flumazenil has been researched along with Psychomotor Agitation in 10 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sedation and restlessness in all patients were controlled by midazolam administered intravenously by the attending anaesthesiologist; these parameters were later objectively confirmed by recorded actigrams." | 2.41 | The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. ( Flaishon, R; Ogorek, D; Szold, O; Weinbroum, AA, 2001) |
| "Bilateral intraocular pressures were monitored before and after the first 7 ECTs and intermittently after ECT for 10 months of maintenance ECT." | 1.40 | Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. ( Reti, IM; Wachtel, LE; Ying, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, NZ | 1 |
| Ernst, M | 1 |
| Treven, M | 1 |
| Cerne, R | 1 |
| Wakulchik, M | 1 |
| Li, X | 1 |
| Jones, TM | 1 |
| Gleason, SD | 1 |
| Morrow, D | 1 |
| Schkeryantz, JM | 1 |
| Rahman, MT | 1 |
| Li, G | 1 |
| Poe, MM | 1 |
| Cook, JM | 1 |
| Witkin, JM | 1 |
| Wachtel, LE | 1 |
| Reti, IM | 1 |
| Ying, H | 1 |
| Heller, M | 1 |
| Hayes, CM | 1 |
| Krejci, NC | 1 |
| McKenzie, WS | 1 |
| Rosenberg, M | 1 |
| Araki, H | 1 |
| Fujiwara, Y | 1 |
| Shimada, Y | 1 |
| George, MS | 1 |
| Sury, MR | 1 |
| Smith, VM | 1 |
| Massanari, M | 1 |
| Novitsky, J | 1 |
| Reinstein, LJ | 1 |
| Weinbroum, AA | 1 |
| Szold, O | 1 |
| Ogorek, D | 1 |
| Flaishon, R | 1 |
| Lopez, A | 1 |
| Rebollo, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PARADOX - the Incidence of Paradoxical Reactions in Pediatric Patients Premedicated With Midazolam[NCT04190537] | 500 participants (Anticipated) | Observational | 2019-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for flumazenil and Psychomotor Agitation
| Article | Year |
|---|---|
The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.
Topics: Aged; Aggression; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Anxiety Agents; Female; Flumazenil; | 2001 |
1 trial available for flumazenil and Psychomotor Agitation
| Article | Year |
|---|---|
Effect of flumazenil on recovery from sevoflurane anesthesia in children premedicated with oral midazolam before undergoing herniorrhaphy with or without caudal analgesia.
Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Inhalation; Chi | 2005 |
8 other studies available for flumazenil and Psychomotor Agitation
| Article | Year |
|---|---|
Negative allosteric modulation of alpha 5-containing GABA
Topics: Aging; Allosteric Regulation; Animals; Antidepressive Agents; Benzodiazepines; Depressive Disorder; | 2018 |
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy.
Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Thera | 2014 |
Paradoxical reaction to midazolam reversed with flumazenil in a patient undergoing tumescent liposuction.
Topics: Antidotes; Axilla; Female; Flumazenil; GABA-A Receptor Antagonists; Humans; Hyperhidrosis; Hypnotics | 2009 |
Paradoxical reaction following administration of a benzodiazepine.
Topics: Adolescent; Anesthesia, Dental; Anesthetics, Intravenous; Antidotes; Female; Flumazenil; GABA-A Rece | 2010 |
Reversal of paradoxical excitement to diazepam sedation.
Topics: Anti-Anxiety Agents; Antidotes; Child; Conscious Sedation; Diazepam; Flumazenil; Humans; Male; Psych | 2008 |
Paradoxical reactions to diazepam.
Topics: Conscious Sedation; Diazepam; Flumazenil; Humans; Psychomotor Agitation | 1995 |
Paradoxical reactions in children associated with midazolam use during endoscopy.
Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An | 1997 |
Benzodiazepine withdrawal syndrome after a benzodiazepine antagonist.
Topics: Adolescent; Akathisia, Drug-Induced; Diazepam; Drug Overdose; Flumazenil; Humans; Injections, Intrav | 1990 |