flumazenil has been researched along with Poisoning in 35 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines." | 9.09 | [The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000) |
| "To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning." | 9.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| "The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min." | 6.67 | Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990) |
| "To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines." | 5.09 | [The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000) |
| "To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning." | 5.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| " Search terms included poisoning, overdose, toxicity, naloxone, glucose, thiamine, and flumazenil." | 4.79 | The poisoned patient with altered consciousness. Controversies in the use of a 'coma cocktail'. ( Goldfrank, LR; Hoffman, RS, 1995) |
| "Included patient were those aged 12 years or younger who received flumazenil, who had evidence of clinical poisoning as defined by an altered mental status, and who were reported to the California Poison Control System for the period 1999 to 2008." | 3.78 | Flumazenil administration in poisoned pediatric patients. ( Cantrell, FL; Clark, RF; Kreshak, AA; Tomaszewski, CA, 2012) |
| " An almost 100% efficacy is seen using specific antagonists, such as naloxone in opiate poisoning or flumazenil in benzodiazepine poisoning, e." | 3.69 | The relative efficacy of antidotes. ( Jacobsen, D, 1995) |
| "The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min." | 2.67 | Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990) |
| "Poisonings are a common problem." | 2.40 | Clinical applications of commonly used contemporary antidotes. A US perspective. ( Bowden, CA; Krenzelok, EP, 1997) |
| "Flumazenil (Ro 15-1788) is a specific benzodiazepine antagonist which can prevent or abolish selectively at the receptor level all centrally mediated effects of benzodiazepines." | 2.37 | Pharmacokinetics and clinical use of flumazenil (Ro 15-1788). ( Kanto, J; Klotz, U, 1988) |
| "Flumazenil has been reported to reverse the CNS effects of zolpidem." | 1.39 | Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013) |
| "Of 947 admissions, 222 (23%) were comatose." | 1.35 | Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome. ( Bjornas, MA; Ekeberg, O; Heyerdahl, F; Hovda, KE; Jacobsen, D; Opdahl, A; Skog, K; Wium, C, 2008) |
| "Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex." | 1.29 | [The effect of flumazenil administration on acute cocaine intoxication of rats]. ( Hirakawa, K; Nihira, M; Uekusa, K; Uki, F, 1994) |
| " The dosage of flumazenil used in this study ranged from 0." | 1.28 | [Clinical experience in benzodiazepine antagonist]. ( Deng, JF; Hung, DZ; Tsai, WJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.29) | 18.7374 |
| 1990's | 18 (51.43) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sud, P | 1 |
| Olsen, D | 1 |
| Litroff, AH | 1 |
| Cipot, S | 1 |
| Thornton, SL | 1 |
| Negus, E | 1 |
| Carstairs, SD | 1 |
| Kreshak, AA | 1 |
| Tomaszewski, CA | 1 |
| Clark, RF | 2 |
| Cantrell, FL | 2 |
| Kreshak, A | 1 |
| Tomaszewski, C | 1 |
| Clark, R | 1 |
| Zhu, XH | 1 |
| Li, JX | 1 |
| Wang, F | 1 |
| Haga, C | 1 |
| Seger, DL | 1 |
| Bartlett, D | 1 |
| Lee, DC | 1 |
| Satz, WA | 1 |
| Dougherty, T | 1 |
| Greene, T | 1 |
| Heyerdahl, F | 1 |
| Bjornas, MA | 1 |
| Hovda, KE | 1 |
| Skog, K | 1 |
| Opdahl, A | 1 |
| Wium, C | 1 |
| Ekeberg, O | 1 |
| Jacobsen, D | 2 |
| Hoffman, RS | 1 |
