flumazenil has been researched along with Panic Disorder in 23 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesised that RTD (compared with the control drink) would result in an increase in anxiety symptoms when provoked by a panicogenic challenge with the benzodiazepine antagonist, flumazenil." | 9.15 | Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder. ( Adrover, M; Argyropoulos, S; Bell, C; Frampton, C; Hince, D; Hood, S; Nash, J; Nutt, D; Potokar, J; Rich, A, 2011) |
| "Flumazenil is a benzodiazepine receptor antagonist thought to be panicogenic in patients with panic disorder but not in control subjects." | 9.09 | Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder. ( Holsboer, F; Kellner, M; Ströhle, A; Wiedemann, K, 1999) |
| "Flumazenil is a benzodiazepine receptor antagonist that has been reported to provoke panic attacks in patients with panic disorder." | 9.08 | Effect of flumazenil in lactate-sensitive patients with panic disorder. ( Holsboer, F; Kellner, M; Ströhle, A; Wiedemann, K; Yassouridis, A, 1998) |
| " We hypothesised that RTD (compared with the control drink) would result in an increase in anxiety symptoms when provoked by a panicogenic challenge with the benzodiazepine antagonist, flumazenil." | 5.15 | Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder. ( Adrover, M; Argyropoulos, S; Bell, C; Frampton, C; Hince, D; Hood, S; Nash, J; Nutt, D; Potokar, J; Rich, A, 2011) |
| "Flumazenil is a benzodiazepine receptor antagonist thought to be panicogenic in patients with panic disorder but not in control subjects." | 5.09 | Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder. ( Holsboer, F; Kellner, M; Ströhle, A; Wiedemann, K, 1999) |
| "The benzodiazepine antagonist, flumazenil, can provoke panic attacks in some panic disorder patients." | 5.09 | Flumazenil challenge in social phobia. ( Bell, C; Coupland, NJ; Dorkins, E; Nutt, DJ; Potokar, JP, 2000) |
| "Flumazenil is a benzodiazepine receptor antagonist that has been reported to provoke panic attacks in patients with panic disorder." | 5.08 | Effect of flumazenil in lactate-sensitive patients with panic disorder. ( Holsboer, F; Kellner, M; Ströhle, A; Wiedemann, K; Yassouridis, A, 1998) |
| " We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder." | 3.70 | Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. ( Bell, CJ; Cunningham, VJ; Jones, T; Liddle, PF; Malizia, AL; Nutt, DJ, 1998) |
| "Flumazenil is a relatively pure benzodiazepine/GABAA antagonist with limited intrinsic activity." | 2.68 | Effects of the benzodiazepine antagonist flumazenil in PTSD. ( Bremner, JD; Charney, DS; Heninger, GR; Krystal, JH; Nagy, LM; Nicolaou, AL; Randall, PK, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernik, M | 1 |
| Ramos, RT | 1 |
| Hetem, LAB | 1 |
| Graeff, F | 1 |
| Hasler, G | 1 |
| Nugent, AC | 1 |
| Carlson, PJ | 1 |
| Carson, RE | 1 |
| Geraci, M | 1 |
| Drevets, WC | 1 |
| Suzuki, K | 1 |
| Takano, T | 1 |
| Fujiyama, K | 1 |
| Tanabe, Y | 1 |
| Matsuoka, H | 1 |
| Bell, C | 3 |
| Hood, S | 2 |
| Potokar, J | 2 |
| Nash, J | 2 |
| Adrover, M | 2 |
| Frampton, C | 1 |
| Hince, D | 1 |
| Rich, A | 2 |
| Argyropoulos, S | 2 |
| Nutt, D | 2 |
| Bell, EC | 1 |
| Baker, GB | 1 |
| Poag, C | 1 |
| Bellavance, F | 1 |
| Khudabux, J | 1 |
| Le Mellédo, JM | 2 |
| Cameron, OG | 1 |
| Huang, GC | 1 |
| Nichols, T | 1 |
| Koeppe, RA | 1 |
| Minoshima, S | 1 |
| Rose, D | 1 |
| Frey, KA | 1 |
| Randall, PK | 1 |
| Bremner, JD | 2 |
| Krystal, JH | 1 |
| Nagy, LM | 1 |
| Heninger, GR | 1 |
| Nicolaou, AL | 1 |
| Charney, DS | 2 |
| Kuikka, JT | 1 |
| Pitkänen, A | 1 |
| Lepola, U | 1 |
| Partanen, K | 1 |
| Vainio, P | 1 |
| Bergström, KA | 1 |
| Wieler, HJ | 1 |
| Kaiser, KP | 1 |
| Mittelbach, L | 1 |
| Koponen, H | 1 |
| Bradwejn, J | 1 |
| Koszycki, D | 1 |
| Couëtoux du Tertre, A | 1 |
| Paradis, M | 1 |
| Bourin, M | 1 |
| Schlegel, S | 1 |
| Steinert, H | 1 |
| Bockisch, A | 1 |
| Hahn, K | 1 |
| Schloesser, R | 1 |
| Benkert, O | 1 |
| Ströhle, A | 2 |
| Kellner, M | 2 |
| Yassouridis, A | 1 |
| Holsboer, F | 2 |
| Wiedemann, K | 2 |
| Maddock, RJ | 1 |
| Bernik, MA | 1 |
| Gorenstein, C | 1 |
| Vieira Filho, AH | 1 |
| Malizia, AL | 3 |
| Cunningham, VJ | 1 |
| Bell, CJ | 2 |
| Liddle, PF | 1 |
| Jones, T | 1 |
| Nutt, DJ | 4 |
| Morimoto, K | 1 |
| Lawson, C | 1 |
| Wilson, S | 1 |
| Innis, RB | 1 |
| White, T | 1 |
| Fujita, M | 1 |
| Silbersweig, D | 1 |
| Goddard, AW | 1 |
| Staib, L | 1 |
| Stern, E | 1 |
| Cappiello, A | 1 |
| Woods, S | 1 |
| Baldwin, R | 1 |
| Coupland, NJ | 2 |
| Potokar, JP | 1 |
| Dorkins, E | 1 |
| Van Driel, M | 1 |
| Lott, P | 1 |
| Jhangri, GS | 1 |
| Forshall, S | 1 |
3 reviews available for flumazenil and Panic Disorder
| Article | Year |
|---|---|
The neurobiology of social phobia.
