Page last updated: 2024-10-27

flumazenil and Poisoning

flumazenil has been researched along with Poisoning in 35 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines."9.09[The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000)
"To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning."9.06Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990)
"The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min."6.67Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990)
"To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines."5.09[The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000)
"To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning."5.06Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990)
" Search terms included poisoning, overdose, toxicity, naloxone, glucose, thiamine, and flumazenil."4.79The poisoned patient with altered consciousness. Controversies in the use of a 'coma cocktail'. ( Goldfrank, LR; Hoffman, RS, 1995)
"Included patient were those aged 12 years or younger who received flumazenil, who had evidence of clinical poisoning as defined by an altered mental status, and who were reported to the California Poison Control System for the period 1999 to 2008."3.78Flumazenil administration in poisoned pediatric patients. ( Cantrell, FL; Clark, RF; Kreshak, AA; Tomaszewski, CA, 2012)
" An almost 100% efficacy is seen using specific antagonists, such as naloxone in opiate poisoning or flumazenil in benzodiazepine poisoning, e."3.69The relative efficacy of antidotes. ( Jacobsen, D, 1995)
"The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min."2.67Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990)
"Poisonings are a common problem."2.40Clinical applications of commonly used contemporary antidotes. A US perspective. ( Bowden, CA; Krenzelok, EP, 1997)
"Flumazenil (Ro 15-1788) is a specific benzodiazepine antagonist which can prevent or abolish selectively at the receptor level all centrally mediated effects of benzodiazepines."2.37Pharmacokinetics and clinical use of flumazenil (Ro 15-1788). ( Kanto, J; Klotz, U, 1988)
"Flumazenil has been reported to reverse the CNS effects of zolpidem."1.39Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013)
"Of 947 admissions, 222 (23%) were comatose."1.35Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome. ( Bjornas, MA; Ekeberg, O; Heyerdahl, F; Hovda, KE; Jacobsen, D; Opdahl, A; Skog, K; Wium, C, 2008)
"Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex."1.29[The effect of flumazenil administration on acute cocaine intoxication of rats]. ( Hirakawa, K; Nihira, M; Uekusa, K; Uki, F, 1994)
" The dosage of flumazenil used in this study ranged from 0."1.28[Clinical experience in benzodiazepine antagonist]. ( Deng, JF; Hung, DZ; Tsai, WJ, 1991)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.29)18.7374
1990's18 (51.43)18.2507
2000's8 (22.86)29.6817
2010's4 (11.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sud, P1
Olsen, D1
Litroff, AH1
Cipot, S1
Thornton, SL1
Negus, E1
Carstairs, SD1
Kreshak, AA1
Tomaszewski, CA1
Clark, RF2
Cantrell, FL2
Kreshak, A1
Tomaszewski, C1
Clark, R1
Zhu, XH1
Li, JX1
Wang, F1
Haga, C1
Seger, DL1
Bartlett, D1
Lee, DC1
Satz, WA1
Dougherty, T1
Greene, T1
Heyerdahl, F1
Bjornas, MA1
Hovda, KE1
Skog, K1
Opdahl, A1
Wium, C1
Ekeberg, O1
Jacobsen, D2
Hoffman, RS1
Goldfrank, LR1
Sage, TA1
Tunget, C1
Manoguerra, AS1
Chern, CH1
Chern, TL1
Hu, SC1
Lee, CH1
Deng, JF2
Rubio, F1
Quintero, S1
Hernandez, A1
Fernandez, S1
Cozar, L1
Lobato, IM1
Pantoja, S1
Uki, F1
Nihira, M1
Hirakawa, K1
Uekusa, K1
Boccuzzi-Chmura, L1
Robertson, DC1
Bowden, CA1
Krenzelok, EP1
Burton, JH1
Lyon, L1
Dorfman, T1
Tomassoni, AJ1
de Haro, L1
Valli, M1
Bourdon, JH1
Iliadis, A1
Hayek-Lanthois, M1
Arditti, J1
Pietilä, K1
Valve, K1
Mordel, A1
Winkler, E1
Almog, S1
Tirosh, M1
Ezra, D1
Hung, DZ1
Tsai, WJ1
Orgill, R1
Höjer, J1
Baehrendtz, S1
Matell, G1
Gustafsson, LL1
Munné, P1
Nogué, S1
Millá, J1
Kadiwar, RM1
Pillay, R1
Crespo Rupérez, E1
Velasco Bernardo, R1
Montalvo Serrano, N1
López Lozano, Y1
Alonso Martín, JA1
Martens, F1
Köppel, C1
Ibe, K1
Wagemann, A1
Tenczer, J1
Leykin, Y1
Halpern, P1
Silbiger, A1
Sorkin, P1
Niv, D1
Rudick, V1
Geller, E1
Redlich, M1
Hofer, P1
Dubach, UC1
Klüppelberg, J1
Fantozzi, R1
Caramelli, L1
Barattini, M1
Botti, P1
Ledda, F1
Masini, E1
Moroni, F1
Peruzzi, S1
Zorn, AM1
Mannaioni, PF1
Rouzioux, JM1
Baud, FJ1
Bismuth, C1
Du Cailar, J1
Ducluzeau, R1
Durocher, A1
Flesch, F1
Bikpi-Benissan, G1
Jaeger, A1
Jean, P1
Klotz, U1
Kanto, J1
Jung, H1
Matei, DB1
Hecser, L1

