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flumazenil and Inflammation

flumazenil has been researched along with Inflammation in 14 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

ExcerptRelevanceReference
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."7.69Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."3.69Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
"Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage."2.50Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014)
"NAFLD is the liver manifestation of metabolic syndrome (MS)."1.40Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study. ( Drazilová, S; Fedacko, J; Gecková, AM; Janicko, M; Jarcuska, P; Kristian, P; Mareková, M; Pella, D; Senajová, G; Siegfried, L; Tkác, M; Veselíny, E, 2014)
"Obesity-induced metabolic syndrome is a multiple risk factor for cardiovascular (CV) risk factors and type 2 diabetes, and ethnic minorities seem to have unfavourable medical risk factors in general more frequently than majority populations."1.40Prevalence of cardiovascular risk factors in relation to metabolic syndrome in the Roma population compared with the non-Roma population in the eastern part of Slovakia. ( Babcák, M; Babinská, I; Cecetková, B; Drazilová, S; Fedacko, J; Gecková, AM; Janicko, M; Jankajová, M; Jarcuska, P; Kalanin, P; Kmec, J; Mareková, M; Pazinka, P; Pella, D; Pella, J; Sabol, F; Siegfried, L; Veselíny, E, 2014)
"At doses producing already maximal antihyperalgesia, HZ166 was devoid of sedation and motor impairment, and showed no loss of analgesic activity during a 9-day chronic treatment period (i."1.37HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. ( Benke, D; Besson, M; Cook, JM; Daali, Y; Desmeules, J; Di Lio, A; Edwankar, R; Wang, ZJ; Zeilhofer, HU, 2011)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's7 (50.00)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Saunders, MJ1
Edwards, BS1
Zhu, J1
Sklar, LA1
Graves, SW1
Ji, MH1
Zhang, L1
Mao, MJ1
Zhang, H1
Yang, JJ1
Qiu, LL1
Kang, Y1
Rúa, SMH1
Kaunzner, UW1
Perumal, J1
Nealon, N1
Qu, W1
Kothari, PJ1
Vartanian, T1
Kuceyeski, A1
Gauthier, SA1
Matsumoto, D1
Ushio, S1
Wada, Y1
Noda, Y1
Esumi, S1
Izushi, Y1
Kitamura, Y1
Sendo, T1
Parente, A1
Vállez García, D1
Shoji, A1
Lopes Alves, I1
Maas, B1
Zijlma, R1
Dierckx, RA1
Buchpiguel, CA1
de Vries, EF1
Doorduin, J1
Heiss, WD2
Di Lio, A1
Benke, D1
Besson, M1
Desmeules, J1
Daali, Y1
Wang, ZJ1
Edwankar, R1
Cook, JM1
Zeilhofer, HU1
Romero Gómez, M1
Bautista, JD1
Grande, L1
Ramos Guerrero, RM1
Sánchez Muñoz, D1
Anseloni, VC1
Gold, MS1
Rahman, AF1
Takahashi, M1
Kaneto, H1
Mediratta, PK1
Sharma, KK1
Singh, S1
Jarcuska, P4
Janicko, M2
Drazilová, S2
Senajová, G1
Veselíny, E2
Fedacko, J2
Siegfried, L2
Kristian, P1
Tkác, M1
Pella, D2
Mareková, M2
Gecková, AM2
Pella, J1
Sabol, F1
Pazinka, P1
Jankajová, M1
Kmec, J1
Babcák, M1
Kalanin, P1
Babinská, I1
Cecetková, B1

Reviews

3 reviews available for flumazenil and Inflammation

ArticleYear
Radionuclide imaging in ischemic stroke.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:11

    Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans;

2014
The ischemic penumbra: how does tissue injury evolve?
    Annals of the New York Academy of Sciences, 2012, Volume: 1268

    Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation;

2012
[New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
    Gastroenterologia y hepatologia, 2004, Volume: 27 Suppl 1

    Topics: Ammonia; Brain; Brain Edema; Dipeptides; Flumazenil; Glutaminase; Glutamine; Hepatic Encephalopathy;

2004

Other Studies

11 other studies available for flumazenil and Inflammation

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr

2010
Overinhibition mediated by parvalbumin interneurons might contribute to depression-like behavior and working memory impairment induced by lipopolysaccharide challenge.
    Behavioural brain research, 2020, 04-06, Volume: 383

    Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fl

2020
A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis.
    Molecular imaging and biology, 2020, Volume: 22, Issue:6

    Topics: Adult; Case-Control Studies; Cohort Studies; Female; Flumazenil; Gray Matter; Humans; Immunity, Inna

2020
Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice.
    European journal of pharmacology, 2021, Aug-05, Volume: 904

    Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Behavior, Animal; Bicuculline; Bumetan

2021
Contribution of neuroinflammation to changes in [
    Nuclear medicine and biology, 2017, Volume: 49

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Flumazenil; Inflammation; Male; Pons; Positron-

2017
HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
    Neuropharmacology, 2011, Volume: 60, Issue:4

    Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Rece

2011
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
    The journal of pain, 2008, Volume: 9, Issue:8

    Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA

2008
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:4

    Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm

1994
Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action.
    Journal of ethnopharmacology, 2002, Volume: 80, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Diazepam; Erythrocytes; Flumazenil; Foot; GABA

2002
Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study.
    Central European journal of public health, 2014, Volume: 22 Suppl

    Topics: Adolescent; Adult; C-Reactive Protein; Comorbidity; Cross-Sectional Studies; Diet; Fatty Liver; Fema

2014
Prevalence of cardiovascular risk factors in relation to metabolic syndrome in the Roma population compared with the non-Roma population in the eastern part of Slovakia.
    Central European journal of public health, 2014, Volume: 22 Suppl

    Topics: Adolescent; Adult; Age Distribution; Body Mass Index; Cardiovascular Diseases; Comorbidity; Dyslipid

2014