flumazenil has been researched along with Parkinson Disease in 9 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured the tremor clinical rating scale score and acquired DASB and Flumazenil PET scans in 10 patients who presented with essential tremor at different stages of clinical severity." | 3.78 | Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study. ( Figueiras, FP; Gironell, A; Gispert, JD; Herance, JR; Pagonabarraga, J; Pascual-Sedano, B; Trampal, C, 2012) |
| "Flumazenil is a short-acting intravenously administered gamma-aminobutyric acid (GABA) antagonist used to reverse the effects of benzodiazepines." | 2.72 | Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial. ( Ondo, WG; Silay, YS, 2006) |
| "Total motor Unified Parkinson's Disease Rating Scale scores modestly improved (P < 0." | 2.71 | Flumazenil, a GABA antagonist, may improve features of Parkinson's disease. ( Hunter, C; Ondo, WG, 2003) |
| "However, there are few reports on Parkinson's disease(PD) regarding the impairment of GABA/BZR in the cerebral cortex." | 2.40 | [Evaluation of benzodiazepine receptor in the cerebral cortex of Parkinson's disease using 123I-iomazenil SPECT]. ( Kawabata, K; Tachibana, H, 1997) |
| "Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit." | 1.34 | Zolpidem modulates GABA(A) receptor function in subthalamic nucleus. ( Chen, L; Fung, KS; Xie, JX; Yung, WH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gironell, A | 1 |
| Figueiras, FP | 1 |
| Pagonabarraga, J | 1 |
| Herance, JR | 1 |
| Pascual-Sedano, B | 1 |
| Trampal, C | 1 |
| Gispert, JD | 1 |
| Ondo, WG | 2 |
| Hunter, C | 1 |
| Silay, YS | 1 |
| Chen, L | 1 |
| Xie, JX | 1 |
| Fung, KS | 1 |
| Yung, WH | 1 |
| Walsh, TJ | 1 |
| Kawabata, K | 2 |
| Tachibana, H | 2 |
| Sugita, M | 1 |
| Fukuchi, M | 1 |
| Onishi, Y | 1 |
| Yonekura, Y | 1 |
| Tanaka, F | 1 |
| Nishizawa, S | 1 |
| Okazawa, H | 1 |
| Ishizu, K | 1 |
| Fujita, T | 1 |
| Konishi, J | 1 |
| Mukai, T | 1 |
| Orliaguet, G | 1 |
| Nguyen, JP | 1 |
| Abay, K | 1 |
| Berberich, E | 1 |
| Melon, E | 1 |
| Duvaldestin, P | 1 |
2 reviews available for flumazenil and Parkinson Disease
| Article | Year |
|---|---|
Site-specific pharmacology for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Cerebral Cortex; Flumazenil; Hippocampus; Humans; Levodopa; Neuro | 1993 |
[Evaluation of benzodiazepine receptor in the cerebral cortex of Parkinson's disease using 123I-iomazenil SPECT].
Topics: Amphetamines; Animals; Cerebral Cortex; Flumazenil; Humans; Iodine Radioisotopes; Iofetamine; Parkin | 1997 |
3 trials available for flumazenil and Parkinson Disease
| Article | Year |
|---|---|
Flumazenil, a GABA antagonist, may improve features of Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Female; Flumazenil; GABA Antagonists; Humans; Infusions, Intravenous; Ma | 2003 |
Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial.
Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia; Cross-Over Studies; Double-Blind Method; Female; Flum | 2006 |
[Impairment of benzodiazepine receptor in Parkinson's disease evaluated by 123I-iomazenil SPECT].
Topics: Aged; Aged, 80 and over; Cerebral Cortex; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Mi | 1996 |
4 other studies available for flumazenil and Parkinson Disease
| Article | Year |
|---|---|
Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.
Topics: Aged; Cerebellum; Essential Tremor; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Image Proce | 2012 |
Zolpidem modulates GABA(A) receptor function in subthalamic nucleus.
Topics: Animals; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antag | 2007 |
Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding: the optimal scan time.
Topics: Alzheimer Disease; Brain; Case-Control Studies; Cerebral Infarction; Computer Simulation; Dementia, | 1996 |
[Anesthesia for thalamic stimulations: value of flumazenil].
Topics: Adult; Aged; Anesthesia, General; Electric Stimulation; Flumazenil; Humans; Intraoperative Period; M | 1991 |