flumazenil has been researched along with Idiopathic Parkinson Disease in 9 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured the tremor clinical rating scale score and acquired DASB and Flumazenil PET scans in 10 patients who presented with essential tremor at different stages of clinical severity." | 3.78 | Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study. ( Figueiras, FP; Gironell, A; Gispert, JD; Herance, JR; Pagonabarraga, J; Pascual-Sedano, B; Trampal, C, 2012) |
| "Flumazenil is a short-acting intravenously administered gamma-aminobutyric acid (GABA) antagonist used to reverse the effects of benzodiazepines." | 2.72 | Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial. ( Ondo, WG; Silay, YS, 2006) |
| "Total motor Unified Parkinson's Disease Rating Scale scores modestly improved (P < 0." | 2.71 | Flumazenil, a GABA antagonist, may improve features of Parkinson's disease. ( Hunter, C; Ondo, WG, 2003) |
| "However, there are few reports on Parkinson's disease(PD) regarding the impairment of GABA/BZR in the cerebral cortex." | 2.40 | [Evaluation of benzodiazepine receptor in the cerebral cortex of Parkinson's disease using 123I-iomazenil SPECT]. ( Kawabata, K; Tachibana, H, 1997) |
| "Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit." | 1.34 | Zolpidem modulates GABA(A) receptor function in subthalamic nucleus. ( Chen, L; Fung, KS; Xie, JX; Yung, WH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gironell, A | 1 |
| Figueiras, FP | 1 |
| Pagonabarraga, J | 1 |
| Herance, JR | 1 |
| Pascual-Sedano, B | 1 |
| Trampal, C | 1 |
| Gispert, JD | 1 |
| Ondo, WG | 2 |
| Hunter, C | 1 |
| Silay, YS | 1 |
| Chen, L | 1 |
| Xie, JX | 1 |
| Fung, KS | 1 |
| Yung, WH | 1 |
| Walsh, TJ | 1 |
| Kawabata, K | 2 |
| Tachibana, H | 2 |
| Sugita, M | 1 |
| Fukuchi, M | 1 |
| Onishi, Y | 1 |
| Yonekura, Y | 1 |
| Tanaka, F | 1 |
| Nishizawa, S | 1 |
| Okazawa, H | 1 |
| Ishizu, K | 1 |
| Fujita, T | 1 |
| Konishi, J | 1 |
| Mukai, T | 1 |
| Orliaguet, G | 1 |
| Nguyen, JP | 1 |
| Abay, K | 1 |
| Berberich, E | 1 |
| Melon, E | 1 |
| Duvaldestin, P | 1 |
2 reviews available for flumazenil and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Site-specific pharmacology for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Cerebral Cortex; Flumazenil; Hippocampus; Humans; Levodopa; Neuro | 1993 |
[Evaluation of benzodiazepine receptor in the cerebral cortex of Parkinson's disease using 123I-iomazenil SPECT].
Topics: Amphetamines; Animals; Cerebral Cortex; Flumazenil; Humans; Iodine Radioisotopes; Iofetamine; Parkin | 1997 |
3 trials available for flumazenil and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Flumazenil, a GABA antagonist, may improve features of Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Female; Flumazenil; GABA Antagonists; Humans; Infusions, Intravenous; Ma | 2003 |
Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial.
Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia; Cross-Over Studies; Double-Blind Method; Female; Flum | 2006 |
[Impairment of benzodiazepine receptor in Parkinson's disease evaluated by 123I-iomazenil SPECT].
Topics: Aged; Aged, 80 and over; Cerebral Cortex; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Mi | 1996 |
4 other studies available for flumazenil and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.
Topics: Aged; Cerebellum; Essential Tremor; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Image Proce | 2012 |
Zolpidem modulates GABA(A) receptor function in subthalamic nucleus.
Topics: Animals; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antag | 2007 |
Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding: the optimal scan time.
Topics: Alzheimer Disease; Brain; Case-Control Studies; Cerebral Infarction; Computer Simulation; Dementia, | 1996 |
[Anesthesia for thalamic stimulations: value of flumazenil].
Topics: Adult; Aged; Anesthesia, General; Electric Stimulation; Flumazenil; Humans; Intraoperative Period; M | 1991 |