Topics: Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Epinephrine; Female; Flumazenil; Human Growth Horm | 1999 |
[Benzodiazepine receptor imaging in the brain: recent developments and clinical validity].
Topics: Brain; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Flumazenil; Humans; Iodine Radioisotopes; Pani | 1999 |
What do brain imaging studies tell us about anxiety disorders?
Topics: Anxiety Disorders; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Flumazenil; Humans; Pan | 1999 |
12 trials available for flumazenil and Panic Disorder
| Article | Year |
|---|---|
Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients.
Topics: Adult; Anxiety; Female; Fenfluramine; Flumazenil; GABA Modulators; Humans; Male; Middle Aged; Panic | 2019 |
Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder.
Topics: Adult; Anxiety; Cognitive Behavioral Therapy; Cross-Over Studies; Double-Blind Method; Female; Fluma | 2011 |
Response to flumazenil in the late luteal phase and follicular phase of the menstrual cycle in healthy control females.
Topics: Adult; Double-Blind Method; Female; Flumazenil; Follicular Phase; GABA Modulators; gamma-Aminobutyri | 2004 |
Effects of the benzodiazepine antagonist flumazenil in PTSD.
Topics: Anxiety Disorders; Arousal; Combat Disorders; Double-Blind Method; Flumazenil; GABA Modulators; GABA | 1995 |
Effects of flumazenil on cholecystokinin-tetrapeptide-induced panic symptoms in healthy volunteers.
Topics: Adult; Amino Acid Sequence; Cross-Over Studies; Double-Blind Method; Female; Flumazenil; GABA-A Rece | 1994 |
Effect of flumazenil in lactate-sensitive patients with panic disorder.
Topics: Adrenocorticotropic Hormone; Adult; Double-Blind Method; Female; Flumazenil; Heart Rate; Humans; Hyd | 1998 |
Acute effects of low-dose flumazenil in panic disorder.
Topics: Adult; Dose-Response Relationship, Drug; Fear; Female; Flumazenil; GABA Modulators; Heart Rate; Huma | 1998 |
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Flumazenil; GABA Modulat | 1998 |
Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder.
Topics: Adrenocorticotropic Hormone; Adult; Affective Symptoms; Analysis of Variance; Arousal; Behavioral Sy | 1999 |
Flumazenil challenge in social phobia.
Topics: Adult; Anxiety; Benzodiazepines; Blood Pressure; Case-Control Studies; Cross-Over Studies; Double-Bl | 2000 |
Response to flumazenil in women with premenstrual dysphoric disorder.
Topics: Cross-Over Studies; Double-Blind Method; Female; Flumazenil; GABA Modulators; Humans; Luteal Phase; | 2000 |
Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine.
Topics: Adult; Affect; Aged; Agoraphobia; Cross-Over Studies; Double-Blind Method; Female; Flumazenil; GABA | 2002 |
8 other studies available for flumazenil and Panic Disorder
| Article | Year |
|---|---|
Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography.
Topics: Adult; Brain; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Comorbidity; Depressive Disorder | 2008 |
Panic attack associated with flumazenil at electroconvulsive therapy session.
Topics: Electroconvulsive Therapy; Female; Flumazenil; GABA Modulators; Humans; Middle Aged; Panic Disorder; | 2009 |
Reduced gamma-aminobutyric acid(A)-benzodiazepine binding sites in insular cortex of individuals with panic disorder.
Topics: Adult; Binding Sites; Brain; Carbon Radioisotopes; Cerebral Cortex; Comorbidity; Depressive Disorder | 2007 |
Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder.
Topics: Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Panic Disorder; | 1995 |
Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary report.
Topics: Adult; Cerebral Ventricles; Female; Flumazenil; Frontal Lobe; Humans; Male; Occipital Lobe; Panic Di | 1994 |
Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Cerebral Cortex; Female; Flumazenil; Functional Laterality | 1998 |
Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder.
Topics: Confounding Factors, Epidemiologic; Flumazenil; GABA Modulators; Hemodynamics; Humans; Panic Disorde | 1999 |
SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder.
Topics: Adolescent; Adult; Aged; Female; Flumazenil; GABA Modulators; Hippocampus; Humans; Iodine Radioisoto | 2000 |