flumazenil has been researched along with Hypothermia in 6 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three behavioral tests, namely, runway activity, horizontal dowel test and hypothermia, were used to compare the effects of Ro15-1788, a specific benzodiazepine antagonist, on the common neuropharmacological actions of chlordiazepoxide (CDP) and ethanol in C57BL/6J mice." | 3.67 | Differential effects of Ro15-1788 in actions of chlordiazepoxide and ethanol. ( Aldrich-Castanik, L; Chan, AW; Langan, MC; Leong, FW; Penetrante, ML; Schanley, DL, 1988) |
| " GHB is frequently combined with other recreational drugs although these interactions are not well characterised." | 1.35 | Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry. ( McGregor, IS; van Nieuwenhuijzen, PS, 2009) |
| "Flumazenil treatment of ethanol-dependent mice 14 hr before isolation of brain membrane vesicles partially reversed the augmentation of Ro15-4513 inhibition of muscimol-stimulated 36Cl- uptake in vitro." | 1.28 | Reversal of alcohol dependence and tolerance by a single administration of flumazenil. ( Buck, KJ; Harris, RA; Heim, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Nieuwenhuijzen, PS | 1 |
| McGregor, IS | 2 |
| Dastur, FN | 1 |
| McLellan, RA | 1 |
| Brown, RE | 1 |
| Buck, KJ | 1 |
| Heim, H | 1 |
| Harris, RA | 1 |
| Syapin, PJ | 1 |
| Jones, BL | 1 |
| Kobayashi, LS | 1 |
| Finn, DA | 1 |
| Alkana, RL | 1 |
| Chan, AW | 1 |
| Langan, MC | 1 |
| Schanley, DL | 1 |
| Penetrante, ML | 1 |
| Leong, FW | 1 |
| Aldrich-Castanik, L | 1 |
| Taylor, SC | 1 |
| Little, HJ | 1 |
| Nutt, DJ | 1 |
| Sellars, N | 1 |
6 other studies available for flumazenil and Hypothermia
| Article | Year |
|---|---|
Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry.
Topics: Animals; Baclofen; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance | 2009 |
Cannabinoid modulation of rat pup ultrasonic vocalizations.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Body Temperature; C | 1996 |
Reversal of alcohol dependence and tolerance by a single administration of flumazenil.
Topics: Alcoholism; Animals; Ataxia; Behavior, Animal; Brain; Carbolines; Chlorides; Drug Administration Sch | 1991 |
Interactions between benzodiazepine antagonists, inverse agonists, and acute behavioral effects of ethanol in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA-A Rece | 1990 |
Differential effects of Ro15-1788 in actions of chlordiazepoxide and ethanol.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Drug Interactions; Ethanol; Flumazenil; Hypothermia; Ma | 1988 |
A benzodiazepine agonist and contragonist have hypothermic effects in rodents.
Topics: Animals; Benzodiazepinones; Body Temperature; Carbolines; Convulsants; Flumazenil; Flurazepam; Hypot | 1985 |