flumazenil has been researched along with Nerve Degeneration in 9 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the benzodiazepine GABA(A) marker [(11)C] flumazenil to study cerebral dysfunction in amyotrophic lateral sclerosis (ALS) with PET." | 3.70 | Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. ( Al-Chalabi, A; Brooks, DJ; Leigh, PN; Lloyd, CM; Richardson, MP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamauchi, H | 1 |
| Nishii, R | 1 |
| Higashi, T | 1 |
| Kagawa, S | 1 |
| Fukuyama, H | 3 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Pareto, D | 1 |
| Herance, JR | 1 |
| Abad, S | 1 |
| Ruíz, A | 1 |
| Flotats, N | 1 |
| Gispert, JD | 1 |
| Llop, J | 1 |
| Gómez-Vallejo, V | 1 |
| Planas, AM | 1 |
| Abe, K | 1 |
| Kashiwagi, Y | 1 |
| Tokumura, M | 1 |
| Hosoi, R | 1 |
| Hatazawa, J | 1 |
| Inoue, O | 1 |
| Ihara, M | 1 |
| Tomimoto, H | 1 |
| Ishizu, K | 1 |
| Yoshida, H | 1 |
| Sawamoto, N | 1 |
| Hashikawa, K | 2 |
| Torizuka, K | 1 |
| Uemura, K | 1 |
| Toru, M | 1 |
| Shinohara, Y | 1 |
| Nishimura, T | 2 |
| Yonekura, Y | 1 |
| Nakagawara, J | 1 |
| Matsuda, H | 1 |
| Sakai, F | 1 |
| Matsuda, K | 1 |
| Morimoto, K | 1 |
| Moriwaki, H | 1 |
| Matsumoto, M | 1 |
| Oku, N | 1 |
| Ishida, M | 1 |
| Seike, Y | 1 |
| Fujita, M | 1 |
| Fukuchi, K | 1 |
| Watanabe, Y | 1 |
| Terakawa, H | 1 |
| Uehara, T | 1 |
| Itoh, Y | 1 |
| Amano, T | 1 |
| Shimizu, T | 1 |
| Hashimoto, J | 1 |
| Kubo, A | 1 |
| Fukuuchi, Y | 1 |
| Chadha, A | 1 |
| Howell, O | 1 |
| Atack, JR | 1 |
| Sur, C | 1 |
| Duty, S | 1 |
| Lloyd, CM | 1 |
| Richardson, MP | 1 |
| Brooks, DJ | 1 |
| Al-Chalabi, A | 1 |
| Leigh, PN | 1 |
2 trials available for flumazenil and Nerve Degeneration
| Article | Year |
|---|---|
[A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 2)--Report on clinical usefulness in diagnosis of degenerative neurological diseases and mental disorders].
Topics: Adult; Aged; Brain; Female; Flumazenil; GABA-A Receptor Agonists; Humans; Iodine Radioisotopes; Japa | 1996 |
[Evaluation of 123I-iomazenil SPECT in patients with ischemic cerebrovascular disease: comparative study with 123I-IMP SPECT].
Topics: Adult; Aged; Amphetamines; Brain; Cerebrovascular Disorders; Female; Flumazenil; Humans; Iodine Radi | 1996 |
7 other studies available for flumazenil and Nerve Degeneration
| Article | Year |
|---|---|
Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease.
Topics: Aged; Carbon Radioisotopes; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Disease | 2009 |
Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.
Topics: Acute Disease; Animals; Binding Sites; Brain Ischemia; Disease Models, Animal; Flumazenil; Male; Ner | 2011 |
Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats.
Topics: Animals; Autoradiography; Benzazepines; Benzilates; Binding Sites; Binding, Competitive; Cerebral Co | 2004 |
Association of vascular parkinsonism with impaired neuronal integrity in the striatum.
Topics: Aged; Aged, 80 and over; Basal Ganglia; Basal Ganglia Cerebrovascular Disease; Carbon Radioisotopes; | 2007 |
Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease.
Topics: Brain; Brain Chemistry; Cerebellar Ataxia; Creutzfeldt-Jakob Syndrome; Female; Flumazenil; Humans; M | 1998 |
Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion.
Topics: Animals; Autoradiography; Flumazenil; GABA Agonists; GABA Modulators; Globus Pallidus; Male; Nerve D | 2000 |
Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Benzodiazepines; Brain Mapping; Carbon Radioisotopes; Ce | 2000 |