flumazenil has been researched along with Infarction, Middle Cerebral Artery in 15 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "PET allowed prediction of malignant MCA infarction within the time window suggested for hemicraniectomy." | 2.71 | Prediction of malignant course in MCA infarction by PET and microdialysis. ( Bosche, B; Brinker, G; Dohmen, C; Graf, R; Heiss, WD; Kracht, L; Neveling, M; Sobesky, J; Staub, F, 2003) |
| "Malignant MCA infarction seems to be determined more by the volume of severe perfusional deficit than that of total perfusional deficit." | 1.38 | The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction. ( Bosche, B; Dohmen, C; Galldiks, N; Graf, R; Kracht, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hughes, JL | 1 |
| Beech, JS | 1 |
| Jones, PS | 1 |
| Wang, D | 1 |
| Menon, DK | 1 |
| Aigbirhio, FI | 1 |
| Fryer, TD | 1 |
| Baron, JC | 2 |
| Schirrmacher, R | 2 |
| Dea, M | 1 |
| Heiss, WD | 3 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 2 |
| Yamauchi, H | 3 |
| Kagawa, S | 2 |
| Kishibe, Y | 1 |
| Takahashi, M | 1 |
| Higashi, T | 2 |
| Massaweh, G | 1 |
| Schirrmacher, E | 1 |
| la Fougere, C | 1 |
| Kovacevic, M | 1 |
| Wängler, C | 1 |
| Jolly, D | 1 |
| Gravel, P | 1 |
| Reader, AJ | 1 |
| Nishii, R | 1 |
| Fukuyama, H | 1 |
| Chida, K | 1 |
| Ogasawara, K | 1 |
| Kuroda, H | 1 |
| Aso, K | 1 |
| Kobayashi, M | 1 |
| Fujiwara, S | 1 |
| Yoshida, K | 1 |
| Terasaki, K | 1 |
| Ogawa, A | 1 |
| Dohmen, C | 3 |
| Galldiks, N | 1 |
| Bosche, B | 3 |
| Kracht, L | 3 |
| Graf, R | 3 |
| Molinaro, P | 1 |
| Cantile, M | 1 |
| Cuomo, O | 1 |
| Secondo, A | 1 |
| Pannaccione, A | 1 |
| Ambrosino, P | 1 |
| Pignataro, G | 1 |
| Fiorino, F | 1 |
| Severino, B | 1 |
| Gatta, E | 1 |
| Sisalli, MJ | 1 |
| Milanese, M | 1 |
| Scorziello, A | 1 |
| Bonanno, G | 1 |
| Robello, M | 1 |
| Santagada, V | 1 |
| Caliendo, G | 1 |
| Di Renzo, G | 1 |
| Annunziato, L | 1 |
| Staub, F | 2 |
| Sobesky, J | 2 |
| Neveling, M | 1 |
| Brinker, G | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Toyota, S | 1 |
| Valentino, M | 1 |
| Abe, K | 1 |
| Kashiwagi, Y | 1 |
| Tokumura, M | 1 |
| Hosoi, R | 1 |
| Hatazawa, J | 1 |
| Inoue, O | 1 |
| Giffard, C | 1 |
| Landeau, B | 1 |
| Kerrouche, N | 1 |
| Young, AR | 1 |
| Barré, L | 1 |
| Koshi, Y | 1 |
| Kitamura, S | 1 |
| Ohyama, M | 1 |
| Komiyama, T | 1 |
| Komaba, Y | 1 |
| Sakayori, O | 1 |
| Mishina, M | 1 |
| Ishiwata, A | 1 |
| Terashi, A | 1 |
| Katayama, Y | 1 |
1 trial available for flumazenil and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Prediction of malignant course in MCA infarction by PET and microdialysis.
Topics: Biomarkers; Blood Flow Velocity; Brain Edema; Carbon Radioisotopes; Cerebrovascular Circulation; Dis | 2003 |
14 other studies available for flumazenil and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Early-stage
Topics: Animals; Antigens, Nuclear; Cerebral Infarction; Female; Flumazenil; Immunohistochemistry; Infarctio | 2020 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Progressive Cortical Neuronal Damage and Chronic Hemodynamic Impairment in Atherosclerotic Major Cerebral Artery Disease.
Topics: Aged; Carotid Artery Diseases; Cerebral Arterial Diseases; Cerebral Cortex; Cerebrovascular Circulat | 2016 |
Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke.
Topics: Brain Ischemia; Flumazenil; Fluorine Radioisotopes; Humans; Infarction, Middle Cerebral Artery; Posi | 2009 |
Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease.
Topics: Aged; Carbon Radioisotopes; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Disease | 2009 |
Central benzodiazepine receptor binding potential and CBF images on SPECT correlate with oxygen extraction fraction images on PET in the cerebral cortex with unilateral major cerebral artery occlusive disease.
Topics: Adult; Aged; Arterial Occlusive Diseases; Basal Ganglia; Carotid Stenosis; Cerebellum; Cerebral Cort | 2011 |
[Ischemic cortical neuronal damage and cognitive impairments in atherosclerotic occlusive disease of the major cerebral artery: a PET study].
Topics: Aged; Brain Ischemia; Carbon Radioisotopes; Carotid Artery Diseases; Cerebral Cortex; Cognition Diso | 2011 |
The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction.
Topics: Aged; Brain Edema; Cerebrovascular Circulation; Chi-Square Distribution; Decompressive Craniectomy; | 2012 |
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA | 2013 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis.
Topics: Amino Acids; Animals; Brain Edema; Cats; Cerebral Infarction; Cerebrovascular Circulation; Flumazeni | 2003 |
Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats.
Topics: Animals; Autoradiography; Benzazepines; Benzilates; Binding Sites; Binding, Competitive; Cerebral Co | 2004 |
Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?
Topics: Animals; Brain Ischemia; Carbon Isotopes; Cerebral Cortex; Chronic Disease; Flumazenil; Hemodynamics | 2008 |
Benzodiazepine receptor imaging with iomazenil SPECT in aphasic patients with cerebral infarction.
Topics: Aged; Aphasia; Brain; Cerebrovascular Circulation; Female; Flumazenil; Functional Laterality; Humans | 1999 |