Reviews

7 reviews available for flumazenil and Poisoning

ArticleYear
Flumazenil--treatment or toxin.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:2

    Topics: Antidotes; Drug Interactions; Drug Therapy, Combination; Emergency Service, Hospital; Flumazenil; Hu

2004
The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route.
    Journal of emergency nursing, 2004, Volume: 30, Issue:6

    Topics: Adult; Antidotes; Child; Coma; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Ov

2004
The poisoned patient with altered consciousness. Controversies in the use of a 'coma cocktail'.
    JAMA, 1995, Aug-16, Volume: 274, Issue:7

    Topics: Consciousness; Flumazenil; Glucose; Humans; Naloxone; Poisoning; Thiamine

1995
Delayed onset lorazepam poisoning successfully reversed by flumazenil in a child. Case report and review of the literature.
    Pediatric emergency care, 1995, Volume: 11, Issue:1

    Topics: Child, Preschool; Female; Flumazenil; Humans; Lorazepam; Poisoning; Sleep Stages; Time Factors

1995
Flumazenil (romazicon) and the patient with benzodiazepine overdose: risks versus benefits.
    Journal of emergency nursing, 1996, Volume: 22, Issue:4

    Topics: Anti-Anxiety Agents; Antidotes; Emergency Nursing; Flumazenil; Humans; Poisoning

1996
Clinical applications of commonly used contemporary antidotes. A US perspective.
    Drug safety, 1997, Volume: 16, Issue:1

    Topics: Acetylcysteine; Antidotes; Antivenins; Atropine; Deferoxamine; Flumazenil; Humans; Hydroxocobalamin;

1997
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
    Clinical pharmacokinetics, 1988, Volume: 14, Issue:1

    Topics: Anesthesia; Benzodiazepines; Diazepam; Flumazenil; Humans; Injections, Intravenous; Poisoning

1988

Trials

5 trials available for flumazenil and Poisoning

ArticleYear
[The efficacy of the native flumazenil for acute poisoning with benzodiazepines].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2000, Dec-28, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidotes; Coma; Female; Flumazenil

2000
Complete and partial response to flumazenil in patients with suspected benzodiazepine overdose.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:3

    Topics: Adult; Aged; Benzodiazepines; Female; Flumazenil; Humans; Male; Middle Aged; Poisoning; Treatment Ou

1995
Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study.
    BMJ (Clinical research ed.), 1990, Dec-08, Volume: 301, Issue:6764

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Coma; Double

1990
Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning.
    Journal of toxicology. Clinical toxicology, 1990, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Benzodiazepines; Chromatography, High Pressure Liqu

1990
The use of anexate (Ro 15-1788) in acute self-poisoning with benzodiazepines alone or combined with other drugs--preliminary results.
    Resuscitation, 1988, Volume: 16 Suppl

    Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female;

1988

Other Studies

23 other studies available for flumazenil and Poisoning

ArticleYear
A response to the article, "Flumazenil administration in poisoned pediatric patients".
    Pediatric emergency care, 2013, Volume: 29, Issue:7

    Topics: Female; Flumazenil; Humans; Male; Poisoning

2013
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
    Pediatric emergency care, 2013, Volume: 29, Issue:11

    Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie

2013
Flumazenil administration in poisoned pediatric patients.
    Pediatric emergency care, 2012, Volume: 28, Issue:5

    Topics: Antidotes; California; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; Fem

