flumazenil has been researched along with Muscle Contraction in 17 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Concomitant medication use, such as benzodiazepines, could alter responses to neuromodulation, and so before the development of a clinical trial to confirm translation of this potential therapy, the potential interactions between acute and chronic use of benzodiazepines and bPNS were examined in a preclinical model." | 1.56 | Benzodiazepines Suppress Neuromodulatory Effects of Pudendal Nerve Stimulation on Rat Bladder Nociception. ( Clodfelder-Miller, B; McNaught, J; Nelson, DE; Ness, TJ; Su, X, 2020) |
| "Midazolam has no effect on the release of stored Ca2+." | 1.29 | Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles. ( Kai, T; Kanaide, H; Kobayashi, S; Nishimura, J; Takahashi, S; Yoshimura, H, 1995) |
| "Treatment with diazepam or progabide produced a dose-related reduction of the spontaneous activity measured in the electromyogram." | 1.27 | Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788. ( Schwarz, M; Sontag, KH; Turski, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Perez-Zoghbi, JF | 1 |
| Sajorda, DR | 1 |
| Webb, DA | 1 |
| Arnold, LA | 1 |
| Emala, CW | 1 |
| Yocum, GT | 1 |
| Ness, TJ | 1 |
| McNaught, J | 1 |
| Clodfelder-Miller, B | 1 |
| Nelson, DE | 1 |
| Su, X | 1 |
| Moriyama, T | 1 |
| Tsuneyoshi, I | 1 |
| Kanmura, Y | 1 |
| Fujii, Y | 1 |
| Uemura, A | 1 |
| Toyooka, H | 1 |
| Schwarz, M | 4 |
| Turski, L | 5 |
| Janiszewski, W | 1 |
| Sontag, KH | 4 |
| Khan, AR | 1 |
| Havemann, U | 1 |
| Kuschinsky, K | 1 |
| Yoshimura, H | 1 |
| Kai, T | 1 |
| Nishimura, J | 1 |
| Kobayashi, S | 1 |
| Takahashi, S | 1 |
| Kanaide, H | 1 |
| Chiou, LC | 1 |
| Chang, CC | 1 |
| Smyth, RJ | 1 |
| Uhlman, EJ | 1 |
| Ruggieri, MR | 1 |
| Dhonneur, G | 1 |
| Combes, X | 1 |
| Leroux, B | 1 |
| Duvaldestin, P | 1 |
| Deacon, RM | 1 |
| Budhram, P | 1 |
| Thomson, TA | 1 |
| Gardner, CR | 1 |
| Klockgether, T | 1 |
| Driessen, JJ | 1 |
| Van Egmond, J | 1 |
| Vree, TB | 1 |
| Booij, LH | 1 |
| Crul, JF | 1 |
| Luzzi, S | 1 |
| Spagnesi, S | 1 |
| Franchi-Micheli, S | 1 |
| Rosi, E | 1 |
| Ciuffi, M | 1 |
| Zilletti, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study[NCT01075087] | 19 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 Hour total opioid consumption translated into IV morphine equivalents. (NCT01075087)
Timeframe: 24 hours
| Intervention | miligram IV morphine equivalents (Median) |
|---|---|
| Placebo | 13 |
| Active Comparator | 7.5 |
Quality of Recovery 40 Score at 24 hours postoperative. (NCT01075087)
Timeframe: 24 hours post operatively
| Intervention | units on scale 40 (low) - 200 (high) (Median) |
|---|---|
| Placebo | 170 |
| Active Comparator | 175.5 |
1 trial available for flumazenil and Muscle Contraction
| Article | Year |
|---|---|
Postoperative obstructive apnea.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Diaphragm; Electromyography; Flumazenil; GABA | 1999 |
16 other studies available for flumazenil and Muscle Contraction
| Article | Year |
|---|---|
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
Topics: Animals; Asthma; Calcium; Calcium Signaling; Flumazenil; gamma-Aminobutyric Acid; Inositol; Ligands; | 2022 |
Benzodiazepines Suppress Neuromodulatory Effects of Pudendal Nerve Stimulation on Rat Bladder Nociception.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Female; | 2020 |
Effects of a novel benzodiazepine derivative, JM-1232(-), on human gastroepiploic artery in vitro.
Topics: Dose-Response Relationship, Drug; Endothelium, Vascular; Flumazenil; GABA Modulators; Gastroepiploic | 2011 |
Flumazenil recovers diaphragm muscle dysfunction caused by midazolam in dogs.
Topics: Anesthetics, Intravenous; Animals; Antidotes; Dogs; Dose-Response Relationship, Drug; Electric Stimu | 2002 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscl | 1983 |
Diazepam receptor in frog muscle fibres.
Topics: Animals; Anura; Benzodiazepinones; Diazepam; Flumazenil; Muscle Contraction; Receptors, Cell Surface | 1983 |
Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788.
Topics: Animals; Benzodiazepinones; Diazepam; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; | 1983 |
Reversal of the muscle relaxant effect of diazepam by the specific benzodiazepine antagonist Ro 15-1788: an electromyographic study in morphine model of muscular rigidity in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Antagonism; Flumazenil; Male; Morphine; | 1983 |
CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; | 1984 |
Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles.
Topics: Animals; Anti-Anxiety Agents; Calcium; Drug Interactions; Flumazenil; Fluorometry; GABA Modulators; | 1995 |
Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle.
Topics: Animals; Benzodiazepinones; Diaphragm; Electric Stimulation; Electrophysiology; Female; Flumazenil; | 1994 |
Identification and characterization of a high-affinity peripheral-type benzodiazepine receptor in rabbit urinary bladder.
Topics: Animals; Flumazenil; Flunitrazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Muscle Contrac | 1994 |
Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Drug | 1990 |
ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Carbolines; Convulsants; Diazepam; | 1985 |
The in vitro effects of benzodiazepines on the rat diaphragm. Structure-activity relationships.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diaphragm; Flumazenil; Hydrogen-Ion Concentration; | 1985 |
Diazepam potentiates GABA-contraction in guinea-pig ileum.
Topics: Animals; Baclofen; Benzodiazepinones; Carbolines; Diazepam; Drug Synergism; Electric Stimulation; Fl | 1986 |