flumazenil has been researched along with Hypoxia in 13 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not known whether hypoxia, associated with upper gastrointestinal endoscopic procedures when midazolam sedation is used without narcotics, persists into the post-procedure recovery period." | 9.07 | The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP. ( Bibbey, D; Green, JR; Haines, DJ, 1992) |
| "The purpose of this study was to investigate whether increases in gamma-aminobutyric acid (GABA) in the brain stem underlie the ventilatory decline observed during hypoxia in man." | 7.68 | Effects of midazolam and flumazenil on ventilation during sustained hypoxia in humans. ( Dorrington, KL; Nagyova, B; Robbins, PA, 1993) |
| " Ventilatory responses to carbon dioxide and to isocapnic hypoxia were determined during four treatment phases: (1) baseline, (2) alfentanil infusion; (3) combined midazolam and alfentanil infusions, and (4) combined alfentanil, midazolam, and "study drug" (consisting of either flumazenil or flumazenil vehicle) infusions." | 5.08 | Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanil. ( Blouin, RT; Conard, PF; Gross, JB; Häussler, J; Zandsberg, S, 1996) |
| "It is not known whether hypoxia, associated with upper gastrointestinal endoscopic procedures when midazolam sedation is used without narcotics, persists into the post-procedure recovery period." | 5.07 | The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP. ( Bibbey, D; Green, JR; Haines, DJ, 1992) |
| "The purpose of this study was to investigate whether increases in gamma-aminobutyric acid (GABA) in the brain stem underlie the ventilatory decline observed during hypoxia in man." | 3.68 | Effects of midazolam and flumazenil on ventilation during sustained hypoxia in humans. ( Dorrington, KL; Nagyova, B; Robbins, PA, 1993) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| "Northern-hemisphere hypoxia- and anoxia-tolerant vertebrates that over-winter under ice alter their inhibitory to excitatory neurotransmitter balance to forestall brain ATP depletion in the absence of oxidative phosphorylation." | 1.36 | Ecophysiology of neuronal metabolism in transiently oxygen-depleted environments: evidence that GABA is accumulated pre-synaptically in the cerebellum. ( Dodd, PR; Renshaw, GM; Wise, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heiss, WD | 1 |
| Hung, A | 1 |
| Marshall, J | 1 |
| Barnett, S | 1 |
| Falchuk, ZM | 1 |
| Sawhney, M | 1 |
| Leffler, DA | 1 |
| Renshaw, GM | 1 |
| Wise, G | 1 |
| Dodd, PR | 1 |
| Cury, AF | 1 |
| Vieira, ML | 1 |
| Fischer, CH | 1 |
| Rodrigues, AC | 1 |
| Cordovil, A | 1 |
| Monaco, C | 1 |
| Naccarato, GA | 1 |
| Tavares, G | 1 |
| Lira Filho, EB | 1 |
| Guimarães, LA | 1 |
| Morhy, SS | 1 |
| Gerónimo Pardo, M | 1 |
| Mateo Cerdán, CM | 1 |
| Moreno Salcedo, JM | 1 |
| Nagyova, B | 1 |
| Dorrington, KL | 1 |
| Robbins, PA | 1 |
| Torjman, M | 2 |
| Mora, CT | 2 |
| White, PF | 2 |
| Blouin, RT | 2 |
| Conard, PF | 2 |
| Perreault, S | 1 |
| Gross, JB | 2 |
| Zandsberg, S | 1 |
| Häussler, J | 1 |
| Luotio, K | 1 |
| Mattila, MA | 1 |
| Haines, DJ | 1 |
| Bibbey, D | 1 |
| Green, JR | 1 |
1 review available for flumazenil and Hypoxia
| Article | Year |
|---|---|
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
3 trials available for flumazenil and Hypoxia
| Article | Year |
|---|---|
The effect of flumazenil on midazolam-induced depression of the ventilatory response to hypoxia during isohypercarbia.
Topics: Adult; Depression, Chemical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interaction | 1993 |
Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanil.
Topics: Adult; Alfentanil; Analgesics, Opioid; Antidotes; Benzodiazepines; Carbon Dioxide; Conscious Sedatio | 1996 |
The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP.
Topics: Aged; Aged, 80 and over; Cholangiopancreatography, Endoscopic Retrograde; Double-Blind Method; Femal | 1992 |
9 other studies available for flumazenil and Hypoxia
| Article | Year |
|---|---|
Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy.
Topics: Age Factors; Anti-Arrhythmia Agents; Antidotes; Atropine; Body Mass Index; Bradycardia; Case-Control | 2016 |
Ecophysiology of neuronal metabolism in transiently oxygen-depleted environments: evidence that GABA is accumulated pre-synaptically in the cerebellum.
Topics: Acclimatization; Animals; Cerebellum; Chromatography, High Pressure Liquid; Energy Metabolism; Fluma | 2010 |
Safety of transesophageal echocardiography in adults: study in a multidisciplinary hospital.
Topics: Aged; Anesthetics, Intravenous; Brazil; Conscious Sedation; Dose-Response Relationship, Drug; Echoca | 2009 |
[Transient decerebrate rigidity from hypoxemia during administration of propofol, midazolam-flumazenil, and remifentanil-naloxone].
Topics: Airway Obstruction; Anesthetics, Intravenous; Bradycardia; Cardiotonic Agents; Cholangiopancreatogra | 2010 |
Effects of midazolam and flumazenil on ventilation during sustained hypoxia in humans.
Topics: Adult; Analysis of Variance; Brain Stem; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypoxia; Infus | 1993 |
Does flumazenil antagonize midazolam-induced depression of ventilatory response to hypoxia?
Topics: Depression, Chemical; Flumazenil; Humans; Hypoxia; Midazolam; Respiration, Artificial | 1994 |
[Parenteral sedation in oral surgical procedures].
Topics: Antidotes; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Hypoxia; Infusions, Pa | 1996 |
Flumazenil and hypoxic ventilatory response.
Topics: Diazepam; Flumazenil; Humans; Hypoxia; Respiration | 1990 |
Effects of diazepam and flumazenil on sedation and hypoxic ventilatory response.
Topics: Adult; Brain; Diazepam; Flumazenil; Humans; Hypnotics and Sedatives; Hypoxia; Respiration | 1989 |