2012
A response to the letter to the editors about "flumazenil administration in poisoned pediatric patients".
    Pediatric emergency care, 2012, Volume: 28, Issue:11

    Topics: Female; Flumazenil; Humans; Male; Poisoning

2012
[Poisonings with benzodiazepine-like drugs].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Feb-20, Volume: 123, Issue:4

    Topics: Acetamides; Antidotes; Azabicyclo Compounds; Flumazenil; Humans; Hypnotics and Sedatives; Norway; Pi

2003
An investigation of flumazenil to antagonize gamma-hydroxybutyrate intoxication in a murine model.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2006, Volume: 2, Issue:2

    Topics: Animals; Antidotes; Behavior, Animal; Disease Models, Animal; Flumazenil; Mice; Pilot Projects; Pois

2006
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Cross-Sectional Studies; Ethanol; Femal

2008
Flumazenil for coma reversal in children after cannabis.
    Lancet (London, England), 1993, Apr-17, Volume: 341, Issue:8851

    Topics: Cannabinoids; Child, Preschool; Coma; Flumazenil; Humans; Infant; Infusions, Intravenous; Male; Pois

1993
[The effect of flumazenil administration on acute cocaine intoxication of rats].
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1994, Volume: 29, Issue:2

    Topics: Acute Disease; Animals; Cocaine; Diazepam; Flumazenil; Male; Poisoning; Rats; Rats, Wistar

1994
The relative efficacy of antidotes.
    Journal of toxicology. Clinical toxicology, 1995, Volume: 33, Issue:6

    Topics: Antidotes; Atropine; Chelating Agents; Diazepam; Flumazenil; Humans; Naloxone; Poisoning

1995
Continuous flumazenil infusion in the treatment of zolpidem (Ambien) and ethanol coingestion.
    Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:7

    Topics: Antidotes; Depressive Disorder; Ethanol; Female; Flumazenil; Humans; Hypnotics and Sedatives; Infusi

1998
Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels.
    Veterinary and human toxicology, 2001, Volume: 43, Issue:3

    Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Flumazenil; Humans; Male; Middl

2001
[Flumazenil-induced contractile seizure in poisoning by a combination of tricyclic antidepressants and benzodiazepine in a young woman].
    Duodecim; laaketieteellinen aikakauskirja, 1991, Volume: 107, Issue:23-24

    Topics: Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans;

1991
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
    Critical care medicine, 1992, Volume: 20, Issue:12

    Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip

1992
[Clinical experience in benzodiazepine antagonist].
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1991, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Female; Flumazenil; Humans; Male; M

1991
Flumazenil.
    The Australian nurses' journal. Royal Australian Nursing Federation, 1991, Volume: 21, Issue:3

    Topics: Anti-Anxiety Agents; Flumazenil; Humans; Poisoning

1991
[The usefulness of flumazenil in benzodiazepine poisoning].
    Revista clinica espanola, 1990, Volume: 187, Issue:5

    Topics: Acute Disease; Adult; Aged; Anti-Anxiety Agents; Drug Evaluation; Female; Flumazenil; Glasgow Coma S

1990
Flumazenil therapy in benzodiazepine self-poisoning.
    Irish medical journal, 1991, Volume: 84, Issue:1

    Topics: Adult; Diazepam; Female; Flumazenil; Humans; Lorazepam; Middle Aged; Poisoning

1991
[Benzodiazepine poisoning treated with flumazenil].
    Anales espanoles de pediatria, 1990, Volume: 32, Issue:5

    Topics: Antidotes; Benzodiazepines; Child; Child, Preschool; Flumazenil; Humans; Male; Poisoning

1990
Acute poisoning treated in the intensive care unit: a case series.
    Israel journal of medical sciences, 1989, Volume: 25, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Critical Care; Female; Flumazenil; Humans

1989
[Intentional drug poisoning from the epidemiological, emergency medical and therapeutic viewpoints].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Nov-18, Volume: 75, Issue:47

    Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Child; Combined Modality Therapy; Female; Flumazenil;

1986
Clinical experiences with Ro 15-1788 (anexate) in benzodiazepine and mixed-drug overdoses.
    Resuscitation, 1988, Volume: 16 Suppl

    Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic

1988
Biostatistical study of suicide features in Mures County (Romania).
    Legal medicine (Tokyo, Japan), 2009, Volume: 11 Suppl 1

    Topics: Adult; Age Distribution; Aged; Alcohol Drinking; Asphyxia; Drowning; Female; Forensic Medicine; Huma

2009