flumazenil has been researched along with Muscle Relaxation in 14 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Combinations using an alpha2-adrenoceptor agonist and ketamine have been shown to be effective for immobilization but are not reversible and can produce severe hypertension and prolonged or rough recoveries." | 3.71 | Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus). ( Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK, 2002) |
| "Diazepam (2 mg/kg) induced significant ataxia and muscle relaxation, which were completely prevented by pretreatment with flumazenil (10 mg/kg) and βCCt (20 mg/kg)." | 1.38 | The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. ( Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML, 2012) |
| " GBL dosing was initiated at 100 mg/kg/day and then progressively increased stepwise by increments of 100 mg/kg to a final dose of 600 mg/kg." | 1.33 | Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons. ( Brown, PR; Froestl, W; Gibson, KM; Goodwin, AK; Griffiths, RR; Jakobs, C; Weerts, EM, 2006) |
| "Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys." | 1.31 | Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil. ( Elías, MM; Monasterolo, LA; Trumper, L, 2002) |
| "For PTZ-induced convulsions, DN-2327, 0." | 1.28 | Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. ( Fukuda, N; Wada, T, 1991) |
| " The drug was administered intramuscularly in ten dogs at a dosage of 10 mg/kg bwt of tiletamine and 10 mg/kg bwt of zolazepam and tested for its effects on hemodynamics, respiration, and the antagonistic effect of flumazenil." | 1.28 | [Anesthesia in dogs with the combination preparation Tilest 500]. ( Hess, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milić, M | 1 |
| Divljaković, J | 1 |
| Rallapalli, S | 1 |
| van Linn, ML | 1 |
| Timić, T | 1 |
| Cook, JM | 1 |
| Savić, MM | 1 |
| Monasterolo, LA | 1 |
| Trumper, L | 1 |
| Elías, MM | 1 |
| Larsen, RS | 1 |
| Loomis, MR | 1 |
| Kelly, BT | 1 |
| Sladky, KK | 1 |
| Stoskopf, MK | 1 |
| Horne, WA | 1 |
| Guerrini, G | 1 |
| Costanzo, A | 1 |
| Ciciani, G | 1 |
| Bruni, F | 1 |
| Selleri, S | 1 |
| Costagli, C | 1 |
| Besnard, F | 1 |
| Costa, B | 1 |
| Martini, C | 1 |
| De Siena, G | 1 |
| Malmberg-Aiello, P | 1 |
| Goodwin, AK | 1 |
| Griffiths, RR | 1 |
| Brown, PR | 1 |
| Froestl, W | 1 |
| Jakobs, C | 1 |
| Gibson, KM | 1 |
| Weerts, EM | 1 |
| Yoon, BH | 1 |
| Jung, JW | 1 |
| Lee, JJ | 1 |
| Cho, YW | 1 |
| Jang, CG | 1 |
| Jin, C | 1 |
| Oh, TH | 1 |
| Ryu, JH | 1 |
| Schwarz, M | 2 |
| Turski, L | 3 |
| Janiszewski, W | 1 |
| Sontag, KH | 2 |
| Havemann, U | 1 |
| Kuschinsky, K | 1 |
| Martin, JR | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Wada, T | 1 |
| Fukuda, N | 1 |
| Hess, L | 1 |
| Haxhiu, MA | 1 |
| van Lunteren, E | 1 |
| Cherniack, NS | 1 |
| Deal, EC | 1 |
| Longo, VG | 1 |
| De Medici, D | 1 |
| Gatta, F | 1 |
| Massotti, M | 1 |
14 other studies available for flumazenil and Muscle Relaxation
| Article | Year |
|---|---|
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Recept | 2012 |
Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil.
Topics: Animals; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Male; Muscle Relaxants, Central; Muscle | 2002 |
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body | 2002 |
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Binding, Competitive; Brain; Cattle; Flumaze | 2006 |
Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Catheters, Indwelling; Conditioning, Operant; Dose-Respo | 2006 |
Anxiolytic-like effects of sinapic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Cerebral Cortex; Chloride Channels; Coumaric Aci | 2007 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscl | 1983 |
Reversal of the muscle relaxant effect of diazepam by the specific benzodiazepine antagonist Ro 15-1788: an electromyographic study in morphine model of muscular rigidity in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Antagonism; Flumazenil; Male; Morphine; | 1983 |
CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; | 1984 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, D | 1995 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diaz | 1991 |
[Anesthesia in dogs with the combination preparation Tilest 500].
Topics: Analgesia; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Dog Diseases | 1991 |
Benzodiazepines acting on ventral surface of medulla cause airway dilation.
Topics: Animals; Atropine; Blood Pressure; Cats; Diazepam; Female; Flumazenil; Lung; Male; Medulla Oblongata | 1989 |
Effects of drugs on the electrical activity of the red nucleus in the rabbit. Activation of benzodiazepine and barbiturate receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; M | 1988 |