| Goldfrank, LR | 1 |
| Sage, TA | 1 |
| Tunget, C | 1 |
| Manoguerra, AS | 1 |
| Chern, CH | 1 |
| Chern, TL | 1 |
| Hu, SC | 1 |
| Lee, CH | 1 |
| Deng, JF | 2 |
| Rubio, F | 1 |
| Quintero, S | 1 |
| Hernandez, A | 1 |
| Fernandez, S | 1 |
| Cozar, L | 1 |
| Lobato, IM | 1 |
| Pantoja, S | 1 |
| Uki, F | 1 |
| Nihira, M | 1 |
| Hirakawa, K | 1 |
| Uekusa, K | 1 |
| Boccuzzi-Chmura, L | 1 |
| Robertson, DC | 1 |
| Bowden, CA | 1 |
| Krenzelok, EP | 1 |
| Burton, JH | 1 |
| Lyon, L | 1 |
| Dorfman, T | 1 |
| Tomassoni, AJ | 1 |
| de Haro, L | 1 |
| Valli, M | 1 |
| Bourdon, JH | 1 |
| Iliadis, A | 1 |
| Hayek-Lanthois, M | 1 |
| Arditti, J | 1 |
| Pietilä, K | 1 |
| Valve, K | 1 |
| Mordel, A | 1 |
| Winkler, E | 1 |
| Almog, S | 1 |
| Tirosh, M | 1 |
| Ezra, D | 1 |
| Hung, DZ | 1 |
| Tsai, WJ | 1 |
| Orgill, R | 1 |
| Höjer, J | 1 |
| Baehrendtz, S | 1 |
| Matell, G | 1 |
| Gustafsson, LL | 1 |
| Munné, P | 1 |
| Nogué, S | 1 |
| Millá, J | 1 |
| Kadiwar, RM | 1 |
| Pillay, R | 1 |
| Crespo Rupérez, E | 1 |
| Velasco Bernardo, R | 1 |
| Montalvo Serrano, N | 1 |
| López Lozano, Y | 1 |
| Alonso Martín, JA | 1 |
| Martens, F | 1 |
| Köppel, C | 1 |
| Ibe, K | 1 |
| Wagemann, A | 1 |
| Tenczer, J | 1 |
| Leykin, Y | 1 |
| Halpern, P | 1 |
| Silbiger, A | 1 |
| Sorkin, P | 1 |
| Niv, D | 1 |
| Rudick, V | 1 |
| Geller, E | 1 |
| Redlich, M | 1 |
| Hofer, P | 1 |
| Dubach, UC | 1 |
| Klüppelberg, J | 1 |
| Fantozzi, R | 1 |
| Caramelli, L | 1 |
| Barattini, M | 1 |
| Botti, P | 1 |
| Ledda, F | 1 |
| Masini, E | 1 |
| Moroni, F | 1 |
| Peruzzi, S | 1 |
| Zorn, AM | 1 |
| Mannaioni, PF | 1 |
| Rouzioux, JM | 1 |
| Baud, FJ | 1 |
| Bismuth, C | 1 |
| Du Cailar, J | 1 |
| Ducluzeau, R | 1 |
| Durocher, A | 1 |
| Flesch, F | 1 |
| Bikpi-Benissan, G | 1 |
| Jaeger, A | 1 |
| Jean, P | 1 |
| Klotz, U | 1 |
| Kanto, J | 1 |
| Jung, H | 1 |
| Matei, DB | 1 |
| Hecser, L | 1 |
7 reviews available for flumazenil and Poisoning
| Article | Year |
|---|---|
Flumazenil--treatment or toxin.
Topics: Antidotes; Drug Interactions; Drug Therapy, Combination; Emergency Service, Hospital; Flumazenil; Hu | 2004 |
The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route.
Topics: Adult; Antidotes; Child; Coma; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Ov | 2004 |
The poisoned patient with altered consciousness. Controversies in the use of a 'coma cocktail'.
Topics: Consciousness; Flumazenil; Glucose; Humans; Naloxone; Poisoning; Thiamine | 1995 |
Delayed onset lorazepam poisoning successfully reversed by flumazenil in a child. Case report and review of the literature.
Topics: Child, Preschool; Female; Flumazenil; Humans; Lorazepam; Poisoning; Sleep Stages; Time Factors | 1995 |
Flumazenil (romazicon) and the patient with benzodiazepine overdose: risks versus benefits.
Topics: Anti-Anxiety Agents; Antidotes; Emergency Nursing; Flumazenil; Humans; Poisoning | 1996 |
Clinical applications of commonly used contemporary antidotes. A US perspective.
Topics: Acetylcysteine; Antidotes; Antivenins; Atropine; Deferoxamine; Flumazenil; Humans; Hydroxocobalamin; | 1997 |
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
Topics: Anesthesia; Benzodiazepines; Diazepam; Flumazenil; Humans; Injections, Intravenous; Poisoning | 1988 |
5 trials available for flumazenil and Poisoning
| Article | Year |
|---|---|
[The efficacy of the native flumazenil for acute poisoning with benzodiazepines].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidotes; Coma; Female; Flumazenil | 2000 |
Complete and partial response to flumazenil in patients with suspected benzodiazepine overdose.
