1 |
| Kopp, EF | 1 |
| Oudesluys-Murphy, AM | 1 |
| Lim, AG | 1 |
| Katz, Y | 1 |
| Gavish, M | 1 |
| Monasta, L | 1 |
| Andersson, N | 1 |
| Ledogar, RJ | 1 |
| Cockcroft, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for flumazenil and Respiratory Insufficiency
| Article | Year |
|---|---|
Reversal of midazolam-induced laryngospasm with flumazenil.
Topics: Anti-Anxiety Agents; Antidotes; Conscious Sedation; Electric Countershock; Flumazenil; GABA Modulato | 1998 |
Midazolam--is antagonism justified?
Topics: Adult; Aged; Cardiovascular Diseases; Flumazenil; Humans; Midazolam; Respiratory Insufficiency | 1988 |
3 trials available for flumazenil and Respiratory Insufficiency
| Article | Year |
|---|---|
Inhalation of 50% Oxygen Does Not Impair Respiratory Depression During Midazolam Sedation.
Topics: Adult; Antidotes; Capnography; Conscious Sedation; Cross-Over Studies; Female; Flumazenil; Healthy V | 2016 |
Flumazenil antagonism of midazolam-induced ventilatory depression.
Topics: Adult; Blood Pressure; Double-Blind Method; Flumazenil; Heart Rate; Humans; Injections, Intravenous; | 1991 |
[Antagonism of flunitrazepam and fentanyl by flumazenil, naloxone or nalbuphine].
Topics: Adult; Double-Blind Method; Fentanyl; Flumazenil; Flunitrazepam; Humans; Middle Aged; Morphinans; Na | 1990 |
19 other studies available for flumazenil and Respiratory Insufficiency
| Article | Year |
|---|---|
Accidental afloqualone intoxication in two dogs.
Topics: Animals; Ataxia; Bradycardia; Dog Diseases; Dogs; Flumazenil; Male; Quinazolines; Respiratory Insuff | 2018 |
Benzodiazepine poisoning in elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Coh | 2016 |
Complications associated with intravenous midazolam sedation in anxious dental patients.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Child; Clinical Audit; Consci | 2011 |
Continuous-infusion flumazenil in the management of chlordiazepoxide toxicity.
Topics: Aged; Chlordiazepoxide; Disease Management; Flumazenil; Humans; Infusions, Intravenous; Male; Respir | 2003 |
Danger of flumazenil use in pediatric status epilepticus.
Topics: Benzodiazepines; Child, Preschool; Female; Flumazenil; Humans; Infant; Male; Recurrence; Respiratory | 2006 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model.
Topics: Administration, Rectal; Administration, Sublingual; Animals; Antidotes; Cross-Over Studies; Disease | 1997 |
[The effects of flumazenil or bicuculline on the respiratory depression by morphine].
Topics: Action Potentials; Animals; Bicuculline; Depression, Chemical; Flumazenil; GABA Antagonists; GABA Mo | 1998 |
[Persisting respiratory depression following intrathecal administration of morphine and simultaneous sedation with midazolam].
Topics: Aged; Analgesics, Opioid; Flumazenil; Humans; Hypnotics and Sedatives; Injections, Spinal; Intubatio | 1999 |
Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.
Topics: Adult; Aged; Aged, 80 and over; Airway Resistance; Anti-Anxiety Agents; Antidotes; Coma; Drug Overdo | 2002 |
[Extreme duration of action of diazepam as a cause of respiratory insufficiency in a female geriatric patient].
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Postoperative Complications; Respiratory Insufficiency; | 1992 |
Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation.
Topics: Adolescent; Adult; Africa; Age Factors; Aged; Baclofen; Blood Gas Analysis; Coma; Creatine Kinase; D | 1992 |
Reversal of ethanol-induced respiratory depression by flumazenil.
Topics: Adult; Benzodiazepines; Ethanol; Flumazenil; Humans; Male; Respiratory Insufficiency | 1992 |
[Flumazenil in the treatment of respiratory encephalopathy].
Topics: Flumazenil; Humans; Lung Diseases, Obstructive; Respiratory Insufficiency | 1991 |
Speed of reversal of midazolam-induced respiratory depression by flumazenil--a study in patients undergoing upper G.I. endoscopy.
Topics: Adult; Aged; Aged, 80 and over; Blood Gas Monitoring, Transcutaneous; Female; Flumazenil; Gastroscop | 1990 |
[The risks of diazepam in newborn infants].
Topics: Diazepam; Flumazenil; Humans; Infant, Newborn; Respiratory Insufficiency | 1990 |
Death after flumazenil.
Topics: Aged; Aged, 80 and over; Antidotes; Female; Flumazenil; Humans; Midazolam; Respiratory Insufficiency | 1989 |
Aminophylline reversal of diazepam intoxication.
Topics: Aminophylline; Diazepam; Flumazenil; Half-Life; Humans; Male; Respiratory Insufficiency | 1989 |
Minority health and small numbers epidemiology: a case study of living conditions and the health of children in 5 foreign Romá camps in Italy.
Topics: Attitude to Health; Child Welfare; Child, Preschool; Cross-Sectional Studies; Diarrhea; Environmenta | 2008 |