Topics: Adult; Aged; Benzodiazepines; Female; Flumazenil; Humans; Male; Middle Aged; Poisoning; Treatment Ou | 1995 |
Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Coma; Double | 1990 |
Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Benzodiazepines; Chromatography, High Pressure Liqu | 1990 |
The use of anexate (Ro 15-1788) in acute self-poisoning with benzodiazepines alone or combined with other drugs--preliminary results.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; | 1988 |
23 other studies available for flumazenil and Poisoning
| Article | Year |
|---|---|
A response to the article, "Flumazenil administration in poisoned pediatric patients".
Topics: Female; Flumazenil; Humans; Male; Poisoning | 2013 |
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie | 2013 |
Flumazenil administration in poisoned pediatric patients.
Topics: Antidotes; California; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; Fem | 2012 |
A response to the letter to the editors about "flumazenil administration in poisoned pediatric patients".
Topics: Female; Flumazenil; Humans; Male; Poisoning | 2012 |
[Poisonings with benzodiazepine-like drugs].
Topics: Acetamides; Antidotes; Azabicyclo Compounds; Flumazenil; Humans; Hypnotics and Sedatives; Norway; Pi | 2003 |
An investigation of flumazenil to antagonize gamma-hydroxybutyrate intoxication in a murine model.
Topics: Animals; Antidotes; Behavior, Animal; Disease Models, Animal; Flumazenil; Mice; Pilot Projects; Pois | 2006 |
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Cross-Sectional Studies; Ethanol; Femal | 2008 |
Flumazenil for coma reversal in children after cannabis.
Topics: Cannabinoids; Child, Preschool; Coma; Flumazenil; Humans; Infant; Infusions, Intravenous; Male; Pois | 1993 |
[The effect of flumazenil administration on acute cocaine intoxication of rats].
Topics: Acute Disease; Animals; Cocaine; Diazepam; Flumazenil; Male; Poisoning; Rats; Rats, Wistar | 1994 |
The relative efficacy of antidotes.
Topics: Antidotes; Atropine; Chelating Agents; Diazepam; Flumazenil; Humans; Naloxone; Poisoning | 1995 |
Continuous flumazenil infusion in the treatment of zolpidem (Ambien) and ethanol coingestion.
Topics: Antidotes; Depressive Disorder; Ethanol; Female; Flumazenil; Humans; Hypnotics and Sedatives; Infusi | 1998 |
Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Flumazenil; Humans; Male; Middl | 2001 |
[Flumazenil-induced contractile seizure in poisoning by a combination of tricyclic antidepressants and benzodiazepine in a young woman].
Topics: Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans; | 1991 |
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip | 1992 |
[Clinical experience in benzodiazepine antagonist].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Female; Flumazenil; Humans; Male; M | 1991 |
Flumazenil.
Topics: Anti-Anxiety Agents; Flumazenil; Humans; Poisoning | 1991 |
[The usefulness of flumazenil in benzodiazepine poisoning].
Topics: Acute Disease; Adult; Aged; Anti-Anxiety Agents; Drug Evaluation; Female; Flumazenil; Glasgow Coma S | 1990 |
Flumazenil therapy in benzodiazepine self-poisoning.
Topics: Adult; Diazepam; Female; Flumazenil; Humans; Lorazepam; Middle Aged; Poisoning | 1991 |
[Benzodiazepine poisoning treated with flumazenil].
Topics: Antidotes; Benzodiazepines; Child; Child, Preschool; Flumazenil; Humans; Male; Poisoning | 1990 |
Acute poisoning treated in the intensive care unit: a case series.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Critical Care; Female; Flumazenil; Humans | 1989 |
[Intentional drug poisoning from the epidemiological, emergency medical and therapeutic viewpoints].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Child; Combined Modality Therapy; Female; Flumazenil; | 1986 |
Clinical experiences with Ro 15-1788 (anexate) in benzodiazepine and mixed-drug overdoses.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic | 1988 |
Biostatistical study of suicide features in Mures County (Romania).
Topics: Adult; Age Distribution; Aged; Alcohol Drinking; Asphyxia; Drowning; Female; Forensic Medicine; Huma | 2009 |